A Study to Learn How Well a Higher Amount of Aflibercept Given as an Injection Into the Eye Works and How Safe it is in People With Reduced Vision Due to Swelling in the Macula, Central Part of the Retina Caused by a Blocked Vein in the Retina (Macula Edema Secondary to Retinal Vein Occlusion)

Trial Title: A Study to Learn How Well a Higher Amount of Aflibercept Given as an Injection Into the Eye Works and How Safe it is in People With Reduced Vision Due to Swelling in the Macula, Central Part of the Retina Caused by a Blocked Vein in the Retina (Macula Edema Secondary to Retinal Vein Occlusion)

NCT ID: NCT05850520

Condition: Macular Edema Secondary to Retinal Vein Occlusion

Conditions: Official terms:
Neoplasm Metastasis
Macular Edema
Retinal Vein Occlusion
Edema
Aflibercept

Study type: Interventional

Study phase: Phase 3

Overall status: Recruiting

Study design:

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Treatment

Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Intervention:

Intervention type: Drug
Intervention name: Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_higher dose
Description: Intravitreally (IVT) injection.
Arm group label: Higher Dose Regimen 1
Arm group label: Higher Dose Regimen 2

Intervention type: Drug
Intervention name: Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_2 mg
Description: Intravitreally (IVT) injection.
Arm group label: Standard of care

Intervention type: Drug
Intervention name: Sham
Description: Sham procedure will be given on visits when an active injection is not planned.
Arm group label: Higher Dose Regimen 1
Arm group label: Higher Dose Regimen 2

Intervention type: Diagnostic Test
Intervention name: Fluorescein
Description: Fluorescein 100 mg/mL solution for injection is a dye that makes the retinal vessels visible during FA examinations, and as such, it will be used as an auxiliary medicinal product (AxMP) in this periodic ophthalmic examination. This medicine is for diagnostic use only. It is not used to treat any condition.
Arm group label: Higher Dose Regimen 1
Arm group label: Higher Dose Regimen 2
Arm group label: Standard of care

Summary: Researchers are looking for a better way to treat people who have macular edema secondary to retinal vein occlusion (RVO). In people with RVO, a blood vessel that carries blood away from the retina (vein) becomes blocked. The retina is the very back part of the eye. The blocked vein causes fluid and blood to leak into the retina and thereby causes a swelling of the macula (the center of the retina responsible for fine vision). This swelling is called macular edema. When a vein in the retina is blocked, the levels of a protein called vascular endothelial growth factor (VEGF) rises. VEGF helps the growth of new blood vessels. This can lead to macular edema and may cause the vision to become blurry. The study treatment intravitreal (IVT) aflibercept is given as an injection into the eye. It works by blocking VEGF and this can help repair vision problems related to RVO. IVT aflibercept is already available and is prescribed by doctors as the standard of care treatment for macula edema secondary to RVO. Standard of care is a treatment that medical experts consider most appropriate for a disease. Standard of care is given every 4 weeks in people with macula edema secondary to RVO. While repeated injections of aflibercept may prevent worsening of vision, it may place a burden on the patient. However, a higher amount (8 mg) compared to the standard of care (2 mg) of IVT aflibercept is being tested in studies. This higher amount could be given less often. The amount of IVT aflibercept given is measured in milligrams, also known as mg. The main purpose of this study is to learn how well a higher amount of the study treatment aflibercept works in people with macular edema secondary to RVO. To answer this, researchers will measure changes in vision called best corrected visual acuity (BCVA) in the study participants between study start and after 36 weeks of treatment. Changes will then be compared between those participants who received the higher amount of IVT aflibercept and those that received standard of care. To learn how safe the study treatment is in the participants, the researchers will count the number of participants from study start and up to 64 weeks later that have: - adverse events - serious adverse events "Adverse events" are any medical problems that the participants have during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think they might be related to the study treatments. An adverse event is considered "serious" when it leads to death, puts the participants' lives at risk, requires hospitalization, causes disability, causes a baby being born with medical problems or is otherwise medically important. Dependent on the treatment group, the participants will either receive the higher amount of aflibercept or standard of care as an intravitreal injection for up to 60 weeks. The study will consist of a test (screening) phase, a treatment phase and an end of study phase. Each participant will be in the study for up to 64 weeks. One visit to the study site is planned during the screening phase, followed by visits approximately every 4 weeks (16 in total) during treatment and one visit at the end of the study. During the study, the study doctors and their team will: - check patients' eye health using various eye examination techniques - measure patients' eye vision (BCVA) - take blood and urine samples - do physical examinations - check vital signs - examine heart health using electrocardiogram (ECG) - do pregnancy tests in women of childbearing age In addition, participants will be asked to fill a questionnaire on vision-related quality of life.

Criteria for eligibility:
Criteria:
Inclusion Criteria: - Adult ≥18 years of age (or country's legal age of adulthood if the legal age is >18 years) at the time of signing the informed consent. - Treatment-naïve macular edema involving the foveal center secondary to RVO (BRVO, HRVO, or CRVO) diagnosed within 16 weeks (112 days) before the screening visit in the study eye. - Early Treatment Diabetic Retinopathy Study BCVA letter score of 73 to 24 (20/40 to 20/320) at screening and baseline visits in the study eye. Decrease in BCVA determined to be primarily the result of RVO in the study eye. - Mean CST ≥300 μm on optical coherence tomography (OCT) if excluding Bruch's membrane (e.g., Cirrus or Topcon) or ≥320 μm if including Bruch's membrane (e.g., Heidelberg Spectralis), confirmed by the reading center at the screening visit and by the site at baseline visit in the study eye. - Capable of giving signed informed consent form (ICF) by study participant or legally acceptable representative, which includes compliance with the requirements and restrictions listed in the ICF and in this protocol. - US participants will be required to have a Health Insurance Portability and Accountability Act (HIPAA) authorization; in other countries, as applicable according to national laws. - Women of childbearing potential (WOCBP) or men who are sexually active with partners of childbearing potential must agree to use highly effective contraception prior to the initial dose/start of the first treatment, during the study, and for at least 4 months after the last administration of study intervention. Contraceptive use by men or women should be consistent with local regulations regarding the methods of contraception for participation in clinical studies and fulfil the conditions set on Section 10.4.2. Exclusion Criteria: - Concurrent disease that causes substantial decrease of BCVA, is expected to limit BCVA recovery or is likely to require medical or surgical intervention during the study in the study eye. - Presence or history of the following ocular conditions: 1. Advanced age-related macular degeneration (neovascular AMD or geographic atrophy) in the study eye. 2. Diabetic macular edema or diabetic retinopathy, defined in diabetic participants as diabetic retinopathy lesions outside the area of the vein occlusion in the study eye and anywhere in the retina in the fellow eye. 3. Anterior segment neovascularization, vitreous hemorrhage, retinal detachment in the study eye. 4. Vitreomacular traction, epiretinal membrane or structural damage to the macula that is considered by the Investigator to significantly affect central vision or preclude improvement in vision in the study eye. 5. Macular hole of stage 2 and above in the study eye. 6. Myopia of a spherical equivalent of at least 8 diopters prior to any refractive or cataract surgery in the study eye. 7. Corneal transplant or corneal dystrophy in the study eye. 8. Idiopathic or autoimmune uveitis in the study or in the fellow eye. - Presence of the following ocular conditions at screening or baseline visit: 1. Significant media opacities, including cataract, that interfere with BCVA, or imaging assessments (e.g., fundus photography [FP], OCT) in the study eye. 2. Aphakia, or pseudophakia with absence of posterior capsule (unless it occurred as a result of a yttrium-aluminum-garnet [YAG] posterior capsulotomy performed more than 30 days before the screening visit), in the study eye. 3. Uncontrolled glaucoma (defined as IOP >25 mmHg despite treatment with anti-glaucoma medication); or history or likely future need of glaucoma surgery in the study eye. 4. Intraocular inflammation/infection (including trace, or above, cells in the anterior chamber and/or vitreous) within 12 weeks (84 days) of the screening visit in the study or in the fellow eye. 5. Extraocular or periocular infection or inflammation (including infectious blepharitis, keratitis, scleritis, or conjunctivitis) in the study or in the fellow eye. - Uncontrolled blood pressure (defined as systolic >160 mmHg or diastolic >95 mmHg) at the screening visit or baseline visit. - Uncontrolled diabetes mellitus, defined by hemoglobin A1c (HbA1c) >12% at the screening visit. - History of cerebrovascular accident or myocardial infarction within 24 weeks (168 days) before the screening visit or between screening and baseline visits. - Renal failure requiring dialysis, or renal transplant at screening or potentially during the study. - Any prior or concomitant ocular or systemic treatment (with an investigational or approved, anti-VEGF or other agent) or surgery for RVO in the study eye. - Previous administration of systemic anti-angiogenic medications for any condition. - Prior treatment of the study eye with any of the following drugs (any route of ophthalmic administration) or procedures: 1. Anti-angiogenic drugs at any time including investigational therapy (e.g., with anti-angiopoietin/anti-VEGF bispecific monoclonal antibodies). 2. Previous use topical steroids within 4 weeks (28 days) from the screening visit, or intraocular or periocular steroids within 16 weeks (112 days) from the screening visit, or steroid implants at any time. 3. Previous treatment with intraocular or periocular implant, gene therapy, or cell therapy at any time. 4. Treatment with ocriplasmin at any time. 5. Vitreoretinal surgery (including scleral buckling) at any time. 6. Any intraocular surgery, including cataract surgery, within 12 weeks (84 days) before the screening visit. 7. Previous treatment with retinal laser photocoagulation. - Prior treatment of the fellow eye with any of the following: a. Gene therapy, or cell therapy in the fellow eye at any time. - Participation in other clinical studies requiring administration of investigational treatments (other than vitamins and minerals) at the time of screening visit, or within 30 days or 5 half-lives of administration of the previous study intervention, whichever is longer.

