Trial Title:
A PoC Study to Evaluate Treatments' Efficacy by Monitoring MRD Using ctDNA in HR-positive/HER2-negative EBC Population
NCT ID:
NCT05708235
Condition:
Breast Cancer
Conditions: Official terms:
Breast Neoplasms
Inavolisib
Study type:
Interventional
Study phase:
Phase 2
Overall status:
Active, not recruiting
Study design:
Allocation:
Non-Randomized
Intervention model:
Sequential Assignment
Primary purpose:
Treatment
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
Giredestrant
Description:
Giredestrant is a highly potent, non-steroidal, oral selective ER antagonist and degrader
(SERD)
Arm group label:
Arm B: Experimental Arm with giredestrant
Arm group label:
Arm C: Experimental Arm with giredestrant + abemaciclib
Arm group label:
Arm D: Experimental Arm with giredestrant + inavolisib
Other name:
GDC-9545
Intervention type:
Drug
Intervention name:
Abemaciclib
Description:
Abemaciclib is an orally administered CDK4/6 inhibitor
Arm group label:
Arm C: Experimental Arm with giredestrant + abemaciclib
Other name:
LY2835219
Intervention type:
Drug
Intervention name:
Inavolisib
Description:
Inavolisib is a potent, selective inhibitor of the Class I phosphatidylinositol 3-kinase
α (PI3K-alpha isoform (p110-alpha)
Arm group label:
Arm D: Experimental Arm with giredestrant + inavolisib
Other name:
GDC-0077
Summary:
This trial is a multicenter, open-label, non-comparative, phase II, biomarker-driven
adjuvant treatment study involving the periodic collection and analysis of blood samples
from patients with HR-positive/HER2-negative early-stage BC at higher risk of relapse,
who have undergone surgery within the previous five years, with no evidence of
locoregional, contralateral, or distant disease.
The study design is composed by an initial pre-screening phase, a molecular follow-up
phase (ctDNA surveillance phase), and an interventional therapeutic phase (treatment
phase).
After informed consent is obtained, a total of1,260 eligible patients will enter a ctDNA
surveillance in which primary tumor tissue and matched normal blood will be collected
from each patient to obtain a patient-specific somatic mutations panel (tumor signature).
At the event of ctDNA positivity, patients will be screened to enter the treatment phase
of the study. Upon confirmed eligibility, a total of 40 patients will be allocated in one
of the following trial's arms adopting a sequential recruitment strategy:
Arm A: Control Arm (N=10) Arm B: Experimental Arm with giredestrant (N=10) Arm C:
Experimental Arm with giredestrant + abemaciclib (N=10) Arm D: Experimental Arm with
giredestrant + inavolisib (N=10)
If the strategy of ctDNA monitoring enables physicians to identify patients at high risk
of relapse and assess whether treatment at molecular relapse can improve outcome, new
cohorts may be added to the study.
Detailed description:
This is a multicenter, open-label, non-comparative, phase II, biomarker-driven adjuvant
treatment study involving the periodic collection and analysis of blood samples from
patients with HR-positive/HER2-negative early-stage BC at higher risk of relapse, who
have undergone surgery within the previous five years, with no evidence of locoregional,
contralateral, or distant disease. Patients must be on adjuvant treatment with ET for at
least two years and no more than four years at the time of study enrolment with an
additional three years of ET planned. At least 12 months prior to enrolment on the same
ET treatment (AI or tamoxifen). For pre-menopausal women and men LHRH is required.
The trial design entails an initial pre-screening phase, a molecular follow-up phase
(ctDNA surveillance phase), and an interventional therapeutic phase (treatment phase).
After informed consent is obtained, 1,260 eligible patients will enter a ctDNA
surveillance in which primary tumor tissue and matched normal blood will be collected
from each patient to obtain a patient-specific somatic mutations panel (tumor signature).
Note: Additional patients may enter the ctDNA surveillance phase if needed, for example
if additional arms are opened.
Then, blood will be collected, processed, and analyzed to detect the presence or absence
of ctDNA at predefined time points for longitudinal surveillance. ctDNA analysis will
occur every three months from study inclusion during the first year and every six months
thereafter until positive result or end of accrual.
