Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer

Trial Title: Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer

NCT ID: NCT05740566

Condition: Small Cell Lung Cancer (SCLC)

Conditions: Official terms:
Lung Neoplasms
Small Cell Lung Carcinoma
Topotecan
Amrubicin
AMG 757

Conditions: Keywords:
Small Cell Lung Cancer
SCLC
AMG 757
Tarlatamab

Study type: Interventional

Study phase: Phase 3

Overall status: Active, not recruiting

Study design:

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: Tarlatamab
Description: Tarlatamab will be administered as an IV infusion.
Arm group label: Tarlatamab

Other name: AMG 757

Intervention type: Drug
Intervention name: Lurbinectedin
Description: Lurbinectedin will be administered per local SOC.
Arm group label: Standard of Care

Intervention type: Drug
Intervention name: Topotecan
Description: Topotecan will be administered per local SOC.
Arm group label: Standard of Care

Intervention type: Drug
Intervention name: Amrubicin
Description: Amrubicin will be administered per local SOC.
Arm group label: Standard of Care

Summary: The main objective is to compare the efficacy of tarlatamab with standard of care (SOC) on prolonging overall survival (OS).

Criteria for eligibility:
Criteria:
Inclusion Criteria: - Participant has provided informed consent prior to initiation of any study specific activities/procedures. - Age ≥ 18 years (or legal adult age within country, whichever is older) at the time of signing the informed consent. - Histologically or cytologically confirmed SCLC with demonstrated progression or relapse. - Participants who progressed or recurred following 1 platinum-based regimen. - Measurable disease as defined per RECIST 1.1 within the 21-day screening period. - Eastern Cooperative Oncology Group (ECOG) PS of 0 or 1. - Minimum life expectancy of 12 weeks. - Adequate organ function. Exclusion Criteria: - Disease Related - Symptomatic central nervous system (CNS) metastases with exceptions defined in the protocol. - Diagnosis or evidence of leptomeningeal disease. - Prior history of immune checkpoint inhibitors resulting in events defined in the protocol. - Other Medical Conditions - Active autoimmune disease that has required systemic treatment (except replacement therapy) within the past 2 years or any other diseases requiring immunosuppressive therapy. - History of solid organ transplantation. - History of other malignancy within the past 2 years, with exceptions defined in the protocol. - Myocardial infarction and/or symptomatic congestive heart failure (New York Heart Association > class II) within 12 months prior to first dose of study treatment. - History of arterial thrombosis (eg, stroke or transient ischemic attack) within 12 months prior to first dose of study treatment. - Presence or history of viral infection based on criteria per protocol. - Receiving systemic corticosteroid therapy or any other form of immunosuppressive therapy within 7 days prior to first dose of study treatment. - Symptoms and/or radiographic signs that indicate an acute and/or uncontrolled active systemic infection requiring antibiotics within 7 days prior to the first dose study treatment. - Evidence of interstitial lung disease or active, non-infectious pneumonitis. - Prior/Concomitant Therapy - Prior therapy with tarlatamab or any of the standard of care chemotherapy included as part of this trial or participation in any tarlatamab or any other DLL3 targeted agent clinical trial. - Prior therapy with any selective inhibitor of the DLL3 pathway. - Participant received more than one prior systemic therapy regimen for SCLC. - Prior anti-cancer therapy within 21 days prior to first dose of study treatment with exceptions defined in protocol. - Current anti-cancer therapy such as chemotherapy, immunotherapy, or targeted therapy with exceptions. - Use of herbal or prescription/non-prescription medications known to inhibit membrane transporters P-glycoprotein (P-gp) and/or breast cancer resistance protein (BCRP) within 7 days prior to the first dose of study treatment. - Use of herbal or prescription/non-prescription medications known to be moderate or strong inhibitors of cytochrome P450 3A (CYP3A) enzymes within 7 days prior to the first dose of study treatment. - Use of herbal or prescription/non-prescription medications known to be moderate or strong inducers of CYP3A enzymes within 28 days prior to first dose of study treatment. - Participants who have reached the limit dose of prior treatment with cardiotoxic drugs. - Major surgical procedures within 28 days prior to first dose of study treatment. - Live and live-attenuated vaccines within 14 days prior to the start of study treatment. - Inactive vaccines and live viral non-replicating vaccines within 3 days prior to the first dose of study treatment. - Currently receiving treatment in another investigational device or drug study, or less than 30 days since ending treatment on another investigational device or drug study(ies). Other investigational procedures while participating in this study are excluded. - Diagnostic Assessments - Any previous diagnosis of transformed non-small cell lung cancer (NSCLC), epidermal growth factor receptor (EGFR) activating mutation positive NSCLC that has transformed to SCLC, with exceptions defined in the protocol. - Other Exclusions - Female participants of childbearing potential unwilling to use protocol specified method of contraception during treatment and for an additional 60 days after the last dose of tarlatamab. - Female participants who are breastfeeding or who plan to breastfeed while on study through 60 days after the last dose of tarlatamab. - Female participants planning to become pregnant or donate eggs while on study through 60 days after the last dose of tarlatamab. - Female participants of childbearing potential with a positive pregnancy test assessed at screening by a serum pregnancy test. - Male participants with a female partner of childbearing potential who are unwilling to practice sexual abstinence (refrain from heterosexual intercourse) or use contraception during treatment and for an additional 60 days after the last dose of tarlatamab. - Male participants with a pregnant partner who are unwilling to practice abstinence or use a condom during treatment and for an additional 60 days after the last dose of tarlatamab. - Male participants unwilling to abstain from donating sperm during treatment and for an additional 60 days after the last dose of tarlatamab. - Contraception requirements for male and female participants receiving SOC therapies are based on regional prescribing information. - Breastfeeding restrictions for female participants receiving SOC therapies are based on regional prescribing information. - Participant has known sensitivity or is contraindicated to any of the products or components to be administered during dosing. - Participant likely to not be available to complete all protocol-required study visits or procedures, and/or to comply with all required study procedures. - History or evidence of any other clinically significant disorder, condition or disease determined by the investigator or Amgen physician that would pose a risk to the subject safety or interfere with the study evaluation..

