Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy

Trial Title: Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy

NCT ID: NCT05840211

Condition: Locally Advanced or Unresectable Metastatic Breast Cancer
Stage IV Breast Cancer

Conditions: Official terms:
Breast Neoplasms
Paclitaxel
Albumin-Bound Paclitaxel
Capecitabine
Sacituzumab govitecan

Study type: Interventional

Study phase: Phase 3

Overall status: Active, not recruiting

Study design:

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: Sacituzumab Govitecan-hziy
Description: Administered intravenously
Arm group label: Sacituzumab Govitecan-hziy (SG)

Other name: Trodelvy™

Other name: GS-0132

Other name: IMMU-132

Intervention type: Drug
Intervention name: Paclitaxel
Description: Administered intravenously
Arm group label: Treatment of Physician's Choice (TPC)

Other name: Taxol®

Intervention type: Drug
Intervention name: Nab-paclitaxel
Description: Administered intravenously
Arm group label: Treatment of Physician's Choice (TPC)

Other name: Abraxane®

Intervention type: Drug
Intervention name: Capecitabine
Description: Administered orally
Arm group label: Treatment of Physician's Choice (TPC)

Other name: Xeloda®

Summary: The goal of this clinical study is to see if sacituzumab govitecan-hziy (SG) can improve life spans of people with HR+/HER2- metastatic breast cancer and their tumor does not grow or spread when compared to currently available standard treatments, such as paclitaxel, nab-paclitaxel or capecitabine. The primary objective is to compare the effect of SG relative to the treatment of physician's choice (TPC) on progression-free survival (PFS).

Criteria for eligibility:
Criteria:
Key Inclusion Criteria: - Able to understand and give written informed consent. - Must have adequate tumor tissue sample preferably from locally recurrent or metastatic site. - Documented evidence of HR+ metastatic breast cancer (mBC) confirmed with the most recently available tumor biopsy preferably from a locally recurrent or metastatic site. - Documented evidence of HER2- status. - Documented PD by computed tomography (CT) or magnetic resonance imaging during or after the most recent therapy per RECIST v1.1 criteria. - Candidate for the first chemotherapy in the locally advanced or metastatic setting. - Eligible for capecitabine, nab-paclitaxel, or paclitaxel. - Individuals must have at least one of the following: - Disease progression on at least 2 or more previous lines of endocrine therapy (ET) with or without a targeted therapy in the metastatic setting. - Disease recurrence while on the first 24 months of starting adjuvant ET will be considered a line of therapy; these individuals will only require 1 line of ET in the metastatic setting. - Disease progression within 6 months of starting first-line ET with or without a cyclin-dependent kinase (CDK) 4/6 inhibitor (if ineligible or if unable to access a CDK 4/6 inhibitor) in the metastatic setting. - Disease recurrence while on the first 24 months of starting adjuvant ET with CDK 4/6 inhibitor and if the individual is no longer a candidate for additional ET in the metastatic setting. - Individuals may have received prior targeted therapies, including but not limited to PARP inhibitors (for those with germline BRCA1 or BRCA2 mutations), phosphatidylinositol 3-kinase (PI3K) inhibitors (for those with PIK3CA mutations), or mammalian target of rapamycin (mTOR) inhibitors. However, individuals can no longer be candidates for additional endocrine treatment with or without targeted therapies. - Individuals with HIV must be on antiretroviral therapy (ART) and have a well-controlled HIV infection/disease. - Demonstrates adequate organ function. - Male individuals and female individuals of childbearing potential who engage in heterosexual intercourse must agree to use protocol-specified method(s) of contraception. - Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Key Exclusion Criteria: - Progressive disease within 6 months of completing (neo)adjuvant chemotherapy. - Locally advanced metastatic breast cancer (mBC) (Stage IIIc) in individuals who are candidates for curative intent therapy at the time of study enrollment. - Current enrollment in another clinical study and use of any investigational device or drug (drugs not marketed for any indication) either within 5 half-lives or 28 days prior to randomization, whichever is longer. - Use of investigational drugs in the category of Selective Estrogen Receptor Degraders are acceptable if last dose was longer than 14 days prior to randomization. - Received any prior treatment (including antibody-drug conjugate (ADC)) containing a chemotherapeutic agent targeting topoisomerase I. - Received any prior treatment with a trophoblast cell-surface antigen 2 (Trop-2)-directed ADC. - Have an active second malignancy. - Have an active serious infection requiring antibiotics. - Have active hepatitis B virus (HBV) or hepatitis C virus (HCV). - Individuals positive for human immunodeficiency virus type 1/2 (HIV-1 or -2) with a history of Kaposi sarcoma and/or Multicentric Castleman Disease. - Have a positive serum pregnancy test or are breastfeeding for individuals who are assigned female at birth. Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers

Address:
City: Chandler
Zip: 85224
Country: United States

Facility:
Name: Los Angeles Hematology Oncology Medical Group

Address:
City: Los Angeles
Zip: 90017
Country: United States

Facility:
Name: Stanford Cancer Institute

Address:
City: Palo Alto
Zip: 94305
Country: United States

Facility:
Name: University of California, San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center

