Trial Title:
SC0245 and Irinotecan in Treating Patients With Relapsed Extensive-Stage Small Cell Lung Cancer (ES-SCLC)
NCT ID:
NCT05731518
Condition:
Small Cell Lung Cancer
Conditions: Official terms:
Lung Neoplasms
Small Cell Lung Carcinoma
Irinotecan
Study type:
Interventional
Study phase:
Phase 1/Phase 2
Overall status:
Recruiting
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Primary purpose:
Treatment
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
SC0245
Description:
SC0245 Quaque Die(QD) administered with a 3-day on and 4-day off schedule in Day 1 Day8
and Day 15 of each cycle. One cycle is consisted of 28 days.
Arm group label:
SC0245 and irinotecan combination
Other name:
SC0245 tablet
Intervention type:
Drug
Intervention name:
Irinotecan
Description:
Irinotecan 80mg/m^2 via IV administered for every 4 weeks (fixed dosing) in Day 1 Day8
and Day 15 of each cycle. One cycle is consisted of 28 days.
Arm group label:
SC0245 and irinotecan combination
Other name:
Irinotecan hydrochloride injection
Summary:
This study is a single arm, multi-center, open label phase Ib/II study of SC0245 and
Irinotecan combination therapy in subjects with extensive-stage small cell lung cancer
(ES-SCLC) as a second therapy. This study will have three parts, phase 1 dose escalation
(Part 1), phase 1 dose expansion (Part 2), and phase 2 combination therapy (Part 3).
Detailed description:
This study will have three parts, phase 1 dose escalation (Part 1), phase 1 dose
expansion (Part 2)， and phase 2 combination therapy (Part 3).
Subjects will receive SC0245 and Irinotecan combination therapy. The study is composed of
67 subjects.
Irinotecan 80mg/m2 via IV administered for every 4 weeks (fixed dosing) in Day 1 Day8 and
Day 15 of each cycle, and SC0245 administered with a 3-day on and 4-day off schedule in
Day 1 Day8 and Day 15 of each cycle. One cycle is consisted of 28 days.
Study treatment will be continued until objective disease progression (unless other
criteria for treatment discontinuation are met). Tumor evaluation using CT or MRI by
RECIST 1.1 every 8weeks(±1week) until objective disease progression. RECIST 1.1 scans
will be analyzed by the investigator on site. If a subject discontinues study treatment
prior to disease progression, they should continue to be assessed using RECIST 1.1 until
disease progression and then followed up for survival.
Primary Objective:
Part 1 (phase 1 dose escalation): To determine the maximum tolerated dose (MTD) and
recommended phase 2 dose (RP2D) of SC0245 in combination with irinotecan in patients with
advanced solid tumors.
Part 2 (phase 1 dose expansion): To evaluate the safety and tolerability of SC0245 in
combination with irinotecan in patients with relapsed extensive-stage small cell lung
cancer (ES-SCLC).
Part 3(phase 2 combination therapy): To evaluate the preliminary anti-tumor activity of
SC0245 in combination with irinotecan in patients with relapsed extensive-stage small
cell lung cancer (ES-SCLC).
Secondary Objective:
Part 1 (phase 1 dose escalation): To characterize the PK profile and the preliminary
anti-tumor activity.
Part 2 (phase 1 dose expansion): To characterize the PK profile, safety and tolerability
and the preliminary anti-tumor activity in patients with relapsed extensive-stage small
cell lung cancer (ES-SCLC).
Part 3(phase 2 combination therapy): To characterize the safety and tolerability and the
preliminary anti-tumor activity in patients with relapsed extensive-stage small cell lung
cancer (ES-SCLC).
Criteria for eligibility:
Criteria:
Inclusion Criteria:
1. Histologically or cytologically confirmed solid tumor.
2. Phase 1b dose-escalation stage: patients with advanced solid tumors, who have
received standard treatment, for who no standard treatment exists, who are not
suitable for standard treatment at the current situation, or who could not tolerate
standard treatment.
Phase 1b dose-expansion stage and phase 2: patients with ES-SCLC who have received
first-line platinum-based regimen chemotherapy with or without immunotherapy or
intolerance to such therapy.
3. Measurable lesions according to RECIST version 1.1 (only applicable for phase 1b
dose-expansion and Phase 2).
4. Male or non-pregnant, non-lactating female patients age ≥18 years on day of signing
the informed consent.
5. Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 1.
6. Life expectancy ≥ 3 months.
7. Adequate organ function .
8. Females of child-bearing potential (nonlactating) must have a negative blood
pregnancy test within 7 days before enrollment, and must agree to use a medically
effective contraception from the time they provided the informed consent until at
least 6 months (or at least 180 days) after the last dose of study drug, unless
surgical sterilization or menopause for more than 1 year. Patients who are sexually
active men with a female partner of child-bearing potential must agree to use
adequate contraception from the time they provided informed consent until at least 6
months after the last dose.
