Trial Title:
Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation
NCT ID:
NCT05609578
Condition:
Advanced NSCLC
Metastatic Lung Cancer
Conditions: Official terms:
Lung Neoplasms
Carboplatin
Pembrolizumab
Pemetrexed
Adagrasib
Conditions: Keywords:
KRAS G12C
NSCLC
Non Small Cell Lung Cancer
Study type:
Interventional
Study phase:
Phase 2
Overall status:
Recruiting
Study design:
Allocation:
Non-Randomized
Intervention model:
Sequential Assignment
Primary purpose:
Treatment
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
Adagrasib oral dose of 400 mg twice daily tablets
Description:
oral dose of 400 mg twice daily tablets
Arm group label:
Cohort A: PD-L1 TPS≥ 1% (Closed)
Arm group label:
Cohort C
Arm group label:
Cohort E
Intervention type:
Combination Product
Intervention name:
Pembrolizumab
Description:
IV infusion once every 3 weeks
Arm group label:
Cohort C
Arm group label:
Cohort E
Intervention type:
Combination Product
Intervention name:
Chemotherapy: Pemetrexed
Description:
IV infusion once every 3 weeks
Arm group label:
Cohort C
Arm group label:
Cohort E
Intervention type:
Combination Product
Intervention name:
Cisplatin/Carboplatin
Description:
IV infusion once every 3 weeks
Arm group label:
Cohort C
Arm group label:
Cohort E
Summary:
Study CA239-0010 is an open-label, Phase 2 clinical trial evaluating the clinical
efficacy of adagrasib in combination with pembrolizumab and chemotherapy in the
first-line setting for patients with advanced NSCLC with TPS ≥ 1%, TPS <50% and KRAS G12C
mutation
Criteria for eligibility:
Criteria:
Cohort A* (closed): Has an untreated and unresectable or metastatic NSCLC with
histologically confirmed (squamous or nonsquamous) KRASG12C mutation and histologically
confirmed PD-L1 TPS ≥1%.
- Cohort C: Has an untreated and unresectable or metastatic NSCLC with histologically
confirmed (non-squamous only) KRASG12C mutation and histologically confirmed PD-L1
TPS < 50% AND previously completed 4 cycles of standard-of-care platinum based
induction chemotherapy with pembrolizumab AND experienced stable disease, partial
response, or complete response per investigator's assessment after 4 cycles OR if
patients received <4 cycles of a platinum-based induction, was stopped early due to
intolerable toxicity
- Cohort E: Has an untreated and unresectable or metastatic NSCLC with histologically
confirmed (non-squamous only) KRASG12C mutation and histologically confirmed PD-L1
TPS < 50%
- Presence of measurable disease per RECIST v1.1
Exclusion Criteria:
- All Cohorts: Any prior therapy targeting KRASG12C mutation in any setting
- Cohorts A & E: Prior systemic therapy for locally advanced or metastatic NSCLC,
including chemotherapy, immune checkpoint inhibitor therapy or chemoimmunotherapy
(note: prior systemic therapy or chemoradiation given in the adjuvant or neoadjuvant
setting are allowed if last dose of prior systemic treatment was >1 year prior to
first dose of study treatment)
- Cohort C: received maintenance therapy (e.g, pembrolizumab and/or pemetrexed
following completion of 4-6 cycles of a platinum-based regimen administered in the
first-line setting
- Radiation to the lung > 30 Gy within 6 months prior to first dose of study treatment
- Active brain metastases
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Local Institution - Unk025
Address:
City:
Anchorage
Zip:
99508
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Local Institution - 017-591
Address:
City:
Glendale
Zip:
85304
Country:
United States
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-821
Address:
City:
Phoenix
Zip:
85004
Country:
United States
Status:
Withdrawn
Facility:
Name:
Local Institution - Unk047
Address:
City:
Anaheim
Zip:
92805
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Local Institution - 017-936C
Address:
City:
Fountain Valley
Zip:
92708
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-936C
Facility:
Name:
MemorialCare - Orange Coast Medical Center
Address:
City:
Fountain Valley
Zip:
92708
Country:
United States
Status:
Recruiting
Contact:
Last name:
Amol Rao, Site 017-936
Phone:
510673-1293
Facility:
Name:
Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton
Address:
City:
Fullerton
Zip:
92835
Country:
United States
Status:
Recruiting
Contact:
Last name:
David Park, Site 017-851
Phone:
310-794-5517
Facility:
Name:
Local Institution - Unk004
Address:
City:
Loma Linda
Zip:
92354
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Local Institution - 017-961
Address:
City:
Los Angeles
Zip:
90095
Country:
United States
Status:
Withdrawn
Facility:
Name:
UCSF Helen Diller Family Comprehensive Cancer Center
Address:
City:
San Francisco
Zip:
94158
Country:
United States
Status:
Recruiting
Contact:
Last name:
Collin Blakely, Site 017-540
Phone:
415-514-6241
Facility:
Name:
Local Institution - 017-872-I
Address:
City:
Aurora
Zip:
80012
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-872-I
Facility:
Name:
Local Institution - 017-872-G
Address:
City:
Boulder
Zip:
80303
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-872-G
Facility:
Name:
Local Institution - 017-872-D
Address:
City:
Colorado Springs
Zip:
80907
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-872-D
Facility:
Name:
Local Institution - 017-872-J
Address:
City:
Colorado Springs
Zip:
80920
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-872-J
Facility:
Name:
Local Institution - 017-872-B
Address:
City:
Denver
Zip:
80218
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-872-B
Facility:
Name:
Local Institution - 017-872-F
Address:
City:
Denver
Zip:
80220
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-872-F
Facility:
Name:
Local Institution - 017-872-A
Address:
City:
Lakewood
Zip:
80228
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-872-A
Facility:
Name:
Local Institution - 017-872-C
Address:
City:
Littleton
Zip:
80218
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-872-C
Facility:
Name:
USOR - Rocky Mountain Cancer Centers - Lone Tree
Address:
City:
Lone Tree
Zip:
80124
Country:
United States
Status:
Recruiting
Contact:
Last name:
Robert Jotte, Site 017-872
Phone:
303-430-2700
Facility:
Name:
Local Institution - 017-872-E
Address:
City:
Pueblo
Zip:
81003
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-872-E
Facility:
Name:
Local Institution - 017-872-H
Address:
City:
Thornton
Zip:
80260
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-872-H
Facility:
Name:
Mayo Clinic - Jacksonville
Address:
City:
Jacksonville
Zip:
32224
Country:
United States
Status:
Recruiting
Contact:
Last name:
Yan Yan Lou, Site 017-829
Phone:
713-878-8182
Facility:
Name:
The Oncology Institute of Hope and Innovation - Lakeland
Address:
City:
Lakeland
Zip:
33812
Country:
United States
Status:
Recruiting
Contact:
Last name:
Kamal Sharma, Site 017-898
Phone:
863-208-6343
Facility:
Name:
Local Institution - Unk076
Address:
City:
Miami
Zip:
33136
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Local Institution - Unk055
Address:
City:
Orlando
Zip:
32803
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Local Institution - Unk062
Address:
City:
Chicago
Zip:
60612
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Local Institution - 017-972
Address:
City:
Chicago
Zip:
60637
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-972
Facility:
Name:
Local Institution - 017-820J
Address:
City:
Fairway
Zip:
66205
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-820J
Facility:
Name:
Local Institution - 017-820A
Address:
City:
Kansas City
Zip:
66160
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-820A
Facility:
Name:
Local Institution - 017-820B
Address:
City:
Kansas City
Zip:
66160
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-820B
Facility:
Name:
Local Institution - 017-820C
Address:
City:
Kansas City
Zip:
66160
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-820C
Facility:
Name:
Local Institution - 017-820H
Address:
City:
Kansas City
Zip:
66160
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-820H
Facility:
Name:
Local Institution - 017-820I
Address:
City:
Overland Park
Zip:
66210
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-820I
