Trial Title:
RC108 Combine With Furmonertinib With/Without Toripalimab in Patients With EGFR-mutated NSCLC
NCT ID:
NCT05821933
Condition:
NSCLC
Conditions: Official terms:
Carcinoma, Non-Small-Cell Lung
Aflutinib
Study type:
Interventional
Study phase:
Phase 1/Phase 2
Overall status:
Recruiting
Study design:
Allocation:
Non-Randomized
Intervention model:
Sequential Assignment
Primary purpose:
Treatment
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
RC108
Description:
RC108 plus Furmonertinib and/or Toripalimab
Arm group label:
cohort 1 RC108 plus Furmonertinib
Arm group label:
cohort 2 RC108 plus Furmonertinib and Toripalimab
Arm group label:
cohort 3 RP2D RC108 plus Furmonertinib
Arm group label:
cohort 4 RP2D RC108 plus Furmonertinib and Toripalimab
Other name:
Furmonertinib
Other name:
Toripalimab
Summary:
an open, single-arm, multicenter phase Ib/II study
Detailed description:
an open, single-arm, multicenter phase Ib/II study evaluated the safety, tolerability,
efficacy and pharmacokinetic profile of RC108 in combination with Furmonertinib or in
combination with Furmonertinib and Toripalimab in patients with locally advanced or
metastatic EGFR MET-expressing mutated NSCLC who have failed EGFR-TKI, and to develop a
reasonable follow-up study for combination dosing regimens
Criteria for eligibility:
Criteria:
Inclusion Criteria:
1. Voluntarily agree to participate in the study and sign an informed consent form.
2. Age between 18 and 75 years old (inclusive).
3. Expected survival period of at least 12 weeks as determined by the investigator.
4. ECOG performance status of 0 or 1.
5. For female subjects: must be surgically sterile, postmenopausal, or willing to use a
medically accepted contraceptive method (such as an intrauterine device, birth
control pills, or condoms) during the study treatment period and for 6 months after
the end of the study treatment. A negative pregnancy test within 7 days before study
treatment initiation is required, and the subject must not be breastfeeding. For
male subjects: must be surgically sterile or willing to use a medically accepted
contraceptive method during the study treatment period and for 6 months after the
end of the study treatment.
6. Able to understand the trial requirements, willing and able to comply with trial and
follow-up procedures.
7. Bone marrow function:
Hemoglobin ≥9 g/dL Absolute neutrophil count (ANC) ≥1.5 × 10^9/L Platelet count ≥100
× 10^9/L
8. Liver function (based on the clinical trial center's normal values):
Serum total bilirubin ≤1.5 times the upper limit of normal (ULN) ALT and AST ≤2.5 ×
ULN and serum total bilirubin ≤1.5 times the ULN if there is no liver metastasis;
ALT and AST ≤5 × ULN and serum total bilirubin ≤2 times the ULN if there is liver
metastasis.
9. Kidney function (based on the clinical trial center's normal values):
Serum creatinine ≤1.5 × ULN, or calculated creatinine clearance (CrCl) by the
Cockcroft-Gault formula ≥60 mL/min, or measured 24-hour urine CrCl ≥60 mL/min.
10. Heart function:
NYHA class <3 Left ventricular ejection fraction (LVEF) ≥50% QTc interval ≤450 ms
11. All subjects must have locally advanced or metastatic non-small cell lung cancer
(NSCLC) confirmed by histology or cytology.
12. Must have at least one EGFR-sensitive mutation: exon 19 deletion, L858R mutation in
exon 21, T790M mutation in exon 20, G719X mutation in exon 18, S768I mutation in
exon 20, or L871Q mutation in exon 21 (inclusion of patients with exon 20 insertion
mutation is allowed).
13. Must have received approved first/second/third-generation EGFR-TKI treatment in the
past and experienced radiological progression during EGFR-TKI treatment. The patient
is allowed to have received other systemic treatments such as chemotherapy and
anti-angiogenic agents, regardless of the sequence with EGFR-TKI treatment.
14. Must provide a tumor tissue sample that meets the central laboratory's testing
requirements and has MET (IHC) expression of 1+, 2+, or 3+ as determined by the
central laboratory.
15. Must agree to provide tumor tissue or blood samples collected during or after
previous EGFR-TKI treatment-induced radiological progression for EGFR T790M
detection or provide the results of EGFR T790M detection in the tumor tissue sample.
16. Must provide the most recent tumor tissue sample for PD-L1 expression testing, which
will be used to stratify subjects for randomization.
17. At least one measurable lesion according to RECIST 1.1 criteria.
Exclusion Criteria:
1. Have used an investigational drug within 4 weeks prior to the start of study dosing.
2. Have undergone major surgery within 4 weeks prior to the start of study dosing and
have not fully recovered.
3. Received a live vaccine within 4 weeks prior to the start of study dosing or are
scheduled to receive any vaccine (except novel inactivated coronavirus vaccine)
during the study period.
4. An arterial/venous thrombotic event such as a cardiovascular accident (including
temporary ischemic attack), deep vein thrombosis and pulmonary embolism within 6
months prior to study dosing.
