Tolerability and Pharmacokinetics Study of TQB3702 Tablets in Hematologic Tumor Subjects

Trial Title: Tolerability and Pharmacokinetics Study of TQB3702 Tablets in Hematologic Tumor Subjects

NCT ID: NCT05610202

Condition: Hematologic Malignancy

Conditions: Official terms:
Hematologic Neoplasms

Study type: Interventional

Study phase: Phase 1

Overall status: Unknown status

Study design:

Allocation: N/A

Intervention model: Single Group Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: TQB3702 tablets
Description: TQB3702 tablets are selective BTK inhibitors.
Arm group label: TQB3702 tablets

Summary: This project is an open, dose escalation and expansion phase I clinical study. The first phase is a dose escalation study, and the second phase is a dose expansion study based on the Maximum tolerated dose (MTD) / Recommended Phase II Dose (RP2D) obtained in the first phase. The purpose is to evaluate the tolerability and preliminary efficacy of TQB3702 tablets in hematological tumor subjects.

Criteria for eligibility:
Criteria:
Inclusion Criteria: - Subjects voluntarily joined the study, signed informed consent form, and with good compliance. - ≥18 years old and ≤ 80 years old; Eastern Cooperative Oncology Group (ECOG) physical status: 0-2; at least 3 months expected survival period. - Clearly diagnosed recurrent / refractory hematological tumors that meet the WHO definition; - At least 1 measurable lesion for efficacy evaluation. - The function of main organs is normal. - Female patients of childbearing age should agree to use contraceptive measures during the study period and for at least 6 months after study is stopped; a negative serum pregnancy test within 7 days prior to study enrollment and must be non-lactating subjects; male patients should agree to use contraception during the study period and for at least 6 months after study is stopped. Exclusion Criteria: - Patients has had or is currently having other malignant tumors within 3 years. The following two conditions can be included in the group: other malignant tumors treated with a single operation to achieved 5 consecutive years of disease free survival (DFS)s. Cured cervical carcinoma in situ, non-melanoma skin cancer, nasopharyngeal carcinoma and superficial bladder tumors [Ta (non-invasive tumor), Tis (carcinoma in situ) and T1 (tumor infiltrating basement membrane)]. - Subjects with central nervous system aggression (CNS); - Received allogeneic hematopoietic stem cell transplantation (allo-HSCT) or had active graft-versus-host disease (GVHD) requiring immunosuppressive therapy within 12 months before the first dose; - Multiple factors that affect the absorption of oral medications (e.g., inability to swallow, chronic diarrhea, and intestinal obstruction); - Unrelieved toxicity of ≥CTC AE grade 1 due to any previous treatment, excluding alopecia and fatigue; - Major surgical treatment, open biopsy, and significant traumatic injury were received within 28 days before the start of study treatment. - The presence of active or uncontrolled primary autoimmune cytopenia, including autoimmune hemolytic anemia (AIHA) and primary immune thrombocytopenia (ITP); - Patients with evidence or history of bleeding constitution; Or any bleeding event (such as gastrointestinal bleeding) greater than or equal to CTC AE level 3 within 4 weeks before the first medication; - Subjects had an arteriovenous thrombosis event within 6 months. - Subjects have history of psychotropic substance abuse and are unable to abstain or have mental disorders; - Subjects with any severe and/or uncontrolled disease. - Within 2 weeks before the first treatment, the subjects had received proprietary Chinese medicines with anti-tumor indications specified in the NMPA approved drug instructions; - Uncontrolled pleural effusion, pericardial effusion, or ascites that still require repeated drainage (investigator judgment); - Study treatment related: subjects received live or mRNA vaccines within 4 weeks before the first treatment or were scheduled to receive live or mRNA vaccines during the study; - Participated in clinical trials of other antitumor drugs within 4 weeks before the first treatment; - According to the investigator's judgment, there are concomitant diseases that seriously endanger the safety of the subjects or affect the completion of the study, or subjects who are considered unsuitable for enrollment for other reasons.

Gender: All

Minimum age: 18 Years

Maximum age: 80 Years

Healthy volunteers: No

Locations:

Facility:
Name: The First Affiliated Hospital of Nanchang University

Address:
City: Nanchang
Zip: 330006
Country: China

Contact:
Last name: Fei Li, Doctor

Phone: +86-13970038386
Email: yx021021@sina.com

Facility:
Name: The Cancer Hospital Affiliated to Shandong First Medical University

Address:
City: Jinan
Zip: 250117
Country: China

Contact:
Last name: Zengjun Li, Doctor

Phone: +86-13642138692
Email: zengjunli@163.com

Start date: November 2022

Completion date: August 2024

Lead sponsor:
Agency: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Agency class: Industry

Source: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT05610202