Address:
City: San Francisco
Zip: 94143
Country: United States

Facility:
Name: Rocky Mountain Cancer Centers, LLP

Address:
City: Littleton
Zip: 80120
Country: United States

Facility:
Name: Yale-New Haven Hospital-Yale Cancer Center

Address:
City: New Haven
Zip: 06510
Country: United States

Facility:
Name: Investigational Drug Services, AdventHealth Orlando

Address:
City: Altamonte Springs
Zip: 32701
Country: United States

Facility:
Name: Florida Cancer Specialists

Address:
City: Brooksville
Zip: 34613
Country: United States

Facility:
Name: Florida Cancer Specialist

Address:
City: Leesburg
Zip: 34748
Country: United States

Facility:
Name: Florida Cancer Specialist

Address:
City: Saint Petersburg
Zip: 33705
Country: United States

Facility:
Name: Piedmont Cancer Institute

Address:
City: Atlanta
Zip: 30318
Country: United States

Facility:
Name: Georgia Cancer Specialist - Annex

Address:
City: Atlanta
Zip: 30341
Country: United States

Facility:
Name: Northwest Georgia Oncology Centers

Address:
City: Marietta
Zip: 30060
Country: United States

Facility:
Name: The University of Kansas Hospital

Address:
City: Kansas City
Zip: 66160
Country: United States

Facility:
Name: Hematology Oncology Clinic

Address:
City: Baton Rouge
Zip: 70809
Country: United States

Facility:
Name: Saint Luke's Cancer Institute

Address:
City: Kansas City
Zip: 64110
Country: United States

Facility:
Name: David C. Pratt Cancer Center

Address:
City: Saint Louis
Zip: 63141
Country: United States

Facility:
Name: Astera Cancer Care

Address:
City: East Brunswick
Zip: 08816
Country: United States

Facility:
Name: Rutgers Cancer Institute of New Jersey

Address:
City: New Brunswick
Zip: 08901
Country: United States

Facility:
Name: Memorial Sloan-Kettering Cancer Center (MSKCC) - New York

Address:
City: New York
Zip: 10065
Country: United States

Facility:
Name: Cleveland Clinic

Address:
City: Cleveland
Zip: 44195
Country: United States

Facility:
Name: Stefanie Spielman Comprehensive Breast Center

Address:
City: Columbus
Zip: 43210
Country: United States

Facility:
Name: Penn State Cancer Institute

Address:
City: Hershey
Zip: 17033
Country: United States

Facility:
Name: Magee-Womens of UPMC

Address:
City: Pittsburgh
Zip: 15213
Country: United States

Facility:
Name: Prisma Health - Upstate

Address:
City: Greenville
Zip: 29605
Country: United States

Facility:
Name: Tennessee Oncology, PLLC

Address:
City: Nashville
Zip: 37203
Country: United States

Facility:
Name: Vanderbilt University Medical Center - Vanderbilt-Ingram Cancer Center

Address:
City: Nashville
Zip: 37203
Country: United States

Facility:
Name: US Oncology Investigational Products Center (IPC)

Address:
City: Fairfax
Zip: 22031
Country: United States

Facility:
Name: US Oncology Investigational Products Center (IPC)

Address:
City: Norfolk
Zip: 23502
Country: United States

Facility:
Name: MultiCare Regional Cancer Center - Auburn

Address:
City: Auburn
Zip: 98001
Country: United States

Facility:
Name: Hospital Britanico de Buenos Aires

Address:
City: Buenos Aires
Zip: 1426
Country: Argentina

Facility:
Name: Instituto de Investigaciones Clinicas de Mar del Plata

Address:
City: Buenos Aires
Zip: B7600
Country: Argentina

Facility:
Name: Instituto Alexander Fleming

Address:
City: C.a.b.a.
Zip: 1426ANZ
Country: Argentina

Facility:
Name: Hospital Alemán

Address:
City: Caba
Zip: 1118
Country: Argentina

Facility:
Name: Centro Privado de RMI Rio Cuarto S.A.

Address:
City: Cordoba
Zip: 5800
Country: Argentina

Facility:
Name: Instituto de Oncología de Rosario

Address:
City: Rosario
Zip: 2000
Country: Argentina

Facility:
Name: CER San Juan Centro Polivalente de Asistencia e Investigación Clínica

Address:
City: San Juan
Zip: 5400
Country: Argentina

Facility:
Name: Royal Brisbane and Women's Hospital

Address:
City: Queensland
Zip: 4029
Country: Australia

Facility:
Name: St Vincent's Hospital Sydney

Address:
City: Darlinghurst
Zip: 2010
Country: Australia

Facility:
Name: Liverpool Hospital

Address:
City: Liverpool
Zip: 2170
Country: Australia

Facility:
Name: GenesisCare North Shore (Oncology)

Address:
City: St Leonards
Zip: 2065
Country: Australia

Facility:
Name: Icon Cancer Centre Wesley

Address:
City: Auchenflower
Zip: 4066
Country: Australia

Facility:
Name: Flinders Medical Centre

Address:
City: Bedford Park
Zip: 5042
Country: Australia

Facility:
Name: Icon Cancer Centre Hobart

Address:
City: Hobart
Zip: 7000
Country: Australia

Facility:
Name: Austin Health

Address:
City: Melbourne
Zip: 3084
Country: Australia

Facility:
Name: Sunshine Hospital (Western Health)

