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Trial Title:
Molecular Characterization of Perivascular Epithelioid Cell Tumors
NCT ID:
NCT05617105
Condition:
Perivascular Epithelioid Cell Tumor, Malignant
Conditions: Official terms:
Perivascular Epithelioid Cell Neoplasms
Conditions: Keywords:
Perivascular epithelioid cell tumors
PEComas
Myomelanocytic markers
Angiomyolipomas
Lymphangioleiomyomatoses
Visceral tumors
Fluorescence In Situ Hybridization
Study type:
Observational
Overall status:
Unknown status
Study design:
Time perspective:
Retrospective
Summary:
Perivascular epithelioid cell tumors (PEComas) are rare and are characterized by the
expression of myomelanocytic markers. They are a complex family that includes
angiomyolipomas, lymphangioleiomyomatoses and other soft tissue and visceral tumors. Due
to the low prevalence of these tumors, the natural history is unclear; furthermore, a
molecular classification integrating clinical, pathological and molecular parameters has
not been described to date.
Criteria for eligibility:
Study pop:
patients having PEComas diagnosed in France between 01/01/1990 and 15/09/2019 and
reviewed by a sarcoma referral pathologist
Sampling method:
Non-Probability Sample
Criteria:
Inclusion criteria:
- Major patient (≥18 years)
- Minor patient (1 to 17 years old)
- PEComas diagnosed in France between 01/01/1990 and 15/09/2019 and reviewed by a
sarcoma referral pathologist
Exclusion criteria :
- Opposition of the patient (or the holders of parental authority) to participate in
the study
- Biological tissue from a patient who does not meet all the inclusion criteria
- Classic triphasic angiomyolipoma or lymphangioleiomyomatosis
- Inability to provide informed information to the subject
- Patient under court protection
- Patient under guardianship or curatorship
Gender:
All
Minimum age:
1 Year
Maximum age:
N/A
Locations:
Facility:
Name:
Service d'Oncologie - CHU de Strasbourg - France
Address:
City:
Strasbourg
Zip:
67091
Country:
France
Status:
Recruiting
Contact:
Last name:
Gabriel MALOUF, MD, PhD
Phone:
33 3 88 11 51 41
Email:
malouf.gabriel@chru-strasbourg.fr
Investigator:
Last name:
Gabriel MALOUF, MD, PhD
Email:
Principal Investigator
Investigator:
Last name:
Agathe Bourgmayer, MD
Email:
Sub-Investigator
Investigator:
Last name:
Céline Charon-Barra, MD
Email:
Sub-Investigator
Investigator:
Last name:
Christine Chevreau, MD
Email:
Sub-Investigator
Investigator:
Last name:
François Bertucci, MD
Email:
Sub-Investigator
Investigator:
Last name:
Loic Chaigneau, MD
Email:
Sub-Investigator
Investigator:
Last name:
Nelly Firmin, MD
Email:
Sub-Investigator
Investigator:
Last name:
François SEVERAC, Statistician
Email:
Sub-Investigator
Investigator:
Last name:
Youenn DAVIDSON, Statistician
Email:
Sub-Investigator
Start date:
December 1, 2019
Completion date:
December 31, 2022
Lead sponsor:
Agency:
University Hospital, Strasbourg, France
Agency class:
Other
Source:
University Hospital, Strasbourg, France
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05617105
