To hear about similar clinical trials, please enter your email below
Trial Title:
Plasma Proteomic Biomarkers for Early Diagnosis of Lung Cancer
NCT ID:
NCT05742204
Condition:
Lung Cancer
Conditions: Official terms:
Lung Neoplasms
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Prospective
Intervention:
Intervention type:
Other
Intervention name:
Plasma protein biomarker analysis
Description:
Plasma samples from lung cancer patients were collected at the time of their diagnosis,
prior to the initiation of treatment.We will use TMT-based proteomics approaches to
analyze more than 2000 proteins in plasma samples from lung cancer patients .
Arm group label:
Lung cancer group
Intervention type:
Other
Intervention name:
Plasma protein biomarker analysis
Description:
Plasma samples of control subjects were collected.
Arm group label:
Control group
Summary:
We will identify plasma proteomics biomarkers for early diagnosis of lung cancer.
Detailed description:
We will use TMT-based proteomics approaches to analyze more than 2000 proteins in plasma
samples from lung cancer patients and controls. Artificial intelligent (AI) assisted
proteomics classifier will be developed for early diagnosis of lung cancer.
Criteria for eligibility:
Study pop:
Study group: Patients with suspected or confirmed diagnosis of lung cancer. Control
group: Non-cancer subjects including healthy volunteers, chronic inflammatory airway
diseases such as chronic obstructive airway disease, asthma, and bronchiectasis, etc.
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- CT screening results showed that the size of pulmonary nodules was more than 5mm
- No treatment related to pulmonary nodules/lung cancer (including surgery,
chemotherapy, radiotherapy, targeted therapy, immunotherapy, interventional therapy,
etc.)
- Complete clinical and imaging data
- Chest CT/ low-dose spiral CT reports can be provided in the last 3 months
- Voluntarily sign informed consent
Exclusion Criteria:
- There is a history of tumor
- Clinically uncontrolled active infections, such as acute pneumonia, tuberculosis,
etc.
- Received any treatment related to pulmonary nodules, such as antibiotics and
hormones, in the past 4 weeks
- Complicated with other tumors and serious diseases of the heart, liver, kidney,
brain, blood and other systems
- Participated in other clinical trials within the last 3 months
- Combined with liver and kidney insufficiency, hypoproteinemia and other diseases
affecting protein content
- You are pregnant or breastfeeding
Gender:
All
Minimum age:
18 Years
Maximum age:
80 Years
Healthy volunteers:
Accepts Healthy Volunteers
Locations:
Facility:
Name:
2nd Affiliated Hospital, School of Medicine, Zhejiang University
Address:
City:
Hangzhou
Zip:
310009
Country:
China
Status:
Recruiting
Contact:
Last name:
Ming Wu, M.D
Phone:
+8613757118715
Email:
iwuming22@zju.edu.cn
Start date:
February 1, 2023
Completion date:
October 31, 2032
Lead sponsor:
Agency:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Agency class:
Other
Source:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05742204
