Trial Title:
A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (IMbrave152)
NCT ID:
NCT05904886
Condition:
Carcinoma, Hepatocellular
Conditions: Official terms:
Carcinoma
Carcinoma, Hepatocellular
Bevacizumab
Atezolizumab
Study type:
Interventional
Study phase:
Phase 3
Overall status:
Recruiting
Study design:
Allocation:
Randomized
Intervention model:
Parallel Assignment
Primary purpose:
Treatment
Masking:
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Intervention:
Intervention type:
Drug
Intervention name:
Atezolizumab
Description:
Atezolizumab will be administered by intravenous (IV) infusion at a fixed dose of 1200 mg
on Day 1 of each 21-day cycle.
Arm group label:
Atezolizumab + Bevacizumab + Placebo
Arm group label:
Atezolizumab + Bevacizumab + Tiragolumab
Other name:
Tecentriq
Intervention type:
Drug
Intervention name:
Bevacizumab
Description:
Bevacizumab will be administered by IV infusion at a dose of 15 mg/kg on Day 1 of each
21-day cycle.
Arm group label:
Atezolizumab + Bevacizumab + Placebo
Arm group label:
Atezolizumab + Bevacizumab + Tiragolumab
Other name:
Avastin
Intervention type:
Drug
Intervention name:
Tiragolumab
Description:
Tiragolumab will be administered by IV infusion at a fixed dose of 600 mg on Day 1 of
each 21-day cycle.
Arm group label:
Atezolizumab + Bevacizumab + Tiragolumab
Other name:
MTIG7192A
Intervention type:
Other
Intervention name:
Placebo
Description:
Placebo matching tiragolumab will be administered by IV infusion on Day 1 of each 21-day
cycle.
Arm group label:
Atezolizumab + Bevacizumab + Placebo
Summary:
The purpose of this study is to assess the efficacy and safety of tiragolumab, an
anti-TIGIT monoclonal antibody, when administered in combination with atezolizumab and
bevacizumab as first-line treatment, in participants with unresectable, locally advanced
or metastatic hepatocellular carcinoma (HCC).
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Locally advanced or metastatic and/or unresectable HCC with diagnosis confirmed by
histology/cytology or clinically by American Association for the Study of Liver
Diseases (AASLD) criteria in cirrhotic participants
- Disease that is not amenable to curative surgical and/or locoregional therapies
- No prior systemic treatment for locally advanced or metastatic and/or unresectable
HCC
- Measurable disease according to RECIST v1.1
- ECOG Performance Status of 0 or 1 within 7 days prior to randomization
- Child-Pugh Class A within 7 days prior to randomization
- Adequate hematologic and end-organ function
- Female participants of childbearing potential must be willing to avoid pregnancy
within 5 months after the final dose of atezolizumab, within 6 months after the
final dose of bevacizumab, and within 90 days after the final dose of
tiragolumab/placebo
- Male participants with a female partner of childbearing potential or pregnant female
partner must remain abstinent or use a condom during the treatment period and for 6
months after the final dose of bevacizumab and for 90 days after the final dose of
tiragolumab/placebo to avoid exposing the embryo.
Exclusion Criteria:
- Pregnancy or breastfeeding within 5 months after the final dose of atezolizumab,
within 6 months after the final dose of bevacizumab, and within 90 days after the
final dose of tiragolumab/placebo
- Prior treatment with CD137 agonists or immune checkpoint blockade therapies
- Treatment with investigational therapy within 28 days prior to initiation of study
treatment
- Treatment with locoregional therapy to liver within 28 days prior to initiation of
study treatment, or non-recovery from side effects of any such procedure
- Treatment with systemic immunostimulatory agents
- Treatment with systemic immunosuppressive medication
- Untreated or incompletely treated esophageal and/or gastric varices with bleeding or
that are at high risk for bleeding
- A prior bleeding event due to esophageal and/or gastric varices within 6 months
prior to initiation of study treatment
- Active or history of autoimmune disease or immune deficiency
- History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced
pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis on
screening chest computed tomography (CT) scan
- History of malignancy other than HCC within 5 years prior to screening, with the
exception of malignancies with a negligible risk of metastasis or death
- Mixed histology or other subtypes/variants of HCC, including, but not limited to,
known liver adenocarcinoma, fibrolamellar HCC, sarcomatoid HCC, other rare HCC
variant, or mixed cholangiocarcinoma and HCC
- Co-infection with hepatitis B virus (HBV) and hepatitis C virus (HCV)
- Acute Epstein-Barr virus (EBV) infection or known or suspected chronic active EBV
infection
- Symptomatic, untreated, or actively progressing central nervous system (CNS)
metastases.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Genesis Cancer Center
Address:
City:
Hot Springs
Zip:
71913
Country:
United States
Status:
Recruiting
Facility:
