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Trial Title:
EpCAM and p53 Expressions in Infiltrating Duct Carcinoma of the Breast
NCT ID:
NCT05703815
Condition:
Invasive Breast Cancer
Conditions: Official terms:
Carcinoma, Ductal
Breast Neoplasms
Conditions: Keywords:
EpCAM, P53 , IDC
Study type:
Observational
Overall status:
Not yet recruiting
Study design:
Time perspective:
Retrospective
Summary:
Breast cancer represents the most frequently diagnosed cancer in women. It represents the
5th leading cause of cancer mortality all over the world.
In Egypt, breast cancer represents the 2nd most diagnosed cancer among all population.
But among Egyptian females it represents the 1st diagnosed cancer representing 32.4%.
The main cause of death in breast cancer patients is tumor metastasis. Although only
5-10% of recently diagnosed breast cancer cases show metastasis to distant sites, but
still there is a high risk for metastasis in patients with localized primary tumor
following successful surgical management.
Epithelial cell adhesion molecule (EpCAM) is a cell adhesion molecule. It modifies
cadherin mediated cell adhesion and it induces epithelial cell migration and
proliferation. Some authors elucidate that EpCAM is involved in metastasis.
P53 is a known tumor suppressor gene involved in the control of cell cycle, DNA repair
and apoptosis. It's one of the most mutated genes in cancer including breast cancer.
Mutant p53 has a big role in tumor progression.
Criteria for eligibility:
Study pop:
formalin-fixed and paraffin embedded tissue blocks from 40 patients with breast cancer
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
- Both incisional and excisional biopsy specimens. 2. All the studied cases include
sufficient materials for the immunohistochemical study.
3. Complete clinical data.
Exclusion Criteria:
1. Patients with recurrence of the primary tumor.
2. Patients with a history of preoperative chemotherapy and/or radiotherapy.
3. Insufficient or tiny tissue biopsies
Gender:
Female
Minimum age:
20 Years
Maximum age:
80 Years
Healthy volunteers:
No
Start date:
January 2023
Completion date:
March 2023
Lead sponsor:
Agency:
Sohag University
Agency class:
Other
Source:
Sohag University
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05703815