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: Retina Consultants of Orange County

Address:
City: Fullerton
Zip: 92835
Country: United States

Status: Active, not recruiting

Facility:
Name: Mountain View | Ophthalmology

Address:
City: Loma Linda
Zip: 92354
Country: United States

Status: Active, not recruiting

Facility:
Name: South Coast Retina Center

Address:
City: Long Beach
Zip: 90807
Country: United States

Status: Active, not recruiting

Facility:
Name: Northern California Retina-Vitreous Associates

Address:
City: Mountain View
Zip: 94040
Country: United States

Status: Active, not recruiting

Facility:
Name: Southern California Desert Retina Consultants - Palm Springs Office

Address:
City: Palm Springs
Zip: 92262
Country: United States

Status: Active, not recruiting

Facility:
Name: California Eye Specialists Medical Group, Inc.

Address:
City: Pasadena
Zip: 91107
Country: United States

Status: Completed

Facility:
Name: Southern California Permanente Medical Group

Address:
City: Riverside
Zip: 92505
Country: United States

Status: Withdrawn

Facility:
Name: Stanford University

Address:
City: Stanford
Zip: 94305
Country: United States

Status: Withdrawn

Facility:
Name: Retina Consultants of Southern Colorado, PC

Address:
City: Colorado Springs
Zip: 80909
Country: United States

Status: Active, not recruiting

Facility:
Name: New England Retina Associates

Address:
City: New London
Zip: 06518
Country: United States

Status: Active, not recruiting

Facility:
Name: Rand Eye Institute

Address:
City: Deerfield Beach
Zip: 33064
Country: United States

Status: Active, not recruiting

Facility:
Name: National Ophthalmic Research Institute

Address:
City: Fort Myers
Zip: 33912
Country: United States

Status: Active, not recruiting

Facility:
Name: The Eye Institute of West Florida

Address:
City: Largo
Zip: 33770
Country: United States

Status: Completed

Facility:
Name: Florida Eye Associates

Address:
City: Melbourne
Zip: 32901
Country: United States

Status: Active, not recruiting

Facility:
Name: Florida Retina Institute

Address:
City: Orlando
Zip: 32806
Country: United States

Status: Active, not recruiting

Facility:
Name: Retina Specialists

Address:
City: Pensacola
Zip: 32503
Country: United States

Status: Completed

Facility:
Name: Fort Lauderdale Eye Institute

Address:
City: Plantation
Zip: 33324
Country: United States

Status: Active, not recruiting

Facility:
Name: Retina Vitreous Associates of Florida - Saint Petersburg

Address:
City: Saint Petersburg
Zip: 33711-1141
Country: United States

Status: Active, not recruiting

Facility:
Name: East Florida Eye Institute

Address:
City: Stuart
Zip: 34994-2579
Country: United States

Status: Active, not recruiting

Facility:
Name: University of South Florida

Address:
City: Tampa
Zip: 33612
Country: United States

Status: Withdrawn

Facility:
Name: Center for Retina and Macular Disease - Winter Haven

Address:
City: Winter Haven
Zip: 33880
Country: United States

Status: Active, not recruiting

Facility:
Name: Marietta Eye Clinic

Address:
City: Marietta
Zip: 30060
Country: United States

Status: Active, not recruiting

Facility:
Name: University of Chicago

Address:
City: Chicago
Zip: 60637-1447
Country: United States

Status: Withdrawn

Facility:
Name: Retina Associates IL

Address:
City: Elmhurst
Zip: 60126
Country: United States

Status: Active, not recruiting

Facility:
Name: University Retina and Macula Associates

Address:
City: Oak Forest
Zip: 60452
Country: United States

Status: Active, not recruiting

Facility:
Name: Retina Associates, LLC

Address:
City: Lenexa
Zip: 66215
Country: United States

Status: Active, not recruiting

Facility:
Name: Retina Care Center

Address:
City: Baltimore
Zip: 21209
Country: United States

Status: Active, not recruiting

Facility:
Name: Cumberland Valley Retina Consultants | Hagerstown, MD

Address:
City: Hagerstown
Zip: 21740
Country: United States

Status: Active, not recruiting

Facility:
Name: Mid Atlantic Retina Specialists

Address:
City: Hagerstown
Zip: 21740
Country: United States

Status: Active, not recruiting

Facility:
Name: Vitreo-Retinal Associates, PC

Address:
City: Grand Rapids
Zip: 49525
Country: United States

Status: Completed

Facility:
Name: Retina Consultants of Minnesota

Address:
City: Saint Louis Park
Zip: 55416
Country: United States

Status: Active, not recruiting

Facility:
Name: Retina Consultants of Nevada

Address:
City: Las Vegas
Zip: 89144
Country: United States

Status: Active, not recruiting

Facility:
Name: Sierra Eye Associates

Address:
City: Reno
Zip: 89502
Country: United States

Status: Withdrawn

Facility:
Name: Retina Center of New Jersey

Address:
City: Bloomfield
Zip: 07470
Country: United States

Status: Active, not recruiting

Facility:
Name: NJ Retina

Address:
City: New Brunswick
Zip: 08901
Country: United States

Status: Active, not recruiting

Facility:
Name: NJ Retina | Teaneck

Address:
City: Teaneck
Zip: 07666
Country: United States

Status: Active, not recruiting

Facility:
Name: Eye Associates of New Mexico

Address:
City: Albuquerque
Zip: 87109-5853
Country: United States

Status: Active, not recruiting

Facility:
Name: Long Island Vitreoretinal Consultants

Address:
City: Great Neck
Zip: 11021
Country: United States

Status: Active, not recruiting

Facility:
Name: Long Island Vitreoretinal Consultants - Hauppauge

Address:
City: Hauppauge
Zip: 11788
Country: United States

Status: Active, not recruiting

Facility:
Name: Ophthalmic Consultants of Long Island

Address:
City: Lynbrook
Zip: 11563
Country: United States

Status: Terminated

Facility:
Name: Retina Associates of Western New York

Address:
City: Rochester
Zip: 14620-4655
Country: United States

Status: Active, not recruiting

Facility:
Name: Ophthalmic Consultants of the Capital Region

Address:
City: Troy
Zip: 12180
Country: United States

Status: Withdrawn

Facility:
Name: University of North Carolina at Chapel Hill (UNC) | Ophthalmology