Address:
City: St Albans
Zip: 3021
Country: Australia

Facility:
Name: Breast Cancer Research Centre - WA

Address:
City: Nedlands
Zip: 6009
Country: Australia

Facility:
Name: University Hospital Innsbruck

Address:
City: Innsbruck
Zip: 06020
Country: Austria

Facility:
Name: Universitätsklinik für Innere Medizin 3 der PMU

Address:
City: Salzburg
Zip: A-5020
Country: Austria

Facility:
Name: Klinikum Wels-Grieskirchen

Address:
City: Wels
Zip: 4710
Country: Austria

Facility:
Name: Medizinische Universitat Wien, Univ. Klinik fur Innere Medizin I Klinische Abteilung fur Onkologie

Address:
City: Wien
Zip: 1090
Country: Austria

Facility:
Name: GZA Ziekenhuizen - Campus Sint-Augustinus

Address:
City: Antwerpen
Zip: 2610
Country: Belgium

Facility:
Name: AZ Klina

Address:
City: Brasschaat
Zip: 2930
Country: Belgium

Facility:
Name: Cliniques Universitaires Saint-Luc

Address:
City: Brussels
Zip: 1200
Country: Belgium

Facility:
Name: Universitaire Ziekenhuis Leuven

Address:
City: Leuven
Zip: 3000
Country: Belgium

Facility:
Name: CHU UCL Namur-Site STE. Elisabeth

Address:
City: Namur
Zip: 5000
Country: Belgium

Facility:
Name: Hospital Haroldo Juaçaba - Instituto do Câncer do Ceará

Address:
City: Fortaleza
Zip: 60430-230
Country: Brazil

Facility:
Name: Hospital Araujo Jorge - Associacao de Combate ao Cancer em Goias

Address:
City: Goiânia
Zip: 74605-070
Country: Brazil

Facility:
Name: Oncosite - Centro de Pesquisa Clinica e Oncologia

Address:
City: Ijui
Zip: 98700-000
Country: Brazil

Facility:
Name: Catarina Pesquisa Clinica

Address:
City: Itajai
Zip: 88301-220
Country: Brazil

Facility:
Name: Oncoclinicas do Brasil Servicos Medicos AS

Address:
City: Minas Gerais
Zip: 30360-680
Country: Brazil

Facility:
Name: Liga Norte-Rio-Grandense Contra o Câncer

Address:
City: Natal
Zip: 59062-000
Country: Brazil

Facility:
Name: CIONC-Centro Integrado de Oncologia de Curitiba

Address:
City: Paraana
Zip: 80810050
Country: Brazil

Facility:
Name: Hospital Erasto Gaertner

Address:
City: Paraná
Zip: 81.520-060
Country: Brazil

Facility:
Name: IMIP - Instituto de Medicina Integral Professor Fernando Figueira

Address:
City: Pernambuco
Zip: 50070550
Country: Brazil

Facility:
Name: Irmandade da Santa Casa de Misericórdia de Porto Alegre

Address:
City: Porto Alegre
Zip: 90020-090
Country: Brazil

Facility:
Name: Hospital de Clínicas de Porto Alegre - HCPA

Address:
City: Porto Alegre
Zip: 90035-903
Country: Brazil

Facility:
Name: HGB - Hospital Giovanni Battista/Mãe de Deus Center

Address:
City: Porto Alegre
Zip: 90110-270
Country: Brazil

Facility:
Name: Hospital São Lucas da PUCRS

Address:
City: Porto Alegre
Zip: 90610001
Country: Brazil

Facility:
Name: Instituto Americas

Address:
City: Rio de Janeiro
Zip: 22775-001
Country: Brazil

Facility:
Name: Clínica de Oncologia de Porto Alegre Ltda - CLINIONCO

Address:
City: Rio Grande Do Sul
Zip: 90430-090
Country: Brazil

Facility:
Name: Unidade de PesquisasClinicas em Oncologia - UPCO

Address:
City: Rio Grande Do Sul
Zip: 96020-080
Country: Brazil

Facility:
Name: Instituto do Câncer - Hospital São Vicente de Paulo

Address:
City: Rio Grande Do Sul
Zip: 99010-090
Country: Brazil

Facility:
Name: CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia

Address:
City: Santo Andre
Zip: 09060-650
Country: Brazil

Facility:
Name: Instituto Hemomed Oncologia e Hematologia

Address:
City: São Paulo
Zip: 01236-030
Country: Brazil

Facility:
Name: Clinica de pesquisa e centro de estudos em oncologia ginecológica e mamaria

Address:
City: São Paulo
Zip: 1317000
Country: Brazil

Facility:
Name: BC Cancer - Kelowna

Address:
City: Kelowna
Zip: V1Y 5L3
Country: Canada

Facility:
Name: The Ottawa Hospital Cancer Centre

Address:
City: Ottawa
Zip: K1H 8L6
Country: Canada

Facility:
Name: CHU de Québec-Université Laval, Hôpital du Saint-Sacrement

Address:
City: Quebec
Zip: G1S 4L8
Country: Canada

Facility:
Name: Humber River Hospital

Address:
City: Toronto
Zip: M3M 0B2
Country: Canada

Facility:
Name: BC Cancer-Victoria

Address:
City: Victoria
Zip: V8R 6V5
Country: Canada

Facility:
Name: Centro de Investigacion Clinica Bradford Hill

Address:
City: Recoleta
Country: Chile

Facility:
Name: Centro del Cancer UC

Address:
City: Region Metropolitana
Zip: 7550000
Country: Chile

Facility:
Name: Centro de Oncología de Precisión (COP)