Facility:
Name:
University of Kansas Cancer Center - Westwood/Richard and Annette Bloch Cancer Care Pavilion
Address:
City:
Westwood
Zip:
66205
Country:
United States
Status:
Recruiting
Contact:
Last name:
Jun Zhang, Site 017-820
Phone:
415-244-4731
Facility:
Name:
Local Institution - 017-965
Address:
City:
Lexington
Zip:
40503
Country:
United States
Status:
Withdrawn
Facility:
Name:
Local Institution - Unk009
Address:
City:
Baltimore
Zip:
21201
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Beth Israel Deaconess Medical Center
Address:
City:
Boston
Zip:
02115
Country:
United States
Status:
Recruiting
Contact:
Last name:
Daniel Costa, Site 017-388
Phone:
617-667-9236
Facility:
Name:
Dana-Farber Cancer Institute
Address:
City:
Boston
Zip:
02215
Country:
United States
Status:
Recruiting
Contact:
Last name:
Pasi Janne, Site 017-808
Phone:
617-632-6036
Facility:
Name:
Local Institution - Unk039
Address:
City:
Burlington
Zip:
01803
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Local Institution - Unk069
Address:
City:
Detroit
Zip:
48201
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Local Institution - Unk018
Address:
City:
Lansing
Zip:
488912
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Henry Ford Medical Center - Columbus
Address:
City:
Novi
Zip:
48377
Country:
United States
Status:
Recruiting
Contact:
Last name:
Shirish Gadgeel, Site 017-811
Phone:
313-399-0508
Facility:
Name:
Local Institution - 017-838B
Address:
City:
Minneapolis
Zip:
55404
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-838B
Facility:
Name:
Local Institution - 017-838C
Address:
City:
Minneapolis
Zip:
55404
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-838C
Facility:
Name:
Mayo Clinic - Rochester
Address:
City:
Rochester
Zip:
55905
Country:
United States
Status:
Recruiting
Contact:
Last name:
Konstantinos Leventakos, Site 017-830
Phone:
507-284-2511
Facility:
Name:
Metro-Minnesota Community Oncology Research Consortium (MMCORC)
Address:
City:
Saint Louis Park
Zip:
55416
Country:
United States
Status:
Recruiting
Contact:
Last name:
Yan Ji, Site 017-838
Phone:
952-993-3252
Facility:
Name:
Local Institution - 017-838A
Address:
City:
Saint Louis Park
Zip:
55426-5000
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-838A
Facility:
Name:
Local Institution - 017-820F
Address:
City:
Kansas City
Zip:
64116
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-820F
Facility:
Name:
Local Institution - 017-820E
Address:
City:
Kansas City
Zip:
64154
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-820E
Facility:
Name:
Local Institution - 017-820D
Address:
City:
Lee's Summit
Zip:
64064
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-820D
Facility:
Name:
Local Institution - 017-820G
Address:
City:
North Kansas City
Zip:
64116
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-820G
Facility:
Name:
Local Institution - Unk008
Address:
City:
Osage Beach
Zip:
65065
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Local Institution - Unk058
Address:
City:
Springfield
Zip:
65807
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Local Institution - 017-080
Address:
City:
Babylon
Zip:
11702
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-080
Facility:
Name:
Local Institution - 017-945
Address:
City:
Bronx
Zip:
10467
Country:
United States
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-083
Address:
City:
Bronx
Zip:
10469
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-083
Facility:
Name:
Local Institution - 017-088
Address:
City:
Brooklyn
Zip:
11210
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-088
Facility:
Name:
Hematology-Oncology Associates of Central New York - Brittonfield - East Syracuse
Address:
City:
East Syracuse
Zip:
13057
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ajeet Gajra, Site 017-587
Phone:
315-425-3456
Facility:
Name:
Local Institution - 017-087
Address:
City:
New Hyde Park
Zip:
11042
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-087
Facility:
Name:
Local Institution - 017-085
Address:
City:
New York
Zip:
10028
