Trial Title:
Surufatinib Combined With KN046 and AG Regimen Chemotherapy as First-Line Treatment for Unresectable Advanced Pancreatic Cancer
NCT ID:
NCT05832892
Condition:
Unresectable Locally Advanced or Metastatic Pancreatic Cancer
Conditions: Official terms:
Pancreatic Neoplasms
Paclitaxel
Albumin-Bound Paclitaxel
Gemcitabine
Conditions: Keywords:
Pancreatic Cancer
Surufatinib
KN046
Nab-paclitaxel
Gemcitabine
Study type:
Interventional
Study phase:
Phase 1/Phase 2
Overall status:
Recruiting
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Primary purpose:
Treatment
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
surufatinib
Description:
In phase Ib, surufatinib will be orally administrated 200 mg once a day (QD) or 250 mg QD
per cohort escalation assignment on a 21-day cycle.
In phase II, surufatinib will be orally administrated at RP2D as determined in phase Ib.
Arm group label:
surufatinib + KN046 + nab-paclitaxel + gemcitabine
Other name:
HMPL-012
Other name:
Sulfatinib
Intervention type:
Drug
Intervention name:
KN046
Description:
Nab-paclitaxel will be administrated at 125 mg/m2 intravenously on day 1 and 8 of each
21-day cycle.
Arm group label:
surufatinib + KN046 + nab-paclitaxel + gemcitabine
Intervention type:
Drug
Intervention name:
gemcitabine
Description:
Gemcitabine will be administrated at 1000 mg/m2 intravenously on day 1 and 8 of each
21-day cycle.
Arm group label:
surufatinib + KN046 + nab-paclitaxel + gemcitabine
Other name:
GEMZAR
Intervention type:
Drug
Intervention name:
Nab paclitaxel
Description:
Nab-paclitaxel will be administrated at 125 mg/m2 intravenously on day 1 and 8 of each
21-day cycle.
Arm group label:
surufatinib + KN046 + nab-paclitaxel + gemcitabine
Other name:
nanoparticle albumin-bound paclitaxel
Other name:
Abraxane
Other name:
ABI-007
Summary:
Advanced pancreatic cancer is a highly aggressive and fatal disease with an extremely low
5-year survival rate. Combined chemotherapy is the mainstay of treatment for patients
with unresectable advanced pancreatic cancer, and the combination of nab-paclitaxel and
gemcitabine (AG regimen) has been one of the most commonly used regimens for more than a
decade. However, chemo-resistance often occurs within half a year and the efficacy
remains unsatisfied with an overall survival of only 9~11 months.
Immune checkpoint inhibitors (ICIs) such as anti-PD-1/L1 antibody and anti-CTLA-4
antibody have demonstrated encouraging anti-tumor efficacy in multiple solid tumors
including lung cancer, gastric cancer, and esophageal cancer, while obtained
controversial results when combined with chemotherapy in pancreatic cancer. Recently, the
immune-suppression tumor microenvironment (TME) of pancreatic cancer has been described
in several pre-clinical studies, which may explain the resistance against ICIs and
chemotherapy.
KN046 is a recombinant humanized PD-L1/CTLA-4 bispecific antibody with innovative designs
include a proprietary CTLA-4 domain antibody with a significantly improved safety
profile, a bispecific antibody fused with PD-L1 antibody targeting the TME with high
PD-L1 expression. Recent clinical studies have shown promising anti-tumor activity of
KN046 in pancreatic cancer.
Surufatinib, also known as HMPL-012 or Sulfatinib, is a small molecular tyrosine kinase
inhibitor (TKI) targeting the Vascular Endothelial Growth Factor Receptor (VEGFR),
Fibroblast Growth Factor Receptor (FGFR) and Colony Stimulating Factor-1 Receptor
(CSF-1R), which has a dual mechanism of action of anti-angiogenesis and regulation of
immune microenvironment. Previous studies have suggested synergic effect of surufatinib
in combination with anti-PD-1 antibodies.
This phase Ib/II clinical trial is intended to investigate the activity and safety of the
combination of surufatinib combined with KN046 and the AG regimen chemotherapy as
first-line treatment in patients with unresectable locally advanced or metastatic
pancreatic cancer.
Detailed description:
Advanced pancreatic cancer is a highly aggressive and fatal disease with an extremely low
5-year survival rate. Combined chemotherapy is the mainstay of treatment for patients
with unresectable advanced pancreatic cancer, and the combination of nab-paclitaxel and
gemcitabine (AG regimen) has been one of the most commonly used regimens for more than a
decade. However, chemo-resistance often occurs within half a year and the efficacy
remains unsatisfied with an overall survival of only 9~11 months.
