Barriers and Facilitators of Parent-Child Communication in Children With Cancer Predisposition

Trial Title: Barriers and Facilitators of Parent-Child Communication in Children With Cancer Predisposition

NCT ID: NCT05849155

Condition: Genetic Predisposition

Conditions: Official terms:
Disease Susceptibility
Genetic Predisposition to Disease

Study type: Observational

Overall status: Recruiting

Study design:

Time perspective: Prospective

Summary: Testing children, adolescents, and young adults (CAYA) for a genetic risk for cancer can help with early prevention and detection of cancers through regular follow-ups and medical care. After receiving genetic test results, CAYA may not accurately understand what their results mean, and parents are often unsure about talking with their CAYA about their genetic risk for cancer. By understanding how parents communicate with their CAYA, the investigators can improve future genetic education to reduce cancer risk. Primary Objectives: - Identify qualities of parent-CAYA (child, adolescent, and young adults) communication about CAYAs' genomic cancer risk, and their association with CAYAs' psychosocial and prevention outcomes. - Examine the association between sociodemographic, cancer-related, and psychosocial factors and parent-CAYA communication regarding CAYAs' genomic risk for cancer. - Identify barriers and facilitators of parent-CAYA communication regarding CAYAs' genomic risk for cancer.

Detailed description: This sequential explanatory mixed-methods, multi-informant study will include CAYAs (ages 10-24 years) with a P/LP germline variant in a known cancer predisposition gene, with this age range selected to inform CAYA informational needs around transition to adult care. CAYAs and parents will complete questionnaires and direct behavioral observations of parent-CAYA communication to (1) observationally characterize the content, qualities, and associates of parent-CAYA cancer predisposition communication and (2) examine the association between qualities of parent-CAYA communication about CAYAs' cancer risk and CAYAs' psychosocial and prevention outcomes. A subset of CAYAs and parents (n = 40 each) will subsequently complete optional qualitative interviews. CAYAs and parents will be purposively selected for these interviews based on their observed communication to identify barriers and facilitators of parent-CAYA communication regarding genetic risk for cancer. Rigor and reproducibility are ensured through a multi-method, multi-informant design; a manualized approach to recruitment and data collection; standardized measures with sound psychometric properties when available (quant); rigorous statistical tests of proposed hypotheses (quant); data saturation and purposeful sampling for transferability (qual); and triangulation (qual)

Criteria for eligibility:

Study pop:
Children, adolescents, and young adults (CAYAs) aged 10-24 years with a pathogenic/likely pathogenic variant in a known cancer predisposition gene and their parents

Sampling method: Non-Probability Sample
Criteria:
Inclusion Criteria: - Patient aged 10 to 24 years (inclusive) - Patient underwent germline genetic testing with a Pathogenic/Likely Pathogenic (P/LP) variant in a known cancer predisposition gene that increases risk for developing cancer - P/LP result disclosed to the patient - Patient has a primary caregiver willing to participate - Patient and participating caregiver able to speak and read English Exclusion Criteria: - Patient is only a carrier of a recessive variant that does not alone increase risk for cancer - Inability or unwillingness of patient or participating caregiver or to give informed consent/assent - Participating caregiver is under the age of 18 years - Patient or participating caregiver has evidence of significant cognitive deficits (per medical record) that would interfere with the ability to comprehend study questions - Patient's medical status or condition precludes completion of study (as determined by medical team, patient, or parent)

Gender: All

Minimum age: 10 Years

Maximum age: 24 Years

Healthy volunteers: No

Locations:

Facility:
Name: St. Jude Children's Research Hospital

Address:
City: Memphis
Zip: 38105
Country: United States

Status: Recruiting

Contact:

Phone: 866-278-5833
Email: referralinfo@stjude.org

Start date: December 12, 2023

Completion date: October 2028

Lead sponsor:
Agency: St. Jude Children's Research Hospital
Agency class: Other

Source: St. Jude Children's Research Hospital

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT05849155
http://www.stjude.org
http://www.stjude.org/protocols