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Trial Title:
Treatment Outcomes of Advanced Neoplasia in IBD
NCT ID:
NCT05674773
Condition:
Inflammatory Bowel Diseases
Conditions: Official terms:
Inflammatory Bowel Diseases
Study type:
Observational
Overall status:
Active, not recruiting
Study design:
Time perspective:
Retrospective
Intervention:
Intervention type:
Procedure
Intervention name:
Endoscopic or surgical resection
Description:
endoscopic or surgical (partial, (sub)total, proctocolectomy) resection
Arm group label:
IBD patients with advanced neoplasia
Summary:
In this study, we aimed to (1) compare cumulative incidences of synchronous and
metachronous colorectal neoplasia as well as mortality following AN in CD and UC patients
who underwent proctocolectomy, (sub)total colectomy, partial colectomy or endoscopic
resection, and (2) to determine factors associated with AN treatment choice.
Detailed description:
In this retrospective multicenter cohort study, using PALGA (the Dutch nationwide
pathology databank), partial colectomy yielded a similar metachronous neoplasia risk
compared to (sub)total colectomy after treatment of advanced neoplasia in inflammatory
bowel disease. High metachronous neoplasia rates after endoscopic resection underline the
importance of strict subsequent endoscopic surveillance.
Criteria for eligibility:
Study pop:
IBD patients with advanced neoplasia
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
- IBD (ulcerative colitis (UC), CD or IBD-unclassified (IBD-U))
- Histological diagnosis of colorectal AN
- Available treatment data
Exclusion Criteria:
- Familial CRC syndrome
- AN prior to IBD diagnosis
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Locations:
Facility:
Name:
Radboudumc
Address:
City:
Nijmegen
Zip:
6525GA
Country:
Netherlands
Start date:
May 21, 2019
Completion date:
July 1, 2023
Lead sponsor:
Agency:
Radboud University Medical Center
Agency class:
Other
Collaborator:
Agency:
Rijnstate Hospital
Agency class:
Other
Collaborator:
Agency:
Jeroen Bosch Ziekenhuis
Agency class:
Other
Collaborator:
Agency:
University Medical Center Groningen
Agency class:
Other
Collaborator:
Agency:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Agency class:
Other
Collaborator:
Agency:
Amsterdam UMC, location VUmc
Agency class:
Other
Collaborator:
Agency:
Erasmus Medical Center
Agency class:
Other
Source:
Radboud University Medical Center
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05674773
