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Trial Title:
Comparison of Expression of Carcinogenesis-related Molecular Markers in the Patients With Colon Cancer and Polyp
NCT ID:
NCT05638542
Condition:
Colorectal Cancer
Colorectal Adenoma
Conditions: Official terms:
Adenoma
Carcinogenesis
Conditions: Keywords:
Carcinogenesis
Sex difference
Tumor location
Study type:
Observational
Overall status:
Active, not recruiting
Study design:
Time perspective:
Prospective
Summary:
A study of carcinogenesis-related molecular markers in the patients with colorectal
cancer and colorectal adenoma.
Detailed description:
The chromosomal instability (CIN) pathway, the CpG island methylator phenotype (CIMP)
pathway and the microsatellite instability (MSI) pathway are three major carcinogenesis
pathways to colorectal cancer (CRC). In this study, the investigators aimed to
investigate distinctive molecular features of carcinogenesis pathways among healthy
control, colorectal adenoma, and CRC and compare their molecular progression according to
patients' sex and tumor location as well as disease stage.
Criteria for eligibility:
Study pop:
Patients who visited Seoul National University Bundang Hospital for gastrointestinal
symptomes or regular check-ups, and agreed to participate.
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- Control group: subjects with no evidence of colorectal adenoma or colorectal cancer
- Colorectal adenoma group: Patients with colorectal adenomas greater than or equal to
10 mm in diameter according to the endoscopic presentation as well as histological
validation of colorectal adenoma.
- Colorectal cancer group: Patients whose biopsy specimen is histologically confirmed
as colorectal adenocarcinoma
Exclusion Criteria:
- Subjects age under 18 years
- Previous history of colorectal neoplasms
- Patients with high bleeding risk or patients who must maintain anti-coagulant or
anti-platelet agents
- Denial to participate in this study
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
Accepts Healthy Volunteers
Locations:
Facility:
Name:
Seoul National University Bundang Hospital
Address:
City:
Seongnam-si
Zip:
463-707
Country:
Korea, Republic of
Start date:
March 1, 2015
Completion date:
December 2023
Lead sponsor:
Agency:
Seoul National University Bundang Hospital
Agency class:
Other
Source:
Seoul National University Bundang Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05638542