Name:
UCLA MEDICAL CENTER; Alhambra
Address:
City:
Alhambra
Zip:
91801
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
UCSF Fresno at Community Cancer Institute
Address:
City:
Clovis
Zip:
93611
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
City of Hope Cancer Center; Division of Medical Oncology & Experimental Therapeutics
Address:
City:
Duarte
Zip:
91010
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
University of California San Diego Moores Cancer Center
Address:
City:
La Jolla
Zip:
92037
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Kaiser Permanente - Los Angeles (N. Vermont)
Address:
City:
Los Angeles
Zip:
90027
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
University of Southern California
Address:
City:
Los Angeles
Zip:
90033
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
USC Norris Cancer Center; Oncology/Hematology - Newport Beach Treatment Center
Address:
City:
Newport Beach
Zip:
92663
Country:
United States
Status:
Recruiting
Facility:
Name:
Kaiser Permanente - Oakland
Address:
City:
Oakland
Zip:
94611
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Stanford Cancer Center
Address:
City:
Palo Alto
Zip:
94304
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Va Palo Alto Health Care System
Address:
City:
Palo Alto
Zip:
94304
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Kaiser Permanente - Roseville
Address:
City:
Roseville
Zip:
95661
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Kaiser Permanente - San Francisco (2238 Geary)
Address:
City:
San Francisco
Zip:
94115
Country:
United States
Status:
Recruiting
Facility:
Name:
Kaiser Permanente - Santa Clara; Oncology Clinical trials
Address:
City:
Santa Clara
Zip:
95051
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
UCLA Cancer Center
Address:
City:
Santa Monica
Zip:
90404
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Kaiser Permanente; Oncology Clinical Trials
Address:
City:
Vallejo
Zip:
94589
Country:
United States
Status:
Recruiting
Facility:
Name:
Kaiser Permanente - Walnut Creek
Address:
City:
Walnut Creek
Zip:
94596
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Rocky Mountain Cancer Center
Address:
City:
Denver
Zip:
80218
Country:
United States
Status:
Recruiting
Facility:
Name:
Hartford Healthcare Cancer Institute at Hartford Hospital
Address:
City:
Hartford
Zip:
06106
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
MedStar Washington Hosp Center
Address:
City:
Washington
Zip:
20010
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Florida Cancer Specialists - Fort Myers (Broadway)
Address:
City:
Fort Myers
Zip:
33901
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Mayo Clinic Cancer Center
Address:
City:
Jacksonville
Zip:
32224
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Miami VA Healthcare System
Address:
City:
Miami
Zip:
33125
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
AdventHealth Cancer Institute
Address:
City:
Orlando
Zip:
32804
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Florida Cancer Specialist, North Region
Address:
City:
Saint Petersburg
Zip:
33705
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Grady Health System
Address:
City:
Atlanta
Zip:
30303
Country:
United States
Status:
Recruiting
Facility:
Name:
Winship Cancer Institute of Emory University
Address:
City:
Atlanta
Zip:
30329
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
University of Illinois
Address:
City:
Chicago
Zip:
60612
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Capt. James A. Lovell Federal Health Care Center
Address:
City:
North Chicago
Zip:
60064
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Norton Cancer Institute - Audubon
Address:
City:
Louisville
Zip:
40217
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Hematology Oncology Clinic
Address:
City:
Baton Rouge
Zip:
70809
Country:
United States
Status:
Recruiting
Facility:
Name:
Ochsner Cancer Inst.
Address:
City:
New Orleans
Zip:
70121
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Mercy Medical Center
Address:
City:
Baltimore
Zip:
21202
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
VA Medical Center - Ann Arbor
Address:
City:
Ann Arbor
Zip:
48105
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Henry Ford Health System
Address:
City:
Detroit
Zip:
48202
Country:
United States
Status:
Recruiting
Facility:
Name:
Cancer & Hematology Centers of Western Michigan
Address:
City:
Grand Rapids
Zip:
49503
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
G.V. (Sonny) Montgomery VA Medical Center
Address:
City:
Jackson
Zip:
39216
Country:
United States
Status:
Recruiting
Facility:
Name:
Mayo Clinic Rochester; Medical Oncology
Address:
City:
Rochester
Zip:
55905
Country:
United States
Status:
Recruiting
Facility:
Name:
Minnesota Oncology Hematology Woodbury
Address:
City:
Woodbury
Zip:
55125
Country:
United States
Status:
Recruiting
Facility:
Name:
Washington Uni School of Medicine
Address:
City:
Saint Louis
Zip:
63110
