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Trial Title: Evaluate Impact of Exercise Program on Fatigue in Breast Cancer During Chemotherapy

NCT ID: NCT05704842

Condition: Breast Cancer

Conditions: Official terms:
Breast Neoplasms

Study type: Interventional

Study phase: N/A

Overall status: Recruiting

Study design:

Allocation: Randomized

Intervention model: Factorial Assignment

Primary purpose: Other

Masking: None (Open Label)

Intervention:

Intervention type: Behavioral
Intervention name: Exercise
Description: Home-based exercise program including core exercises as follows: Core Stabilization, core extension, leg extensions, squats with and without weights, shoulder and arm exercises.
Arm group label: Exercise

Other name: Exercise program

Summary: Assess feasibility of home exercise in reducing fatigue in subjects with breast cancer receiving curative intent chemotherapy. Subjects are randomized to control (no exercise) or intervention group (exercise). The PRO-CTCAE tool and FACIT Fatigue Scale are used to collect patient reported outcomes. Subjects submit data via mobile phone, tablet or computer. Assessments are weekly during chemotherapy (10-20 wks), at end of chemotherapy and 1, 3 and 6 months after chemotherapy.

Detailed description: The goal of this project is to determine the feasibility of a specific home-based exercise intervention in reducing cancer-related fatigue (CRF) in breast cancer patients undergoing curative-intent chemotherapy. The outcome will be measured by using the FACIT Fatigue Scale, administered by using the Carevive PROmptĀ® platform. Primary Objectives: 1. . To examine the feasibility of recruitment and retention of women undergoing treatment for breast cancer over the duration of the chemotherapy regimen. 2. To examine the adherence to the exercise regime for those in the intervention group and compare the retention rates between treatment and control groups 3. To compute the means and standard deviations (SD) of the FACIT responses over time in both groups for use in future power analyses to aid in the design of a futre hypothesis testing RCT. Secondary Objectives: 1. To quantify the change over time in PRO-CTCAE derived symptoms and other PROs by computing means and SD. 2. To test for group differences in the trajectory of change over time in FACT using a Mixed Model repeated analysis

Criteria for eligibility:
Criteria:
Inclusion Criteria: - Women with curative-intent breast cancer who plan to undergo at least 4 cycles of chemotherapy. - Age > 18 years - ECOG performance score < 3 - English-speaking - with sufficient vision/hearing or family support - Coronary artery disease, if cleared by cardiologist - Subject must have smart phone, computer or tablet. - Willingness to be randomized Exclusion Criteria: - Medical or psychiatric conditions (beyond those related to breast cancer and its treatment) that would impair our ability to test study hypotheses (psychotic disorders, dementia, inability to give informed consent or follow instructions). - Patients with overt evidence of a psychiatric disorder. - Coronary artery disease, not cleared by cardiologist. - Contraindication to exercise. - Chronic fatigue syndrome.

Gender: Female

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: Virtua Health

Address:
City: Voorhees
Zip: 08043
Country: United States

Status: Recruiting

Contact:
Last name: Susan VanLoon, RN, CCRP

Phone: 856-247-7382
Email: svanloon@virtua.org

Start date: December 22, 2022

Completion date: June 1, 2026

Lead sponsor:
Agency: Virtua Health, Inc.
Agency class: Other

Collaborator:
Agency: Carevive Systems, Inc.
Agency class: Industry

Source: Virtua Health, Inc.

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT05704842

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