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Trial Title:
Ovarian Tissue Cryopreservation and Subsequent Auto-Transplantation for Female Cancer Patients
NCT ID:
NCT05830929
Condition:
Neoplasms
Study type:
Interventional
Study phase:
N/A
Overall status:
Recruiting
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Primary purpose:
Other
Masking:
None (Open Label)
Intervention:
Intervention type:
Procedure
Intervention name:
Ovarian tissue freezing and subsequent auto-transplantation after thawing
Description:
Removal of the ovarian tissue will be retrieved via laparoscopic surgery under general
anesthesia. The ovarian cortical tissue obtained will be transferred on ice to the
laboratory for cryopreservation. After medical treatment, if the patient would like to
start a family but has experienced premature ovarian failure, she will have ovarian
tissue auto-transplantation after thawing.
Arm group label:
Ovarian tissue freezing and subsequent auto-transplantation after thawing
Summary:
Ovarian Tissue Cryopreservation will be provided to cancer patients to allow them to have
their fertility preserved.
Detailed description:
This project hopes to provide Ovarian Tissue Cryopreservation to patients who do not have
adequate time for ovarian stimulation in oocyte or embryo freezing and in prepubertal
girls where oocyte freezing is not possible. All the patients will have fertility
preservation consultations with a fertility specialist in our unit to go through the
details of ovarian Tissue Cryopreservation service and risks related to ovarian tissue
cryopreservation procedures. After undergoing ovarian tissue collection via surgery, the
collected ovarian tissue will be cryopreserved either by slow freezing or vitrification
in our unit.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Patients aged from 0-35 years old and diagnosed with cancer e.g., leukaemia,
myeloproliferative or myelodysplastic diseases, lymphoma, bone tumours, neurological
neoplasms and sarcoma, Paediatric bone marrow transplant patients
- Patients with any illness or who will undergo any type of treatment that may cause
irreversible damage to their fertility, such as extensive abdominal surgery, high
toxicity medication and treatments;
- Patients suffering from hormone-sensitive malignancies who will undergo medical
treatment, such as radiotherapy and chemotherapy that is liable to damage their
ovaries and deter them from conception in the future.
Exclusion Criteria:
- Patients with no anticipated oncologic therapies
- Patients who are pregnant
- Children with one ovary
- Children deemed high risk for perioperative complications
- Patients unable to provide consent/assent (i.e. significant psychiatric
problems/cognitive delay)
Gender:
Female
Minimum age:
1 Month
Maximum age:
35 Years
Healthy volunteers:
No
Locations:
Facility:
Name:
Prince of Wales Hospital
Address:
City:
Hong Kong
Country:
Hong Kong
Status:
Recruiting
Contact:
Last name:
Jacqueline Pui Wah Chung, MBBS
Phone:
+852 35051537
Email:
jacquelinechung@cuhk.edu.hk
Start date:
August 1, 2023
Completion date:
December 30, 2043
Lead sponsor:
Agency:
Chinese University of Hong Kong
Agency class:
Other
Source:
Chinese University of Hong Kong
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05830929