At the event of ctDNA positivity, patients will be screened to enter the treatment phase
of the study. Upon confirmed eligibility, a total of 40 patients will be allocated in one
of the following trial's arms adopting a sequential recruitment strategy:
Arm A: Control Arm (N=10) • Patients must continue the same standard ET, prescribed as
per standard practice, used in the surveillance phase. Changes in ET are not allowed.
Arm B: Experimental Arm with giredestrant (N=10)
• Giredestrant: 30 mg will be administered PO QD on Days 1 to 28 of each 28-day cycle up
to five years or until disease recurrence, unacceptable toxicity, or treatment/study
discontinuation (whichever occurs first).
Arm C: Experimental Arm with giredestrant + abemaciclib (N=10)
- Giredestrant: 30 mg will be administered PO QD on Days 1 to 28 of each 28-day cycle
up to five years or until disease recurrence, unacceptable toxicity, or
treatment/study discontinuation (whichever occurs first).
- Abemaciclib 150 mg will be taken PO BID (two intakes for a total daily dose of 300
mg) during each 28-day cycle up to two years or until disease recurrence,
unacceptable toxicity, or treatment/study discontinuation (whichever occurs first).
Arm D: Experimental Arm with giredestrant + inavolisib (N=10)
- Giredestrant: 30 mg will be administered PO QD on Days 1 to 28 of each 28-day cycle
up to five years or until disease recurrence, unacceptable toxicity, or
treatment/study discontinuation (whichever occurs first).
- Inavolisib: 9 mg will be administered PO QD on Days 1 to 28 of each 28-day cycle up
to two years or until disease recurrence, unacceptable toxicity, or treatment/study
discontinuation (whichever occurs first).
Note I: In addition to the treatments described on each of the treatment arms, LHRH
agonist will be administered to male participants and premenopausal/perimenopausal
participants according to local prescribing information. The patient should be supplied
with the previous LHRH they were taking.
Note II: During the length of the study, additional treatment arms may open to stay up to
date with the most recent advances in oncology, and to be able to provide the best
treatment options to patients in this study. Because of that, the N of patients screened
to enter the treatment phase may increase.
In the meanwhile, serial assessment of ctDNA will be continuously performed every three
months during the first year and every six months thereafter until EoS to correlate any
ctDNA variations with response.
Patients discontinuing the study treatment period will enter a post-treatment follow-up
period during which survival and new anti-cancer therapy information will be collected
every three months (±14 days) from the last dose of study treatment up to the EoS.
Telephone contact is acceptable (in some countries medical information can only be shared
directly in person with the patient).
Arm extensions
After initiation of study treatments, data obtained from serial assessment of ctDNA will
also be used to confirm feasibility of eventual arms extensions, with maximum two arms
that could be expanded (10 additional patients will be enrolled in each of the selected
arms). The expansion will be approved when the arm complies with the following criteria:
- If at three months, a 90% ctDNA decrease is observed in at least 30% patients and if
after three additional months, a 90% ctDNA decrease is maintained in at least 20%
patients In this case, 10 additional patients will be enrolled in the specific
experimental arms that meet these requirements (N=20).
- If all three experimental arms fulfill the criteria, the two arms with the highest
proportion of patients with the highest proportion of 90% decrease will be the ones
expanded.
- If cohorts remain too similar (no clear "winners"), the decision will be taken by
the Steering Committee based on the duration of the response and the safety and
toxicity of each specific treatment.
- If none of the arms fulfill the specific expansion criteria, the Steering Committee
will evaluate the data further and may nominate the two arms with the strongest
signal of ctDNA decreases for further expansion.
If the strategy of ctDNA monitoring enables physicians to identify patients at high risk
of relapse and assess whether treatment at molecular relapse can improve outcome, new
cohorts may be added to the study.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
Eligibility criteria for patient registration for ctDNA surveillance phase:
1. Signed informed consent form (ICF) prior to participation in any study-related
activities.
2. Male or female patients aged 18 years or older.
3. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.
4. Histologically proven primary HR-positive according to the updated American Society
of Clinical Oncology (ASCO)/College of American Pathologists (CAP) 2020 guidelines
and HER2-negative BC as per ASCO/CAP 2018 criteria based on local testing on the
most recent analyzed biopsy.
