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Trial Title:
Describing Treatment Outcomes and Responses in Lymphoma-associated Hemophagocytic Lymphohistiocytosis
NCT ID:
NCT05898477
Condition:
Lymphoma
Hemophagocytic Lymphohistiocytoses
Conditions: Official terms:
Lymphoma
Lymphohistiocytosis, Hemophagocytic
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Retrospective
Summary:
The purpose of the study is to describe Hemophagocytic lymphohistiocytosis (HLH) in
patients with lymphoma to identify possible therapeutic strategies to improve overall
survival of the patients with lymphoma associated hemophagocytic lymphohistiocytosis.
Detailed description:
Retrospective, multi-institutional study focused on describing the clinical features,
laboratory parameters, treatments, and outcomes among individuals presenting with HLH in
the setting of a lymphoma
Criteria for eligibility:
Study pop:
Patients with diagnosis of Hemophagocytic lymphohistiocytosis (HLH)
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- Patients with lymphoma that are fulfilling at least one of the following:
A. Meeting 5 of 8 HLH-2004 diagnostic criteria OR B. Are OHI index positive (sCD25>3,900
U/mL and ferritin>1,000 ng/mL)
Exclusion Criteria:
- Patients developing HLH> 1 month after lymphoma diagnosis (for aggressive lymphomas)
- Patients with incomplete treatment and response documentation
Gender:
All
Minimum age:
N/A
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
University of Alabama at Birmingham
Address:
City:
Birmingham
Zip:
35294
Country:
United States
Status:
Recruiting
Contact:
Last name:
Gaurav Goyal, MD
Phone:
205-934-6770
Email:
ggoyal@uabmc.edu
Start date:
May 1, 2023
Completion date:
July 2026
Lead sponsor:
Agency:
University of Alabama at Birmingham
Agency class:
Other
Source:
University of Alabama at Birmingham
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05898477
