Trial Title:
Prognostic and Predictive Markers of Treatment Response in Patients With PAC.
NCT ID:
NCT05776342
Condition:
Pancreatic Adenocarcinoma
Conditions: Official terms:
Adenocarcinoma
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Other
Summary:
The objective of this study is to identify prognosis and predictive markers of response
to treatments (surgery, chemotherapy,...) in patients with pancreatic adenocarcinoma. The
effectiveness and tolerance of these treatments in current practice is also evaluated.
Detailed description:
The modest efficacy of current therapies for pancreatic cancer calls for the development
of prognostic factors to guide patient selection and clinical decision-making based on
tumor aggressiveness and risk of death.
The aim of this study is to identify prognostic and predictive factors of response to
treatments administered in pancreatic adenocarcinoma, based on a multicenter cohort
established on a population derived from current clinical practice. By accurately
stratifying patients according to their estimated survival, prognostic tools could aid
therapeutic decisions and optimize patient selection in future clinical trials.
Criteria for eligibility:
Study pop:
Retro-prospective (diagnosis between 2003 and 2022) and prospective (diagnosis between
2023 and 2030) cohorts of patients with pancreatic adenocarcinoma
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- Patient with histologically confirmed pancreatic adenocarcinoma.
- Disease at a resectable, borderline, locally advanced, initially metastatic, or
recurrent stage after surgery
- Diagnosis between January 1, 2003, and December 31, 2030.
- First-line treatment with chemotherapy and/or radiotherapy and/or clinical trials.
- Age ≥ 18 years.
- Written informed consent
Exclusion Criteria:
- Patient under guardianship, curatorship, or judicial protection.
- Pregnant or breastfeeding women.
- Any medical, psychological, or social situation that could prevent compliance with
the protocol as assessed by the investigator.
- Refusal to participate in the study
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
CHU Jean Minjoz
Address:
City:
Besançon
Country:
France
Status:
Recruiting
Contact:
Last name:
Angélique VIENOT, MD
Investigator:
Last name:
Angélique VIENOT, MD
Email:
Principal Investigator
Facility:
Name:
Hôpital Beaujon
Address:
City:
Clichy
Country:
France
Status:
Recruiting
Contact:
Last name:
Louis DE MESTIER, MD
Facility:
Name:
CHU - Henri Mondor
Address:
City:
Créteil
Country:
France
Status:
Not yet recruiting
Contact:
Last name:
Christophe TOURNIGAND, MD
Facility:
Name:
CHU Lille
Address:
City:
Lille
Country:
France
Status:
Recruiting
Contact:
Last name:
Anthony TURPIN, MD
Facility:
Name:
Centre Léon Bérard
Address:
City:
Lyon
Country:
France
Status:
Not yet recruiting
Contact:
Last name:
Pauline ROCHEFORT, MD
Facility:
Name:
HRU Nancy Site Brabois
Address:
City:
Nancy
Country:
France
Status:
Recruiting
Contact:
Last name:
Marie MULLER, MD
Facility:
Name:
Hôpital Georges Pompidou
Address:
City:
Paris
Country:
France
Status:
Recruiting
Contact:
Last name:
Jeanne NETTER, MD
Facility:
Name:
Hôpital Saint Antoine
Address:
City:
Paris
Country:
France
Status:
Recruiting
Contact:
Last name:
Antoine DARDENNE
Facility:
Name:
Institut Mutualiste Montsouris
Address:
City:
Paris
Country:
France
Status:
Not yet recruiting
Contact:
Last name:
David MALKA, MD
Facility:
Name:
CHU Poitiers
Address:
City:
Poitiers
Country:
France
Status:
Not yet recruiting
Contact:
Last name:
David TOUGERON, MD
Investigator:
Last name:
David TOUGERON, MD
Email:
Principal Investigator
Facility:
Name:
CHU Reims
Address:
City:
Reims
Country:
France
Status:
Not yet recruiting
Contact:
Last name:
Olivier BOUCHE, MD
Facility:
Name:
CHU Pontchaillou
Address:
City:
Rennes
Country:
France
Status:
Not yet recruiting
Contact:
Last name:
Astrid LIEVRE, MD
Investigator:
Last name:
Astrid LIEVRE, MD
Email:
Principal Investigator
Facility:
Name:
Institut Curie
Address:
City:
Saint-Cloud
Country:
France
Status:
Not yet recruiting
Contact:
Last name:
Cindy NEUZILLET, MD
Facility:
Name:
IHU - Institut de chirurgie guidée par l'imagerie
Address:
City:
Strasbourg
Country:
France
Status:
Not yet recruiting
Contact:
Last name:
Julieta MONTANELLI, MD
Facility:
Name:
Hôpital Paul Brousse
Address:
City:
Villejuif
Country:
France
Status:
Recruiting
Contact:
Last name:
Pascal HAMMEL, MD
Start date:
January 1, 2003
Completion date:
December 31, 2031
Lead sponsor:
Agency:
GERCOR - Multidisciplinary Oncology Cooperative Group
Agency class:
Other
Source:
GERCOR - Multidisciplinary Oncology Cooperative Group
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05776342
