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Trial Title:
CLIMB: CNS Lymphoma Imaging and Molecular Biomarkers Study
NCT ID:
NCT05828628
Condition:
CNS Lymphoma
Conditions: Official terms:
Lymphoma
Study type:
Observational
Overall status:
Not yet recruiting
Study design:
Time perspective:
Prospective
Summary:
A prospective imaging and translational tissue study in CNS lymphoma to enable further
disease characterisation and the development of potential predictive and prognostic
biomarkers.
Detailed description:
As a single centre exploratory study, this trial will recruit patients with newly
diagnosed primary CNS lymphoma and will look at the molecular aspects of the disease in
the tissue collection and imaging response assessments using CCA with respect to
progression free survival.
Criteria for eligibility:
Study pop:
Patients with newly diagnosed primary CNS lymphoma
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- Subjects capable of giving informed consent, or if appropriate, if subject's
capacity is deemed limited due to CNS involvement, a consultee can provide consent
on their behalf. Some patients with PCNSL may be incapable of providing their own
consent due to the neurological effects of their disease. In these cases the patient
will be classed as an incapacitated adult and a legal representative will be sought
in accordance with English or Scottish law as applicable (see 7.2.1)
- A radiological or histological diagnosis of primary CNS lymphoma.
- Have not received prior CNS directed therapy. Prior use of steroids is permitted.
- Participants aged ≥18 years old.
Exclusion Criteria:
- Involvement of lymphoma outside of the CNS
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
The Royal Marsden NHS Foundation Trust
Address:
City:
London
Zip:
SW3 6JJ
Country:
United Kingdom
Contact:
Last name:
Rachel Powell
Phone:
0203 186 5176
Email:
rachel.powell@rmh.nhs.uk
Start date:
June 2023
Completion date:
June 2031
Lead sponsor:
Agency:
Royal Marsden NHS Foundation Trust
Agency class:
Other
Source:
Royal Marsden NHS Foundation Trust
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05828628