Address:
City: Santiago Region
Zip: 8330032
Country: Chile

Facility:
Name: James Lind Centro de Investigacion del Cancer

Address:
City: Temuco
Country: Chile

Facility:
Name: Oncocentro APYS

Address:
City: Vina del Mar
Zip: 2520612
Country: Chile

Facility:
Name: The First Affiliated Hospital of USTC (Anhui Provincial Hospital)

Address:
City: Anhui
Zip: 230001
Country: China

Facility:
Name: Peking University People's Hospital

Address:
City: Beijing
Zip: 100044
Country: China

Facility:
Name: The First Hospital of Jilin University

Address:
City: Changchun
Zip: 130021
Country: China

Facility:
Name: Xiangya Hospital Central South University

Address:
City: Changsha
Zip: 410008
Country: China

Facility:
Name: West China Hospital Sichuan University

Address:
City: Chengdu
Zip: 610041
Country: China

Facility:
Name: Chongqing University Cancer Hospital

Address:
City: Chongqing
Zip: 404100
Country: China

Facility:
Name: Fujian Cancer Hospital

Address:
City: Fujian
Zip: 350015
Country: China

Facility:
Name: Fujian Medical University Union Hospital

Address:
City: Fuzhou
Zip: 350001
Country: China

Facility:
Name: Sun Yat-Sen University Cancer Center

Address:
City: Guangdong
Zip: 510060
Country: China

Facility:
Name: Guangdong Provincial People's Hospital

Address:
City: Guangzhou
Zip: 510080
Country: China

Facility:
Name: The First Affiliated Hospital of Sun Yat-sen University

Address:
City: Guangzhou
Zip: 510080
Country: China

Facility:
Name: Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University

Address:
City: Guangzhou
Zip: 510120
Country: China

Facility:
Name: Sir Run Run Shaw Hospital,Zhejiang University School of Medicine

Address:
City: Hangzhou
Zip: 310000
Country: China

Facility:
Name: Zhejiang Cancer Hospital

Address:
City: Hangzhou
Zip: 310022
Country: China

Facility:
Name: Harbin Medical University Cancer Hospital

Address:
City: Heilongjiang
Zip: 150081
Country: China

Facility:
Name: Jiangsu Province Hospital

Address:
City: Jiangsu
Zip: 210029
Country: China

Facility:
Name: The First Affiliated Hospital of Soochow University

Address:
City: Jiangsu
Zip: 215004
Country: China

Facility:
Name: The Nanchang Third Hospital

Address:
City: Jiangxi
Zip: 330009
Country: China

Facility:
Name: The Second Hospital of Jilin University

Address:
City: Jilin Sheng
Zip: 130041
Country: China

Facility:
Name: Affiliated Cancer Hospital of Shandong First Medical University

Address:
City: Jinan
Zip: 250117
Country: China

Facility:
Name: The First Affiliated Hospital of Nanchang University

Address:
City: Nanchang
Zip: 330006
Country: China

Facility:
Name: General Hospital of Ningxia Medical University

Address:
City: Ningxia Hui
Zip: 750004
Country: China

Facility:
Name: The Affiliated Hospital Of Qingdao University

Address:
City: Qingdao
Zip: 266071
Country: China

Facility:
Name: Fudan University Shanghai Cancer Center

Address:
City: Shanghai
Zip: 200030
Country: China

Facility:
Name: Tianjin Medical University Cancer Institute & Hospital

Address:
City: Tianjin
Zip: 453000
Country: China

Facility:
Name: Hubei Cancer Hospital

Address:
City: Wuhan
Zip: 430079
Country: China

Facility:
Name: The First Affiliated Hospital of Xi'an Jiaotong University

Address:
City: Xi'an
Zip: 710061
Country: China

Facility:
Name: The Second Affiliated Hospital of Zhejiang University School of Medicine