Immune checkpoint inhibitors (ICIs) such as anti-PD-1/L1 antibody and anti-CTLA-4
antibody have demonstrated encouraging anti-tumor efficacy in multiple solid tumors
including lung cancer, gastric cancer, and esophageal cancer, while obtained
controversial results when combined with chemotherapy in pancreatic cancer. Recently, the
immune-suppression tumor microenvironment (TME) of pancreatic cancer has been described
in several pre-clinical studies, which may explain the resistance against ICIs and
chemotherapy.
KN046 is a recombinant humanized PD-L1/CTLA-4 bispecific antibody with innovative designs
include a proprietary CTLA-4 domain antibody with a significantly improved safety
profile, a bispecific antibody fused with PD-L1 antibody targeting the TME with high
PD-L1 expression. Recent clinical studies have shown promising anti-tumor activity of
KN046 in pancreatic cancer.
Surufatinib, also known as HMPL-012 or Sulfatinib, is a small molecular tyrosine kinase
inhibitor (TKI) targeting the Vascular Endothelial Growth Factor Receptor (VEGFR),
Fibroblast Growth Factor Receptor (FGFR) and Colony Stimulating Factor-1 Receptor
(CSF-1R), which has a dual mechanism of action of anti-angiogenesis and regulation of
immune microenvironment. Previous studies have suggested synergic effect of surufatinib
in combination with anti-PD-1 antibodies.
This phase Ib/II clinical trial is intended to investigate the activity and safety of the
combination of surufatinib combined with KN046 and the AG regimen chemotherapy as
first-line treatment in patients with unresectable locally advanced or metastatic
pancreatic cancer.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Signed informed content obtained prior to treatment.
- Male or female, age ≥ 18 years and ≤ 75 years.
- Patients must have histologically or cytologically confirmed pancreatic
adenocarcinoma that originated from the pancreatic ductal epithelial, with
image-documented unresectable locally advanced or distant metastatic disease.
- Patients have received no previous local treatment such as surgery, radiotherapy,
ablation, or any systemic treatment for advanced/metastatic pancreatic cancer,
including neoadjuvant and/or adjuvant therapy.
- Have at least one measurable lesion according to the Response Evaluation Criteria in
Solid Tumors (RECIST) version 1.1.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
- Expected overall survival of ≥ 6 months.
- Laboratory test results within 7 days prior to first dose of study drugs must meet
the following criteria:
1. absolute neutrophil count (ANC) ≥ 1.5 × 109/L, platelet count (PLT) ≥ 100 ×
109/L and hemoglobin (HGB) ≥ 90 g/L.
2. total bilirubin (TBil) ≤ 1.5 × the upper limit of normal (ULN).
3. alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 1.5 × ULN
in the absence of liver metastases; ALT and AST ≤ 3 × ULN in the presence of
liver metastases.
4. serum creatinine (SCr) ≤ 1.5 × ULN and creatinine clearance (CCl) ≥ 50 mL/min
(calculated according to the Cockcroft-Gault formula).
5. urine protein <2+ in urine analysis; if urine protein ≥2+, 24-hour urine
protein quantification should be <1g.
6. international normalized ratio (INR) ≤ 1.5 and partial activation prothrombin
time (APTT) ≤ 1.5 × ULN.
- Female subjects of childbearing age or male subjects whose partner is a female of
childbearing age should use effective contraception from at least 1 month prior to
the first dose of study drugs to 6 months after the last dose of study drugs.
Exclusion Criteria:
- Adverse events (AEs) due to previous anti-tumor therapy have not recovered to CTCAE
Grade ≤1 (except for hair loss, skin pigment changes, or Grade ≤ 2 neurotoxicity).
- Other malignancies diagnosed within past 5 years (except basal cell carcinoma of the
skin or squamous cell carcinoma and carcinoma in situ of the cervix that have been
effectively controlled).
- Presence of central nervous system (CNS) metastases at screening, or have a history
of CNS metastases.
- Patients who have received approved systemic anti-tumor therapy within 4 weeks
before the first dose of study drugs, including chemotherapy, biological therapy,
targeted therapy, hormone therapy, traditional Chinese medicine therapy (with clear
anti-tumor indications in the label), etc.
- Patients who have received radical radiotherapy (including radiotherapy involving >
25% bone marrow) within 4 weeks prior to the first study drugs reception; Or
brachytherapy (e.g., implanted radioparticles) within 60 days prior to the first
dose of the study drugs; Or palliative radiotherapy for bone metastases within 1
week prior to first dose of the study drugs.