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Renown Regional Medical Center
Address:
City:
Reno
Zip:
89502
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Montefiore Medical Center
Address:
City:
Bronx
Zip:
10461
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
James J Peters VA Hospital / Mental Illness Research Education and Clinic Center
Address:
City:
Bronx
Zip:
10468
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
NYU Langone
Address:
City:
New York
Zip:
10003
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Icahn School of Medicine at Mount Sinai
Address:
City:
New York
Zip:
10029
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Columbia University
Address:
City:
New York
Zip:
10032-3725
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
University of North Carolina at Chapel Hill
Address:
City:
Chapel Hill
Zip:
27514
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
University of Cincinnati
Address:
City:
Cincinnati
Zip:
45203-0542
Country:
United States
Status:
Recruiting
Facility:
Name:
Univ Hospitals of Cleveland
Address:
City:
Cleveland
Zip:
44106
Country:
United States
Status:
Withdrawn
Facility:
Name:
OU Health Stephenson Cancer Center
Address:
City:
Oklahoma City
Zip:
73104
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Thomas Jefferson Uni
Address:
City:
Philadelphia
Zip:
19107
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
VA Pittsburgh Healthcare System
Address:
City:
Pittsburgh
Zip:
15240
Country:
United States
Status:
Recruiting
Facility:
Name:
Abington Mem Hosp-Abington; Rose. Can Ctr,Gyn Onc Ins
Address:
City:
Willow Grove
Zip:
19090
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Texas Oncology - Austin
Address:
City:
Austin
Zip:
78745
Country:
United States
Status:
Recruiting
Facility:
Name:
North Texas VA Medical Center
Address:
City:
Dallas
Zip:
75216
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Texas Oncology - DFW
Address:
City:
Dallas
Zip:
75246
Country:
United States
Status:
Recruiting
Facility:
Name:
Kelsey Seybold Clnic
Address:
City:
Houston
Zip:
77025
Country:
United States
Status:
Recruiting
Facility:
Name:
Houston Methodist Cancer Center
Address:
City:
Houston
Zip:
77030
Country:
United States
Status:
Recruiting
Facility:
Name:
Michael E Debakey VA Medical Center
Address:
City:
Houston
Zip:
77030
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Texas Oncology - Northeast Texas
Address:
City:
Tyler
Zip:
75702
Country:
United States
Status:
Recruiting
Facility:
Name:
Virginia Cancer Specialists - Arlington
Address:
City:
Arlington
Zip:
22205
Country:
United States
Status:
Recruiting
Facility:
Name:
Virginia Commonwealth Uni Health Center
Address:
City:
Richmond
Zip:
23298
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Swedish Cancer Institute - Edmonds Campus
Address:
City:
Edmonds
Zip:
98026
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Swedish Cancer Institute - Issaquah
Address:
City:
Issaquah
Zip:
98029
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Virginia Mason Medical Center
Address:
City:
Seattle
Zip:
98101
Country:
United States
Status:
Recruiting
Facility:
Name:
Swedish Cancer Inst.
Address:
City:
Seattle
Zip:
98104
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Univ of Wisconsin-Madison
Address:
City:
Madison
Zip:
53705
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
William S Middleton Memorial Veterans Hospital (CARES); Research ATTN: Pharmacy 119
Address:
City:
Madison
Zip:
53705
Country:
United States
Status:
Active, not recruiting
Facility:
Name:
Imeldaziekenhuis
Address:
City:
Bonheiden
Zip:
2820
Country:
Belgium
Status:
Withdrawn
Facility:
Name:
Hospital Erasme
Address:
City:
Bruxelles
Zip:
1070
Country:
Belgium
Status:
Withdrawn
Facility:
Name:
Cliniques Universitaires St-Luc
Address:
City:
Bruxelles
Zip:
1200
Country:
Belgium
Status:
Active, not recruiting
Facility:
Name:
UZ Antwerpen
Address:
City:
Edegem
Zip:
2650
Country:
Belgium
Status:
Active, not recruiting
Facility:
Name:
UZ Leuven Gasthuisberg
Address:
City:
Leuven
Zip:
3000
Country:
Belgium
Status:
Withdrawn
Facility:
Name:
AZ Delta (Campus Rumbeke)
Address:
City:
Roeselare
Zip:
8800
Country:
Belgium
Status:
Active, not recruiting
Facility:
Name:
CEDOES - Diagnóstico e Pesquisa
Address:
City:
Vitoria
Zip:
29055-450
Country:
Brazil
Status:
Active, not recruiting
Facility:
Name:
Oncoclínicas do Brasil - BELO HORIZONTE
Address:
City:
Belo Horizonte
Zip:
30170-080
Country:
Brazil
Status:
Active, not recruiting
Facility:
Name:
Hospital do Cancer de Pernambuco - HCP
Address:
City:
Recife
Zip:
50040-000
Country:
Brazil
Status:
Active, not recruiting
Facility:
Name:
Clinicas Oncologicas Integradas - COI
Address:
City:
Rio De Janeiro
Zip:
22290-160
Country:
Brazil
Status:
Active, not recruiting
Facility:
Name:
Hospital de Amor Amazônia
Address:
City:
Porto Velho
Zip:
76834-899
Country:
Brazil
Status:
Withdrawn
Facility:
Name:
Santa Casa de Misericordia de Porto Alegre
Address:
City:
Porto Alegre
Zip:
90020-090
Country:
Brazil
Status:
Active, not recruiting
Facility:
Name:
Hospital Sao Lucas - PUCRS
Address:
City:
Porto Alegre
Zip:
90610-000
Country:
Brazil
Status:
Active, not recruiting
Facility:
Name:
Hospital de Cancer de Barretos
Address:
City:
Barretos
Zip:
14784-400
Country:
Brazil
Status:
Active, not recruiting
Facility:
Name:
Instituto do Cancer do Estado de Sao Paulo - ICESP
Address:
City:
Sao Paulo
Zip:
01246-000
Country:
Brazil
Status:
Active, not recruiting
Facility:
Name:
Hospital A. C. Camargo; Oncologia
Address:
City:
Sao Paulo
Zip:
01509-010
Country:
Brazil
Status:
Active, not recruiting
Facility:
Name:
Centro Paulista de Oncologia
Address:
City:
Sao Paulo
Zip:
04538-132
Country:
Brazil
Status:
Withdrawn
Facility:
Name:
Cross Cancer Institute
Address:
City:
Edmonton
Zip:
T6G 1Z2
Country:
Canada
Status:
Withdrawn
Facility:
Name:
William Osler Health Centre
Address:
City:
Etobicoke
Zip:
M9V 1R8
Country:
Canada
Status:
Withdrawn
Facility:
Name:
Juravinski Hospital
Address:
City:
Hamilton
Zip:
L8V 1C3
Country:
Canada
Status:
Active, not recruiting
Facility:
Name:
Sunnybrook Health Sciences Centre
Address:
City:
Toronto
Zip:
M4N 3M5
Country:
Canada
Status:
Active, not recruiting
Facility:
Name:
Jewish General Hospital
Address:
City:
Montreal
Zip:
H3T 1E2
Country:
Canada
Status:
Active, not recruiting
Facility:
Name:
McGill University Health Centre - Glen Site
Address:
City:
Montreal
Zip:
H4A 3J1
Country:
Canada
Status:
Active, not recruiting
Facility:
Name:
Baoji Central Hospital
Address:
City:
Baoji City
Zip:
721008
Country:
China
Status:
Completed
Facility:
Name:
Beijing Youan Hospital, Capital Medical University; Center for Infectious Diseases
Address:
City:
Beijing City
Zip:
100069
Country:
China
Status:
Recruiting
Facility:
Name:
Beijing Cancer Hospital
Address:
City:
Beijing
Zip:
100142
Country:
China
Status:
Active, not recruiting
Facility:
Name:
The First Hospital of Jilin University
Address:
City:
Changchun City
Zip:
130021
Country:
China
Status:
Active, not recruiting
Facility:
Name:
Hunan Cancer Hospital
Address:
City:
Changsha CITY
Zip:
410013
Country:
China
Status:
Active, not recruiting
Facility:
Name:
Peoples Hospital of Hunan Province
Address:
City:
Changsha
Zip:
410007
Country:
China
Status:
Active, not recruiting
Facility:
Name:
West China Hospital - Sichuan University
Address:
City:
Chengdu City
Zip:
610047
Country:
China
Status:
Active, not recruiting
Facility:
Name:
The First Affliated Hospital Of Fujian Medical University; Intervention Department
Address:
City:
Fuzhou City
Zip:
350005
Country:
China
Status:
Active, not recruiting
Facility:
Name:
Mengchao Hepatobiliary Hospital Of Fujian Medical University
Address:
City:
Fuzhou City
Zip:
350025
Country:
China
Status:
Active, not recruiting
Facility:
Name:
The First Affiliated Hospital of Sun Yat-sen University
Address:
City:
Guangzhou City
Zip:
510080
Country:
China
Status:
Recruiting
Facility:
Name:
Nanfang Hospital, Southern Medical University
Address:
City:
Guangzhou
Zip:
510515
Country:
China
Status:
Active, not recruiting
Facility:
Name:
Sun yat-sen University Cancer Center; Department of Liver Surgery
Address:
City:
Guangzhou
Country:
China
Status:
Active, not recruiting
Facility:
Name:
The First Affiliated Hospital of College of Medicine, Zhejiang University
Address:
City:
Hangzhou
Zip:
310003
Country:
China
Status:
Active, not recruiting
Facility:
Name:
Zhejiang Provincial People?s Hospital
Address:
City:
Hangzhou
Zip:
310014
Country:
China
Status:
Active, not recruiting
Facility:
Name:
Harbin Medical University Cancer Hospital
Address:
City:
Harbin
Zip:
150081
Country:
China
Status:
Active, not recruiting
Facility:
Name:
Anhui Provincial Hospital
Address:
City:
Hefei
Zip:
230001
Country:
China
Status:
Active, not recruiting
Facility:
Name:
The Second Affiliated Hospital of Anhui Medical University
Address:
City:
Hefei
Country:
China
Status:
Active, not recruiting
Facility:
Name:
Shandong Cancer Hospital
Address:
City:
Jinan
Zip:
250117
Country:
China
Status:
Active, not recruiting
Facility:
Name:
Lishui Central Hospital
Address:
City:
Lishui City
Zip:
323000
Country:
China
Status:
Recruiting
Facility:
Name:
Guangxi Cancer Hospital of Guangxi Medical University
Address:
City:
Nanning City
Zip:
530021
Country:
China
Status:
Withdrawn
Facility:
Name:
The First Affiliate Hospital of Guangxi Medical University
Address:
City:
Nanning
Zip:
530021
Country:
China
Status:
Withdrawn
Facility:
Name:
Zhongshan Hospital Fudan Unvierstiy
Address:
City:
Shanghai City
Zip:
200032
Country:
China
Status:
Active, not recruiting
Facility:
Name:
Renji Hospital Shanghai Jiaotong University School of Medicine
Address:
City:
Shanghai City
Zip:
200127
Country:
China
Status:
Active, not recruiting
Facility:
Name:
Shengjing Hospital of China Medical University
Address:
City:
ShenYang
Zip:
110004
Country:
China
Status:
Active, not recruiting
Facility:
Name:
Tianjin Cancer Hospital
Address:
City:
Tianjin
Zip:
300060
Country:
China
Status:
Recruiting
Facility:
Name:
Tongji Hospital Tongji Medical College Huazhong University of Science and Technology