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: University of South Alabama Mitchell Cancer Institute

Address:
City: Mobile
Zip: 36604
Country: United States

Facility:
Name: Alaska Oncology and Hematology

Address:
City: Anchorage
Zip: 99508
Country: United States

Facility:
Name: University of Arkansas for Medical Sciences

Address:
City: Little Rock
Zip: 72205
Country: United States

Facility:
Name: University of California Los Angeles

Address:
City: Santa Monica
Zip: 90404
Country: United States

Facility:
Name: Northwestern University

Address:
City: Chicago
Zip: 60611
Country: United States

Facility:
Name: University of Illinois Chicago

Address:
City: Chicago
Zip: 60612
Country: United States

Facility:
Name: Indiana University

Address:
City: Indianapolis
Zip: 46202
Country: United States

Facility:
Name: University of Iowa

Address:
City: Iowa City
Zip: 52242
Country: United States

Facility:
Name: Pikeville Medical Center

Address:
City: Pikeville
Zip: 41501
Country: United States

Facility:
Name: Our Lady of the Lake Cancer Institute

Address:
City: Baton Rouge
Zip: 70808
Country: United States

Facility:
Name: Trinity Health Saint Joseph Mercy Ann Arbor

Address:
City: Ann Arbor
Zip: 48106
Country: United States

Facility:
Name: University of Minnesota Cancer Center

Address:
City: Minneapolis
Zip: 55455
Country: United States

Facility:
Name: University of Missouri Health Care

Address:
City: Columbia
Zip: 65212
Country: United States

Facility:
Name: Summit Medical Group, Overlook Oncology Center

Address:
City: Summit
Zip: 91010
Country: United States

Facility:
Name: New York University Grossman School of Medicine and New York University Langone Hospitals

Address:
City: New York
Zip: 10016
Country: United States

Facility:
Name: Perlmutter Cancer Center at New York University Langone Hospital----Long Island