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-085
Facility:
Name:
Local Institution - 017-082
Address:
City:
Patchogue
Zip:
11772
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-082
Facility:
Name:
Local Institution - 017-081
Address:
City:
Port Jefferson Station
Zip:
11776
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-081
Facility:
Name:
New York Cancer & Blood Specialists - Cancer Center - Research Headquarters
Address:
City:
Port Jefferson Station
Zip:
11776
Country:
United States
Status:
Recruiting
Contact:
Last name:
Richard Zuniga, Site 017-535
Phone:
631-675-5075
Facility:
Name:
Local Institution - 017-086
Address:
City:
Port Jefferson
Zip:
11776
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-086
Facility:
Name:
Local Institution - 017-084
Address:
City:
Riverhead
Zip:
11901
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-084
Facility:
Name:
Cleveland Clinic Main Campus
Address:
City:
Cleveland
Zip:
44195
Country:
United States
Status:
Recruiting
Contact:
Last name:
Nathan Pennell, Site 017-818
Phone:
216-445-9282
Facility:
Name:
Local Institution - 017-836
Address:
City:
Kettering
Zip:
45429
Country:
United States
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-916
Address:
City:
Memphis
Zip:
38104
Country:
United States
Status:
Withdrawn
Facility:
Name:
Texas Oncology - Dallas Fort Worth (DFW) - Baylor Charles A. Sammons Cancer Center
Address:
City:
Dallas
Zip:
75246
Country:
United States
Status:
Recruiting
Contact:
Last name:
Kartik Konduri, Site 017-879
Phone:
214-370-1000
Facility:
Name:
Local Institution - Unk056
Address:
City:
Dallas
Zip:
75390
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Local Institution - 017-848
Address:
City:
Houston
Zip:
77030
Country:
United States
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-999
Address:
City:
Irving
Zip:
75063
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-999
Facility:
Name:
USOR - Texas Oncology Northeast Texas - Longview Cancer Center
Address:
City:
Longview
Zip:
75601
Country:
United States
Status:
Recruiting
Contact:
Last name:
Donald Richards, Site 017-878
Phone:
903-579-9800
Facility:
Name:
Local Institution - 017-878-B
Address:
City:
Palestine
Zip:
75801
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-878-B
Facility:
Name:
Local Institution - 017-878-C
Address:
City:
Paris
Zip:
75460
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-878-C
Facility:
Name:
Local Institution - 017-878-A
Address:
City:
Tyler
Zip:
75702
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-878-A
Facility:
Name:
Local Institution - Unk010
Address:
City:
Salt Lake City
Zip:
84106
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Local Institution - 017-814-A
Address:
City:
Arlington
Zip:
22205
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-814-A
Facility:
Name:
Local Institution - Unk066
Address:
City:
Fairfax
Zip:
22031
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Virginia Cancer Specialists - Fairfax Office
Address:
City:
Fairfax
Zip:
22031
Country:
United States
Status:
Recruiting
Contact:
Last name:
Alexander Spira, Site 017-814
Phone:
703-280-5390
Facility:
Name:
Local Institution - 017-814-B
Address:
City:
Gainesville
Zip:
20155
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-814-B
Facility:
Name:
Local Institution - 017-814-C
Address:
City:
Reston
Zip:
20190
Country:
United States
Status:
Not yet recruiting
Contact:
Last name:
Site 017-814-C
Facility:
Name:
PeaceHealth St. Joseph Medical Center
Address:
City:
Bellingham
Zip:
98225
Country:
United States
Status:
Recruiting
Contact:
Last name:
Drew Murray, Site 017-909
Phone:
360-788-8222
Facility:
Name:
Local Institution - Unk036
Address:
City:
Huntington
Zip:
25705
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Local Institution - 017-458
Address:
City:
Natal
Zip:
59062-000
Country:
Brazil
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-446
Address:
City:
Ijui
Zip:
98700-000
Country:
Brazil
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-453
Address:
City:
Itajai
Zip:
88301-220
Country:
Brazil