Address:
City:
Wuhan City
Zip:
430030
Country:
China
Status:
Active, not recruiting
Facility:
Name:
First Affiliated Hospital of Medical College of Xi'an Jiaotong University
Address:
City:
Xi'an
Zip:
710061
Country:
China
Status:
Active, not recruiting
Facility:
Name:
Xi'an Inernational Medical Center Hospital
Address:
City:
Xi'an
Zip:
710119
Country:
China
Status:
Active, not recruiting
Facility:
Name:
Polyclinique Internationale Sainte Anne- Marie (PISAM)
Address:
City:
Abidjan
Zip:
BP 1463 Abidjan
Country:
Côte D'Ivoire
Status:
Recruiting
Facility:
Name:
Centre National d'Oncologie Médicale et de Radiothérapie Alassane Ouattara (CNRAO)
Address:
City:
Abidjan
Country:
Côte D'Ivoire
Status:
Active, not recruiting
Facility:
Name:
CHU CAEN - Hôpital de la Côte de Nacre; Service Hepatogastroenterologie
Address:
City:
Caen Cedex
Zip:
14033
Country:
France
Status:
Recruiting
Facility:
Name:
Hôpital Albert Michallon
Address:
City:
La Tronche
Zip:
38700
Country:
France
Status:
Withdrawn
Facility:
Name:
CHRU de Lille - Hopital Claude Huriez
Address:
City:
Lille
Zip:
59037
Country:
France
Status:
Active, not recruiting
Facility:
Name:
Hopital Dupuytren; Hepatologie Gastro Enterologie
Address:
City:
Limoges
Zip:
87042
Country:
France
Status:
Active, not recruiting
Facility:
Name:
Fondation Hopital Saint Joseph; Gastro-Enterologie
Address:
City:
Marseille
Zip:
13285
Country:
France
Status:
Active, not recruiting
Facility:
Name:
CH Saint Eloi
Address:
City:
Montpellier
Zip:
34295
Country:
France
Status:
Active, not recruiting
Facility:
Name:
Hopital Hotel Dieu Et Hme; Hepatologie Gastro Enterologie
Address:
City:
Nantes
Zip:
44093
Country:
France
Status:
Active, not recruiting
Facility:
Name:
APHP - Hopital Saint Antoine
Address:
City:
Paris
Zip:
75571
Country:
France
Status:
Active, not recruiting
Facility:
Name:
Hopital Robert Debre; Gastro Enterologie
Address:
City:
Reims
Zip:
51092
Country:
France
Status:
Recruiting
Facility:
Name:
Centre Hospitalier Valence
Address:
City:
Valence
Zip:
26953
Country:
France
Status:
Recruiting
Facility:
Name:
Hopitaux de Brabois - Gastro-Entereologie
Address:
City:
Vandoeuvre-les-nancy
Zip:
54511
Country:
France
Status:
Active, not recruiting
Facility:
Name:
Hopital Paul Brousse; Centre Hepatologie Biliaire
Address:
City:
Villejuif
Zip:
94804
Country:
France
Status:
Active, not recruiting
Facility:
Name:
Klinikum Esslingen; Allg. Innere Med., Onkologie, Hämatologie, Gastroenterologie und Infektiologie
Address:
City:
Esslingen
Zip:
73730
Country:
Germany
Status:
Active, not recruiting
Facility:
Name:
Klinik für Gastroenterologie und Gastrointestinale Onkologie der UMG
Address:
City:
Göttingen
Zip:
37075
Country:
Germany
Status:
Withdrawn
Facility:
Name:
Universitätsklinikum Schleswig-Holstein / Campus Lübeck; Medizinische Klinik I
Address:
City:
Lübeck
Zip:
23562
Country:
Germany
Status:
Withdrawn
Facility:
Name:
Universitätsklinikum Magdeburg Klinik für Gastroenterologie und Hepatologie
Address:
City:
Mageburg
Zip:
39120
Country:
Germany
Status:
Active, not recruiting
Facility:
Name:
Uniklinik Mainz; I. Medizinische Klinik
Address:
City:
Mainz
Zip:
55131
Country:
Germany
Status:
Active, not recruiting
Facility:
Name:
Universität Tübingen; Med. Klinik; Innere Medizin I
Address:
City:
Tübingen
Zip:
72076
Country:
Germany
Status:
Active, not recruiting
Facility:
Name:
Universitätsklinikum Ulm; Zentrum für Innere Medizin Klinik für Innere Medizin I
Address:
City:
Ulm
Zip:
89081
Country:
Germany
Status:
Active, not recruiting
Facility:
Name:
Queen Mary Hospital; Dept. Of Haematology & Oncology
Address:
City:
Hong Kong
Country:
Hong Kong
Status:
Active, not recruiting
Facility:
Name:
Prince of Wales Hosp; Dept. Of Clinical Onc
Address:
City:
Shatin
Country:
Hong Kong
Status:
Active, not recruiting
Facility:
Name:
Azienda Osp Uni Seconda Università Degli Studi Di Napoli; Unità Operativa Oncologia Medica
Address:
City:
Napoli
Zip:
80131
Country:
Italy
Status:
Active, not recruiting
Facility:
Name:
A.O. S. Orsola Malpighi; Ambulatorio Epatocarcinoma (Bolondi)
Address:
City:
Bologna
Zip:
40138
Country:
Italy
Status:
Active, not recruiting
Facility:
Name:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Address:
City:
Rome
Zip:
00168
Country:
Italy
Status:
Active, not recruiting
Facility:
Name:
Az. Osp. Uni Ria San Martino; Cliniche Uni Rie Convenzionate U.O. Oncologia Medical
Address:
City:
Genova
Zip:
16132
Country:
Italy
Status:
Active, not recruiting
Facility:
Name:
IRCCS Istituto Clinico Humanitas; Oncologia
Address:
City:
Rozzano (MI)
Zip:
20089
Country:
Italy
Status:
Active, not recruiting
Facility:
Name:
Az. Osp. G. Panico; U.O. Oncologia
Address:
City:
Tricase (LE)
Zip:
73039
Country:
Italy
Status:
Active, not recruiting
Facility:
Name:
A.O.U. Policlinico Paolo Giaccone; Gastroenterologia ed Epatologia
Address:
City:
Palermo
Zip:
90100
Country:
Italy
Status:
Active, not recruiting
Facility:
Name:
A.O.U.I. VERONA-OSPEDALE POLICLINICO G.B. ROSSI BORGO ROMA;ONCOLOGIA MEDICA-d.U.
