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Trial Title:
Comparision of Various Biomarkers Between Peripheral and Pulmonary Blood
NCT ID:
NCT05587114
Condition:
Lung Cancer
Diagnosis
Conditions: Official terms:
Lung Neoplasms
Conditions: Keywords:
Exosome
biomarker
lung cancer
diagnosis
prognosis
liquid biopsy
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Retrospective
Intervention:
Intervention type:
Diagnostic Test
Intervention name:
frozen blood plasma samples
Description:
Analysis of various biomarkers using frozen blood samples
Summary:
Lung cancer is a leading cause of cancer death worldwide. Early diagnosis is linked to a
better prognosis. Further, surgical resection at the early stages of non-small cell lung
cancer (NSCLC) results in markedly improved survival rates. Computed tomography (CT)- or
bronchoscopy-guided needle biopsies are standard definitive diagnostic procedures for
lung cancer and are used to obtain tissue for pathological examination. However, these
procedures are invasive, difficult to repeat, expensive, and risk exposure to radiation.
Conversely, liquid biopsies, such as circulating tumor cells (CTCs), circulating tumor
DNA (ctDNA), and extracellular vesicles (EVs), are simple and less invasive procedures
that can be repeated more frequently than tissue biopsies.
This study is a retrospective blood sample obtained and prospectively comparative
analysis of various biomarkers (cancer markers, and exosome markers) derived from
peripheral blood and pulmonary venous blood from patients who underwent lung cancer
surgery.
And treatment monitoring using biomarkers compare with peripheral and pulmonary blood.
Criteria for eligibility:
Study pop:
For this study, Koreans, regardless of gender, were studied for adults over 40 years of
age.
Blood plasma samples are optained from stored in the biobank of Korea University Guro
Hospital or the Department of Thoracic and Cardiovascular Surgery of Korea University
Guro Hospital
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- Adults with Korean nationality
- Patients who did not receive neoadjuvant therapy before surgery
- Patients not diagnosed with any other cancer before surgery
- Patients who agreed to the consent form for a donation of human materials during
surgery
Exclusion Criteria:
- Patients who do not meet the inclusion criteria
Gender:
All
Minimum age:
40 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Korea University Guro Hospital
Address:
City:
Seoul
Zip:
08308
Country:
Korea, Republic of
Status:
Recruiting
Contact:
Last name:
Byeong Hyeon Choi, PhD
Phone:
82-2-2626-1978
Email:
bhchoi1001@korea.ac.kr
Contact backup:
Last name:
Seunghoe Song, MBE
Phone:
82-2-2626-1635
Email:
ssessong@korea.ac.kr
Start date:
October 13, 2022
Completion date:
December 31, 2025
Lead sponsor:
Agency:
Korea University Guro Hospital
Agency class:
Other
Source:
Korea University Guro Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05587114
