Trial Title:
Development and Validation of a Deep Learning System for Nasopharyngeal Carcinoma Using Endoscopic Images
NCT ID:
NCT05627310
Condition:
Nasopharyngeal Carcinoma
Conditions: Official terms:
Carcinoma
Nasopharyngeal Carcinoma
Conditions: Keywords:
nasopharyngeal carcinoma
deep learning
tumor screening
Study type:
Observational
Overall status:
Unknown status
Study design:
Time perspective:
Other
Intervention:
Intervention type:
Other
Intervention name:
Diagnostic
Description:
Training dataset was used to train the deep learning model, which was validated and
tested by external dataset.
Arm group label:
Testing Cohort
Arm group label:
Validation Cohort
Summary:
Develop a deep learning algorithm via nasal endoscopic images from eight NPC treatment
centerto detect and screen nasopharyngeal carcinoma(NPC).
Detailed description:
Nasopharyngeal carcinoma (NPC) is an epithelial cancer derived from nasopharyngeal
mucosa. Nasal endoscopy is the conventional examination for NPC screening. It is a major
challenge for inexperienced endoscopists to accurately distinguish NPC and other benign
dieseases. In this study, we collcet multi-center endoscopic images and train a deep
learning model to detect NPC and indicate tumor location. Then, the model perfomance will
be compared with endoscopists and be tested prospectively with external dataset.
Criteria for eligibility:
Study pop:
Nasopharyngeal endoscopic images were collected from 8 hospital in NPC epidemic area all
over China.
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
- The quality of endoscopic images should clinical acceptable.
- Patients were diagnosed with biopsy(NPC, benign hyperplasia). Control corhort(normal
nasopharynx) don't require bispsy result.
Exclusion Criteria:
- images with spots from lens flares or stains, and overexposure were excluded from
further analysis.
- image can not expose most part of lesion clearly.
Gender:
All
Minimum age:
N/A
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Fujian Medical University Union Hospital
Address:
City:
Fuzhou
Country:
China
Status:
Recruiting
Contact:
Last name:
De-Sheng Wang, MD PhD
Facility:
Name:
Quan Zhou First Affiliated Hospital of Fujian Medical University
Address:
City:
Quanzhou
Country:
China
Status:
Recruiting
Contact:
Last name:
Jun Liao, MD PhD
Facility:
Name:
The People' s Hospital of Jiangmen
Address:
City:
Jiangmen
Country:
China
Status:
Recruiting
Contact:
Last name:
Ming-Zhang Chang, MD
Facility:
Name:
First Affiliated Hospital of Guangxi Medical University
Address:
City:
Nanning
Country:
China
Status:
Recruiting
Contact:
Last name:
Jie-En Li, MD PhD
Facility:
Name:
The People' s Hospital of Guangxi Zhuang Autonomous Region
Address:
City:
Nanning
Country:
China
Status:
Recruiting
Contact:
Last name:
Shen-Hong Qu, MD PhD
Facility:
Name:
Xiangya Hospital of Central South University
Address:
City:
Changsha
Country:
China
Status:
Recruiting
Contact:
Last name:
Wei-Hong Jiang, MD PhD
Facility:
Name:
The First Affiliated Hospital of Nanchang University
Address:
City:
Nanchang
Country:
China
Status:
Recruiting
Contact:
Last name:
Jing Ye, MD PhD
Facility:
Name:
Eye&ENT Hospital of Fudan University
Address:
City:
Shanghai
Country:
China
Status:
Recruiting
Contact:
Last name:
Yu-Xuan Shi, MD PhD
Start date:
November 1, 2022
Completion date:
March 31, 2024
Lead sponsor:
Agency:
Eye & ENT Hospital of Fudan University
Agency class:
Other
Collaborator:
Agency:
Xiangya Hospital of Central South University
Agency class:
Other
Collaborator:
Agency:
The First Affiliated Hospital of Nanchang University
Agency class:
Other
Collaborator:
Agency:
Fujian Medical University Union Hospital
Agency class:
Other
Collaborator:
Agency:
Quan Zhou First Affiliated Hospital of Fujian Medical University
Agency class:
Other
Collaborator:
Agency:
First Affiliated Hospital of Guangxi Medical University
Agency class:
Other
Collaborator:
Agency:
The People' s Hospital of Guangxi Zhuang Autonomous Region
Agency class:
Other
Collaborator:
Agency:
The People' s Hospital of Jiangmen
Agency class:
Other
Source:
Eye & ENT Hospital of Fudan University
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05627310