Address:
City: New York
Zip: 10016
Country: United States

Facility:
Name: Memorial Sloan Kettering Cancer Center

Address:
City: New York
Zip: 10021
Country: United States

Facility:
Name: Northport Veterans Affairs Medical Center

Address:
City: Northport
Zip: 11768
Country: United States

Facility:
Name: Sanford Roger Maris Cancer Center

Address:
City: Fargo
Zip: 58102
Country: United States

Facility:
Name: Sanford Oncology Clinic and Pharmacy

Address:
City: Sioux Falls
Zip: 57104
Country: United States

Facility:
Name: University of Tennessee Medical Center Knoxville

Address:
City: Knoxville
Zip: 37920
Country: United States

Facility:
Name: Baptist Cancer Center

Address:
City: Memphis
Zip: 38120
Country: United States

Facility:
Name: Virginia Commonwealth University

Address:
City: Richmond
Zip: 23298
Country: United States

Facility:
Name: Swedish Cancer Institute Medical Oncology

Address:
City: Edmonds
Zip: 98026
Country: United States

Facility:
Name: The Medical College of Wisconsin

Address:
City: Milwaukee
Zip: 53226
Country: United States

Facility:
Name: Cemic

Address:
City: Ciudad Autonoma de Buenos Aires
Zip: C1431FWO
Country: Argentina

Facility:
Name: Hospital Universitario Austral

Address:
City: Pilar
Zip: B1629ODT
Country: Argentina

Facility:
Name: Sociedad de Beneficencia Hospital Italiano

Address:
City: Cordoba
Zip: X5004BAL
Country: Argentina

Facility:
Name: Clinica Viedma

Address:
City: Viedma
Zip: R8500ACE
Country: Argentina

Facility:
Name: Sanatorio Parque SA

Address:
City: Rosario
Zip: 2000
Country: Argentina

Facility:
Name: Instituto Argentino de Diagnostico y Tratamiento IADT

Address:
City: Buenos Aires
Zip: C1122AAL
Country: Argentina

Facility:
Name: Sanatorio Allende

Address:
City: Córdoba
Zip: X5000JHQ
Country: Argentina

Facility:
Name: Liverpool Hospital

Address:
City: Liverpool
Zip: 2170
Country: Australia

Facility:
Name: Calvary Mater Newcastle Hospital

Address:
City: Waratah
Zip: 2298
Country: Australia

Facility:
Name: Monash Medical Centre

Address:
City: Clayton
Zip: 3168
Country: Australia

Facility:
Name: The Alfred Hospital

Address:
City: Melbourne
Zip: 3004
Country: Australia

Facility:
Name: Medizinische Universitaet Graz

Address:
City: Graz
Zip: 8036
Country: Austria

Facility:
Name: Universitaetsklinikum Krems

Address:
City: Krems
Zip: 3500
Country: Austria

Facility:
Name: Universitair Ziekenhuis Gent

Address:
City: Gent
Zip: 9000
Country: Belgium

Facility:
Name: Jessa Ziekenhuis - Campus Virga Jesse

Address:
City: Hasselt
Zip: 3500
Country: Belgium

Facility:
Name: AZ Delta Campus Rumbeke

Address:
City: Roeselare
Zip: 8800
Country: Belgium

Facility:
Name: Vitaz campus Sint-Niklaas Moerland

Address:
City: Sint-Niklaas
Zip: 9100
Country: Belgium

Facility:
Name: Hospital Santa Izabel

Address:
City: Salvador
Zip: 40050-410
Country: Brazil

Facility:
Name: Instituto de Ensino e Pesquisa do Hospital da Bahia

Address:
City: Salvador
Country: Brazil

Facility:
Name: Liga Norte-Riograndense Contra O Cancer

Address:
City: Natal
Zip: 59075-740
Country: Brazil

Facility:
Name: Oncosite Centro de Pesquisa Clinica Em Oncologia Ltda

Address:
City: Ijui
Zip: 98700-000
Country: Brazil

Facility:
Name: Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul

Address:
City: Porto Alegre
Zip: 90610-000
Country: Brazil

Facility:
Name: Hospital de Amor da Amazonia

Address:
City: Porto Velho
Zip: 76834-899
Country: Brazil

Facility:
Name: Beneficencia Portuguesa de Sao Paulo - Bp

Address:
City: Sao Paulo
Zip: 01323-900
Country: Brazil

Facility:
Name: Oncologia Rede D Or

Address:
City: Sao Paulo
Zip: 04502-001
Country: Brazil

Facility:
Name: Hospital de Base de Sao Jose do Rio Preto

Address:
City: São José do Rio Preto
Zip: 15090-000
Country: Brazil

Facility:
Name: Instituto Coi

Address:
City: Rio de Janeiro
Zip: 22793-080
Country: Brazil

Facility:
Name: Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira Icesp

Address:
City: São Paulo
Zip: 01246-000
Country: Brazil

Facility:
Name: London Health Sciences Centre

Address:
City: London
Zip: N6A 5W9
Country: Canada

Facility:
Name: Princess Margaret Cancer Centre

Address:
City: Toronto
Zip: M5G 2M9
Country: Canada

Facility:
Name: Anhui Chest Hospital

Address:
City: Hefei
Zip: 230022
Country: China

Facility:
Name: Beijing Tongren Hospital affiliated to Capital Medical University

