Early Blocking Strategy for Metachronous Liver Metastasis of Colorectal Cancer Based on Pre-hepatic CTC Detection

Trial Title: Early Blocking Strategy for Metachronous Liver Metastasis of Colorectal Cancer Based on Pre-hepatic CTC Detection

NCT ID: NCT05720559

Condition: Preventive Effect of Quintuple Therapy on Metachronous Liver Metastases in Patients With Colorectal Cancer

Conditions: Official terms:
Colorectal Neoplasms
Neoplasm Metastasis
Liver Neoplasms
Folic Acid
Vitamin A
Metronidazole
Capecitabine
Oxaliplatin
Cetuximab

Study type: Interventional

Study phase: Phase 2

Overall status: Not yet recruiting

Study design:

Allocation: Randomized

Intervention model: Single Group Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: Oxaliplatin
Description: Oxaliplatin via intravenous drip on d1 at a dose of 130mg/m2 × patient 's body surface area
Arm group label: Conventional treatment group
Arm group label: Quintuple method treatment group

Intervention type: Drug
Intervention name: S1
Description: Orally on d2-d15 at 20 mg three times daily
Arm group label: Quintuple method treatment group

Intervention type: Drug
Intervention name: Cetuximab
Description: Cetuximab combined with chemotherapy was administered simultaneously, once every three weeks,and intravenous drip was performed before oxaliplatin at a dose of 250 mg/m2 × body surface area.
Arm group label: Quintuple method treatment group

Intervention type: Drug
Intervention name: Metronidazole
Description: Metronidazole 0.4g/time, qd
Arm group label: Quintuple method treatment group

Intervention type: Drug
Intervention name: Vitamin A
Description: Vitamin A 25,000 units/time, qd
Arm group label: Quintuple method treatment group

Intervention type: Drug
Intervention name: Folic acid
Description: Folic acid 0.4 mg/time, qd
Arm group label: Quintuple method treatment group

Intervention type: Drug
Intervention name: Capecitabine
Description: Capecitabine via orally on d2-d15 two times daily at a dose of 1000mg/m2 × patient 's body surface area.
Arm group label: Conventional treatment group

Summary: In this study, the Quintuple method was applied for early intervention of prehepatic CTC-positive bowel cancer patients without dominant liver metastasis, aiming to explore the blocking effect of the Quintuple method on the metachronous liver metastases of colorectal cancer. A one-arm randomized clinical trial was conducted, and the patients were grouped according to their treatment methods. The patients with metachronous liver metastases were used as the end point of the experiment to evaluate the blocking effect of quintuple therapy.

Detailed description: Patients diagnosed with colorectal cancer, clinical stage I to III, underwent radical surgery, and prehepatic CTC≥1 were enrolled. Patients were randomly divided into Conventional treatment group and Quintuple method treatment group. Patients in the Conventional treatment group received conventional treatment according to the NCCN Guidelines for Colorectal Cancer 2023 edition. For patients in the Quintuple method treatment group, Quintuple method intervention was adopted, that is, combined with SOX regimen chemotherapy, low-dose cetuximab targeted therapy and three-drug regimen of folic acid, vitamin A and metronidazole. Specific drug dosages were as follows: SOX regimen was administered every three weeks, d1 was given oxaliplatin intravenously, the dosage was 130mg/ m2 * patient's body surface area, d2-d15 was taken orally by Digio, 20mg three times a day each time. Cetuximab combined with chemotherapy was administered intravenously, once every three weeks, before oxaliplatin, and the dosage was 250mg/ m2 * patient's body surface area. Metronidazole 0.4g/ time, once a day; Vitamin A 25,000 units/time, once a day; Folic acid 0.4mg/ time, once a day. The last three drugs were continued until the end of all chemotherapy cycles. The above regimen lasted for 6 to 8 sessions, and enrolled patients were reviewed every 3 months for colorectal cancer-related tumor markers, including MRI and CT imaging. The primary endpoint was radiographically confirmed metachronous liver metastases, and the secondary endpoint was death, observed for 3 years.

Criteria for eligibility:
Criteria:
Inclusion Criteria: 1. Ages 18-80 at the time of signing the informed consent; 2. Histologically or cytologically confirmed adenocarcinoma of the colon or rectum; 3. Radical surgery has been performed; 4. Imaging examination showed no liver metastasis; 5. Prehepatic CTC number ≥1; 6. The ECOG performance status is 0-1. 7. No combination of other life-threatening diseases; 8. Willingness and ability to follow scheduled visits, treatment plans, laboratory tests and other research procedures. Exclusion Criteria: 1. Patients with non-primary colorectal cancer; 2. Patients with liver metastasis or other organ metastasis; 3. Patients without prehepatic CTC or whose prehepatic CTC were negative; 4. People who are severely allergic to one or more of the drugs required in the test; 5. Patients with severe underlying diseases of respiratory, circulatory, urinary and hematopoietic systems.

Gender: All

Minimum age: 18 Years

Maximum age: 80 Years

Healthy volunteers: No

Start date: March 1, 2023

Completion date: September 1, 2026

Lead sponsor:
Agency: Liaoning Tumor Hospital & Institute
Agency class: Other

Source: Liaoning Tumor Hospital & Institute

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT05720559