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Trial Title:
Proteomics in Small Cell Lung Cancer
NCT ID:
NCT05623956
Condition:
Small Cell Lung Cancer
Conditions: Official terms:
Lung Neoplasms
Small Cell Lung Carcinoma
Conditions: Keywords:
Proteomics
Biomarkers
Study type:
Observational
Overall status:
Not yet recruiting
Study design:
Time perspective:
Prospective
Summary:
The aim of this study is to gather insight into tumor-derived circulating extracellular
vesicles-proteins in patients with newly diagnosed small cell lung cancer.
Detailed description:
The study will include 50 patients with newly diagnosed SCLC, referred to systemic
antineoplastic treatment at the Dept. of Oncology, Aalborg University Hospital and blood
samples from 50 healthy blood donors.
The blood samples from SCLC patients will be collected before chemotherapy with
Carboplatin and Etoposide and after 2 cycles of chemotherapy.
Imaging will be performed at the Dept. of Radiology, Aalborg University Hospital before
chemotherapy and after 3 cycles of the treatment.
Criteria for eligibility:
Study pop:
The study will include 50 patients with newly diagnosed SCLC, referred to systemic
antineoplastic treatment at the Dept. of Oncology, Aalborg University Hospital.
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
- Written and signed informed consent
- Histopathologically and/or cytologically newly-diagnosed SCLC
- Measurable disease on CT scans
- Eligibility to receive standard chemotherapy consisting of carboplatin and etoposide
Exclusion Criteria:
- Active biopsy-verified second malignancy other than non-melanoma skin cancer or
cervical carcinoma in situ
- Prior treatment for any malignant diseases other than non-melanoma skin cancer and
cervical carcinoma in situ
- Concomitant anticoagulation treatment (acetylsalicylic acid and clopidogrel are
allowed)
- Treatment with any other investigational agent
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
Accepts Healthy Volunteers
Start date:
March 2023
Completion date:
May 2025
Lead sponsor:
Agency:
Aalborg University Hospital
Agency class:
Other
Source:
Aalborg University Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05623956