Address:
City: Beijing
Zip: 100010
Country: China

Facility:
Name: Beijing Cancer Hospital

Address:
City: Beijing
Zip: 100142
Country: China

Facility:
Name: The Second Affiliated Hospital of Army Medical University, PLA

Address:
City: Chongqing
Zip: 400037
Country: China

Facility:
Name: Army Special Medical Center of Peoples Liberation Army

Address:
City: Chongqing
Zip: 400042
Country: China

Facility:
Name: Fujian Medical University Union Hospital

Address:
City: Fuzhou
Zip: 350001
Country: China

Facility:
Name: Mengchao Hepatobiliary Hospital of Fujian Medical University

Address:
City: Fuzhou
Zip: 350025
Country: China

Facility:
Name: Sun Yat-Sen University Cancer Center

Address:
City: Guangzhou
Zip: 510060
Country: China

Facility:
Name: Jiangmen Central Hospital

Address:
City: Jiangmen
Zip: 529030
Country: China

Facility:
Name: The 4th Hospital of Hebei Medical University

Address:
City: Shijiazhuang
Zip: 050000
Country: China

Facility:
Name: Affiliated Cancer Hospital of Harbin Medical University

Address:
City: Harbin
Zip: 150000
Country: China

Facility:
Name: Union Hospital Tongji Medical College Huazhong University of Science and Technology

Address:
City: Wuhan
Zip: 430022
Country: China

Facility:
Name: Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

Address:
City: Wuhan
Zip: 430030
Country: China

Facility:
Name: Hunan Cancer Hospital

Address:
City: Changsha
Zip: 410013
Country: China

Facility:
Name: Subei Peoples Hospital

Address:
City: Yangzhou
Zip: 225009
Country: China

Facility:
Name: The First Affiliated Hospital of Nanchang University

Address:
City: Nanchang
Zip: 330006
Country: China

Facility:
Name: Jilin Cancer Hospital

Address:
City: Changchun
Zip: 130012
Country: China

Facility:
Name: Jinan Central Hospital

Address:
City: Jinan
Zip: 250013
Country: China

Facility:
Name: Shandong Tumor Hospital

Address:
City: Jinan
Zip: 250117
Country: China

Facility:
Name: Linyi Cancer Hospital

Address:
City: Linyi
Zip: 276034
Country: China

Facility:
Name: Shanghai Chest Hospital

Address:
City: Shanghai
Zip: 200030
Country: China

Facility:
Name: Fudan University Shanghai Cancer Center

Address:
City: Shanghai
Zip: 200032
Country: China

Facility:
Name: Shanxi Province Cancer Hospital

Address:
City: Taiyuan
Zip: 30009
Country: China

Facility:
Name: West China Hospital of Sichuan University

Address:
City: Chengdu
Zip: 610041
Country: China

Facility:
Name: The First Affiliated Hospital Zhejiang University School of Medicine

Address:
City: Hangzhou
Zip: 310003
Country: China

Facility:
Name: The Second Affiliated Hospital Zhejiang University School of Medicine

