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Trial Title:
Definition of Mutational Profile of Papillary Thyroid Tumors by Mass-ARRAY
NCT ID:
NCT05766098
Condition:
Papillary Thyroid Cancer
Conditions: Official terms:
Thyroid Cancer, Papillary
Thyroid Diseases
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Prospective
Intervention:
Intervention type:
Genetic
Intervention name:
Genotyping
Description:
Characterization of genetic profile of tumor tissues
Arm group label:
Patients with papillary thyroid cancer
Summary:
Somatic mutations in the MAP (mitogen-activated protein) kinase pathway have been found
in about 80% of papillary thyroid tumors (PTCs). The evaluation of the PTC mutational
profile is crucial for the definition of the prognosis and for predicting the effects of
targeted and personalized therapies. Molecular characterization by mass spectrometry
(Mass ARRAY) allows the search for multiple mutations in a single experiment, in a
sensitive, fast and economic way. A Mass ARRAY platform (PTC-MA) was developed, capable
of identifying the presence of the most common somatic point mutations and rearrangements
in PTC (Pesenti et al., Endocrine 2017). The aim of the study is to characterize the
mutational profile of a large series of papillary thyroid carcinomas (PTC). Tumor samples
will be analyzed using our PTC-MA platform. The molecular profile of PTCs will be
correlated with the clinical and prognostic characteristics of the patients.
Criteria for eligibility:
Study pop:
Patients diagnosed with papillary thyroid cancer, operated and followed by our Center of
Excellence for the Diagnosis and Treatment of Thyroid Tumors
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- patients with papillary thyroid cancer
- patients whose tumor tissue can be recovered for genetic analysis
Exclusion Criteria:
- patients who did not give consent
- patients lost to follow-up
- tumor samples not suitable for genetic analysis
Gender:
All
Minimum age:
N/A
Maximum age:
N/A
Locations:
Facility:
Name:
Istituto Auxologico Italiano
Address:
City:
Milan
Zip:
20145
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Gianfranco Parati, MD
Phone:
0261911
Phone ext:
2890
Email:
gianfranco.parati@unimib.it
Start date:
January 8, 2019
Completion date:
December 31, 2027
Lead sponsor:
Agency:
Istituto Auxologico Italiano
Agency class:
Other
Source:
Istituto Auxologico Italiano
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05766098