Address:
City: Chapel Hill
Zip: 27599
Country: United States

Status: Active, not recruiting

Facility:
Name: Wake Forest Baptist Health

Address:
City: Winston-Salem
Zip: 27157
Country: United States

Status: Withdrawn

Facility:
Name: Cincinnati Eye Institute - Blue Ash

Address:
City: Blue Ash
Zip: 45242-5664
Country: United States

Status: Active, not recruiting

Facility:
Name: Midwest Retina - Main Office

Address:
City: Dublin
Zip: 43016
Country: United States

Status: Active, not recruiting

Facility:
Name: Retina Consultants, LLC

Address:
City: Salem
Zip: 97302-2152
Country: United States

Status: Active, not recruiting

Facility:
Name: University of Pennsylvania

Address:
City: Philadelphia
Zip: 19104
Country: United States

Status: Withdrawn

Facility:
Name: Mid Atlantic Retina

Address:
City: Philadelphia
Zip: 19107
Country: United States

Status: Active, not recruiting

Facility:
Name: Retina Consultants of Charleston

Address:
City: Charleston
Zip: 29414
Country: United States

Status: Active, not recruiting

Facility:
Name: Palmetto Retina Center, LLC - Florence

Address:
City: Florence
Zip: 29501
Country: United States

Status: Active, not recruiting

Facility:
Name: Palmetto Retina Center, LLC - Florence

Address:
City: Florence
Zip: 29501
Country: United States

Status: Terminated

Facility:
Name: Charles Retina Institute

Address:
City: Memphis
Zip: 38119
Country: United States

Status: Completed

Facility:
Name: Austin Retina Associates - Central

Address:
City: Austin
Zip: 78705
Country: United States

Status: Active, not recruiting

Facility:
Name: Retinal Consultants of Texas - Bellaire

Address:
City: Bellaire
Zip: 77401
Country: United States

Status: Active, not recruiting

Facility:
Name: Retinal Consultants of Texas

Address:
City: Bellaire
Zip: 77401
Country: United States

Status: Active, not recruiting

Facility:
Name: Texas Retina Associates

Address:
City: Fort Worth
Zip: 76104
Country: United States

Status: Active, not recruiting

Facility:
Name: Medical Center Ophthalmology Associates

Address:
City: San Antonio
Zip: 78240
Country: United States

Status: Active, not recruiting

Facility:
Name: Retinal Consultants of Texas - San Antonio

Address:
City: San Antonio
Zip: 78240
Country: United States

Status: Active, not recruiting

Facility:
Name: Rocky Mountain Retina Consultants - Main Office

Address:
City: Salt Lake City
Zip: 84107
Country: United States

Status: Completed

Facility:
Name: The Retina Group of Washington | Fairfax

Address:
City: Fairfax
Zip: 22031
Country: United States

Status: Active, not recruiting

Facility:
Name: Spokane Eye Clinical Research

Address:
City: Spokane
Zip: 99204
Country: United States

Status: Active, not recruiting

Facility:
Name: University of Wisconsin - Madison

Address:
City: Madison
Zip: 53792
Country: United States

Status: Completed

Facility:
Name: Eyeclinic Albury Wodonga

Address:
City: Albury
Zip: 2640
Country: Australia

Status: Active, not recruiting

Facility:
Name: Marsden Eye Surgery Center

Address:
City: Parramatta
Zip: 2150
Country: Australia

Status: Active, not recruiting

Facility:
Name: Strathfield Retina Clinic

Address:
City: Strathfield
Zip: 2135
Country: Australia

Status: Active, not recruiting

Facility:
Name: Sydney Eye Hospital

Address:
City: Sydney
Zip: 2000
Country: Australia

Status: Active, not recruiting

Facility:
Name: Sydney Retina Clinic

Address:
City: Sydney
Zip: 2000
Country: Australia

Status: Active, not recruiting

Facility:
Name: Sydney West Retina Pty Ltd

Address:
City: Westmead
Zip: 2145
Country: Australia

Status: Active, not recruiting

Facility:
Name: Adelaide Eye and Retina Centre

Address:
City: Adelaide
Zip: 5000
Country: Australia

Status: Completed

Facility:
Name: Hobart Eye Surgeons

Address:
City: Hobart
Zip: 7000
Country: Australia

Status: Active, not recruiting

Facility:
Name: Centre for Eye Research

Address:
City: East Melbourne
Zip: 3002
Country: Australia

Status: Active, not recruiting

Facility:
Name: Lion Eye Institute

Address:
City: Nedlands
Zip: 6009
Country: Australia

Status: Completed

Facility:
Name: Klinikum Klagenfurt am Wörthersee

Address:
City: Klagenfurt
Zip: 9020
Country: Austria

Status: Active, not recruiting

Facility:
Name: Konventhospital Barmherzige Brüder Linz

Address:
City: Linz
Zip: 4021
Country: Austria

Status: Active, not recruiting

Facility:
Name: Medizinische Universität Graz

Address:
City: Graz
Zip: 8036
Country: Austria

Status: Active, not recruiting

Facility:
Name: Kepler Universitätsklinikum Campus III

Address:
City: Linz
Zip: 4021
Country: Austria

Status: Withdrawn

Facility:
Name: Universitätsklinikum AKH Wien

Address:
City: Wien
Zip: 1090
Country: Austria

Status: Active, not recruiting

Facility:
Name: Hanusch-Krankenhaus Wien

Address:
City: Wien
Zip: 1140
Country: Austria

Status: Active, not recruiting

Facility:
Name: SEHAT Pentagram

Address:
City: Sofia
Zip: 1309
Country: Bulgaria

Status: Completed

Facility:
Name: University Multiprofile Hospital For Active Treatment 'Alexandrovska' EAD

Address:
City: Sofia
Zip: 1431
Country: Bulgaria

Status: Withdrawn

Facility:
Name: Multiprofile Hospital for Active Treatment Sveta Sofia - Opthalmology Department

Address:
City: Sofia
Zip: 1618
Country: Bulgaria

Status: Withdrawn

Facility:
Name: Specialized Hospital For Active Treatment of Eye Diseases Zora

Address:
City: Sofia
Zip: 1784
Country: Bulgaria

Status: Active, not recruiting

Facility:
Name: Spec. Hosp. of Ophthalm. Disease for Active Treatment Varna

Address:
City: Varna
Zip: 9000
Country: Bulgaria

Status: Completed

Facility:
Name: The Second Hospital of Anhui medical university

Address:
City: Hefei
Zip: 230601
Country: China

Status: Active, not recruiting

Facility:
Name: Guangzhou Aier Eye Hospital

Address:
City: Guangzhou
Zip: 634050
Country: China

Status: Active, not recruiting

Facility:
Name: Hebei eye hospital

Address:
City: Hebei
Zip: 050010
Country: China

Status: Active, not recruiting

Facility:
Name: Shijiazhuang General Hospital

Address:
City: Shijiazhuang
Zip: 50000
Country: China

Status: Active, not recruiting

Facility:
Name: Henan Provincial Eye Hospital

Address:
City: Henan
Zip: 450008
Country: China

Status: Active, not recruiting

Facility:
Name: Tongji Hosp. of Tongji Med Coll, Huazhong Uni of Sci & Tech.