- Patients who have undergone major surgery within 4 weeks before receiving first dose
of study drugs, or have unhealed wounds, ulcers or fractures.
- Vaccination within 4 weeks before the first dose of study drugs or plan to have
during the study period, except for inactivated vaccines.
- Patients who have previously received anti-VEGF/VEGFR agents and have experienced
disease progression during treatment or within 3 months after the last dose.
- Patients with uncontrollable malignant pleural effusion, ascites, or pericardial
effusion (no response to diuretics or puncture as per the investigator's judgement).
- Presence of gastrointestinal diseases such as active gastric and duodenal ulcers,
ulcerative colitis, or active bleeding in unresected tumors, or other conditions
that may cause gastrointestinal bleeding or perforation as determined by the
investigator.
- Patients with evidence or history of thrombosis or significant bleeding tendency
(bleeding >30 mL within 2 months, hematemesis, melena, hematochezia, or hemoptysis
>5mL within 4 weeks) within 2 months prior to the first dose of the study drugs.
- Patients who have arterial thrombosis or deep vein thrombosis within 6 months, or
have thromboembolic events (including stroke and/or transient ischaemic attack)
within 12 months prior to first dose of the study drugs.
- Patients who are receiving anti-tuberculosis therapy for active pulmonary
tuberculosis, or have had anti-tuberculosis therapy within 1 year prior to first
dose of the study drugs.
- Patients with a previous or current history of pulmonary disorder that may interfere
the identification and management of suspected drug-related pulmonary toxicity,
including pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation
pneumonia, drug-related pneumonia, severe impairment of lung function, etc.
(radiation pneumonia in radiotherapy areas is allowed).
- Presence of corneal lesions, including but not limited to bullous keratopathy,
shingle corneal degeneration, corneal abrasions, corneal ulcers, keratitis, etc.
- History of clinically significant hepatic disease, including, but not limited to,
known hepatitis B virus (HBV) infection with HBV DNA positive; known Hepatitis C
virus (HCV) infection with HCV RNA positive; or other hepatitis, liver cirrhosis,
etc.
- Positive for human immunodeficiency virus (HIV) antibodies.
- Meet any of the following criteria for cardiac function:
1. Clinically significant arrhythmias or conduction abnormalities requiring
clinical intervention.
2. Electrocardiogram (ECG) indicating an QT interval (QTcF) of > 480 msec.
3. Clinically significant cardiovascular diseases, including acute myocardial
infarction within 6 months prior to enrollment, severe/unstable angina
pectoris, coronary artery bypass grafting, congestive heart failure according
to the New York Heart Association (NYHA) classification III/IV, ventricular
arrhythmias needing drug intervention, LVEF <50%.
- Previous or current autoimmune diseases, including but not limited to Crohn's
disease, ulcerative colitis, systemic lupus erythematosus, sarcoidosis, Wegener
syndrome, Graves' disease, rheumatoid arthritis, pituitary inflammation, ocular
pigmentitis, autoimmune hepatitis, systemic sclerosis, Hashimoto's thyroiditis,
autoimmune vasculitis, autoimmune neuropathy (Guillain-Barre syndrome), with
exceptions as follows: type I diabetes, hormone replacement therapy-stabilized
hypothyroidism, psoriasis or vitiligo that does not require systemic therapy.
- Women who are pregnant or lactating.
- Known history of allergy to the relevant ingredients of the study drugs.
- Subjects who have received investigational treatments in other clinical studies
within 4 weeks prior to first dose of study drugs.
- Patients who have any disorder or condition that may affect absorption of the study
drugs, or who are unable to take oral medication.
- Patients unsuitable for participating due to other reasons as per investigator's
determination.
Gender:
All
Minimum age:
18 Years
Maximum age:
75 Years
Healthy volunteers:
No
Locations:
Facility:
Name:
Zhongshan Hospital
Address:
City:
Shanghai
Zip:
200000
Country:
China
Status:
Recruiting
Contact:
Last name:
Wen-Quan Wang, MD, PhD
Phone:
+86 21 31587861
Email:
wang.wenquan@zs-hospital.sh.cn
Start date:
November 1, 2023
Completion date:
June 1, 2025
Lead sponsor:
Agency:
Shanghai Zhongshan Hospital
Agency class:
Other
Collaborator:
Agency:
Fudan University
Agency class:
Other
Source:
Shanghai Zhongshan Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05832892
