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Trial Title:
68Ga-N188 PET/CT Imaging in Malignancy
NCT ID:
NCT05593107
Condition:
Neoplasms
Conditions: Official terms:
Neoplasms
Conditions: Keywords:
[68Ga]N188
Nectin-4
PET/CT
Neoplasms
Study type:
Interventional
Study phase:
N/A
Overall status:
Recruiting
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Primary purpose:
Diagnostic
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
[68Ga]N188
Description:
68Ga-N188 is injected intravenously with a dose of 0.06-0.08 mCi/kg.
Arm group label:
[68Ga]N188
Other name:
68Ga-N188
Other name:
Nectin-4 specific PET imaging
Summary:
The Nectin-4 protein belongs to the cell adhesion factors family and has a
tissue-specific expression spectrum in normal human tissues. However, Nectin-4 is
overexpressed in various malignancies, especially those of epithelial origins, such as
uroepithelial carcinoma, making Nectin-4 a highly specific and significant imaging target
for malignancies.
[68Ga]N188, a novel molecular probe of PET imaging agent that targets Nectin-4, can be
used in the diagnosis and research of a wide variety of Nectin-4 high-expression
malignancies, including bladder cancer.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- patients with confirmed or suspected cancer;
- 18F-FDG PET/CT within 1 week;
- Signed written informed consent.
Exclusion Criteria:
- Pregnant and lactating women;
- Female patients plan to become pregnant within 6 months.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
Accepts Healthy Volunteers
Locations:
Facility:
Name:
Peking University First Hospital
Address:
City:
Beijing
Zip:
100034
Country:
China
Status:
Recruiting
Contact:
Last name:
Jianhua Zhang
Phone:
+861083572791
Email:
zjhjn820@163.com
Investigator:
Last name:
Jianhua Zhang, Dr.
Email:
Principal Investigator
Start date:
August 12, 2022
Completion date:
July 31, 2025
Lead sponsor:
Agency:
Peking University First Hospital
Agency class:
Other
Source:
Peking University First Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05593107