Address:
City: Wuhan
Zip: 430030
Country: China

Status: Active, not recruiting

Facility:
Name: Renmin Hospital of Wuhan University

Address:
City: Wuhan
Zip: 430040
Country: China

Status: Withdrawn

Facility:
Name: The First People's Hospital of Xuzhou

Address:
City: Xuzhou
Zip: 221002
Country: China

Status: Withdrawn

Facility:
Name: Eye Center of the second Bethune Hospital, jinlin University

Address:
City: Changchun
Zip: 130022
Country: China

Status: Active, not recruiting

Facility:
Name: The Fourth People's Hospital of Shenyang

Address:
City: Shenyang
Zip: 110082
Country: China

Status: Active, not recruiting

Facility:
Name: Aier Eye Hospital(SHENYANG)

Address:
City: Shenyang
Country: China

Status: Active, not recruiting

Facility:
Name: People's Hospital of Ningxia Hui Autonomous Region - Opthalmology

Address:
City: Ningxia
Zip: 750002
Country: China

Status: Active, not recruiting

Facility:
Name: Shanxi Eye Hospital

Address:
City: Shanxi
Zip: 030002
Country: China

Status: Active, not recruiting

Facility:
Name: The First Affiliated Hospital of Xi'an Jiaotong University

Address:
City: Xi'an
Zip: 710061
Country: China

Status: Withdrawn

Facility:
Name: Qilu Hosp., Shandong Univ.

Address:
City: Jinan
Zip: TBC
Country: China

Status: Active, not recruiting

Facility:
Name: West China Hospital,Sichuan University

Address:
City: Chengdu
Zip: 610041
Country: China

Status: Withdrawn

Facility:
Name: Aier Eye Hospital (Chengdu)

Address:
City: Chengdu
Country: China

Status: Active, not recruiting

Facility:
Name: ZheJiang Provincial People's Hospital

Address:
City: Hangzhou
Zip: 310014
Country: China

Status: Active, not recruiting

Facility:
Name: Dongyang People's Hospital

Address:
City: Jinhua
Zip: 322199
Country: China

Status: Active, not recruiting

Facility:
Name: The Affiliated Eye Hospital of Wenzhou Medical College

Address:
City: Wenzhou
Country: China

Status: Withdrawn

Facility:
Name: Beijing Aier Intech Eye Hospital

Address:
City: Beijing
Zip: 100000
Country: China

Status: Active, not recruiting

Facility:
Name: China-Japan Friendship Hospital

Address:
City: Beijing
Zip: 100029
Country: China

Status: Active, not recruiting

Facility:
Name: Peking University First Hospital

Address:
City: Beijing
Zip: 100034
Country: China

Status: Active, not recruiting

Facility:
Name: Capital Medical University (CMU) - Beijing Tongren Hospital

Address:
City: Beijing
Zip: 100062
Country: China

Status: Active, not recruiting

Facility:
Name: Beijing Hospital

Address:
City: Beijing
Zip: 100730
Country: China

Status: Active, not recruiting

Facility:
Name: Beijing Tongren Hospital, Capital Medical University (West)

Address:
City: Beijing
Zip: 100730
Country: China

Status: Withdrawn

Facility:
Name: Peking Union Medical College Hospital CAMS

Address:
City: Beijing
Zip: 100730
Country: China

Status: Completed

Facility:
Name: Chongqing Aier Ophthalmology Hospital

Address:
City: Chongqing
Zip: 400020
Country: China

Status: Completed

Facility:
Name: The First Affiliated Hospital of Chongqing Medical Universit

Address:
City: Chongqing
Zip: 401147
Country: China

Status: Withdrawn

Facility:
Name: Second Hospital Affiliated of Chongqing Medical University

Address:
City: Chongqing
Country: China

Status: Withdrawn

Facility:
Name: Zhejiang University School of Medicine - The First Affiliated Hospital - Kidney Disease Center

Address:
City: Hangzhou
Zip: 310003
Country: China

Status: Withdrawn

Facility:
Name: Lanzhou University - The Second Hospital (The Second Clinical Medical College of Lanzhou University)

Address:
City: Lanzhou
Zip: 730030
Country: China

Status: Active, not recruiting

Facility:
Name: Eye & Ent Hospital of Fudan University

Address:
City: Shanghai
Country: China

Status: Withdrawn

Facility:
Name: China Medical University (CMU) - First Affiliated Hospital

Address:
City: Shenyang
Zip: 110001
Country: China

Status: Withdrawn

Facility:
Name: Tianjin Medical University General Hospital

Address:
City: Tianjin
Zip: 300052
Country: China

Status: Withdrawn

Facility:
Name: Tianjin Medical University Eye Hospital

Address:
City: Tianjin
Zip: 300384
Country: China

Status: Active, not recruiting

Facility:
Name: TianJin eye hospital

Address:
City: Tianjin
Country: China

Status: Withdrawn

Facility:
Name: Fakultni Nemocnice Hradec Kralove

Address:
City: Hradec Kralove
Zip: 500 05
Country: Czechia

Status: Terminated

Facility:
Name: Fakultni nemocnice Ostrava

Address:
City: Ostrava
Zip: 708 52
Country: Czechia

Status: Active, not recruiting

Facility:
Name: Nemocnice Pardubickeho kraje, a.s., Pardubicka nemocnice

Address:
City: Pardubice
Zip: 530 03
Country: Czechia

Status: Active, not recruiting

Facility:
Name: Fakultní nemocnice Královské Vinohrady - Urologická klinikay

Address:
City: Praha 10
Zip: 10034
Country: Czechia

Status: Active, not recruiting

Facility:
Name: Vseobecna fakultni nemocnice v Praze

Address:
City: Praha 2
Zip: 12808
Country: Czechia

Status: Active, not recruiting

Facility:
Name: Lexum a.s., Evropska ocni klinika

Address:
City: Praha 4
Zip: 140 00
Country: Czechia

Status: Active, not recruiting

Facility:
Name: AXON Clinical s.r.o.

Address:
City: Praha 5
Zip: 150 00
Country: Czechia

Status: Active, not recruiting

Facility:
Name: East Tallinn Central Hospital

Address:
City: Tallinn
Zip: 10138
Country: Estonia

Status: Active, not recruiting

Facility:
Name: Turman Eye Clinic

Address:
City: Tallinn
Zip: 11314
Country: Estonia

Status: Withdrawn

Facility:
Name: Dr. Kai Noor Silmakabinet OU

Address:
City: Tallinn
Zip: 11412
Country: Estonia

Status: Terminated

Facility:
Name: Tartu University Hospital

Address:
City: Tartu
Zip: 50406
Country: Estonia

Status: Active, not recruiting

Facility:
Name: Centre Hospitalier National d'Ophthalmologie Quinze-Vingt

Address:
City: Paris
Zip: 75557
Country: France

Status: Withdrawn

Facility:
Name: Clinique Rétine Tourny

Address:
City: Bordeaux
Zip: 33000
Country: France

Status: Active, not recruiting

Facility:
Name: CHU Bordeaux - Hopital Pellegrin - Ophtalmologie

Address:
City: Bordeaux
Zip: 33076
Country: France

Status: Active, not recruiting

Facility:
Name: Hôpital Intercommunal - Créteil Cedex

Address:
City: Creteil Cedex
Zip: 94010
Country: France

Status: Terminated

Facility:
Name: Hôpital François Mitterrand - Dijon

Address:
City: Dijon
Zip: 21000
Country: France

Status: Active, not recruiting

Facility:
Name: Hôpital de la Croix Rousse

Address:
City: Lyon
Zip: 69004
Country: France

Status: Completed

Facility:
Name: Centre d'Ophtalmologie - Paradis-Monticelli

Address:
City: Marseille
Zip: 13008
Country: France

Status: Active, not recruiting

Facility:
Name: Clinique Jules Verne - Nantes

Address:
City: Nantes
Zip: 44000
Country: France

Status: Active, not recruiting

Facility:
Name: Centre d'ophtalmologie de l'Odéon

Address:
City: Paris
Zip: 75006
Country: France

Status: Completed

Facility:
Name: Centre Ophthalmologie d'Imagerie et de Laser

Address:
City: Paris
Zip: 75015
Country: France

Status: Active, not recruiting

Facility:
Name: Hôpital Lariboisière - Paris

Address:
City: Paris
Zip: 75475
Country: France

Status: Active, not recruiting

Facility:
Name: CM Wolff

Address:
City: Strasbourg
Zip: 67000
Country: France

Status: Active, not recruiting

Facility:
Name: Centre Ophtalmologique Transparence - Tours

Address:
City: Tours
Zip: 37000
Country: France

Status: Active, not recruiting

Facility:
Name: LTD "IQ Clinic"- Ophthalmology

Address:
City: Tbilisi
Zip: 0162
Country: Georgia

Status: Active, not recruiting

Facility:
Name: LTD Israeli-Georgian Medical Research Clinic "Helsicore"