Address:
City:
Verona
Zip:
37134
Country:
Italy
Status:
Active, not recruiting
Facility:
Name:
Fujita Health University Hospital
Address:
City:
Aichi
Zip:
470-1192
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Chiba University Hospital
Address:
City:
Chiba
Zip:
260-8677
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
National Cancer Center Hospital East
Address:
City:
Chiba
Zip:
277-8577
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Ehime Prefectural Central Hospital
Address:
City:
Ehime
Zip:
790-0024
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Kurume University Hospital
Address:
City:
Fukuoka
Zip:
830-0011
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Hiroshima University Hospital
Address:
City:
Hiroshima
Zip:
734-8551
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Sapporo Kosei Genaral Hospital
Address:
City:
Hokkaido
Zip:
060-0033
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Hokkaido University Hospital
Address:
City:
Hokkaido
Zip:
060-8648
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Japanese Red Cross Society Himeji Hospital
Address:
City:
Hyogo
Zip:
670-8540
Country:
Japan
Status:
Completed
Facility:
Name:
Kanazawa University Hospital
Address:
City:
Ishikawa
Zip:
920-8641
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Iwate Medical University Hospital
Address:
City:
Iwate
Zip:
028-3695
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Toranomon Branch Hospital
Address:
City:
Kanagawa
Zip:
213-8587
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Kanagawa Cancer Center
Address:
City:
Kanagawa
Zip:
241-8515
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Kitasato University Hospital
Address:
City:
Kanagawa
Zip:
252-0375
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
University Hospital Kyoto Prefectural University of Medicine
Address:
City:
Kyoto
Zip:
602-8566
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Kyoto University Hospital
Address:
City:
Kyoto
Zip:
606-8507
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Osaka University Hospital
Address:
City:
Osaka
Zip:
565-0871
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Kindai University Hospital
Address:
City:
Osaka
Zip:
589-8511
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Jichi Medical University Hospital
Address:
City:
Tochigi
Zip:
329-0498
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Toranomon Hospital
Address:
City:
Tokyo
Zip:
105-8470
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
Japanese Red Cross Musashino Hospital
Address:
City:
Tokyo
Zip:
180-8610
Country:
Japan
Status:
Active, not recruiting
Facility:
Name:
University of Nairobi - Institute of Tropical and Infectious Diseases
Address:
City:
Nairobi
Zip:
19676-00202
Country:
Kenya
Status:
Recruiting
Facility:
Name:
National Cancer Center
Address:
City:
Goyang-si
Zip:
10408
Country:
Korea, Republic of
Status:
Active, not recruiting
Facility:
Name:
CHA Bundang Medical Center
Address:
City:
Gyeonggi-do
Zip:
13496
Country:
Korea, Republic of
Status:
Active, not recruiting
Facility:
Name:
Chonnam National University Hwasun Hospital
Address:
City:
Jeollanam-do
Zip:
58128
Country:
Korea, Republic of
Status:
Active, not recruiting
Facility:
Name:
Seoul National University Hospital
Address:
City:
Seoul
Zip:
03080
Country:
Korea, Republic of
Status:
Active, not recruiting
Facility:
Name:
Severance Hospital, Yonsei University Health System
Address:
City:
Seoul
Zip:
03722
Country:
Korea, Republic of
Status:
Active, not recruiting
Facility:
Name:
Asan Medical Center
Address:
City:
Seoul
Zip:
05505
Country:
Korea, Republic of
Status:
Active, not recruiting
Facility:
Name:
Samsung Medical Center
Address:
City:
Seoul
Zip:
06351
Country:
Korea, Republic of
Status:
Active, not recruiting
Facility:
Name:
Ulsan University Hosiptal
Address:
City:
Ulsan
Zip:
44033
Country:
Korea, Republic of
Status:
Active, not recruiting
Facility:
Name:
OncoMed; Supportive Care
Address:
City:
Ciudad de México
Zip:
03100
Country:
Mexico
Status:
Active, not recruiting
Facility:
Name:
Centro Medico Nacional Siglo Xxi - Imss; Hospital de Oncologia
Address:
City:
Mexico City
Zip:
06720
Country:
Mexico
Status:
Active, not recruiting
Facility:
Name:
Instituto Nacional de Ciencias Médicas Y de Nutricion Salvador Zubirán
Address:
City:
Mexico DF
Zip:
14000
Country:
Mexico
Status:
Active, not recruiting
Facility:
Name:
Oncare
Address:
City:
San Pedro Garza García
Zip:
66220
Country:
Mexico
Status:
Withdrawn
Facility:
Name:
Centro de Investigacion Clinica de Oaxaca
Address:
City:
Oaxaca de Juárez
Zip:
68020
Country:
Mexico
Status:
Active, not recruiting
Facility:
Name:
CHU Ibn Rochd _ Centre Mohammed VI pour le traitement des cancers; Oncology
Address:
City:
Casablanca
Zip:
20502
Country:
Morocco
Status:
Withdrawn
Facility:
Name:
Centre Hospitalier Universitaire Hassan II
Address:
City:
FES
Zip:
30000
Country:
Morocco
Status:
Withdrawn
Facility:
Name:
Centre Hospitalier Universitaire Mohamed VI; Oncologie-Hématologie
Address:
City:
Marrakech
Zip:
40000
Country:
Morocco
Status:
Withdrawn
Facility:
Name:
Institut National D'oncologie Sidi Med Benabdellah
Address:
City:
Rabat
Zip:
6213
Country:
Morocco
Status:
Withdrawn
Facility:
Name:
Auckland City Hospital
Address:
City:
Auckland
Zip:
1023
Country:
New Zealand
Status:
Active, not recruiting
Facility:
Name:
Christchurch Hospital; Gastroenterology Dept
Address:
City:
Christchurch
Zip:
8011
Country:
New Zealand
Status:
Active, not recruiting
Facility:
Name:
Wellington Hospital
Address:
City:
Wellington
Zip:
6021
Country:
New Zealand
Status:
Active, not recruiting
Facility:
Name:
Jos University Teaching Hospital; Internal medicine and Gastroenterology
Address:
City:
JOS
Zip:
930232
Country:
Nigeria
Status:
Recruiting
Facility:
Name:
Lagos University Teaching Hospital Lagos (LUTH), Lagos State
Address:
City:
Lagos
Country:
Nigeria
Status:
Recruiting
Facility:
Name:
Copernicus Podmiot Medyczny Sp. z o.o. Wojewodzkie Centrum Onkologii; Oddzia? Onkologii Klinicznej
Address:
City:
Gdansk
Zip:
80-219
Country:
Poland
Status:
Recruiting
Facility:
Name:
Szpital Uniwersytecki w Krakowie, Oddzia? Kliniczny Kliniki Onkologii
Address:
City:
Kraków
Zip:
30-688
Country:
Poland
Status:
Recruiting
Facility:
Name:
ID Clinic
Address:
City:
Myslowice
Zip:
41-400
Country:
Poland
Status:
Recruiting
Facility:
Name:
NIO im Marii Sklodowskiej-Curie; Klinika Onkologii i Radioterapii
Address:
City:
Warszawa
Zip:
02-034
Country:
Poland
Status:
Recruiting
Facility:
Name:
PanOncology Trials; Hospital Oncológico, Puerto Rico Medical Center
Address:
City:
San Juan
Zip:
00935
Country:
Puerto Rico
Status:
Active, not recruiting
Facility:
Name:
National University Hospital; National University Cancer Institute, Singapore (NCIS)
Address:
City:
Singapore
Zip:
119228
Country:
Singapore
Status:
Withdrawn
Facility:
Name:
National Cancer Centre; Medical Oncology
Address:
City:
Singapore
Zip:
168583
Country:
Singapore
Status:
Active, not recruiting
Facility:
Name:
Tan Tock Seng Hospital; Oncology
Address:
City:
Singapore
Zip:
308433
Country:
Singapore
Status:
Withdrawn
Facility:
Name:
Curie Oncology
Address:
City:
Singapore
Zip:
329563
Country:
Singapore
Status:
Withdrawn
Facility:
Name:
Charlotte Maxeke Johannesburg Academic Hospital
Address:
City:
Johannesburg
Zip:
2193
Country:
South Africa
Status:
Recruiting
Facility:
Name:
Limpopo Cancer Research Institute
Address:
City:
Polokwane
Zip:
0700
Country:
South Africa
Status:
Active, not recruiting
Facility:
Name:
University of Pretoria; Department of Medical Oncology
Address:
City:
Pretoria
Zip:
0002
Country:
South Africa
Status:
Recruiting
Facility:
Name:
Hospital Universitario Central de Asturias; Servicio de Hepatología
Address:
City:
Oviedo
Zip:
33011
Country:
Spain
Status:
Active, not recruiting
Facility:
Name:
Clinica Universitaria de Navarra; Servicio de Hepatologia
Address:
City:
Pamplona/iruña
Zip:
31008
Country:
Spain
Status:
Active, not recruiting
Facility:
Name:
Hospital Universitari Vall d'Hebron; Servicio de Hepatologia
Address:
City:
Barcelona
Zip:
08035
Country:
Spain
Status:
Active, not recruiting
Facility:
Name:
Hospital Clinic i Provincial; Servicio de Hepatología
Address:
City:
Barcelona
Zip:
08036
Country:
Spain
Status:
Active, not recruiting
Facility:
Name:
Hospital Duran i Reynals; Oncologia
Address:
City:
Barcelona
Zip:
08907
Country:
Spain
Status:
Active, not recruiting
Facility:
Name:
Hospital Universitario de Burgos; Oncología
Address:
City:
Burgos
Zip:
09006
Country:
Spain
Status:
Withdrawn
Facility:
Name:
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia
Address:
City:
Jaen
Zip:
23007
Country:
Spain
Status:
Active, not recruiting
Facility:
Name:
Hospital General Universitario Gregorio Marañon; Servicio de Aparato Digestivo
Address:
City:
Madrid
Zip:
28007
Country:
Spain
Status:
Active, not recruiting
Facility:
Name:
Clinica Universitaria de Navarra de Madrid; Servicio de Hepatologia; Servicio de Hepatologia
Address:
City:
Madrid
Zip:
28027
Country:
Spain
Status:
Active, not recruiting
Facility:
Name:
Hospital Clinico San Carlos; Servicio de Oncologia
Address:
City:
Madrid
Zip:
28040
Country:
Spain
Status:
Active, not recruiting
Facility:
Name:
Hospital Universitario Puerta de Hierro; Servicio de Gastroenterologia
Address:
City:
Madrid
Zip:
28222
Country:
Spain
Status:
Active, not recruiting
Facility:
Name:
Hospital de Navarra; Servicio de Oncologia
Address:
City:
Navarra
Zip:
31008
Country:
Spain
Status:
Active, not recruiting
Facility:
Name:
Hospital Clinico de Valencia; Servicio de Hepatologia
Address:
City:
Valencia
Zip:
46010
Country:
Spain
Status:
Active, not recruiting
Facility:
Name:
China Medical University Hospital; Surgery
Address:
City:
Taichung
Zip:
404
Country:
Taiwan
Status:
Active, not recruiting
Facility:
Name:
National Cheng Kung University Hospital; Oncology
Address:
City:
Tainan
Zip:
00704
Country:
Taiwan
Status:
Active, not recruiting
Facility:
Name:
Chi-Mei Medical Centre; Hematology & Oncology
Address:
City:
Tainan
Zip:
710
Country:
Taiwan
Status:
Active, not recruiting
Facility:
Name:
National Taiwan Uni Hospital; Dept of Oncology
Address:
City:
Taipei
Zip:
100
Country:
Taiwan
Status:
Active, not recruiting
Facility:
Name:
Chang Gung Medical Foundation - Linkou; Dept. of Hepato-Gastroenterology
Address:
City:
Taoyuan
Zip:
333
Country:
Taiwan
Status:
Active, not recruiting
Facility:
Name:
Chulalongkorn Hospital; Medical Oncology
Address:
City:
Bangkok
Zip:
10330
Country:
Thailand
Status:
Active, not recruiting
Facility:
Name:
Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc
Address:
City:
Bangkok
Zip:
10400
Country:
Thailand
Status:
Active, not recruiting
Facility:
Name:
Maharaj Nakorn Chiang Mai Hospital; Department of Medicine
Address:
City:
ChiangMai
Zip:
50200
Country:
Thailand
Status:
Completed
Facility:
Name:
Khon Kaen Uni ; Faculty of Medicine, Division of Gastroenterology
Address:
City:
Khon Kaen
Zip:
40002
Country:
Thailand
Status:
Active, not recruiting
Facility:
Name:
Adana Baskent University Medical Faculty; Oncology
Address:
City:
Adana
Zip:
01220
Country:
Turkey
Status:
Active, not recruiting
Facility:
Name:
Ankara Bilkent City Hospital
Address:
City:
Ankara
Zip:
06490
Country:
Turkey
Status:
Active, not recruiting
Facility:
Name:
Gazi Uni Medical Faculty Hospital; Oncology Dept
Address:
City:
Ankara
Zip:
06500
Country:
Turkey
Status:
Active, not recruiting
Facility:
Name:
Dicle University Faculty of Medicine
Address:
City:
Diyarbakir
Zip:
21280
Country:
Turkey
Status:
Active, not recruiting
Facility:
Name:
Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi
Address:
City:
Edirne
Zip:
22030
Country:
Turkey
Status:
Active, not recruiting
Facility:
Name:
?zmir Medical Point; Oncology
Address:
City:
Kar?iyaka
Zip:
35575
Country:
Turkey
Status:
Active, not recruiting
Facility:
Name:
Western General Hospital; Dept of Oncology
Address:
City:
Edinburgh
Zip:
EH4 2XU
Country:
United Kingdom
Status:
Active, not recruiting
Facility:
Name:
Royal Free Hospital; Dept of Oncology
Address:
City:
London
Zip:
NW3 2QG
Country:
United Kingdom
Status:
Active, not recruiting
Facility:
Name:
Hammersmith Hospital; Clinical trials unit
Address:
City:
London
Zip:
W12 0HS
Country:
United Kingdom
Status:
Active, not recruiting
Start date:
September 14, 2023
Completion date:
September 1, 2026
Lead sponsor:
Agency:
Hoffmann-La Roche
Agency class:
Industry
Collaborator:
Agency:
Chugai Pharmaceutical
Agency class:
Industry
Source:
Hoffmann-La Roche
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05904886
