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Trial Title:
Lung Tumor Protein Synthesis Rates in Lung Cancer Patients
NCT ID:
NCT05794529
Condition:
Lung Cancer
Conditions: Official terms:
Lung Neoplasms
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Other
Intervention:
Intervention type:
Other
Intervention name:
There are no interventions in the present study
Description:
There are no interventions in the present study
Arm group label:
Lung cancer patient
Summary:
The current study will recruit lung cancer patients to measure tissue protein synthesis
rates of non-small cell lung carcinomas and healthy lung tissue. The protein synthesis
rates of healthy lung tissue will be compared to lung tumor tissue to establish the
remodeling characteristics of healthy versus cancerous lung tissues. We will also examine
whether tissue protein synthesis rates of non-small cell lung carcinomas are associated
with various tumor- (i.e., size, subclassification) and patient-derived (i.e.,
inflammation, lung function, smoking status, and smoking history) parameters.
Criteria for eligibility:
Study pop:
In total, we will recruit 30 lung cancer patients (diagnosed with a NSCLC) scheduled to
undergo surgery. The nature and the risks of the experimental procedures will be
explained to all subjects before their informed consent will be obtained. All subjects
will be recruited through contact with their Surgeon at the Department of surgery at
Zuyderland Medical Centre, Heerlen.
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
1. Aged 18-65 years
2. Compos mentis
3. Diagnosed with lung cancer, with treatment requiring a thoracotomy or VATS lobectomy
Exclusion Criteria:
1. Neoadjuvant chemo- or radiotherapy in the past four weeks
2. Use of systemic steroids in the past four week
3. Insulin-dependent diabetes mellitus
4. Pregnancy
Gender:
All
Minimum age:
18 Years
Maximum age:
65 Years
Locations:
Facility:
Name:
Zuyderland Medical Center
Address:
City:
Heerlen
Zip:
6419 PC
Country:
Netherlands
Status:
Recruiting
Contact:
Last name:
Erik de Loos, MD
Email:
e.deloos@zuyderland.nl
Start date:
March 2023
Completion date:
March 2026
Lead sponsor:
Agency:
Maastricht University Medical Center
Agency class:
Other
Source:
Maastricht University Medical Center
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05794529
