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Trial Title:
The Diagnostic Pattern and Prognosis of Multiple Myeloma Patients With Myocardial Amyloidosis Were Evaluated by NMR Based Metabolomics
NCT ID:
NCT05718401
Condition:
Multiple Myeloma
Amyloidosis Cardiac
Conditions: Official terms:
Multiple Myeloma
Neoplasms, Plasma Cell
Amyloidosis
Study type:
Observational
Overall status:
Enrolling by invitation
Study design:
Time perspective:
Prospective
Intervention:
Intervention type:
Device
Intervention name:
NMR
Description:
nuclear magnetic resonance in genomics
Arm group label:
Control group
Arm group label:
Intervention group
Summary:
In this clinical study, a single-center retrospective cohort study was used to explore
the clinical characteristics and risk factors of patients with multiple myeloma
myocardial amyloidosis. An exploratory study was conducted to compare the effects of
various sublayer factors (M protein, electrocardiogram, echocardiography, CD138,
chromosome abnormalities, etc.) on patients' survival. On this basis, a hierarchical
diagnostic model (1-2-3-4) for patients with multiple myeloma complicated with myocardial
amyloidosis was established based on the phenoomics of NMR and mass spectrometry, and the
prognosis was evaluated simultaneously, in order to create an early, non-invasive,
sensitive and quantitative diagnostic model for multiple myeloma complicated with
myocardial amyloidosis, and lay a foundation for the early application of effective
treatment.
Detailed description:
The purpose of this study was to collect clinical data of patients with multiple myeloma
complicated with myocardial amyloidosis, analyze and collate the data through statistical
methods, and explore the clinical characteristics of patients with MM complicated with
myocardial amyloidosis, the factors that may lead to the occurrence of myocardial
amyloidosis and the differences in the data of cardiac ultrasound and other biochemical
tests, so as to evaluate the prognosis of patients.
To investigate the clinical features, risk factors and prognosis of patients with
multiple myeloma myocardial amyloidosis. The clinical experience of diagnosis and
treatment of this complication was summarized. On this basis, a standard database
suitable for the northwest population was established based on NMR phenoomics, and a
hierarchical diagnostic model (1-2-3-4) was explored for multiple myeloma patients with
myocardial amyloidosis, and the prognosis was evaluated simultaneously. In order to
establish an early, non-invasive, sensitive and quantitative diagnostic model for
multiple myeloma complicated with myocardial amyloidosis, and to provide clinical basis
for further research on early diagnosis, early prevention and early treatment of the
disease. To provide the basis for individualized stratified prevention and treatment of
patients with multiple myeloma myocardial amyloidosis, reduce the family medical burden
and related side effects, improve the quality of life of patients with myeloma myocardial
amyloidosis, prolong the survival period, and improve the cure rate
Criteria for eligibility:
Study pop:
Patients with multiple myeloma complicated with myocardial amyloidosis
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
A patient with multiple myeloma complicated with myocardial amyloidosis was diagnosed in
our hospital since January 1, 2018
Exclusion Criteria:
A patient without multiple myeloma complicated with myocardial amyloidosis was diagnosed
in our hospital since January 1, 2018
Gender:
All
Minimum age:
N/A
Maximum age:
N/A
Healthy volunteers:
Accepts Healthy Volunteers
Locations:
Facility:
Name:
First Affiliated Hospital of Xian Jiaotong University
Address:
City:
Xi'an
Zip:
710061
Country:
China
Start date:
November 1, 2022
Completion date:
December 31, 2024
Lead sponsor:
Agency:
First Affiliated Hospital Xi'an Jiaotong University
Agency class:
Other
Source:
First Affiliated Hospital Xi'an Jiaotong University
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05718401