Address:
City: Tbilisi
Zip: 112
Country: Georgia

Status: Withdrawn

Facility:
Name: LTD "Chichua Medical Center MZERA"

Address:
City: Tbilisi
Zip: 114
Country: Georgia

Status: Active, not recruiting

Facility:
Name: Caucasus Medical Center- Opthamology

Address:
City: Tbilisi
Country: Georgia

Status: Withdrawn

Facility:
Name: Universitätsklinikum Freiburg

Address:
City: Freiburg
Zip: 79106
Country: Germany

Status: Withdrawn

Facility:
Name: Knappschaftskrankenhaus Sulzbach

Address:
City: Sulzbach
Zip: 66280
Country: Germany

Status: Completed

Facility:
Name: Uniklinik Bonn / Eye Clinic

Address:
City: Bonn
Zip: 53127
Country: Germany

Status: Active, not recruiting

Facility:
Name: Universitätsklinikum Düsseldorf / Ophthalmology

Address:
City: Düsseldorf
Zip: 40225
Country: Germany

Status: Withdrawn

Facility:
Name: Universitätsmedizin Göttingen - Ophthalmology

Address:
City: Göttingen
Zip: 37075
Country: Germany

Status: Withdrawn

Facility:
Name: Medizinische Hochschule Hannover (MHH) - University Clinic for Ophthalmology

Address:
City: Hannover
Zip: 30625
Country: Germany

Status: Recruiting

Facility:
Name: Uni Heidelberg / Augenklinik

Address:
City: Heidelberg
Zip: 0
Country: Germany

Status: Active, not recruiting

Facility:
Name: Universitaetsklinikum Jena - Ophthalmology

Address:
City: Jena
Zip: 07747
Country: Germany

Status: Withdrawn

Facility:
Name: Klinikum d. Stadt Ludwigshafen - Ophthalmology

Address:
City: Ludwigshafen
Zip: 67063
Country: Germany

Status: Active, not recruiting

Facility:
Name: Universitätsklinik Gießen und Marburg GmbH (UKGM) - Ophthalmology

Address:
City: Marburg
Zip: 35043
Country: Germany

Status: Withdrawn

Facility:
Name: St. Franziskus-Hospital Münster - Eye Center

Address:
City: Muenster
Zip: 48145
Country: Germany

Status: Active, not recruiting

Facility:
Name: Ludwig-Maximilians-Universitaet Muenchen (LMU) Klinikum - Eye Clinic and Polyclinic

Address:
City: Munich
Zip: 80336
Country: Germany

Status: Withdrawn

Facility:
Name: Universitaetsklinikum Tuebingen - Ophthalmology

Address:
City: Tuebingen
Zip: 72076
Country: Germany

Status: Withdrawn

Facility:
Name: Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet

Address:
City: Budapest
Zip: 1024
Country: Hungary

Status: Withdrawn

Facility:
Name: Magyar Honvedseg Egeszsegugyi Kozpont

Address:
City: Budapest
Zip: 1062
Country: Hungary

Status: Active, not recruiting

Facility:
Name: University of Semmelweis/ Semmelweis Egyetem

Address:
City: Budapest
Zip: 1083
Country: Hungary

Status: Active, not recruiting

Facility:
Name: Budapesti Bajcsy-Zsilinszky Korhaz es Rendelointezet

Address:
City: Budapest
Zip: 1106
Country: Hungary

Status: Active, not recruiting

Facility:
Name: Budapest Retina Associates

Address:
City: Budapest
Zip: 1133
Country: Hungary

Status: Completed

Facility:
Name: Debreceni Egyetem Klinikai Kozpont

Address:
City: Debrecen
Zip: 4032
Country: Hungary

Status: Active, not recruiting

Facility:
Name: Ganglion Medical Center

Address:
City: Pecs
Zip: 7621
Country: Hungary

Status: Active, not recruiting

Facility:
Name: SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont

Address:
City: Szeged
Zip: 6720
Country: Hungary

Status: Active, not recruiting

Facility:
Name: Clalit Health | Soroka Medical Center - Internal Medicine Department

Address:
City: Beer Sheva
Zip: 8410101
Country: Israel

Status: Active, not recruiting

Facility:
Name: Rambam Health Corporation

Address:
City: Haifa
Zip: 3109601
Country: Israel

Status: Active, not recruiting

Facility:
Name: Lady Davis Carmel Medical Center

Address:
City: Haifa
Zip: 3436212
Country: Israel

Status: Active, not recruiting

Facility:
Name: Edith Wolfson Medical Center | Internal Medicine Department

Address:
City: Holon
Zip: 5822012
Country: Israel

Status: Active, not recruiting

Facility:
Name: Hadassah Hebrew University Hospital Ein Kerem

Address:
City: Jerusalem
Zip: 9112001
Country: Israel

Status: Active, not recruiting

Facility:
Name: Meir Medical Center

Address:
City: Kfar Saba
Zip: 4428164
Country: Israel

Status: Completed

Facility:
Name: Rabin Medical Center | Beilinson Hospital - Internal Medicine C Department

Address:
City: Petach Tikva
Zip: 4941492
Country: Israel

Status: Active, not recruiting

Facility:
Name: Kaplan Medical Center

Address:
City: Rehovot
Zip: 7610001
Country: Israel

Status: Active, not recruiting

Facility:
Name: Tel-Aviv Sourasky Medical Center

Address:
City: Tel Aviv
Zip: 6423906
Country: Israel

Status: Active, not recruiting

Facility:
Name: Assuta Medical Centers - HaShalom

Address:
City: Tel Aviv
Zip: 6789140
Country: Israel

Status: Active, not recruiting

Facility:
Name: Shamir Medical Center (Assaf Harofeh)

Address:
City: Zerifin
Zip: 7030000
Country: Israel

Status: Active, not recruiting

Facility:
Name: Azienda Ospedaliera Policlinico Universitario Tor Vergata - Patologie Retiniche

Address:
City: Roma
Zip: 00133
Country: Italy

Status: Active, not recruiting

Facility:
Name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Oculistica

Address:
City: Roma
Zip: 00136
Country: Italy

Status: Active, not recruiting

Facility:
Name: IRCCS Fondazione G.B. Bietti Studio e Ricerca in Otalmologia

Address:
City: Roma
Zip: 198
Country: Italy

Status: Active, not recruiting

Facility:
Name: ASST Fatebenefratelli Sacco

Address:
City: Milano
Zip: 20122
Country: Italy

Status: Withdrawn

Facility:
Name: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Address:
City: Milano
Zip: 20122
Country: Italy

Status: Withdrawn

Facility:
Name: Ospedale San Raffaele s.r.l.

