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Trial Title:
Using Digestive Microbial Information to Enhance the Early Detection of Pancreatic Cancer
NCT ID:
NCT05689138
Condition:
Pancreatic Cancer
Conditions: Official terms:
Pancreatic Neoplasms
Study type:
Observational
Overall status:
Active, not recruiting
Study design:
Time perspective:
Prospective
Intervention:
Intervention type:
Other
Intervention name:
Oral and Fecal Sample Collection
Description:
No interventions
Arm group label:
NC
Arm group label:
PCA
Summary:
Pancreatic cancer (PCA) is a leading death-related cancer. There is an urgent need for
accurate, noninvasive diagnostic options in the early detection of pancreatic cancer
(PCA), since delayed diagnosis increases the risk of metastasis and recurrence. In this
study, by analyzing gut and fecal microbial data among the pancreatic versus healthy
populations, we aim to establish an early detection tool to improve PCA detection, and to
explore potential diagnostic biomarkers.
Criteria for eligibility:
Study pop:
Present/ past diagnosis of (a) other malignancy, (b) infectious diseases, (c) oral or
digestive diseases, (d) mental psychiatric or neurodegenerative diseases, (e) chronic
diseases that may affect the organ function; Have received certain medical examinations
or interventions within specific periods, including (a) antibiotics, hormonotherapy, or
immunosuppressor in the past three months, (b) digestive tract reconstructive operation
in the past three months, (c) Frequent use of a cathartic, antidiarrheal, or therapeutic
dose of probiotics throughout the past one month, (d) Change of diet throughout the past
one month, (e) local antibiotics usage in 1 week(skin, antibacterial mouth wash) (f) oral
or digestive examination in 3 days.
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
PCA Newly diagnosed pancreatic cancer patients; No symptoms of jaundice; Did not yet
receive any treatment
NC Individuals who were undergoing routine screenings or physical examination
Exclusion Criteria:
Gender:
All
Minimum age:
N/A
Maximum age:
N/A
Healthy volunteers:
Accepts Healthy Volunteers
Locations:
Facility:
Name:
PUMCH
Address:
City:
Beijing
Zip:
100730
Country:
China
Start date:
September 1, 2020
Completion date:
December 30, 2023
Lead sponsor:
Agency:
Peking Union Medical College Hospital
Agency class:
Other
Source:
Peking Union Medical College Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05689138