Address:
City: Hangzhou
Zip: 310003
Country: China

Facility:
Name: Zhejiang Cancer Hospital

Address:
City: Hangzhou
Zip: 310005
Country: China

Facility:
Name: Taizhou Hospital of Zhejiang Province

Address:
City: Taizhou
Zip: 317099
Country: China

Facility:
Name: The First Affiliated Hospital of Wenzhou Medical University

Address:
City: Wenzhou
Zip: 325015
Country: China

Facility:
Name: Beijing Chest Hospital, Capital Medical University

Address:
City: Beijing
Zip: 101149
Country: China

Facility:
Name: Fujian Cancer Hospital

Address:
City: Fuzhou
Zip: 350011
Country: China

Facility:
Name: Tianjin Peoples Hospital

Address:
City: Tianjin
Zip: 300131
Country: China

Facility:
Name: Weihai Municipal Hospital

Address:
City: Weihai
Zip: 264200
Country: China

Facility:
Name: Fakultni nemocnice Brno

Address:
City: Brno
Zip: 625 00
Country: Czechia

Facility:
Name: Masarykuv onkologicky ustav

Address:
City: Brno
Zip: 656 53
Country: Czechia

Facility:
Name: Fakultni nemocnice Olomouc

Address:
City: Olomouc
Zip: 779 00
Country: Czechia

Facility:
Name: Nemocnice Agel Ostrava-Vitkovice as

Address:
City: Ostrava-Vitkovice
Zip: 703 00
Country: Czechia

Facility:
Name: Vseobecna fakultni nemocnice v Praze

Address:
City: Praha 2
Zip: 128 08
Country: Czechia

Facility:
Name: Rigshospitalet

Address:
City: Copenhagen
Zip: 2100
Country: Denmark

Facility:
Name: Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon

Address:
City: Grenoble
Zip: 38700
Country: France

Facility:
Name: Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon

Address:
City: Lille Cedex
Zip: 59037
Country: France

Facility:
Name: Centre Hospitalier Regional Universitaire de Limoges - Hopital Dupuytren

Address:
City: Limoges Cedex
Zip: 87042
Country: France

Facility:
Name: Centre Leon Berard

Address:
City: Lyon
Zip: 69008
Country: France

Facility:
Name: Centre Hospitalier Universitaire Nord

Address:
City: Marseille Cedex 20
Zip: 13915
Country: France

Facility:
Name: Institut Curie

Address:
City: Paris
Zip: 75005
Country: France

Facility:
Name: Centre Hospitalier Lyon Sud

Address:
City: Pierre-Benite cedex
Zip: 69495
Country: France

Facility:
Name: Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou

Address:
City: Rennes Cedex 9
Zip: 35033
Country: France

Facility:
Name: Centre Hospitalier Universitaire de Strasbourg - Nouvel Hopital Civil