9. Subjects voluntarily participate in this study and sign the informed consent form.
Exclusion Criteria:
1. Received chemotherapy within 3 weeks before first dose of study drug (6 weeks for
nitrosoureas or mitomycin C)
2. Received wide field radiotherapy within 4 weeks before first dose of study drug
(previous palliative radiation therapy for metastatic disease is permitted if it has
been completed at least 1 week before first dose of study drug and related toxicity
has recovered to ≤ grade 1)
3. Received any monoclonal antibody, radioimmunoconjugate or antibody-drug conjugates
(ADC) within 5 half-lives or 4 weeks (whichever is shorter) before first dose.
4. Received any other type of anti-tumor therapy including other investigational drugs
or treatments not listed above within 4 weeks before first dose of study drug.
5. Had major organ surgery, except diagnostic biopsy, or significant trauma within 4
weeks, or not fully recovered from surgery within 4 weeks before first dose of study
drug.
6. Received traditional Chinese herbal medicines with anti-tumor indications within 2
weeks before first dose of study drug.
7. Previously received any Ataxia-Telangiectasia and Rad3 Related（ATR）inhibitor.
8. Continuous toxicities due to prior treatments that do not recover to ≤ Grade 1
severity per NCI CTCAE v5.0 except for clinically non-significant events judged by
the Investigator (e.g., alopecia, grade 2 peripheral neurotoxicity, stable
hypothyroidism with hormone replacement therapy, etc.)
9. Allergy to any component of the SC0245 tablets and irinotecan injection or who meet
contraindications to irinotecan. In addition, the prohibited concomitant drugs in
irinotecan label should be avoided.
10. Crigler-Najjar syndrome (Type I and II) or UGT1A1 mutation that increases irinotecan
toxicity (Gilbert's syndrome).
11. Central nervous system (CNS) metastases meeting any of the following condition:
- Presence of new or progressive lesions in brain by imaging within 4 weeks prior
to first dose of study drug
- Presence of symptoms of CNS metastasis
- Received corticosteroids, radiotherapy, or dehydration drugs within 1 week to
control symptoms of CNS metastasis (except for patients who completed
radiotherapy for brain metastases, no use of cortisol and dehydration drugs
without neurologic symptoms for more than 1 week, and brain metastases are in a
stable state or have shrinkage during follow-up visit at least 2 weeks later,
which need to be confirmed before first dose of study drug)
- Carcinomatous meningitis
- Brain stem (midbrain, pons, medulla oblongata) and spinal cord metastases
12. Active infections that require systematic treatment
13. Severe cardiovascular disorder, who meet any of the following conditions:
- corrected QT interval(QTc)> 470 ms
- Severe cardiac rhythm or conduction abnormalities, including but not limited to
complete left bundle branch block, atrioventricular block of degree II or
above, rapid ventricular tachycardia (including frequent premature ventricular
contractions), torsades de pointes.
- Any risk factors that increase the prolongation of the QTc interval, such as
uncorrectable hypokalemia, genetic long QT syndrome, taking medications that
prolong the QTc interval (mainly antiarrhythmic drugs of Class Ia, Ic, or III)
- Congestive heart failure (New York Heart Association Class≥3), or a left
ventricular ejection fraction of less than 50%
- Clinically uncontrolled hypertension, defined as systolic blood pressure (SBP)
≥ 160 mmHg and diastolic blood pressure (DBP) ≥ 100 mmHg after medication.
- Acute coronary syndrome, aortic dissection, myocardial infarction, unstable
angina pectoris, cerebrovascular accident, or other Grade 3 or higher
cardiovascular or cerebrovascular event within 6 months prior to the first dose
14. Major gastrointestinal surgery, or malabsorption syndrome, or are unable to swallow
tablets that may impair the absorption of SC0245 tablets, or other active diseases
or pathological conditions that may impact absorption, distribution, metabolism,
excretion of SC0245 (such as uncontrollable nausea, vomiting, diarrhea, intestinal
obstruction) as judged by the Investigator within 4 weeks before first dose of study
drug.
15. Tertiary-interstitial effusion (e.g., pericardial, pleural, and peritoneal effusion)
requiring repeated drainage or other treatments, but still could not be controlled
within two weeks before first dose of study drug and are judged unsuitable to
participate in the study by the Investigator.
16. Patients with other known malignant diseases. Exceptions: History of curative
treatment for malignancy with no recurrence within 5 years; adequately treated
non-melanoma skin cancer or lentigo malign; carcinoma in situ adequately treated
with no signs of recurrence
17. UGT1A1 mutation.
18. Patients with underlying medical conditions (including laboratory abnormalities),
alcohol or drug abuse or dependence that may affect study drug administration or the
interpretation of drug toxicity or adverse events (AEs), or result in poor
compliance, and are judged unsuitable to participate in the study by the
Investigator.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Shanghai Chest Hospital
Address:
City:
Shanghai
Zip:
200030
Country:
China
Status:
Recruiting
Contact:
Last name:
SHUN LU, Prof
Phone:
13601813062
Email:
Shun_lu@hotmail.com
Contact backup:
Last name:
YONGFENG YU, Chief
Phone:
18017321559
Email:
yuyongfeng212@126.com
Start date:
February 23, 2023
Completion date:
February 28, 2026
Lead sponsor:
Agency:
Biocity Biopharmaceutics Co., Ltd.
Agency class:
Industry
Source:
Biocity Biopharmaceutics Co., Ltd.
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05731518
