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Trial Title:
GastroIntestinal Cancer in Children and Adolescents
NCT ID:
NCT05693519
Condition:
Gastrointestinal Cancer
Colorectal Cancer
Gastric Cancer
Hepatoblastoma
Hepatocellular Carcinoma
Burkitt Lymphoma
Neuroendocrine Tumors
Conditions: Official terms:
Burkitt Lymphoma
Neuroendocrine Tumors
Gastrointestinal Neoplasms
Hepatoblastoma
Conditions: Keywords:
SEER
Gastrointestinal
Cancer
Malignant
Child
Pediatric
Adolescent
Study type:
Observational
Overall status:
Active, not recruiting
Study design:
Time perspective:
Retrospective
Summary:
The goal of this observational population-based cohort study is to investigate the
clinical characteristics and outcomes of children and adolescents with primary
gastrointestinal malignancies registered in the publicly available Surveillance,
Epidemiology, and End Results (SEER) 17 database during 2000-2019.
Detailed description:
The investigators aim to describe the patient and tumor characteristics, treatments, and
outcomes of children and adolescents diagnosed with primary gastrointestinal
malignancies, and to analyze these data for trends over time. In addition, the
investigators want to explore independent prognostic factors for overall survival.
Finally, the investigators want to describe subsequent primary malignancies diagnosed
among patients from the study cohort, as well as to calculate their risk of developing a
second primary cancer relative to the general population. Data on children (aged 0-17
years at diagnosis) and young people aged 18-24 years at diagnosis are analyzed
separately. Special focus is laid on patients with primary carcinomas of the
gastrointestinal tract; particularly colorectal carcinoma.
Criteria for eligibility:
Study pop:
All patients aged 0-24 years with a diagnosis of a primary gastrointestinal malignancy as
their first primary malignancy in the SEER 17 database from 2000 until (and including)
2019.
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
- Age at primary gastrointestinal cancer diagnosis <25 years
- Diagnosis of a primary gastrointestinal malignancy as an individual's first primary
malignancy
Exclusion Criteria:
- None
Gender:
All
Minimum age:
0 Years
Maximum age:
24 Years
Healthy volunteers:
No
Locations:
Facility:
Name:
Leiden University Medical Center
Address:
City:
Leiden
Zip:
2333ZA
Country:
Netherlands
Facility:
Name:
Juliana Children's Hospital
Address:
City:
The Hague
Zip:
2545 AA
Country:
Netherlands
Start date:
December 22, 2022
Completion date:
June 22, 2023
Lead sponsor:
Agency:
Paul G. Kemps, MD
Agency class:
Other
Collaborator:
Agency:
Juliana Children's Hospital
Agency class:
Other
Source:
Leiden University Medical Center
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05693519