Address:
City: Zhejiang
Zip: 310009
Country: China

Facility:
Name: Henan Cancer Hospital

Address:
City: Zhengzhou
Zip: 450003
Country: China

Facility:
Name: Fakultni Nemocnice Brno

Address:
City: Brno
Zip: 62500
Country: Czechia

Facility:
Name: Masaryk Memorial Cancer Institute

Address:
City: Brno
Zip: 656 53
Country: Czechia

Facility:
Name: University Hospital Olomouc

Address:
City: Olomouc
Zip: 779 00
Country: Czechia

Facility:
Name: Multiscan s.r.o

Address:
City: Pardubice
Zip: 532 01
Country: Czechia

Facility:
Name: Fakultni nemocnice v Motole

Address:
City: Prague 4
Zip: 14059
Country: Czechia

Facility:
Name: Charles General University Hospital, Prague

Address:
City: Prague
Zip: 12808
Country: Czechia

Facility:
Name: Krajska nemocnice Tomase Bati Zlin

Address:
City: Zlin
Zip: 760 01
Country: Czechia

Facility:
Name: CHU Jean Minjoz

Address:
City: Besancon
Zip: 25030
Country: France

Facility:
Name: Institut Bergonié

Address:
City: Bordeaux
Zip: 33076
Country: France

Facility:
Name: Centre Georges François Leclerc

Address:
City: Dijon
Zip: 21000
Country: France

Facility:
Name: Centre Oscar Lambret

Address:
City: Lille
Zip: 59000
Country: France

Facility:
Name: Clinique Francois Chenieux

Address:
City: Limoges
Zip: 87039
Country: France

Facility:
Name: Ico René Gauducheau

Address:
City: Loire Atlantique
Zip: 44 805
Country: France

Facility:
Name: Centre Leon Berard

Address:
City: Lyon
Zip: 69373
Country: France

Facility:
Name: Institut Paoli Calmettes

Address:
City: Marseille
Zip: 13009
Country: France

Facility:
Name: Institut Regional du Cancer de Montpellier

Address:
City: Montpellier Cedex 5
Zip: 34298
Country: France

Facility:
Name: Institut Curie

Address:
City: Paris
Zip: 75248
Country: France

Facility:
Name: Centre Hospitalier Lyon-Sud

Address:
City: Pierre-benite
Zip: 69310
Country: France

Facility:
Name: Hopital Privé des Cotes d'Armor

Address:
City: Plerin
Zip: 22190
Country: France

Facility:
Name: Centre Jean Bernard Service d'Oncologie Médicale

Address:
City: Rennes Cedex
Zip: 35042
Country: France

Facility:
Name: Centre Henri Becquerel

Address:
City: Rouen
Country: France

Facility:
Name: Institut Universitaire du Cancer de Toulouse Oncopole

Address:
City: Toulouse Cedex 9
Zip: 31059
Country: France

Facility:
Name: Institut Gustave Roussy

Address:
City: Villejuif
Zip: 94800
Country: France

Facility:
Name: Universitaetsklinikum Freiburg, Klinik fuer Frauenheilkunde

Address:
City: Baden-Württemberg
Zip: 79106
Country: Germany

Facility:
Name: University Hospital rechts der Isar Technical University of Munich

Address:
City: Bayern
Zip: 81675
Country: Germany

Facility:
Name: Vivantes Klinikum am Urban

Address:
City: Berlin
Zip: 10967
Country: Germany

Facility:
Name: HELIOS Klinikum Berlin-Buch

Address:
City: Berlin
Zip: 13125
Country: Germany

Facility:
Name: Marienhospital Bottrop

Address:
City: Bottrop
Zip: 46236
Country: Germany

Facility:
Name: Universitätsklinik Erlangen

Address:
City: Erlangen
Zip: 91054
Country: Germany

Facility:
Name: SRH Wald-Klinikum Gera GmbH

Address:
City: Gera
Zip: 07548
Country: Germany

Facility:
Name: Universitatsklinikum Hamburg-Eppendorf

Address:
City: Hamburg
Zip: 20246
Country: Germany

Facility:
Name: Medizinische Hochschule Hannover

Address:
City: Hannover
Zip: D-30625
Country: Germany

Facility:
Name: Nationales Centrum für Tumorerkrankungen Heidelberg

Address:
City: Heidelberg
Zip: 69120
Country: Germany

Facility:
Name: Universitätsklinikum Mannheim

Address:
City: Mannheim
Zip: 68167
Country: Germany

Facility:
Name: Universitatsklinikum Munster

Address:
City: Munster
Zip: 48149
Country: Germany

Facility:
Name: LMU Klinikum der Universitat München

Address:
City: München
Zip: 81377
Country: Germany

Facility:
Name: Universitäts - Frauenklinik

Address:
City: Tübingen
Zip: 72076
Country: Germany

Facility:
Name: Alexandra General Hospital

Address:
City: Athens
Zip: 11528
Country: Greece

Facility:
Name: Attikon Hospital

Address:
City: Athens
Zip: 124 62
Country: Greece

Facility:
Name: University Hospital of Heraklion

Address:
City: Heraklion
Country: Greece

Facility:
Name: University Hospital of Larissa

Address:
City: Larissa
Zip: 41110
Country: Greece

Facility:
Name: University Hospital of Patras

Address:
City: Patras
Zip: 26 500
Country: Greece

Facility:
Name: Bioclinic of Thessaloniki

Address:
City: Thessaloniki
Zip: 546 22
Country: Greece

Facility:
Name: Euromedica General Clinic of Thessaloniki

Address:
City: Thessaloniki
Zip: 546 45
Country: Greece

Facility:
Name: Hong Kong Integrated Oncology Centre

Address:
City: Hong Kong
Zip: 0
Country: Hong Kong

Facility:
Name: Prince of Wales Hospital

Address:
City: New Territories
Country: Hong Kong

Facility:
Name: Queen Mary Hospital

Address:
City: Pok Fu Lam
Zip: 0
Country: Hong Kong

Facility:
Name: Semmelweis Egyetem, Belgyogyaszati es Onkologiai Klinika

Address:
City: Budapest
Zip: 1083
Country: Hungary

Facility:
Name: Debreceni Egyetem Klinikai Központ

Address:
City: Debrecen
Zip: 4032
Country: Hungary

Facility:
Name: Bács-Kiskun Varmegyei Oktatokorhaz, Onkaradiologiai Kozpont

Address:
City: Kecskemét
Zip: 6000
Country: Hungary

Facility:
Name: Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz, Onkoradiologia