Address:
City: Strasbourg Cedex
Zip: 67091
Country: France

Facility:
Name: Centre Hospitalier Universitaire de Toulouse - Hopital Larrey

Address:
City: Toulouse Cedex 9
Zip: 31059
Country: France

Facility:
Name: Gustave Roussy

Address:
City: Villejuif
Zip: 94805
Country: France

Facility:
Name: Charite Universitaetsmedizin Berlin, Campus Virchow

Address:
City: Berlin
Zip: 13353
Country: Germany

Facility:
Name: Universitaetsklinikum Dresden

Address:
City: Dresden
Zip: 01307
Country: Germany

Facility:
Name: Universitaetsklinikum Essen

Address:
City: Essen
Zip: 45147
Country: Germany

Facility:
Name: Asklepios Fachkliniken Muenchen Gauting

Address:
City: Gauting
Zip: 82130
Country: Germany

Facility:
Name: LungenClinic Grosshansdorf GmbH

Address:
City: Grosshansdorf
Zip: 22927
Country: Germany

Facility:
Name: Universitaetsklinikum Koeln

Address:
City: Koeln
Zip: 50937
Country: Germany

Facility:
Name: Robert-Bosch-Krankenhaus

Address:
City: Stuttgart
Zip: 70376
Country: Germany

Facility:
Name: Universitaetsklinikum Wuerzburg

Address:
City: Wuerzburg
Zip: 97078
Country: Germany

Facility:
Name: Saint Savas Hospital

Address:
City: Athens
Zip: 11522
Country: Greece

Facility:
Name: Henry Dunant Hospital Center

Address:
City: Athens
Zip: 11526
Country: Greece

Facility:
Name: Thoracic General Hospital Of Athens Sotiria

Address:
City: Athens
Zip: 11527
Country: Greece

Facility:
Name: Alexandra Hospital

Address:
City: Athens
Zip: 11528
Country: Greece

Facility:
Name: University Hospital of Heraklion

Address:
City: Heraklion - Crete
Zip: 71500
Country: Greece

Facility:
Name: Olympion Therapeftirio General Clinic Of Patras

Address:
City: Patra
Zip: 26443
Country: Greece

Facility:
Name: Saint Luke Hospital

Address:
City: Thessaloniki
Zip: 55236
Country: Greece

Facility:
Name: European Interbalkan Medical Center

Address:
City: Thessaloniki
Zip: 57001
Country: Greece

Facility:
Name: Semmelweis Egyetem

Address:
City: Budapest
Zip: 1083
Country: Hungary

Facility:
Name: Orszagos Koranyi Pulmonologiai Intezet

Address:
City: Budapest
Zip: 1121
Country: Hungary

Facility:
Name: Matrai Gyogyintezet

Address:
City: Gyongyos
Zip: 3200
Country: Hungary

Facility:
Name: Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz

Address:
City: Szekesfehervar
Zip: 8000
Country: Hungary

Facility:
Name: Komarom-Esztergom Varmegyei Szent Borbala Korhaz

Address:
City: Tatabanya
Zip: 2800
Country: Hungary

Facility:
Name: Reformatus Pulmonologiai Centrum

Address:
City: Torokbalint
Zip: 2045
Country: Hungary

Facility:
Name: Beaumont Hospital

Address:
City: Dublin
Zip: 9
Country: Ireland

Facility:
Name: Rambam Medical Center

Address:
City: Haifa
Zip: 3109601
Country: Israel

Facility:
Name: Hadassah Ein-Kerem Medical Center

Address:
City: Jerusalem
Zip: 9112001
Country: Israel

Facility:
Name: Meir Medical Center

Address:
City: Kfar Saba
Zip: 4428164
Country: Israel

Facility:
Name: Rabin Medical Center

Address:
City: Petah Tikva
Zip: 4941492
Country: Israel

Facility:
Name: Humanitas Gavazzeni

Address:
City: Bergamo
Zip: 24125
Country: Italy

Facility:
Name: Azienda Ospedaliera Universitaria Renato Dulbecco

Address:
City: Catanzaro
Zip: 88100
Country: Italy

Facility:
Name: Ospedale Policlinico San Martino IRCCS

Address:
City: Genova
Zip: 16132
Country: Italy

Facility:
Name: Istituto Romagnolo per lo Studio dei Tumori Dino Amadori

Address:
City: Meldola (FC)
Zip: 47014
Country: Italy

Facility:
Name: Azienda Ospedaliera Universitaria San Luigi Gonzaga

Address:
City: Orbassano
Zip: 10043
Country: Italy

Facility:
Name: Azienda Ospedaliera San Giovanni Addolorata

Address:
City: Roma
Zip: 00144
Country: Italy

Facility:
Name: National Hospital Organization Nagoya Medical Center

Address:
City: Nagoya-shi
Zip: 460-0001
Country: Japan

Facility:
Name: Aichi Cancer Center

Address:
City: Nagoya-shi
Zip: 464-8681
Country: Japan

Facility:
Name: National Cancer Center Hospital East

Address:
City: Kashiwa-shi
Zip: 277-8577
Country: Japan

Facility:
Name: National Hospital Organization Shikoku Cancer Center

Address:
City: Matsuyama-shi
Zip: 791-0280
Country: Japan

Facility:
Name: Kurume University Hospital

Address:
City: Kurume-shi
Zip: 830-0011
Country: Japan

Facility:
Name: National Hospital Organization Hokkaido Cancer Center

Address:
City: Sapporo-shi
Zip: 003-0804
Country: Japan

Facility:
Name: Hyogo Cancer Center

Address:
City: Akashi-shi
Zip: 673-8558
Country: Japan

Facility:
Name: Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center

Address:
City: Yokohama-shi
Zip: 241-8515
Country: Japan

Facility:
Name: Sendai Kousei Hospital

Address:
City: Sendai-shi
Zip: 981-0914
Country: Japan

Facility:
Name: Niigata Cancer Center Hospital

Address:
City: Niigata-shi
Zip: 951-8566
Country: Japan

Facility:
Name: Okayama University Hospital

Address:
City: Okayama-shi
Zip: 700-8558
Country: Japan

Facility:
Name: Kansai Medical University Hospital

Address:
City: Hirakata-shi
Zip: 573-1191
Country: Japan

Facility:
Name: Osaka International Cancer Institute

Address:
City: Osaka-shi
Zip: 541-8567
Country: Japan

Facility:
Name: Kindai University Hospital

Address:
City: Osakasayama-shi
Zip: 589-8511
Country: Japan

Facility:
Name: Saitama Medical University International Medical Center

Address:
City: Hidaka-Shi
Zip: 350-1298
Country: Japan

Facility:
Name: Shizuoka Cancer Center

Address:
City: Sunto-gun
Zip: 411-8777
Country: Japan

Facility:
Name: Juntendo University Hospital

Address:
City: Bunkyo-ku
Zip: 113-8431
Country: Japan

Facility:
Name: National Cancer Center Hospital

Address:
City: Chuo-ku
Zip: 104-0045
Country: Japan

Facility:
Name: The Cancer Institute Hospital of Japanese Foundation for Cancer Research