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-457
Address:
City:
Barretos
Zip:
14784-400
Country:
Brazil
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-442
Address:
City:
Curitiba
Zip:
81520-060
Country:
Brazil
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-452
Address:
City:
Fortaleza
Zip:
60810-180
Country:
Brazil
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-455
Address:
City:
Jau
Zip:
17210-180
Country:
Brazil
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-454
Address:
City:
Rio De Janeiro
Zip:
22250-905
Country:
Brazil
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-456
Address:
City:
Sao Paolo
Zip:
01246-000
Country:
Brazil
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-695
Address:
City:
Vina Del Mar
Zip:
2520612
Country:
Chile
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-697
Address:
City:
Providencia
Zip:
7500006
Country:
Chile
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-696
Address:
City:
Santiago
Zip:
0
Country:
Chile
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-698
Address:
City:
Temuco
Zip:
4810469
Country:
Chile
Status:
Withdrawn
Facility:
Name:
Institut de Cancerologie de lOuest - Angers
Address:
City:
Angers Cedex 02
Zip:
49055
Country:
France
Status:
Recruiting
Contact:
Last name:
Frederic Bigot, Site 017-689
Phone:
33241352700
Facility:
Name:
Centre Francois Baclesse
Address:
City:
Caen Cedex 5
Zip:
14076
Country:
France
Status:
Recruiting
Contact:
Last name:
Hubert CURCIO, Site 017-196
Phone:
0231455050
Facility:
Name:
Centre Hospitalier Intercommunal de Creteil
Address:
City:
Creteil
Zip:
94000
Country:
France
Status:
Recruiting
Contact:
Last name:
Christos Chouaid, Site 017-190
Phone:
33157022070
Facility:
Name:
Centre Georges Francois Leclerc
Address:
City:
Dijon cedex
Zip:
21079
Country:
France
Status:
Recruiting
Contact:
Last name:
Coureche Kaderbhai, Site 017-192
Phone:
33380737504
Facility:
Name:
Hopital Michallon
Address:
City:
La Tronche
Zip:
38700
Country:
France
Status:
Recruiting
Contact:
Last name:
Denis Moro-Sibilot, Site 017-683
Phone:
+0033476765453 00000
Facility:
Name:
Local Institution - 017-688
Address:
City:
Lille
Zip:
59000
Country:
France
Status:
Withdrawn
Facility:
Name:
Local Institution - Unk078
Address:
City:
Lyon
Zip:
69008
Country:
France
Status:
Active, not recruiting
Facility:
Name:
Institut Paoli-Calmettes
Address:
City:
Marseille
Zip:
13009
Country:
France
Status:
Recruiting
Contact:
Last name:
Anne Madroszyk-Flandin, Site 017-199
Phone:
+33491223748+3349122
Facility:
Name:
Local Institution - Unk067
Address:
City:
Marseille
Zip:
13015
Country:
France
Status:
Active, not recruiting
Facility:
Name:
Local Institution - 017-200
Address:
City:
Montpellier
Zip:
34090
Country:
France
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-664
Address:
City:
Paris cedex 05
Zip:
75248
Country:
France
Status:
Withdrawn
Facility:
Name:
Local Institution - Unk029
Address:
City:
Paris
Zip:
75018
Country:
France
Status:
Active, not recruiting
Facility:
Name:
Hopital Tenon
Address:
City:
Paris
Zip:
75020
Country:
France
Status:
Recruiting
Contact:
Last name:
Jacques Cadranel, Site 017-686
Phone:
33156016531
Facility:
Name:
Local Institution - 017-198
Address:
City:
Saint Herblain
Zip:
44805
Country:
France
Status:
Withdrawn
Facility:
Name:
Hopital Foch
Address:
City:
Suresnes
Zip:
92150
Country:
France
Status:
Recruiting
Contact:
Last name:
Jaafar Bennouna, Site 017-667
Phone:
33240679993
Facility:
Name:
Hopital Larrey
Address:
City:
Toulouse cedex 9
Zip:
31059
Country:
France
Status:
Recruiting
Contact:
Last name:
Julien Mazieres, Site 017-663
Phone:
+0567771837
Facility:
Name:
Gustave Roussy
Address:
City:
Villejuif
Zip:
94805
Country:
France
Status:
Recruiting
Contact:
Last name:
Fabrice Barlesi, Site 017-202
Phone:
33142114211
Facility:
Name:
Local Institution - 017-790
Address:
City:
Batumi
Zip:
6000
Country:
Georgia
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-789
Address:
City:
Tbilisi
Zip:
0144
Country:
Georgia
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-794
Address:
City:
Tbilisi
Zip:
0159
Country:
Georgia
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-791
Address:
City:
Tbilisi
Zip:
0177
Country:
Georgia
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-792
Address:
City:
Tbilisi
Zip:
0259
Country:
Georgia
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-793
Address:
City:
Tbilisi
Zip:
380077
Country:
Georgia
Status:
Withdrawn
Facility:
Name:
University General Hospital of Heraklion (PAGNI)
Address:
City:
Heraklion
Zip:
71110
Country:
Greece
Status:
Recruiting
Contact:
Last name:
Dimitrios Mavroudis, Site 017-238
Phone:
2810392750
Facility:
Name:
University General Hospital of Larissa
Address:
City:
Larissa
Zip:
41110
Country:
Greece
Status:
Recruiting
Contact:
Last name:
Athanasios Kotsakis, Site 017-235
Phone:
+302413502785+302413
Facility:
Name:
Metropolitan Hospital
Address:
City:
Peiraias
Zip:
185 47
Country:
Greece
Status:
Recruiting
Contact:
Last name:
Helena Linardou, Site 017-234
Phone:
+302104809852
Facility:
Name:
Orszagos Koranyi Pulmonologiai Intezet
Address:
City:
Budapest
Zip:
1121
Country:
Hungary
Status:
Recruiting
Contact:
Last name:
Andrea Fulop, Site 017-244
Phone:
+3613913228
Facility:
Name:
Orszagos Onkologiai Intezet
Address:
City:
Budapest
Zip:
1122
Country:
Hungary
Status:
Recruiting
Contact:
Last name:
Tunde Nagy, Site 017-241
Phone:
3612248600
Facility:
Name:
Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz
Address:
City:
Szekesfehervar
Zip:
8000
Country:
Hungary
Status:
Recruiting
Contact:
Last name:
Zsolt Papai-Szekely, Site 017-759
Phone:
+3622535722
Facility:
Name:
Reformatus Pulmonologiai Centrum
Address:
City:
Torokbalint
Zip:
2045
Country:
Hungary
Status:
Recruiting
Contact:
Last name:
Gabriella Galffy, Site 017-240
Phone:
36307005601
Facility:
Name:
Local Institution - 017-767 - B
Address:
City:
Faenza
Zip:
48018
Country:
Italy
Status:
Not yet recruiting
Contact:
Last name:
Site 017-767 - B
Facility:
Name:
Local Institution - 017-767 - A
Address:
City:
Lugo
Zip:
48022
Country:
Italy
Status:
Not yet recruiting
Contact:
Last name:
Site 017-767 - A
Facility:
Name:
Azienda Ospedaliera San Giuseppe Moscati - Avellino
Address:
City:
Avellino
Zip:
83100
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Assunta Sgambato, Site 017-292
Phone:
+390825203945
Facility:
Name:
Local Institution - 017-274
Address:
City:
Aviano
Zip:
33081
Country:
Italy
Status:
Not yet recruiting
Contact:
Last name:
Site 017-274
Facility:
Name:
Ospedale Santo Spirito
Address:
City:
Casale Monferrato
Zip:
15033
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Roberta Buosi, Site 017-773
Phone:
+3903213733989
Facility:
Name:
Azienda Ospedaliero - Universitaria Careggi
Address:
City:
Firenze
Zip:
50134
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Lorenzo Antonuzzo, Site 017-762
Phone:
00390557947298
Facility:
Name:
Istituto Europeo di Oncologia
Address:
City:
Milan
Zip:
20141
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Filippo de Marinis, Site 017-278
Phone:
390257489440
Facility:
Name:
Azienda Ospedaliero - Universitaria San Luigi Gonzaga
Address:
City:
Orbassano
Zip:
10043
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Silvia Novello, Site 017-788
Phone:
390119026322
Facility:
Name:
Local Institution - 017-297
Address:
City:
Padova
Zip:
35128
Country:
Italy
Status:
Withdrawn
Facility:
Name:
Ospedale Santa Maria delle Croci di Ravenna
Address:
City:
Ravenna
Zip:
48121
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Manolo DArcangelo, Site 017-767
Phone:
+390544286223
Facility:
Name:
Istituto Nazionale Tumori Regina Elena
Address:
City:
Roma
Zip:
00144
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Federico Cappuzzo, Site 017-295
Phone:
390586223189
Facility:
Name:
Local Institution - 017-280
Address:
City:
Roma
Zip:
00168
Country:
Italy
Status:
Active, not recruiting
Facility:
Name:
Local Institution - 017-076
Address:
City:
Kota Bharu
Zip:
15586
Country:
Malaysia
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-075
Address:
City:
Kuantan
Zip:
25100
Country:
Malaysia
