To hear about similar clinical trials, please enter your email below
Trial Title:
Two Bed SPECT/CT Versus Planar Bone Scintigraphy in Detection of Osseous Metastases in Patients With Genitourinary Malignancies
NCT ID:
NCT05597215
Condition:
Bone Metastases
Urogenital Cancer
Conditions: Official terms:
Neoplasm Metastasis
Urogenital Neoplasms
Technetium Tc 99m Medronate
Conditions: Keywords:
Bone scintigraphy
Study type:
Observational
Overall status:
Not yet recruiting
Study design:
Time perspective:
Prospective
Intervention:
Intervention type:
Radiation
Intervention name:
Tc-99m MDP and gamma camera
Description:
Injection of radioactive element (Tc-99m MDP) then imaging with gamma camera and low dose
CT (SPECT/CT)
Summary:
The study aims to compare the diagnostic performance of planar bone scan and two bed
SPECT/CT in detection of bone metastases in patients with urogenital cancer.
Detailed description:
Genitourinary malignancies represent a heterogeneous group of diseases linked by
anatomical and physiological function. Renal cell carcinoma (RCC); urothelial carcinoma
of the bladder, ureter, and renal pelvis, and prostate adenocarcinoma (PC) are the most
commonly encountered histological subtypes within this group. Planar bone scintigraphy
(PBS) with di-phosphonate compounds is widely used, cost-effective and sensitive imaging
modality for detecting osseous metastases especially in prostate cancer. However, it
suffers from low specificity as well as low sensitivity in purely osteolytic lesions.
Single-photon emission computed tomography (SPECT) is a three-dimensional acquisition
method that has demonstrated greater sensitivity and specificity compared to planar
images, especially for detecting vertebral metastases. The introduction of SPECT/CT
images improves the lesion-to-background ratio, allows anatomic lesion localization,
removes the superimposition of anatomical structures, such as urinary bladder activity,
and provides anatomical data, thereby increasing the sensitivity, specificity and
positive predictive value of bone scan. As the technology advances, current SPECT/CT
machines have become capable of sequentially covering, and accurately merging, more than
one field of view (FOV) in a reasonable time. In this study, we aim to compare the
diagnostic performance of two-bed SPECT/CT images and planar bone scintigraphy in
detection of bone metastases in genitourinary malignancies.
Criteria for eligibility:
Study pop:
All adult patients with known genitourinary cancer who are referred for bone scan as a
part of metastatic workup.
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- Adult patients with urogenital cancer referred for bone scan.
Exclusion Criteria:
- Patients with claustrophobia.
- Patients refuse to do the scan.
- Patients with relative or absolute contraindications to do the scan (eg. pregnancy).
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Start date:
December 2022
Completion date:
December 2024
Lead sponsor:
Agency:
Assiut University
Agency class:
Other
Source:
Assiut University
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05597215
