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Trial Title:
Genomics and Prognosis in GI Cancers
NCT ID:
NCT05767697
Condition:
GI Cancer
Liver Cancer
Conditions: Official terms:
Liver Neoplasms
Study type:
Observational [Patient Registry]
Overall status:
Recruiting
Study design:
Time perspective:
Prospective
Summary:
This study aims to collect biospecimens and explore the correlation of genomics and
prognosis in alimentary tract cancers.
Detailed description:
In this study, the investigators will collect clinical specimens of alimentary tract
cancers and perform DNA and RNA analysis to identify genetic alterations for the
development of a comprehensive somatic mutation databases and investigate their potential
correlation with clinical, radiological and pathological variables. The genomics study
included but not limited to target gene panel sequencing, whole exome sequencing, whole
genome sequencing, bulk RNA sequencing, single cell RNA sequencing and metagenomics.
Criteria for eligibility:
Study pop:
Histology proved pancreatic cancer, esophageal cancer, gastric cancer, hepatocellular
carcinoma, cholangiocarcinoma, colorectal cancer
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- Able to sign the informed consent
- Age >= 20
- Histology proved pancreatic cancer, esophageal cancer, gastric cancer,
hepatocellular carcinoma, cholangiocarcinoma, colorectal cancer
- Agree to provide tumor/normal tissue including but not limited to surgical specimen,
biopsy, cytology specimen, bile, urine or stool
- Agree to receive blood sampling 20ml at first time and 10ml during each follow-up
(total sampling amount no more than 30ml per month)
Exclusion Criteria:
- Cannot cooperate with blood sampling
Gender:
All
Minimum age:
20 Years
Maximum age:
N/A
Locations:
Facility:
Name:
National Cheng-Kung University Hospital
Address:
City:
Tainan
Country:
Taiwan
Status:
Recruiting
Contact:
Last name:
Yung-Yeh Su, MD
Phone:
+886-6-7000123
Phone ext:
65181
Email:
yysu@nhri.edu.tw
Investigator:
Last name:
Li-Tzong Chen, MD PhD
Email:
Principal Investigator
Facility:
Name:
National Institute of Cancer Research
Address:
City:
Tainan
Country:
Taiwan
Status:
Recruiting
Contact:
Last name:
Yung-Yeh Su, MD
Phone:
+8867-7000123
Phone ext:
65181
Email:
yysu@nhri.edu.tw
Investigator:
Last name:
Li-Tzong Chen, MD, PhD
Email:
Principal Investigator
Start date:
April 15, 2020
Completion date:
December 31, 2025
Lead sponsor:
Agency:
National Health Research Institutes, Taiwan
Agency class:
Other
Collaborator:
Agency:
National Cheng-Kung University Hospital
Agency class:
Other
Source:
National Health Research Institutes, Taiwan
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05767697
