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Trial Title:
Psyco Quality of Life and Procreation BRCA1/2
NCT ID:
NCT05857670
Condition:
Breast Cancer
Genetic Predisposition
Conditions: Official terms:
Genetic Predisposition to Disease
Study type:
Observational [Patient Registry]
Overall status:
Recruiting
Study design:
Time perspective:
Cross-Sectional
Intervention:
Intervention type:
Behavioral
Intervention name:
Genetic predisposition to breast cancer
Description:
Guilt feelings about procreating
Summary:
Women with breast and/or ovarian cancer or with a family history carried these
pathologies can makeo genetic counseling in order to investigate whether they are
carriers of the BRCA1/2 genetic mutation. This mutation exposes them to develop breast
cancer from 50 to 80% and from 27 to 65% of developing ovarian cancer. BRCA1/2 mutations
are inherited as an autosomal dominant manner and therefore there is a 50% probability of
transmitting the mutation to the progeny. For this reason, women who have BRCA 1/2
mutation may be less likely to want children than those who test negative. The decision
to have children could worry both for the probability to transfer the genetic mutation or
because the parenthood could be compromised by the illness and/or by premature death. In
previous studies, the psychological condition of patients with BRCA 1/2 mutations, with
or without children, was only partially investigated. For this reason the main goal of
the study is to deeply investigate the specific psychological condition, with particular
attention to the guilt feelings on the possibility to transfer the genetic mutation to
the progeny. In this wai it could be useful to development a therapeutic strategies aimed
at the best adaptation of the patients to the new health condition.
Criteria for eligibility:
Study pop:
Women with BRCA1/2 mutation
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- Women with BRCA1/2 mutation affected or not by breast neoplasm
- Women with BRCA1/2 mutation affected or not by breast neoplasm and with at least a
son/daughter
- Women with at list middle school diploma
- Women available to do interviews
Exclusion Criteria:
- Women with other oncological pathology
- Women with cognitive deficient and/or inability to comply to the requirements of the
study
Gender:
Female
Gender based:
Yes
Minimum age:
25 Years
Maximum age:
45 Years
Healthy volunteers:
Accepts Healthy Volunteers
Locations:
Facility:
Name:
"Regina Elena" National Cancer Institute
Address:
City:
Rome
Zip:
00144
Country:
Italy
Status:
Recruiting
Facility:
Name:
Università dell'Insubria
Address:
City:
Varese
Zip:
21100
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Marco Bellani
Start date:
May 31, 2022
Completion date:
December 31, 2024
Lead sponsor:
Agency:
Regina Elena Cancer Institute
Agency class:
Other
Source:
Regina Elena Cancer Institute
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05857670