Address:
City: Milano
Zip: 20132
Country: Italy

Status: Withdrawn

Facility:
Name: A.O.U. Ospedali Riuniti "Umberto I - G.M.Lancisi - G.Salesi"

Address:
City: Ancona
Zip: 60126
Country: Italy

Status: Active, not recruiting

Facility:
Name: A.O. Ordine Mauriziano

Address:
City: Torino
Zip: 10128
Country: Italy

Status: Withdrawn

Facility:
Name: A.O.U. Consorziale Policlinico

Address:
City: Bari
Zip: 70124
Country: Italy

Status: Withdrawn

Facility:
Name: Aichi Medical University Hospital

Address:
City: Nagakute
Zip: 480-1195
Country: Japan

Status: Not yet recruiting

Facility:
Name: Nagoya City University Hospital

Address:
City: Nagoya
Zip: 467-8602
Country: Japan

Status: Recruiting

Facility:
Name: International University of Health & Welfare Narita Hospital

Address:
City: Narita
Zip: 286-8520
Country: Japan

Status: Not yet recruiting

Facility:
Name: Toho University Sakura Medical Center

Address:
City: Sakura
Zip: 285-8741
Country: Japan

Status: Active, not recruiting

Facility:
Name: University of Fukui Hospital

Address:
City: Yoshida
Zip: 910-1193
Country: Japan

Status: Active, not recruiting

Facility:
Name: Kurume University Hospital

Address:
City: Kurume
Zip: 830-0011
Country: Japan

Status: Active, not recruiting

Facility:
Name: Southern Tohoku Eye Clinic

Address:
City: Koriyama
Zip: 963-8052
Country: Japan

Status: Active, not recruiting

Facility:
Name: Gunma University Hospital

Address:
City: Maebashi
Zip: 371-8511
Country: Japan

Status: Active, not recruiting

Facility:
Name: Hyogo Prefectural Amagasaki General Medical Center

Address:
City: Amagasaki
Zip: 660-8550
Country: Japan

Status: Active, not recruiting

Facility:
Name: Kobe University Hospital

Address:
City: Kobe
Zip: 650-0017
Country: Japan

Status: Active, not recruiting

Facility:
Name: Hyogo Medical University Hospital

Address:
City: Nishinomiya
Zip: 663-8501
Country: Japan

Status: Recruiting

Facility:
Name: Kozawa Eye Hospital and Diabetes Center

Address:
City: Mito
Zip: 310-0845
Country: Japan

Status: Active, not recruiting

Facility:
Name: Matsumoto Eye Clinic

Address:
City: Toride
Zip: 302-0014
Country: Japan

Status: Active, not recruiting

Facility:
Name: Kagawa University Hospital

Address:
City: Kita-gun
Zip: 761-0793
Country: Japan

Status: Active, not recruiting

Facility:
Name: Medical corporation Eiwakai Dannoue Ophthalmology clinic

Address:
City: Kawasaki
Zip: 211-0053
Country: Japan

Status: Active, not recruiting

Facility:
Name: St. Marianna University Hospital

Address:
City: Kawasaki
Zip: 216-8511
Country: Japan

Status: Active, not recruiting

Facility:
Name: Yokohama City University Medical Center

Address:
City: Yokohama
Zip: 232-0024
Country: Japan

Status: Active, not recruiting

Facility:
Name: Mie University Hospital

Address:
City: Tsu
Zip: 514-8507
Country: Japan

Status: Active, not recruiting

Facility:
Name: Mie University Hospital

Address:
City: Tsu
Zip: 514-8507
Country: Japan

Status: Withdrawn

Facility:
Name: Shinshu University Hospital

Address:
City: Matsumoto
Zip: 390-8621
Country: Japan

Status: Active, not recruiting

Facility:
Name: National Defense Medical College Hospital

Address:
City: Tokorozawa
Zip: 359-8513
Country: Japan

Status: Active, not recruiting

Facility:
Name: Shiga University of Medical Science Hospital

Address:
City: Otsu
Zip: 520-2192
Country: Japan

Status: Not yet recruiting

Facility:
Name: Shida Eye Clinic

Address:
City: Fujieda-shi
Zip: 426-0029
Country: Japan

Status: Active, not recruiting

Facility:
Name: Nihon University Hospital

Address:
City: Chiyoda-ku
Zip: 101-8309
Country: Japan

Status: Recruiting

Facility:
Name: The University of Tokyo Hospital

Address:
City: Bunkyo-ku
Zip: 113-8655
Country: Japan

Status: Active, not recruiting

Facility:
Name: Chofu Eye Clinic

Address:
City: Chofu
Zip: 182-0024
Country: Japan

Status: Active, not recruiting

Facility:
Name: Tokyo Medical University Hachioji Medical Center

Address:
City: Hachioji
Zip: 193-0998
Country: Japan

Status: Active, not recruiting

Facility:
Name: Tokyo Metropolitan Institute for Geriatrics and Gerontology

Address:
City: Itabashi-ku
Zip: 173-0015
Country: Japan

Status: Recruiting

Facility:
Name: Tokiwadai Muranaka Eye Clinic

Address:
City: Itabashi-ku
Zip: 174-0071
Country: Japan

Status: Active, not recruiting

Facility:
Name: National Hospital Organization Tokyo Medical Center

Address:
City: Meguro-ku
Zip: 152-8902
Country: Japan

Status: Active, not recruiting

Facility:
Name: Keio University Hospital

Address:
City: Shinjuku-ku
Zip: 160-8582
Country: Japan

Status: Recruiting

Facility:
Name: Tokyo Women's Medical University Hospital

Address:
City: Shinjuku-ku
Zip: 162-8666
Country: Japan

Status: Not yet recruiting

Facility:
Name: Yamaguchi University Hospital

Address:
City: Ube
Zip: 755-8505
Country: Japan

Status: Recruiting

Facility:
Name: University of Yamanashi Hospital

Address:
City: Chuo
Zip: 409-3898
Country: Japan

Status: Active, not recruiting

Facility:
Name: Akita University Hospital

Address:
City: Akita
Zip: 010-8543
Country: Japan

Status: Active, not recruiting

Facility:
Name: Hayashi Eye Hospital

Address:
City: Fukuoka
Zip: 812-0011
Country: Japan

Status: Active, not recruiting

Facility:
Name: Murakami Karindoh Hospital

Address:
City: Fukuoka
Zip: 819-8585
Country: Japan

Status: Active, not recruiting

Facility:
Name: Fukushima Medical University Hospital

Address:
City: Fukushima
Zip: 960-1295
Country: Japan

Status: Active, not recruiting

Facility:
Name: Kagoshima University Hospital

Address:
City: Kagoshima
Zip: 890-8520
Country: Japan

Status: Active, not recruiting

Facility:
Name: University of Miyazaki Hospital

Address:
City: Miyazaki
Zip: 889-1692
Country: Japan

Status: Active, not recruiting

Facility:
Name: Japanese Red Cross Nagasaki Genbaku Hospital

Address:
City: Nagasaki
Zip: 852-8511
Country: Japan

Status: Active, not recruiting

Facility:
Name: Okayama University Hospital

Address:
City: Okayama
Zip: 700-8558
Country: Japan

Status: Not yet recruiting

Facility:
Name: Osaka Metropolitan University Hospital

Address:
City: Osaka
Zip: 545-8586
Country: Japan

Status: Active, not recruiting

Facility:
Name: Japanese Red Cross Saitama Hospital

Address:
City: Saitama
Zip: 330-8553
Country: Japan

Status: Recruiting

Facility:
Name: Toyama University Hospital

Address:
City: Toyama
Zip: 930-0194
Country: Japan

Status: Not yet recruiting

Facility:
Name: Japanese Red Cross Wakayama Medical Center

Address:
City: Wakayama
Zip: 640-8558
Country: Japan

Status: Active, not recruiting

Facility:
Name: Yamagata University Hospital

Address:
City: Yamagata
Zip: 990-9585
Country: Japan

Status: Active, not recruiting

Facility:
Name: Seoul National University Bundang Hospital

Address:
City: Seongnam-si
Zip: 13620
Country: Korea, Republic of

Status: Active, not recruiting

Facility:
Name: Seoul National University Hospital

Address:
City: Seoul
Zip: 3080
Country: Korea, Republic of

Status: Active, not recruiting

Facility:
Name: Gangnam Severance Hospital, Yonsei University Health System

Address:
City: Seoul
Zip: 6273
Country: Korea, Republic of

Status: Active, not recruiting

Facility:
Name: Pusan National University Hospital

Address:
City: Busan
Zip: 49241
Country: Korea, Republic of

Status: Active, not recruiting

Facility:
Name: Yeungnam University Medical Center

Address:
City: Daegu
Zip: 42415
Country: Korea, Republic of

Status: Active, not recruiting

Facility:
Name: Korea University Ansan Hospital

Address:
City: Gyeonggi-do
Zip: 425-707
Country: Korea, Republic of

Status: Active, not recruiting

Facility:
Name: Severance Hospital, Yonsei University Health System

Address:
City: Seoul
Zip: 03722
Country: Korea, Republic of

Status: Active, not recruiting

Facility:
Name: St. Mary Hospital

Address:
City: Seoul
Zip: 137-701
Country: Korea, Republic of

Status: Active, not recruiting

Facility:
Name: Asan Medical Center

Address:
City: Seoul
Zip: 138-736
Country: Korea, Republic of

Status: Active, not recruiting

Facility:
Name: Kim's Eye Hospital

Address:
City: Seoul
Zip: 150-034
Country: Korea, Republic of

Status: Active, not recruiting

Facility:
Name: Samsung Medical Center

Address:
City: Seoul
Zip: 6351
Country: Korea, Republic of

Status: Active, not recruiting

Facility:
Name: Department of Ophthalmology

Address:
City: Riga
Zip: 1002
Country: Latvia

Status: Active, not recruiting

Facility:
Name: Latvian American Eye Center

Address:
City: Riga
Zip: LV-1009
Country: Latvia

Status: Withdrawn

Facility:
Name: Riga East Clinical University Hospital "Gailezers"