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-073
Address:
City:
Kuala Lumpur
Zip:
50586
Country:
Malaysia
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-072
Address:
City:
Putrajaya
Zip:
62250
Country:
Malaysia
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-381
Address:
City:
Konin
Zip:
62-500
Country:
Poland
Status:
Withdrawn
Facility:
Name:
Instytut MSF
Address:
City:
Lodz
Zip:
90-302
Country:
Poland
Status:
Recruiting
Contact:
Last name:
Ewa Kalinka, Site 017-757
Facility:
Name:
Med Polonia Sp. z o. o. - Obornicka
Address:
City:
Poznan
Zip:
60-693
Country:
Poland
Status:
Recruiting
Contact:
Last name:
Rodryg Ramlau, Site 017-382
Phone:
+48616643330+4861854
Facility:
Name:
Wojskowy Instytut Medyczny
Address:
City:
Warsaw
Zip:
04-349
Country:
Poland
Status:
Recruiting
Contact:
Last name:
Renata Duchnowska, Site 017-774
Phone:
+48602609988
Facility:
Name:
Local Institution - 017-692
Address:
City:
Belgrade
Zip:
11000
Country:
Serbia
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-690
Address:
City:
Belgrade
Zip:
11080
Country:
Serbia
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-693
Address:
City:
Beograd
Zip:
11000
Country:
Serbia
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-694
Address:
City:
Kragujevac
Zip:
34000
Country:
Serbia
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-691
Address:
City:
Sremska Kamenica
Zip:
21204
Country:
Serbia
Status:
Withdrawn
Facility:
Name:
Complejo Hospitalario Universitario A Coruna
Address:
City:
A Coruna
Zip:
15006
Country:
Spain
Status:
Recruiting
Contact:
Last name:
Maria Rosario Garcia Campelo, Site 017-613
Phone:
+34981178353292856
Facility:
Name:
Hospital General Universitario Gregorio Maranon
Address:
City:
Madrid
Zip:
28007
Country:
Spain
Status:
Recruiting
Contact:
Last name:
Antonio Calles Blanco, Site 017-619
Phone:
+34915868115
Facility:
Name:
Hospital Universitario La Paz
Address:
City:
Madrid
Zip:
28046
Country:
Spain
Status:
Recruiting
Contact:
Last name:
Javier De Castro Carpeno, Site 017-624
Phone:
+34917277516
Facility:
Name:
Hospital Universitario Puerta de Hierro - Majadahonda
Address:
City:
Majadahonda
Zip:
28222
Country:
Spain
Status:
Recruiting
Contact:
Last name:
Mariano Provencio Pulla, Site 017-626
Phone:
34911917759
Facility:
Name:
Local Institution - Unk001
Address:
City:
Malaga
Zip:
29010
Country:
Spain
Status:
Active, not recruiting
Facility:
Name:
Hospital Universitario Son Espases
Address:
City:
Palma de Mallorca
Zip:
07120
Country:
Spain
Status:
Recruiting
Contact:
Last name:
Aitor Azkarate, Site 017-602
Phone:
0000000000
Facility:
Name:
Hospital Son Llàtzer
Address:
City:
Palma de Mallorca
Zip:
07198
Country:
Spain
Status:
Recruiting
Contact:
Last name:
Juan Coves Sarto, Site 017-771
Phone:
348712020001629
Facility:
Name:
Hospital Universitario Virgen Macarena
Address:
City:
Sevilla
Zip:
41009
Country:
Spain
Status:
Recruiting
Contact:
Last name:
David Vicente Baz, Site 017-772
Phone:
349550089325008932
Facility:
Name:
Hospital Clinico Universitario Lozano Blesa
Address:
City:
Zaragoza
Zip:
50009
Country:
Spain
Status:
Recruiting
Contact:
Last name:
Maria Dolores Isla Casado, Site 017-603
Facility:
Name:
Local Institution - 017-395
Address:
City:
Geneve
Zip:
1205
Country:
Switzerland
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-132
Address:
City:
Bang Phlat
Zip:
10700
Country:
Thailand
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-136
Address:
City:
Bangkok
Zip:
10400
Country:
Thailand
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-135
Address:
City:
Chom Thong
Zip:
50200
Country:
Thailand
Status:
Withdrawn
Facility:
Name:
Local Institution - 017-137
Address:
City:
Khon Kaen
Zip:
40002
Country:
Thailand
Status:
Withdrawn
Start date:
November 30, 2022
Completion date:
December 1, 2026
Lead sponsor:
Agency:
Mirati Therapeutics Inc.
Agency class:
Industry
Source:
Mirati Therapeutics Inc.
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05609578
https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html
https://www.bmsclinicaltrials.com/us/en/clinical-trials/NCT05609578.html
