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Trial Title:
Brain Representation of Acquisition in Humans of Motor-Sensory Skills
NCT ID:
NCT05688683
Condition:
Epilepsy
Cerebral Tumor
Conditions: Official terms:
Epilepsy
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Prospective
Intervention:
Intervention type:
Other
Intervention name:
use of a theremin-type musical instrument
Description:
The patient will perform the task of reproducing sounds by manipulating an object. The
settings of the object will be changed and the patient will have to reproduce the sounds
a second time by manipulating the object.
Summary:
Interactions between the perceptual and motor systems are fundamental to the performance
of complex motor tasks and are at the heart of the fine motor control required for the
production of complex sounds such as speech production or playing a musical instrument.
In such situations, the brain must learn to generate relevant motor commands to a
sound-producing system with fixed physical characteristics, such as the vocal tract or a
musical instrument.
No study has yet been able to directly test the dynamic aspect of this sensorimotor
learning in an acoustic production task with fine motor control.
The Adolphe de Rothschild Foundation Hospital takes care of patients requiring awake
surgery. During these procedures, a direct cortical recording, called
electro-corticography, is performed in order to better delineate the tumor or
epileptogenic resection area. Reference recordings are made in healthy areas at a
distance from the lesion site making it possible to record normal brain activity.
In this case, we would propose to the patient to use a tool similar to the theremin (a
musical instrument the size of a golf ball whose displacement in space modulates the
frequency and the harmonics of a sound). The patient should therefore learn in order to
create relevant motor patterns.
Criteria for eligibility:
Study pop:
Patient benefiting from an intracranial brain recording during a programmed surgery for
epilepsy or cerebral tumor resection in awake condition.
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- Benefiting from an intracranial brain recording during a programmed surgery in awake
condition.
Exclusion Criteria:
- Patient with complete deafness
- Patient with a disorder or impairment that does not allow him/her to perform the
experimental task according to the investigator's judgment
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Fondation Adolphe de Rothschild
Address:
City:
Paris
Zip:
75010
Country:
France
Status:
Recruiting
Contact:
Last name:
Pierre Bourdillon, MD
Phone:
+33 1 48 03 66 12
Email:
pbourdillon@for.paris
Start date:
January 4, 2023
Completion date:
March 2028
Lead sponsor:
Agency:
Fondation Ophtalmologique Adolphe de Rothschild
Agency class:
Other
Source:
Fondation Ophtalmologique Adolphe de Rothschild
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05688683