Address:
City: Nyiregyhaza
Zip: 4400
Country: Hungary

Facility:
Name: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

Address:
City: Szeged
Zip: 6720
Country: Hungary

Facility:
Name: Oncology Institute Rambam Health Care Campus

Address:
City: Haifa
Zip: 31096
Country: Israel

Facility:
Name: Shaare Zedek Medical Center

Address:
City: Jerusalem
Zip: 9103102
Country: Israel

Facility:
Name: Hadassah Medical Center

Address:
City: Jerusalem
Country: Israel

Facility:
Name: Rabin Medical Center

Address:
City: Petah Tikva
Zip: 4941492
Country: Israel

Facility:
Name: Sheba Medical Center

Address:
City: Ramat Gan
Zip: 52621
Country: Israel

Facility:
Name: Tel Aviv Sourasky Medical Center

Address:
City: Tel Aviv
Zip: 64239
Country: Israel

Facility:
Name: Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona

Address:
City: Ancona AN
Zip: 60126
Country: Italy

Facility:
Name: Centro di Riferimento Oncologico - IRCCS

Address:
City: Aviano
Zip: 33081
Country: Italy

Facility:
Name: Humanitas Gavazzeni

Address:
City: Bergamo
Zip: 24125
Country: Italy

Facility:
Name: ASST Papa Giovanni XXIII

Address:
City: Bergamo
Zip: 24127
Country: Italy

Facility:
Name: IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico di Sant'Orsola

Address:
City: Bologna
Country: Italy

Facility:
Name: Humanitas Istituto Clinico Catanese

Address:
City: Catania
Zip: 95045
Country: Italy

Facility:
Name: Azienda Ospedaliera Mater Domini

Address:
City: Catanzaro
Zip: 88100
Country: Italy

Facility:
Name: IRCCS Ospedale Policlinico San Martino

Address:
City: Genova GE
Zip: 16132
Country: Italy

Facility:
Name: Fondazione IRCCS San Raffaele del Monte Tabor

Address:
City: Milano
Zip: 20132
Country: Italy

Facility:
Name: Istituto Europeo di Oncologia

Address:
City: Milan
Zip: 20141
Country: Italy

Facility:
Name: Azienda Ospedaliera San Gerardo

Address:
City: Monza
Zip: 20090
Country: Italy

Facility:
Name: Istituto Nazionale Tumori IRCCS Fondazione G. Pascale

Address:
City: Napoli
Zip: 80131
Country: Italy

Facility:
Name: Istituto Oncologico Veneto IOV

Address:
City: Padova
Zip: 35128
Country: Italy

Facility:
Name: Irccs Crob

Address:
City: Rionero in Vulture
Zip: 85028
Country: Italy

Facility:
Name: Azienda Ospedaliero-Universitaria Policlinico Umberto I

Address:
City: Roma
Zip: 161
Country: Italy

Facility:
Name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Address:
City: Roma
Zip: 168
Country: Italy

Facility:
Name: Istituto Clinico Humanitas

Address:
City: Rozzano
Zip: 20089
Country: Italy

Facility:
Name: Aichi Cancer Center Hospital

Address:
City: Aichi
Zip: 464-8681
Country: Japan

Facility:
Name: Tohoku University Hospital

Address:
City: Aoba-ku
Zip: 980-8574
Country: Japan

Facility:
Name: Juntendo University Hospital

Address:
City: Bunkyo-ku
Zip: 113-8431
Country: Japan

Facility:
Name: Chiba Cancer Center

Address:
City: Chiba
Zip: 260-8717
Country: Japan

Facility:
Name: National Cancer Center Hospital

Address:
City: Chuo-ku
Zip: 1040045
Country: Japan

Facility:
Name: Osaka Prefectural Hospital Organization Osaka International Cancer Institute

Address:
City: Chuo-ku
Zip: 541-8567
Country: Japan

Facility:
Name: National Hospital Organization Shikoku Cancer Center

Address:
City: Ehime
Zip: 791-0280
Country: Japan

Facility:
Name: Fukushima Medical University Hospital

Address:
City: Fukushima
Country: Japan

Facility:
Name: Social Medical Corporation Hakuaikai Sagara Hospital

Address:
City: Kagoshima-shi
Zip: 892-0833
Country: Japan

Facility:
Name: Tokai University Hospital

Address:
City: Kanagawa
Zip: 259-1193
Country: Japan

Facility:
Name: National Cancer Center Hospital East

Address:
City: Kashiwa
Zip: 277-8577
Country: Japan

Facility:
Name: Saitama Cancer Center

Address:
City: Kitaadachi-gun
Zip: 362-0806
Country: Japan

Facility:
Name: Cancer Institute Hospital of JFCR

Address:
City: Koto-Ku
Zip: 135-8550
Country: Japan

Facility:
Name: Kumamoto University Hospital

Address:
City: Kumamoto- shi
Zip: 860-8556
Country: Japan

Facility:
Name: Kyoto University Hospital

Address:
City: Kyoto-shi
Zip: 606-8507
Country: Japan

Facility:
Name: National Hospital Organization Kyushu Cancer Center

Address:
City: Minami-ku
Zip: 811-1395
Country: Japan

Facility:
Name: Nagoya University Hospital

Address:
City: Nagoya
Zip: 466-8560
Country: Japan

Facility:
Name: Hiroshima City Hiroshima Citizens Hospital

Address:
City: Naka-ku
Zip: 730-8518
Country: Japan

Facility:
Name: Hyogo Medical University Hospital

Address:
City: Nishinomiya-shi
Zip: 663-8501
Country: Japan

Facility:
Name: Okayama University Hospital

Address:
City: Okayama
Zip: 700-8558
Country: Japan

Facility:
Name: Gunma Prefectural Cancer Center

Address:
City: Ota
Zip: 373-8550
Country: Japan

Facility:
Name: National Hospital Organization Hokkaido Cancer Center

Address:
City: Sapporo
Zip: 003-0804
Country: Japan

Facility:
Name: Center Hospital of the National Center for Global Health and Medicine