Address:
City: Riga
Zip: LV-1038
Country: Latvia

Status: Active, not recruiting

Facility:
Name: Hospital of LT University of Health Sciences Kaunas Clinics

Address:
City: Kaunas
Zip: LT-50161
Country: Lithuania

Status: Active, not recruiting

Facility:
Name: Vilnius University Hospital Santaros Klinikos

Address:
City: Vilnius
Zip: LT-08661
Country: Lithuania

Status: Active, not recruiting

Facility:
Name: Hospital Al-Sultan Abdullah, UiTM | Opthalmology

Address:
City: Bandar Puncak Alam
Zip: 42300
Country: Malaysia

Status: Active, not recruiting

Facility:
Name: Hospital Shah Alam | Ophthalmology

Address:
City: Shah Alam
Zip: 40000
Country: Malaysia

Status: Active, not recruiting

Facility:
Name: Hospital Selayang

Address:
City: Shah Alam
Zip: 68100
Country: Malaysia

Status: Active, not recruiting

Facility:
Name: OasisEye Specialists

Address:
City: Kuala Lumpur
Zip: 59200
Country: Malaysia

Status: Active, not recruiting

Facility:
Name: Fundacion Hospital Nuestra Señora de la Luz

Address:
City: Mexico City
Zip: 6030
Country: Mexico

Status: Withdrawn

Facility:
Name: Santa Lucia Clinica | Oftalmologica

Address:
City: Guadalajara
Zip: 44670
Country: Mexico

Status: Withdrawn

Facility:
Name: Instituto de Oftalmología FAP Conde de Valenciana, IAP. | Oftalmología

Address:
City: Mexico City
Zip: 06800
Country: Mexico

Status: Withdrawn

Facility:
Name: Hospital Angeles Mocel | Oftalmologia

Address:
City: Mexico City
Zip: 11850
Country: Mexico

Status: Withdrawn

Facility:
Name: Instituto Mexicano de Oftalmologia, IMO

Address:
City: Queretaro
Zip: 76090
Country: Mexico

Status: Withdrawn

Facility:
Name: Instituto de la Retina del Bajío SC

Address:
City: Queretaro
Zip: 76187
Country: Mexico

Status: Withdrawn

Facility:
Name: Prywatna Klinika Okulistyczna OFTALMIKA

Address:
City: Bydgoszcz
Zip: 85-631
Country: Poland

Status: Active, not recruiting

Facility:
Name: Specjalistyczny Osrodek Okulistyczny Oculomedica

Address:
City: Bydgoszcz
Zip: 85-870
Country: Poland

Status: Active, not recruiting

Facility:
Name: NZOZ Poradnia Okulistyczna Dobry Wzrok

Address:
City: Gdansk
Zip: 80-402
Country: Poland

Status: Withdrawn

Facility:
Name: Profesorskie Centrum Okulistyki

Address:
City: Gdansk
Zip: 80-809
Country: Poland

Status: Active, not recruiting

Facility:
Name: Gabinet Okulistyczny Prof. Edward Wylegala

Address:
City: Katowice
Zip: 40-594
Country: Poland

Status: Active, not recruiting

Facility:
Name: Centrum Medyczne Dietla 19 Sp. z o.o.

Address:
City: Krakow
Zip: 31-070
Country: Poland

Status: Active, not recruiting

Facility:
Name: Centrum Medyczne PROMED

Address:
City: Krakow
Zip: 31-411
Country: Poland

Status: Active, not recruiting

Facility:
Name: Centrum Diagnostyki i Mikrochirurgii Oka Lens

Address:
City: Olsztyn
Zip: 10-424
Country: Poland

Status: Active, not recruiting

Facility:
Name: Osrodek Chirurgii Oka prof. Zagorskiego Sp. z o.o.

Address:
City: Rzeszow
Zip: 35-017
Country: Poland

Status: Active, not recruiting

Facility:
Name: Centrum Medyczne Piasta 47

Address:
City: Walbrzych
Zip: 58-304
Country: Poland

Status: Active, not recruiting

Facility:
Name: AIBILI

Address:
City: Coimbra
Zip: 3000-548
Country: Portugal

Status: Active, not recruiting

Facility:
Name: Espaco Medico de Coimbra

Address:
City: Coimbra
Zip: 3000-548
Country: Portugal

Status: Active, not recruiting

Facility:
Name: CHLC - Hospital dos Capuchos - Servico de Oftalmologia

Address:
City: Lisboa
Zip: 1169-050
Country: Portugal

Status: Active, not recruiting

Facility:
Name: Centro Hospitalar Universitario do Porto

Address:
City: Porto
Zip: 4099-001
Country: Portugal

Status: Withdrawn

Facility:
Name: Centro Hospitalar Universitario de Sao Joao | Polo Porto - Centro de Investigacao e Ensaios Clinicos

Address:
City: Porto
Zip: 4200-319
Country: Portugal

Status: Active, not recruiting

Facility:
Name: Centro Hospitalar Vila Nova de Gaia e Espinho | Unit 1 - Clinical Research Center

Address:
City: Porto
Zip: 4434-502
Country: Portugal

Status: Active, not recruiting

Facility:
Name: Clinical Center of Serbia

Address:
City: Belgrade
Zip: 11000
Country: Serbia

Status: Active, not recruiting

Facility:
Name: Clinical hospital center Zvezdara

Address:
City: Belgrade
Zip: 11000
Country: Serbia

Status: Active, not recruiting

Facility:
Name: Klinicki centar Vojvodine

Address:
City: Novi Sad
Zip: 21000
Country: Serbia

Status: Active, not recruiting

Facility:
Name: Fakultna Nemocnica s poliklinikou F.D.Roosevelta

Address:
City: Banska Bystrica
Zip: 97517
Country: Slovakia

Status: Active, not recruiting

Facility:
Name: Univerzitna nemocnica Bratislava, Nemocnica Ruzinov

Address:
City: Bratislava
Zip: 826 06
Country: Slovakia

Status: Active, not recruiting

Facility:
Name: Univerzitna nemocnica Bratislava, Nem. Sv. Cyrila a Metoda

Address:
City: Bratislava
Zip: 851 07
Country: Slovakia

Status: Active, not recruiting

Facility:
Name: Fakultna nemocnica Nitra

Address:
City: Nitra
Zip: 950 01
Country: Slovakia

Status: Active, not recruiting

Facility:
Name: Nemocnica Poprad, a.s.

