Measurement and Analysis of Gas Composition in Digestive Tract

Trial Title: Measurement and Analysis of Gas Composition in Digestive Tract

NCT ID: NCT05810805

Condition: Inflammatory Bowel Diseases
Irritable Bowel Syndrome
Functional Dyspepsia
Colorectal Neoplasms
Helicobacter Pylori Infection

Conditions: Official terms:
Colorectal Neoplasms
Inflammatory Bowel Diseases
Irritable Bowel Syndrome
Dyspepsia

Study type: Observational

Overall status: Not yet recruiting

Study design:

Time perspective: Prospective

Intervention:

Intervention type: Other
Intervention name: gas component of digestive tract
Description: Analyze the differences in gas components in different segments of the digestive tract in patients with different diseases, and analyze the correlation between specific gases and digestive tract diseases and non-specific symptoms.
Arm group label: Colorectal neoplasms group
Arm group label: Control group
Arm group label: Helicobacter pylori infection group
Arm group label: Imflammtory bowel disease group
Arm group label: Irritable bowel syndrome group
Arm group label: functional dyspepia group

Summary: The purpose of this study is to detect the concentration of various gases，including hydrogen, methane, hydrogen sulfide, nitric oxide in different parts of the digestive tract by a safe and direct method, and to establish a human digestive tract gas profiles. Analyze the differences in gas components in different segments of the digestive tract in patients with different diseases, and analyze the correlation between specific gases and digestive tract diseases and non-specific symptoms.

Criteria for eligibility:

Study pop:
Patients undergoing endoscopy at Qilu Hospital of Shandong University

Sampling method: Non-Probability Sample
Criteria:
Inclusion Criteria: - Patients aged 18 to 70 years. - Patients undergoing endoscopic examination Exclusion Criteria: - Patients with serious underlying diseases, such as liver insufficiency, renal insufficiency, immunosuppression, coronary heart disease (angina pectoris or coronary artery stenosis ≥ 75%). - Patients have history of gastrointestinal surgery - Patients who failed to complete the endoscopic examination due to various reasons - Patients Boston score of Bowel preparation≤ 6 points - Patients who have medication history of probiotics, antibiotics, PPIs and prokinetic drugs in the last 4 weeks - Patients who combined with thyroid disease and other diseases that affect gastrointestinal motility - Patients who combined with other risk factors such as mental illness, alcoholism, and drug abuse - Patients who unable or unwilling to provide informed consent

Gender: All

Minimum age: 18 Years

Maximum age: 70 Years

Healthy volunteers: Accepts Healthy Volunteers

Locations:

Facility:
Name: Qilu Hospital, Shandong University

Address:
City: Jinan
Zip: 250012
Country: China

Start date: April 1, 2023

Completion date: March 2, 2024

Lead sponsor:
Agency: Xiuli Zuo
Agency class: Other

Source: Shandong University

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT05810805