Address:
City: Koto-ku
Zip: 135-8550
Country: Japan

Facility:
Name: Wakayama Medical University Hospital

Address:
City: Wakayama-shi
Zip: 641-8510
Country: Japan

Facility:
Name: Chungbuk National University Hospital

Address:
City: Cheongju Chungbuk
Zip: 28644
Country: Korea, Republic of

Facility:
Name: National Cancer Center

Address:
City: Goyang-si Gyeonggi-do
Zip: 10408
Country: Korea, Republic of

Facility:
Name: Gachon University Gil Hospital

Address:
City: Incheon
Zip: 21565
Country: Korea, Republic of

Facility:
Name: Gyeongsang National University Hospital

Address:
City: Jinju-si
Zip: 52727
Country: Korea, Republic of

Facility:
Name: Seoul National University Bundang Hospital

Address:
City: Seongnam-si, Gyeonggi-do
Zip: 13620
Country: Korea, Republic of

Facility:
Name: Severance Hospital Yonsei University Health System

Address:
City: Seoul
Zip: 03722
Country: Korea, Republic of

Facility:
Name: Asan Medical Center

Address:
City: Seoul
Zip: 05505
Country: Korea, Republic of

Facility:
Name: Samsung Medical Center

Address:
City: Seoul
Zip: 06351
Country: Korea, Republic of

Facility:
Name: The Catholic University of Korea Seoul St Marys Hospital

Address:
City: Seoul
Zip: 06591
Country: Korea, Republic of

Facility:
Name: Ulsan University Hospital

Address:
City: Ulsan
Zip: 44033
Country: Korea, Republic of

Facility:
Name: Hospital Tengku Ampuan Afzan

Address:
City: Kuantan
Zip: 25100
Country: Malaysia

Facility:
Name: Sarawak General Hospital

Address:
City: Kuching
Zip: 93586
Country: Malaysia

Facility:
Name: University Malaya Medical Centre

Address:
City: Kuala Lumpur
Zip: 59100
Country: Malaysia

Facility:
Name: Oncare

Address:
City: Ciudad de México
Zip: 03810
Country: Mexico

Facility:
Name: Health Pharma Professional Research SA de CV

Address:
City: Mexico City
Zip: 03100
Country: Mexico

Facility:
Name: coi Centro Oncologico Internacional sapi de cv

Address:
City: Tlajomulco de Zúñiga
Zip: 45640
Country: Mexico

Facility:
Name: Universitair Medisch Centrum Groningen

Address:
City: Groningen
Zip: 9713 GZ
Country: Netherlands

Facility:
Name: Leids Universitair Medisch Centrum

Address:
City: Leiden
Zip: 2333 ZA
Country: Netherlands

Facility:
Name: Erasmus Medisch Centrum

Address:
City: Rotterdam
Zip: 3015 GD
Country: Netherlands

Facility:
Name: Universitair Medisch Centrum Utrecht

Address:
City: Utrecht
Zip: 3584 CX
Country: Netherlands

Facility:
Name: Centrum Pulmonologii i Torakochirurgii w Bystrej

Address:
City: Bystra
Zip: 43-360
Country: Poland

Facility:
Name: Szpital Specjalistyczny imienia Ludwika Rydygiera w Krakowie Sp zoo

Address:
City: Krakow
Zip: 31-826
Country: Poland

Facility:
Name: Wielkopolskie Centrum Pulmonologii i Torakochirurgii imienia Eugenii i Janusza Zeylandow