Address:
City: Shinjuku-ku
Zip: 162-8655
Country: Japan

Facility:
Name: Showa University Hospital

Address:
City: Tokyo
Zip: 142-8555
Country: Japan

Facility:
Name: Kanagawa Cancer Center

Address:
City: Yokohama
Zip: 241-8515
Country: Japan

Facility:
Name: Samsung Medical Center

Address:
City: Gangnam-Gu
Zip: 06351
Country: Korea, Republic of

Facility:
Name: National Cancer Center

Address:
City: Goyang-si Gyeonggi-do
Zip: 10408
Country: Korea, Republic of

Facility:
Name: Kyungpook National University Chilgok Hospital

Address:
City: Gyeongsangbuk-do
Zip: 41404
Country: Korea, Republic of

Facility:
Name: Gachon University Gil Medical Center

Address:
City: Incheon
Zip: 21565
Country: Korea, Republic of

Facility:
Name: Seoul National University Bundang Hospital

Address:
City: Seongnam
Zip: 13620
Country: Korea, Republic of

Facility:
Name: Korea University Anam Hospital

Address:
City: Seoul
Zip: 02841
Country: Korea, Republic of

Facility:
Name: Seoul National University Hospital

Address:
City: Seoul
Zip: 03080
Country: Korea, Republic of

Facility:
Name: Severance Hospital, Yonsei University Health System

Address:
City: Seoul
Zip: 03722
Country: Korea, Republic of

Facility:
Name: Asan Medical Center

Address:
City: Seoul
Zip: 05505
Country: Korea, Republic of

Facility:
Name: Hospital Kuala Lumpur

Address:
City: Kuala Lumpur
Zip: 50586
Country: Malaysia

Facility:
Name: University Malaya Medical Centre

Address:
City: Kuala Lumpur
Zip: 59100
Country: Malaysia

Facility:
Name: Sarawak General Hospital

Address:
City: Kuching
Zip: 93586
Country: Malaysia

Facility:
Name: Institut Kanser Negara

Address:
City: Putrajaya
Zip: 62250
Country: Malaysia

Facility:
Name: Centro de Investigacion y Avances Medicos Especializados

Address:
City: Cancún
Zip: 77550
Country: Mexico

Facility:
Name: COI Centro Oncologico Internacional S.A.P.I. de C.V.

Address:
City: Mexico City
Zip: 04700
Country: Mexico

Facility:
Name: Hospital Universitario Dr. José Eleuterio González

Address:
City: Monterrey
Zip: 64460
Country: Mexico

Facility:
Name: FUCAM

Address:
City: México
Zip: 4980
Country: Mexico

Facility:
Name: Clinica Integral Internacional de Oncologia S de RL de CV

Address:
City: Puebla
Zip: 72530
Country: Mexico

Facility:
Name: Centro Medico Zambrano Hellion

Address:
City: San Pedro Garza García
Zip: 64710
Country: Mexico

Facility:
Name: Centro de Atención e Investigación Clínica en Oncología

Address:
City: Yucatán
Zip: 97134
Country: Mexico

Facility:
Name: Copemicus Podmiot Leczniczy Wojewodzkie Centrum Okologii w Gdansku

Address:
City: Gdansk
Zip: 80-219
Country: Poland

Facility:
Name: Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z.o.o

Address:
City: Krakow
Zip: 31-826
Country: Poland

Facility:
Name: Instytut MSF Sp. z o.o.

Address:
City: Lodz
Zip: 90-302
Country: Poland

Facility:
Name: Wojewodzki Szpital Specjalistyczny lm. Stefana Kardynala Wyszynsklego SPZOZ w Lublinie

Address:
City: Lublin
Zip: 19713
Country: Poland

Facility:
Name: LUX MED Onkologia Sp. Zo.o.

Address:
City: Warszawa
Zip: 01-748
Country: Poland

Facility:
Name: Maria Sklodowska - Curie Institute of Oncology

Address:
City: Warszawa
Zip: 02-781
Country: Poland

Facility:
Name: Centro Clinico Academico - Hospital de Braga

Address:
City: Braga
Country: Portugal

Facility:
Name: Hospital da Senhora da Oliveira Guimaraes

Address:
City: Guimarães
Zip: 4835-044
Country: Portugal

Facility:
Name: Centro Hospitalar de Lisboa Central, E.P.E . - Hospital de Santo Antonio dos Capuchos

Address:
City: Lisbon
Zip: 1153-302
Country: Portugal

Facility:
Name: Fundacao Champalimaud

Address:
City: Lisbon
Zip: 1400-038
Country: Portugal

Facility:
Name: Centro Hospitalar Lisboa Norte, EPE

Address:
City: Lisbon
Zip: 1649-035
Country: Portugal

Facility:
Name: Unidade Local de Saude de Matosinhos EPE - Hospital Pedro Hispano

