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Trial Title:
Dissecting the Mechanism of DNA Methylation on the Invasiveness of Pituitary Tumors.
NCT ID:
NCT05634655
Condition:
Pituitary Tumors
Conditions: Official terms:
Pituitary Neoplasms
Pituitary Diseases
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Retrospective
Intervention:
Intervention type:
Other
Intervention name:
no interventions between two groups
Description:
no interventions between two groups
Arm group label:
invasive PAs
Arm group label:
non-invasive PAs
Summary:
DNA methylation is one of the important ways of protein post-translational
modification.Pituitary adenoma (PA) is a benign neuroendocrine tumor that originates from
adenohypophysial 45 cells, and accounts for 10%-20% of all primary intracranial tumors.
However some PAs can present with high invasiveness and irregular growth, which tend to
compresses the optic chiasm and third ventricle, encase the internal carotid artery, and
affect hormone secretion from the pituitary gland and hypothalamus. In this study we
focus on the mechanism of DNA methylation on the invasiveness of pituitary tumors.
Criteria for eligibility:
Study pop:
The patients with PAs who underwent TSS at The Second Affiliated 62 Hospital Zhejiang
University School of Medicine was retrospectively analyzed.
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
-
1) histologically confirmed PAs, 2) Non-function pituitary adenomas
Exclusion Criteria:
-
1) Associated with other tumors or serious underlying diseases, 2) the medical
records were not complete, or the follow-up data were missing.
Gender:
All
Minimum age:
N/A
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
2ndAffiliated Hospital, School of Medicine
Address:
City:
Hanzhou
Country:
China
Status:
Recruiting
Contact:
Last name:
wu qun
Phone:
13605810393
Email:
2192010@zju.edu.cn
Start date:
January 1, 2022
Completion date:
January 1, 2025
Lead sponsor:
Agency:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Agency class:
Other
Source:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05634655