Address:
City: Poprad
Zip: 058 45
Country: Slovakia

Status: Withdrawn

Facility:
Name: Fakultna nemocnica Trencin

Address:
City: Trencin
Zip: 911 71
Country: Slovakia

Status: Active, not recruiting

Facility:
Name: Specialized hospital for ophthalmology OPHTAL

Address:
City: Zvolen
Zip: 96001
Country: Slovakia

Status: Active, not recruiting

Facility:
Name: Instituto Oftalmológico Francisco Gomez Ulla

Address:
City: Santiago de Compostela
Zip: 15706
Country: Spain

Status: Active, not recruiting

Facility:
Name: Hospital General de Catalunya

Address:
City: Sant Cugat del Valles
Zip: 08195
Country: Spain

Status: Active, not recruiting

Facility:
Name: Hospital Universitario Clinica Puerta de Hierro

Address:
City: Majadahonda
Zip: 28222
Country: Spain

Status: Terminated

Facility:
Name: Hospital Vall d'Hebron - Servei d'Oftalmologia

Address:
City: Barcelona
Zip: 08035
Country: Spain

Status: Active, not recruiting

Facility:
Name: Hospital de la Santa Creu i de Sant Pau

Address:
City: Barcelona
Zip: 8025
Country: Spain

Status: Withdrawn

Facility:
Name: Hospital Clínic i Provincial de Barcelona

Address:
City: Barcelona
Zip: 8036
Country: Spain

Status: Active, not recruiting

Facility:
Name: Hospital Reina Sofía

Address:
City: Córdoba
Zip: 14004
Country: Spain

Status: Withdrawn

Facility:
Name: Clínica Universidad de Navarra CUN

Address:
City: Pamplona
Zip: 31008
Country: Spain

Status: Withdrawn

Facility:
Name: Hospital General Universitario de Valencia

Address:
City: Valencia
Zip: 46014
Country: Spain

Status: Active, not recruiting

Facility:
Name: Hospital del Rio Hortega

Address:
City: Valladolid
Zip: 47012
Country: Spain

Status: Active, not recruiting

Facility:
Name: Hospital Miguel Servet

Address:
City: Zaragoza
Zip: 50009
Country: Spain

Status: Active, not recruiting

Facility:
Name: RétinElysée

Address:
City: Lausanne
Zip: 1006
Country: Switzerland

Status: Active, not recruiting

Facility:
Name: Inselspital Universitätsspital Bern

Address:
City: Bern
Zip: 3010
Country: Switzerland

Status: Active, not recruiting

Facility:
Name: Berner Augenklinik am Lindenhofspital

Address:
City: Bern
Zip: TBC
Country: Switzerland

Status: Active, not recruiting

Facility:
Name: Vista Klinik

Address:
City: Binningen
Zip: 4102
Country: Switzerland

Status: Active, not recruiting

Facility:
Name: University Eye Hospital Jules Gonin

Address:
City: Lausanne
Zip: 1004
Country: Switzerland

Status: Active, not recruiting

Facility:
Name: Chiangmai University

Address:
City: Chiangmai
Zip: 50200
Country: Thailand

Status: Active, not recruiting

Facility:
Name: Srinagarind Hospital

Address:
City: Khon Kaen
Zip: 40002
Country: Thailand

Status: Completed

Facility:
Name: Thammasat University

Address:
City: Pathum Thani,
Zip: 12120
Country: Thailand

Status: Withdrawn

Facility:
Name: Cukurova Universitesi Tip Fakultesi Hastanesi

Address:
City: Adana
Zip: TBC
Country: Turkey

Status: Withdrawn

Facility:
Name: Ankara Etlik City Hospital | Ophthalmology

Address:
City: Ankara
Zip: 06170
Country: Turkey

Status: Active, not recruiting

Facility:
Name: Baskent Universitesi Tip Fakultesi Hastanesi

Address:
City: Ankara
Zip: 06490
Country: Turkey

Status: Withdrawn

Facility:
Name: SBU Gulhane Egitim ve Arastirma Hastanesi

Address:
City: Ankara
Zip: 6010
Country: Turkey

Status: Active, not recruiting

Facility:
Name: Ankara Numune Egitim ve Arastirma Hastanesi

Address:
City: Ankara
Zip: 6100
Country: Turkey

Status: Active, not recruiting

Facility:
Name: Ankara Universitesi Tip Fakultesi Hastanesi

Address:
City: Ankara
Zip: 6100
Country: Turkey

Status: Withdrawn

Facility:
Name: Hacettepe Universitesi Tip Fakultesi

Address:
City: Ankara
Zip: 6100
Country: Turkey

Status: Completed

Facility:
Name: Gazi Universitesi Tip Fakultesi

Address:
City: Ankara
Zip: 6560
Country: Turkey

Status: Withdrawn

Facility:
Name: Adnan Menderes Universitesi Tip fakultesi

Address:
City: Aydin
Zip: 9100
Country: Turkey

Status: Active, not recruiting

Facility:
Name: Ankara Bilkent Sehir Hastanesi

Address:
City: Bilkent Çankaya
Zip: 6800
Country: Turkey

Status: Active, not recruiting

Facility:
Name: Istanbul Universitesi Istanbul Tip Fakultesi

Address:
City: Istanbul
Zip: 34093
Country: Turkey

Status: Withdrawn

Facility:
Name: Beyoglu Eye Training and Research Hospital

Address:
City: Istanbul
Zip: 34420
Country: Turkey

Status: Withdrawn

Facility:
Name: Ege Universitesi Tip Fakultesi

Address:
City: Izmir
Zip: 35100
Country: Turkey

Status: Withdrawn

Facility:
Name: Kocaeli Universitesi Tip Fakultesi

Address:
City: Kocaeli
Zip: 41380
Country: Turkey

Status: Active, not recruiting

Facility:
Name: Colchester General Hospital

Address:
City: Colchester
Zip: CO4 5JR
Country: United Kingdom

Status: Withdrawn

Facility:
Name: Barnet General Hospital

Address:
City: London Borough Of Barnet
Zip: EN53DJ
Country: United Kingdom

Status: Withdrawn

Facility:
Name: Leicester Royal Infirmary

Address:
City: Leicester
Zip: LE1 5WW
Country: United Kingdom

Status: Active, not recruiting

Facility:
Name: James Paget Hospital

Address:
City: Great Yarmouth
Zip: NR316LA
Country: United Kingdom

Status: Withdrawn

Facility:
Name: Epsom General Hospital

Address:
City: Epsom
Zip: KT18 7EG
Country: United Kingdom

Status: Withdrawn

Facility:
Name: Frimley Park Hospital NHS

Address:
City: Frimley
Zip: GU167UJ
Country: United Kingdom

Status: Active, not recruiting

Facility:
Name: Sunderland Eye Infirmary

Address:
City: Sunderland
Zip: SR29HP
Country: United Kingdom

Status: Completed

Facility:
Name: University Hospitals Coventry and Warwickshire NHS Trust

Address:
City: Coventry
Zip: CV2 2DX
Country: United Kingdom

Status: Withdrawn

Facility:
Name: New Cross Hospital

Address:
City: Wolverhampton
Zip: WV100QP
Country: United Kingdom

Status: Active, not recruiting

Facility:
Name: Bradford Royal Infirmary

Address:
City: Bradford
Zip: BD9 6RJ
Country: United Kingdom

Status: Active, not recruiting

Facility:
Name: St James' University Hospital

Address:
City: Leeds
Zip: LS9 7TF
Country: United Kingdom

Status: Active, not recruiting

Facility:
Name: Hull and East Yorkshire Eye Hospital Hull and East Yorkshire

Address:
City: Hull
Zip: HU32JZ
Country: United Kingdom

Status: Active, not recruiting

Facility:
Name: Royal Liverpool University Hospital

Address:
City: Liverpool
Zip: L7 8XP
Country: United Kingdom

Status: Active, not recruiting

Facility:
Name: Moorfields Eye Hospital

Address:
City: London
Zip: EC1V2PD
Country: United Kingdom

Status: Active, not recruiting

Facility:
Name: York Teaching Hospital

Address:
City: York
Zip: YO611DW
Country: United Kingdom

Status: Active, not recruiting

Start date: May 15, 2023

Completion date: May 16, 2025

Lead sponsor:
Agency: Bayer
Agency class: Industry

Collaborator:
Agency: Regeneron Pharmaceuticals
Agency class: Industry

Source: Bayer

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT05850520
https://clinicaltrials.bayer.com/