5. Patients with high-risk early-stage BC according to at least one of the following
criteria:
1. If no previous neoadjuvant chemotherapy:
i. pN2/N3 or ii. pN1,
1. pT3/T4 and/or 2. high genomic risk defined as Oncotype Dx Recurrence Score > 25 if
post-menopausal; > 20 if pre-menopausal , Prosigna score ≥ 41, Mammaprint high risk
category or similar and/or 3. histological grade II/III and Ki67>20%. b. If patients
have received previous neoadjuvant chemotherapy, they must have had significant
residual invasive disease defined as at least one of the following: i. Residual
invasive disease in the breast ypT3 or ypT4. and/or ii. Any macroscopic, ≥ 2 mm,
residual lymph node involvement regardless of primary tumor site involvement
(includes no residual disease in the breast).
Note: Genomic risk using platforms such as Oncotype Dx, Prosigna or Mammaprint won't be
assessed for the screening to participate in the study. However, patients with the
detailed scores assessed prior to study inclusion, may be eligible to enter the study if
they comply with all the inclusion and exclusion criteria.
6. On adjuvant treatment with ET for at least two years and no more than four years at
the time of study enrolment with an additional three years of ET planned. At least
12 months prior to enrolment on the same ET treatment with AI or tamoxifen
(luteinizing hormone-releasing hormone [LHRH] for pre-menopausal women and men is
required).
Note: Male and pre-menopausal patients treated with tamoxifen alone are excluded.
7. No prior treatment with cyclin-dependent kinases 4/6 (CDK4/6) inhibitors. 8. No
prior treatment with fulvestrant. 9. Willingness and ability to provide tissue from
one archival tumor tissue sample (either from diagnostic biopsy, primary surgery, or
where available from a residual disease post-neoadjuvant therapy).
Note: Patients with multifocal BC may be enrolled, if archival tissue samples from at
least two tumors are available and after histopathological examination, all tumors meet
pathologic criteria for HR-positive and HER2-negative BC.
10. Absence of metastatic disease by routine clinical assessment (computed tomography
[CT] scan of the thorax and abdomen, and bone scan) confirmed no longer than three
months prior to study inclusion.
11. Patients must have had surgery for their primary BC with documented clear margins
(as per local guidelines) within the past five years.
12. Patients must be able and willing to adhere to study procedures.
Eligibility criteria for entry into the treatment phase:
Patients will be considered eligible to be allocated to standard ET only, giredestrant
monotherapy, giredestrant plus abemaciclib, or giredestrant plus inavolisib if they
fulfill all the inclusion and none of the exclusion criteria listed below. In order to
enter the treatment phase, patients will have had to fulfill first the criteria needed to
enter the surveillance phase (which are listed above).
1. Signed ICF prior to study inclusion.
2. ctDNA positivity with no evidence of clinical or radiologic recurrence by standard
assessments (e.g.: breast ultrasound, staging scans, RMN).
3. ECOG performance status 0, 1 or 2.
4. Patients must have received the same ET during at least the last 12 months. A
temporary discontinuation of < 90 days during the surveillance phase is allowed.
5. Receiving LHRH agonist therapy alongside the same ET treatment for at least 90 days
prior to initiation of one of the available study treatments if male or
pre-menopausal.
6. Female of reproductive potential and male patients with female partners of
childbearing potential, must remain abstinent and truly abstain from sexual activity
(refrains from heterosexual intercourse) or use locally recognized adequate methods
of contraception (described as that with a failure rate <1%) for the duration of
trial treatment. In addition, patients must follow these guidelines for a certain
period of time after the last dose of trial treatment, specified in the protocol
(Section 7.4.4) depending on which treatment arm the patient is allocated in.
During this indicated period of time, female and male patients must as well refrain
from donating eggs or sperm.
Note: Female patients will be deemed not of childbearing potential if they are
post-menopausal or have had irreversible sterilization. Well-defined pre-menopausal
status refers to women who have not reached the post-menopausal state because they
are not permanently infertile due to prior bilateral oophorectomy, age ≥60 years or
age <60 years with amenorrhea for ≥12 months and estradiol and follicle-stimulating
hormone (FSH) levels in the post-menopausal range.
7. Resolution of all acute toxic effects of prior anti-cancer therapy to Grade ≤1 as
determined by the National Cancer Institute - Common Terminology Criteria for
Adverse Events (NCI-CTCAE) version (v) 5.0 (except for alopecia, or other toxicities
not considered a safety risk for the patient at investigator's discretion). Adverse
events (AEs) of current ET treatment are not included.