5. Clinically significant QT interval prolongation or other arrhythmias or clinical
states that, in the opinion of the investigator, have the potential to increase the
risk of QT interval prolongation; e.g., resting state ECG QTc > 450 ms, complete
left bundle branch block, third degree AV block, congenital long QT syndrome, severe
hypokalemia, or ongoing medication that can cause QT interval prolongation.
6. The presence of preexisting or ongoing interstitial lung disease (ILD), drug-induced
interstitial lung disease, radiation pneumonia requiring steroid medication, or
those with clinical manifestations of suspected interstitial lung disease.
7. The presence of clinically uncontrollable third interstitial fluid, such as pleural
effusion, peritoneal effusion, or pericardial effusion that is clinically
symptomatic and cannot be controlled by drainage or other means and is, in the
judgment of the investigator, unenrollable.
8. Suffering from systemic diseases that are not under stable control, including
diabetes, hypertension, pulmonary fibrosis, acute and chronic lung disease,
interstitial lung disease, cirrhosis of the liver, etc.
9. Known to have a psychiatric or substance abuse disorder that may have an impact on
compliance with trial requirements
10. Ongoing active infection requiring systemic treatment, such as severe pneumonia,
sepsis, etc.
11. The presence or suspicion of active tuberculosis.
12. Known presence and activity of any of the following infectious diseases: positive
HIV antibody test result; positive HBsAg with positive HBV DNA (i.e., copy number ≥
2000 copies/ml); positive HCV antibody with positive HCV RNA.
13. Those who have used a strong inhibitor of cytochrome P450 3A4 (CYP3A4) within 7 days
prior to the first dose or a strong inducer of CYP3A4 within 21 days
14. Have any other disease, metabolic abnormality, physical examination abnormality, or
laboratory test abnormality that, in the judgment of the investigator, gives reason
to suspect that the patient has a disease or condition that is inappropriate for the
use of the study drug, or that will affect the interpretation of the study results,
or that places the patient at high risk
15. Women who are pregnant or breastfeeding or women/men who are planning to have
children.
16. Subjects who are estimated to have insufficient patient compliance to participate in
this clinical study or who, in the opinion of the investigator, have other factors
that make them inappropriate for participation in this study.
17. Known small cell lung cancer transformation or the presence of a small cell
component.
18. Presence of brain metastases and/or cancerous meningitis. Subjects who have been
treated for brain metastases may be considered for participation in this study
provided that the disease has been stable for at least 3 months, no disease
progression has occurred as determined by imaging within 4 weeks prior to the first
dose of study treatment, all neurological symptoms have returned to baseline levels,
there is no evidence of new or expanding brain metastases, and treatment with
radiation, surgery, or steroids has been discontinued at least 28 days prior to the
first dose of study treatment . This exception does not include meningeal metastases
and carcinomatous meningitis, which should be excluded regardless of their clinical
stability.
19. Other malignancies (except non-melanoma skin cancer, cervical carcinoma in situ or
other tumors that have been effectively treated and are considered cured) within 5
years prior to signing the informed consent form.
20. Known hypersensitivity or delayed allergic reactions to certain components of RC108
for injection, vomitinib or similar drugs, in addition to non-enrollment in Cohort 2
and Cohort 4 for hypersensitivity or delayed allergic reactions to certain
components of treprolizumab or similar drugs
21. Have received drugs targeting the HGF and/or MET pathways prior to study
administration.
22. Prior use of PD-1/L1 inhibitors is inadmissible to Cohort 2 and Cohort 4.
23. Chemotherapy, radiotherapy, immunotherapy and targeted therapy received prior to the
start of study dosing less than 4 weeks or less than 5 half-lives (whichever is
shorter) from the first dose of this study.
24. Hormonal therapy received within 2 weeks prior to the start of study dosing for the
tumor(s) affected.
25. Received palliative radiotherapy targeting bone metastases within 2 weeks prior to
the start of study dosing.
26. Having received antitumor herbal therapy within 2 weeks prior to the start of study
dosing
27. Toxicity of prior antitumor therapy that have not recovered to CTCAE [version 5.0]
grade 0-1, with the following exceptions: a. alopecia; b. hyperpigmentation; c.
long-term toxicity due to radiotherapy that, in the judgment of the investigator,
cannot be recovered.
Gender:
All
Minimum age:
18 Years
Maximum age:
75 Years
Healthy volunteers:
No
Locations:
Facility:
Name:
Cancer Hospital Chinese Academy of Medical Sciences
Address:
City:
Beijing
Zip:
100021
Country:
China
Status:
Recruiting
Contact:
Last name:
Zhengang Xu, PHD
Phone:
8610-87788495
Email:
cancergcp@163.com
Investigator:
Last name:
Yuankai Shi, PHD
Email:
Principal Investigator
Start date:
September 7, 2023
Completion date:
September 1, 2026
Lead sponsor:
Agency:
RemeGen Co., Ltd.
Agency class:
Industry
Source:
RemeGen Co., Ltd.
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05821933
