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Trial Title:
Radiomics for prEdiction of lunG cAncer biologY
NCT ID:
NCT05819905
Condition:
Non Small Cell Lung Cancer
PET/CT
PD-L1
Gene Mutation-Related Cancer
Conditions: Official terms:
Lung Neoplasms
Study type:
Observational
Overall status:
Active, not recruiting
Study design:
Time perspective:
Retrospective
Intervention:
Intervention type:
Diagnostic Test
Intervention name:
PET/CT
Description:
Pre treatment staging 18F-FDG PET/CT
Summary:
Therapeutic progress for subgroups of Non Small Cell Lung Cancer can largely be
attributed to the accumulation of molecular knowledge and the development of new drugs
that specifically target molecular abnormalities. An understanding of the immune
landscape of tumors, including immune-evasion strategies, has also led to breakthrough
therapeutic advances.These new options require prior treatment tumoral sampling to
identify patients who have neoplasms with specific genomic aberrations or favorable
immune environment. Medical imaging and radiomic approach may provides surrogate markers
non invasively.The objective of the present retrospective study is to build and validate
a predictive model of common molecular alterations and PD-L1 expression in NSCLC using
pre treatment PET/CT derived radiomics.
Criteria for eligibility:
Study pop:
Histologically proven NSCLC with molecular biology analysis and initial staging PET/CT
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- Histologically proven NSCLCC
- pre treatment 18F FDG PET/CT
- available molecular biology and histology results
Exclusion Criteria:
- non available PET/CT images
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
CHU Poitiers
Address:
City:
Poitiers
Zip:
86000
Country:
France
Start date:
January 1, 2023
Completion date:
January 1, 2024
Lead sponsor:
Agency:
Poitiers University Hospital
Agency class:
Other
Source:
Poitiers University Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05819905