8. Adequate hematologic and organ function within 14 days before the first study
treatment on Day 1 of Cycle 1, defined by the following:
• Hematological (without platelet, red blood cell (RBC) transfusion, and/or
granulocyte colony-stimulating factor support within 7 days before first study
treatment dose): White blood cell (WBC) count > 3.0 x 109/L, absolute neutrophil
count (ANC) ≥ 1.5 x 109/L, platelet count ≥ 100.0 x109/L, and hemoglobin ≥ 9.0 g/dL
(≥ 5.6 mmol/L).
- Hepatic: Serum albumin ≥ 3 g/dL; Bilirubin ≤ 1.5 times the upper limit of
normal (ULN) (≤ 3 x ULN in the case of Gilbert's disease); aspartate
transaminase (AST) and alanine transaminase (ALT) ≤ 2.5 × ULN; alkaline
phosphatase (ALP) ≤ 2 × ULN.
- Renal: serum creatinine ≤ 1.5 x ULN or creatinine clearance ≥ 50 mL/min based
on Cockcroft-Gault glomerular filtration rate estimation.
9. Participants who are able and willing to swallow, retain, and absorb oral
medication.
Additional inclusion criteria for Arm C (giredestrant + abemaciclib arm)
1. Patients with prior diagnosis of thrombosis might be included as long as they are
under stable anti-coagulation regimen therapy 28 days prior to starting treatment
with abemaciclib.
Additional inclusion criteria for Arm D (giredestrant + inavolisib arm)
1. Confirmation of biomarker eligibility (detection of specified mutation(s) of PIK3CA
via specified test).
2. No prior treatment with any phosphatidylinositol 3-kinase (PI3K), Akt, or mammalian
target of rapamycin (mTOR) inhibitors, or any agent whose mechanism of action is to
inhibit the PI3K/Akt/mTOR pathway.
Exclusion Criteria for patient registration for ctDNA surveillance phase:
1. Any concurrent or planned treatment for the current diagnosis of BC other than
adjuvant ET.
2. Diagnosis of an alternative cancer in the five years prior to primary BC diagnosis
other than for non-melanoma carcinoma of the skin or cervical carcinoma in situ.
Other stage I tumors will be discussed case by case prior to inclusion with
theMedical Monitor of the study. 3.Active or prior documented inflammatory bowel
disease (i.e.Crohn's disease, ulcerative colitis, or a preexisting chronic condition
resulting in baseline grade ≥1 diarrhea)that may significantly alter the absorption
of oral drugs.
4.Active cardiac disease or history of cardiac dysfunction including any of the
following:a.History (within two years from screening) or presence of idiopathic
bradycardia or resting heart rate <50 beats per minute at screening.b.History of angina
pectoris or symptomatic coronary heart disease within 12 months prior to study entry.c.QT
interval corrected through use of Fridericia's formula (QTcF) > 450 ms for women and >
470 ms for men by at least three electrocardiograms(ECGs)> 30 minutes apart.d.History or
presence of an abnormal ECG that is clinically significant in the investigator's
opinion,e.History of ventricular dysrhythmias or risk factors for ventricular
dysrhythmias such as structural heart disease (e.g., severe left ventricular systolic
dysfunction, left ventricular hypertrophy cardiomyopathy, infiltrative cardiomyopathy,
moderate-to-severe valve disease), coronary heart disease (symptomatic or with ischemia
demonstrated by diagnostic testing), clinically significant electrolyte EudraCT#:
2022-002616-24Study Code#: MEDOPP485_MIRADORCSP Version 1.0, Date:
23-Dec-202210abnormalities (e.g., hypokalemia, hypomagnesemia, hypocalcemia), or family
history of long QT syndrome within 12 months.
5.History of pneumonitis, interstitial lung disease(ILD), or pulmonary fibrosis.
6.Known history of Human Immunodeficiency Virus (HIV) infection(testing not required as
part of study screening).
7.Clinically significant liver disease consistent with Child-Pugh C, including active
hepatitis (e.g., hepatitis B virus [HBV] or hepatitis C virus [HCV]), current alcohol
abuse, cirrhosis, or positive test for viral hepatitis 8.Active bleeding diathesis venous
thromboembolism, previous history of bleeding diathesis, or chronic anti-coagulation
treatment, or any indications or history of Disseminated Intravascular Coagulation (DIC)
or Deep vein thrombosis (DVT). Low molecular weight heparin (LMWH), low dose aspirin or
clopidogrel are permitted.