Address:
City: Matosinhos
Zip: 4464-513
Country: Portugal

Facility:
Name: National University Hospital

Address:
City: Singapore
Zip: 119228
Country: Singapore

Facility:
Name: National Cancer Centre Singapore

Address:
City: Singapore
Zip: 169610
Country: Singapore

Facility:
Name: Tan Tock Seng Hospital

Address:
City: Singapore
Zip: 308433
Country: Singapore

Facility:
Name: Wilgers Oncology Centre

Address:
City: Gauteng
Zip: 0081
Country: South Africa

Facility:
Name: Wits Clinical Research

Address:
City: Johannesburg
Zip: 2192
Country: South Africa

Facility:
Name: The Medical Oncology Centre of Rosebank

Address:
City: Johannesburg
Zip: 2196
Country: South Africa

Facility:
Name: Cape Town Oncology Trials

Address:
City: Kraaifontein
Zip: 7570
Country: South Africa

Facility:
Name: Hospital Universitari Dexeus

Address:
City: Barcelona
Zip: 08028
Country: Spain

Facility:
Name: Hospital Clinic de Barcelona

Address:
City: Barcelona
Zip: 08036
Country: Spain

Facility:
Name: Hospital Universitari Vall D'Hebron

Address:
City: Barcelona
Zip: 8035
Country: Spain

Facility:
Name: Hospital de Basurto

Address:
City: Bilbo
Zip: 48013
Country: Spain

Facility:
Name: Hospital Universitario Reina Sofia

Address:
City: Córdoba
Zip: 14004
Country: Spain

Facility:
Name: Hospital General Universitario De Elche

Address:
City: Elche
Zip: 3203
Country: Spain

Facility:
Name: Hospital Universitario de Jaen

Address:
City: Jaen
Zip: 23007
Country: Spain

Facility:
Name: Hospital Beata María Ana

Address:
City: Madrid
Zip: 28007
Country: Spain

Facility:
Name: Hospital General Universitario Gregorio Marañón

Address:
City: Madrid
Zip: 28007
Country: Spain

Facility:
Name: MD Anderson Cancer Center

Address:
City: Madrid
Zip: 28033
Country: Spain

Facility:
Name: Hospital Universitario Ramón y Cajal

Address:
City: Madrid
Zip: 28034
Country: Spain

Facility:
Name: Hospital Clinico San Carlos

Address:
City: Madrid
Zip: 28040
Country: Spain

Facility:
Name: Hospital Universitario 12 de Octubre

Address:
City: Madrid
Zip: 28041
Country: Spain

Facility:
Name: Hospital Universitario de Salamanca

Address:
City: Salamanca
Zip: 37002
Country: Spain

Facility:
Name: Hospital Clínico Universitario de Santiago de Compostela - CHUS

Address:
City: Santiago de Compostela
Zip: 15706
Country: Spain

Facility:
Name: Hospital Universitario Virgen Macarena

Address:
City: Sevilla
Zip: 41071
Country: Spain

Facility:
Name: Hospital Universitario Virgen del Rocio

Address:
City: Seville
Zip: 41013
Country: Spain

Facility:
Name: Instituto Valenciano De Oncologia (IVO)

Address:
City: Valencia
Zip: 46009
Country: Spain

Facility:
Name: Hospital Clínico Universitario de Valencia

Address:
City: Valencia
Zip: 46010
Country: Spain

Facility:
Name: Kaohsiung Chang Gung Memorial Hospital

Address:
City: Kaohsiung City
Zip: 83301
Country: Taiwan

Facility:
Name: Kaohsiung Medical University Chung-Ho Memorial Hospital

Address:
City: Kaohsiung
Zip: 807
Country: Taiwan

Facility:
Name: Taipei Medical University - Shuang Ho Hospital, Ministry of Health and Welfare

Address:
City: New Taipei City
Zip: 235
Country: Taiwan

Facility:
Name: Chi Mei Hospital, Liouying

Address:
City: Tainan City
Zip: 73657
Country: Taiwan

Facility:
Name: National Cheng Kung University Hospital

Address:
City: Tainan
Zip: 704
Country: Taiwan

Facility:
Name: Taipei Veterans General Hospital

Address:
City: Taipei City
Zip: 11217
Country: Taiwan

Facility:
Name: National Taiwan University Hospital

Address:
City: Taipei
Zip: 10048
Country: Taiwan

Facility:
Name: Tri-Service General Hospital

Address:
City: Taipei
Zip: 11490
Country: Taiwan

Facility:
Name: Koo Foundation Sun Yat-Sen Cancer Center

Address:
City: Taipei
Zip: 999999
Country: Taiwan

Facility:
Name: Chang Gung Memorial Hospital, Linkou

Address:
City: Taoyuan City
Zip: 33305
Country: Taiwan

Facility:
Name: Barts Cancer Institute

Address:
City: London
Zip: EC1A 7BE
Country: United Kingdom

Facility:
Name: University College London Hospitals

Address:
City: London
Zip: NW1 2PG
Country: United Kingdom

Facility:
Name: The Royal Marsden NHS Foundation Trust

Address:
City: London
Zip: SW10 9NH
Country: United Kingdom

Facility:
Name: The Christie NHS Foundation Trust

Address:
City: Manchester
Zip: M20 4BX
Country: United Kingdom

Facility:
Name: Nottingham University Hospitals NHS Trust

Address:
City: Nottingham
Zip: NG5 1PB
Country: United Kingdom

Start date: May 8, 2023

Completion date: December 2028

Lead sponsor:
Agency: Gilead Sciences
Agency class: Industry

Source: Gilead Sciences

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT05840211
https://www.gileadclinicaltrials.com/study?nctid=NCT05840211