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Trial Title:
Addressing Tetrachloroethylene Exposure in an Impacted Community
NCT ID:
NCT05819996
Condition:
Vapors; Inhalation
Cancer
Volatile Organic Compounds
Conditions: Official terms:
Respiratory Aspiration
Conditions: Keywords:
Tetrachloroethylene
Trichloroethylene
PCE
TCE
Community environmental contamination
Chlorinated volatile organic compounds
Study type:
Interventional
Study phase:
N/A
Overall status:
Recruiting
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Intervention model description:
An educational campaign targeting the community
Primary purpose:
Other
Masking:
None (Open Label)
Intervention:
Intervention type:
Behavioral
Intervention name:
Environmental educational campaign
Description:
Educational campaign will be conducted to promote participation in indoor air testing.
Arm group label:
Martinsville Residents
Summary:
Groundwater in Martinsville, IN, is contaminated by volatile organic compounds (VOCs),
tetrachloroethylene (PCE) and trichloroethylene (TCE). Indoor air in some residential and
commercial buildings is also contaminated with PCE and TCE. This study is being conducted
to better understand the impact of low-level exposures to these compounds on community
members' health. Data collected in this study will be used to help the community identify
a course of action.
Detailed description:
Martinsville, IN, is a community of 11,000 people that overlays four groundwater
contamination sites, including a U.S. Environmental Protection Agency (EPA)-designated
Superfund site. The total area of groundwater contamination is over 60 acres and lies
within a single aquifer. The contaminates are chlorinated volatile organic compounds
(VOCs), primarily tetrachloroethylene (PCE) and trichloroethylene (TCE). These
contaminants are thought to originate from several dry cleaning and metal degreasing
operations. An activated carbon filtration system has been in operation since 2005 to
remove PCE and chlorinated VOCs from the municipal water, which now meets EPA drinking
water standards. However, a recent report from the Agency for Toxic Substances and
Disease Registry concludes that people's health may be harmed by breathing indoor air
contaminated via vapor intrusion, the migration of volatile compounds from contaminated
groundwater and soil into buildings above. The long-term goal of this research is to
understand how PCE exposure in communities affects health and to empower community
members' participation in environmental health decision-making. In this project
researchers will work with the community of Martinsville, IN to:
1. Determine the extent and exposure levels to the contaminants by measuring the
contamination in residents and at their homes.
2. Assess the community's concern and perceptions about the contamination and
associated health risks.
3. Study the impact of the contaminants on visual and neurocognitive functions.
4. Compare cancer rates in Martinsville to county and state rates.
The above information will help researchers and community partners co-design a targeted
educational campaign to reduce community members' exposure to the contaminants.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Residents of Martinsville, Indiana
- 18 years or older
Gender:
All
Minimum age:
18 Years
Maximum age:
99 Years
Healthy volunteers:
No
Locations:
Facility:
Name:
Purdue University
Address:
City:
West Lafayette
Zip:
47907
Country:
United States
Status:
Recruiting
Contact:
Last name:
Sa Liu, PhD
Phone:
765-496-6240
Email:
saliu@purdue.edu
Contact backup:
Last name:
Monica M Bozymski, MS
Phone:
765-496-4823
Email:
mbozymsk@purdue.edu
Start date:
February 17, 2023
Completion date:
May 31, 2027
Lead sponsor:
Agency:
Purdue University
Agency class:
Other
Collaborator:
Agency:
University of Illinois at Chicago
Agency class:
Other
Collaborator:
Agency:
Indiana University School of Medicine
Agency class:
Other
Collaborator:
Agency:
Mackey Children's Cancer Foundation
Agency class:
Other
Source:
Purdue University
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05819996
