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Trial Title:
Value of Screening MRI Brain in Stage IV Non-small Cell Lung Cancer
NCT ID:
NCT05864794
Condition:
Non Small Cell Lung Cancer Metastatic
Conditions: Official terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Conditions: Keywords:
brain metastasis
screening
Study type:
Interventional
Study phase:
N/A
Overall status:
Recruiting
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Primary purpose:
Screening
Masking:
None (Open Label)
Intervention:
Intervention type:
Diagnostic Test
Intervention name:
MRI
Description:
MRI scan of the brain
Arm group label:
Screening population
Summary:
Patients with newly diagnosed stage IV non-oncogene addicted NSCLC, who are fit for
systemic treatment and don't have any symptoms of brain disease will undergo an MRI of
the brain to screen for brain disease.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Histologically or cytologically confirmed stage IV metastatic NSCLC, not amenable to
curative treatment.
- Fit for systemic treatment (PS 0-2) according to standard of care.
- No symptoms of brain disease disease assessed according to standard clinical care by
the thoracic oncologist.
Exclusion Criteria:
- Prior/concomitant therapy for stage IV disease.
- Oncogenic diver mutation (e.g. EGFR, ALK, ROS1, RET, MET, and BRAF) with approved
targeted treatment.
- Contraindications for MRI scan with contrast as per standard of care protocol of the
institution.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
University Medical Center Groningen
Address:
City:
Groningen
Zip:
9713LZ
Country:
Netherlands
Status:
Recruiting
Contact:
Last name:
Frederike Bensch, MD, PhD
Start date:
May 13, 2024
Completion date:
July 1, 2026
Lead sponsor:
Agency:
University Medical Center Groningen
Agency class:
Other
Source:
University Medical Center Groningen
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05864794