9.Creatinine clearance < 30mL/min. 10.Participants with renal dysfunction who require
dialysis. 11.Patient has any other concurrent severe and/or uncontrolled medical
condition that would, in the Investigator' opinion cause unacceptable safety risks,
contraindicate patient participation in the clinical trial or compromise compliance with
the protocol.
12.Females who are known to be breastfeeding or pregnant as determined by a serum
pregnancy test,Human chorionic gonadotropin(β-HCG),prior to the administration of any
trial treatment. Since β-HCG over expression can be also elevated in some tumor types, a
positive result should be confirmed with a validated alternative test (e.g., ultrasound).
13.Female or male participants planning a pregnancy.
Exclusion criteria for entry into the treatment phase:
1. Known hypersensitivity reaction to any investigational or therapeutic compound or
their incorporated substances.
2. Undergoing any other simultaneous anti-cancer treatment since enrolling in the
study, other than hormonal therapy or a bisphosphonate (or denosumab).
3. Major surgery (defined as requiring general anesthesia) or significant traumatic
injury within 28 days of start of study drug, or patients who have not recovered
from the side effects of any major surgery.
4. Treatment with strong Cytochrome P450 3A4 (CYP3A4) inhibitors or strong CYP3A4
inducers within 14 days or five drug-elimination half-lives, whichever is longer,
prior to initiation of one of the available study treatments.
5. Patient has a history of non-compliance to medical regimen.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Hospital General Universitario Dr. Balmis
Address:
City:
Alicante
Country:
Spain
Facility:
Name:
Hospital Virgen de los Lirios
Address:
City:
Alicante
Country:
Spain
Facility:
Name:
Hospital Clínic i Provincial de Barcelona
Address:
City:
Barcelona
Country:
Spain
Facility:
Name:
Hospital Universitari Dexeus
Address:
City:
Barcelona
Country:
Spain
Facility:
Name:
Hospital Universitario de Basurto
Address:
City:
Bilbao
Country:
Spain
Facility:
Name:
Hospital Provincial de Castellón
Address:
City:
Castellón De La Plana
Country:
Spain
Facility:
Name:
Hospital Universitario Clínico San Cecilio de Granada
Address:
City:
Granada
Country:
Spain
Facility:
Name:
Complejo Hospitalario de Jaén
Address:
City:
Jaén
Country:
Spain
Facility:
Name:
Hospital Universitario Arnau de Vilanova de Lleida
Address:
City:
Lleida
Country:
Spain
Facility:
Name:
Clínica Universidad de Navarra
Address:
City:
Madrid
Country:
Spain
Facility:
Name:
Hospital Beata María Ana
Address:
City:
Madrid
Country:
Spain
Facility:
Name:
Hospital Universitario de Torrejón
Address:
City:
Madrid
Country:
Spain
Facility:
Name:
Hospital Universitario Doce de Octubre
Address:
City:
Madrid
Country:
Spain
Facility:
Name:
Hospitalario Universitario de Navarra
Address:
City:
Pamplona
Country:
Spain
Facility:
Name:
Hospital Universitario Virgen del Rocío
Address:
City:
Sevilla
Country:
Spain
Facility:
Name:
Hospital Universitari Sant Joan de Reus
Address:
City:
Tarragona
Country:
Spain
Facility:
Name:
Hospital Arnau de Vilanova de Valencia
Address:
City:
Valencia
Country:
Spain
Facility:
Name:
Hospital Clínico Universitario de Valencia
Address:
City:
Valencia
Country:
Spain
Facility:
Name:
Hospital Universitario La Ribera, Alzira
Address:
City:
Valencia
Country:
Spain
Facility:
Name:
Complejo Hospitalario Universitario de Vigo
Address:
City:
Vigo
Country:
Spain
Facility:
Name:
Hospital Universitario Miguel Servet
Address:
City:
Zaragoza
Country:
Spain
Facility:
Name:
Barts Cancer Institute
Address:
City:
London
Country:
United Kingdom
Facility:
Name:
Imperial College Healthcare NHS Trust
Address:
City:
London
Country:
United Kingdom
Start date:
April 1, 2024
Completion date:
December 30, 2028
Lead sponsor:
Agency:
MedSIR
Agency class:
Other
Source:
MedSIR
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05708235