Address:
City: Poznan
Zip: 60-569
Country: Poland

Facility:
Name: Hospital da Luz, SA

Address:
City: Lisboa
Zip: 1500-650
Country: Portugal

Facility:
Name: Hospital Cuf Descobertas

Address:
City: Lisboa
Zip: 1998-018
Country: Portugal

Facility:
Name: Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano

Address:
City: Matosinhos
Zip: 4464-513
Country: Portugal

Facility:
Name: Hospital Cuf porto

Address:
City: Porto
Zip: 4100-180
Country: Portugal

Facility:
Name: Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca

Address:
City: Cluj Napoca
Zip: 400015
Country: Romania

Facility:
Name: Centrul de Oncologie Sf Nectarie SRL

Address:
City: Craiova
Zip: 200542
Country: Romania

Facility:
Name: Institutul Regional de Oncologie Iasi

Address:
City: Iasi
Zip: 700483
Country: Romania

Facility:
Name: SC Oncomed SRL

Address:
City: Timisoara
Zip: 300239
Country: Romania

Facility:
Name: National Cancer Centre Singapore

Address:
City: Singapore
Zip: 168583
Country: Singapore

Facility:
Name: Tan Tock Seng Hospital

Address:
City: Singapore
Zip: 308433
Country: Singapore

Facility:
Name: Hospital Regional Universitario de Malaga

Address:
City: Malaga
Zip: 29011
Country: Spain

Facility:
Name: Hospital Clinico Universitario Lozano Blesa

Address:
City: Zaragoza
Zip: 50009
Country: Spain

Facility:
Name: Hospital del Mar

Address:
City: Barcelona
Zip: 08003
Country: Spain

Facility:
Name: Hospital Universitari Vall d Hebron

Address:
City: Barcelona
Zip: 08035
Country: Spain

Facility:
Name: Hospital de la Santa Creu i Sant Pau

Address:
City: Barcelona
Zip: 08041
Country: Spain

Facility:
Name: Complexo Hospitalario Universitario A Coruna Hospital Teresa Herrera

Address:
City: A Coruña
Zip: 15006
Country: Spain

Facility:
Name: Hospital Universitario Puerta de Hierro Majadahonda

Address:
City: Majadahonda
Zip: 28222
Country: Spain

Facility:
Name: Fundacion Jimenez Diaz

Address:
City: Madrid
Zip: 28040
Country: Spain

Facility:
Name: Hospital Clinico San Carlos

Address:
City: Madrid
Zip: 28040
Country: Spain

Facility:
Name: Hospital Universitario 12 de Octubre

Address:
City: Madrid
Zip: 28041
Country: Spain

Facility:
Name: Kantonsspital Graubuenden

Address:
City: Chur
Zip: 7000
Country: Switzerland

Facility:
Name: Freiburg Spital

Address:
City: Fribourg
Zip: 1708
Country: Switzerland

Facility:
Name: Hopitaux universitaires de Geneve

Address:
City: Geneve 14
Zip: 1211
Country: Switzerland

Facility:
Name: Kantonsspital Sankt Gallen

Address:
City: Sankt Gallen
Zip: 9007
Country: Switzerland

Facility:
Name: Kantonsspital Winterthur

Address:
City: Winterthur
Zip: 8401
Country: Switzerland

Facility:
Name: Kaohsiung Medical University Chung-Ho Memorial Hospital

Address:
City: Kaohsiung
Zip: 80756
Country: Taiwan

Facility:
Name: Veterans General Hospital - Taichung

Address:
City: Taichung
Zip: 40705
Country: Taiwan

Facility:
Name: National Cheng Kung University Hospital

Address:
City: Tainan
Zip: 70403
Country: Taiwan

Facility:
Name: National Taiwan University Hospital

Address:
City: Taipei
Zip: 10002
Country: Taiwan

Facility:
Name: Taipei Veterans General Hospital

Address:
City: Taipei
Zip: 11217
Country: Taiwan

Facility:
Name: Memorial Ankara Hastanesi

Address:
City: Ankara
Zip: 06520
Country: Turkey

Facility:
Name: Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi Hastanesi

Address:
City: Ankara
Zip: 06560
Country: Turkey

Facility:
Name: Ankara Bilkent Sehir Hastanesi

Address:
City: Ankara
Zip: 06800
Country: Turkey

Facility:
Name: Pamukkale Universitesi Tip Fakultesi Hastanesi

Address:
City: Denizli
Zip: 20070
Country: Turkey

Facility:
Name: Bagcilar Medipol Mega Universite Hastanesi

Address:
City: Istanbul
Zip: 34214
Country: Turkey

Facility:
Name: Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi

Address:
City: Istanbul
Zip: 34722
Country: Turkey

Facility:
Name: Ege Universitesi Tip Fakultesi Hastanesi

Address:
City: Izmir
Zip: 35100
Country: Turkey

Facility:
Name: Izmir Ekonomi Universitesi Medical Point Hastanesi

Address:
City: Izmir
Zip: 35575
Country: Turkey

Facility:
Name: Inonu Universitesi Turgut Ozal Tip Merkezi

Address:
City: Malatya
Zip: 44280
Country: Turkey

Facility:
Name: University College London Hospital

Address:
City: London
Zip: NW1 2PG
Country: United Kingdom

Facility:
Name: Guys Hospital

Address:
City: London
Zip: SE1 9RT
Country: United Kingdom

Facility:
Name: Christie Hospital

Address:
City: Manchester
Zip: M20 4BX
Country: United Kingdom

Start date: May 31, 2023

Completion date: July 31, 2027

Lead sponsor:
Agency: Amgen
Agency class: Industry

Source: Amgen

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT05740566
http://www.amgentrials.com