Trial Title:
Adebrelimab, Camrelizumab Plus Apatinib as First-line Therapy in Patients With Advanced Hepatocellular Carcinoma
NCT ID:
NCT05924997
Condition:
Advanced Hepatocellular Carcinoma
Conditions: Official terms:
Carcinoma
Carcinoma, Hepatocellular
Apatinib
Conditions: Keywords:
adebrelimab
camrelizumab
apatinib
hepatocellular carcinoma
first-line therapy
Study type:
Interventional
Study phase:
Phase 1/Phase 2
Overall status:
Recruiting
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Primary purpose:
Treatment
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
adebrelimab, camrelizumab plus apatinib
Description:
adebrelimab (RP2D, Q3W)+ camrelizumab 200mg Q3W+ apatinib 250mg qd, with 3 weeks (21
days) as a treatment cycle
Arm group label:
Interventional arm
Summary:
This is a prospective, single-arm, phase Ib/II trial . The objective of this study is to
evaluate the efficacy and safety of adebrelimab, camrelizumab plus apatinib as first-line
therapy in patients with advanced hepatocellular carcinoma
Detailed description:
This study is divided into two stages: in the Ib stage, the tolerance and safety of
adebrelimab, camrelizumab plus apatinib in the treatment of patients with advanced solid
tumors were studied; The second phase is a single-arm, open and multi-center clinical
study. The improvement of objective response rate (ORR) in patients with advanced HCC by
first-line treatment with adebrelimab, camrelizumab plus apatinib was observed and
evaluated.
■ The first stage
In order to effectively investigate the safety of adebrelimab, camrelizumab plus apatinib
in the treatment of patients with advanced solid tumors, the following cohort (dose
level) studies are planned:
Queue 1: adebrelimab 10mg/kgQ3W+ camrelizumab 200mgQ3W+ apatinib 250mgqd. Queue 2:
adebrelimab 20mg/kgQ3W+ camrelizumab 200mgQ3W+ apatinib 250mgqd. Using i3+3 design, 3~6
subjects are expected to be enrolled in each cohort. Every 3 weeks (21 days) is a
treatment cycle, and DLT observation period is the first and second cycles of combined
administration. After passing the safety evaluation of DLT observation period, the next
dose group experiment can be gradually entered.
■ The second stage According to the results of the first phase, the recommended dose of
phase II study (RP2D) was selected for further efficacy and safety evaluation in patients
with advanced hepatocellular carcinoma who had not received systematic treatment before.
The objective remission rate (ORR) was the main end point of the study, and 46 subjects
were planned to be enrolled. After fully knowing and signing the informed consent form,
the subjects will receive the study treatment: adebrelimab (RP2D, Q3W)+ camrelizumab
200mgQ3W+ apatinib 250mgqd, with 3 weeks (21 days) as a treatment cycle.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Patients volunteered to join this study and signed informed consent;
- ≥ 18 years old (calculated on the day of signing the informed consent), both men and
women can be used;
- Patients with advanced or metastatic solid tumor confirmed by histology or cytology
(stage Ⅰb); Patients with hepatocellular carcinoma diagnosed by EASL/AASLD
diagnostic criteria, histopathology or cytology are not suitable for surgery or
local treatment, or progress after surgery and/or local treatment (stage II);
- Subjects must be able to provide fresh or archived tumor tissues (formalin-fixed,
paraffin-embedded [FFPE] tissue blocks or at least 5 unstained FFPE slides) and
their pathological reports. If the subjects can provide less than 5 unstained slides
or the tumor tissue is unavailable (for example, because of previous diagnostic
tests), after discussion, they may be allowed to join the group according to the
specific circumstances;
- For patients who have progressed after local treatment, local treatment (including
but not limited to surgery, radiotherapy, hepatic artery embolization, TACE, hepatic
artery perfusion, radiofrequency ablation, cryoablation or percutaneous ethanol
injection) has been completed at least 4 weeks before the baseline imaging scan, and
the toxic reactions caused by local treatment (except alopecia) must be restored to
the fifth edition of the National Cancer Institute-General Terminology Standard for
Adverse Events (NCI-CTCAEV 5. 0) rating ≤1 level;
- Never received any systematic treatment for HCC before;
- There is at least one measurable lesion (according to the requirements of
RECISTv1.1, the long diameter of the measurable lesion in spiral CT scanning is
≥10mm or the short diameter of swollen lymph nodes is ≥ 15 mm; Lesions that have
received local treatment in the past can be used as target lesions after definite
progress according to RECISTv1.1 standard);
- Child-Pugh liver function classification: A or B)
- The score of physical condition of the Eastern Cancer Cooperative Group (ECOG) is 0
~ 2;
- The expected survival time is ≥12 weeks;
- The functions of major organs are basically normal, with serious dysfunction of
blood, heart, lung, liver, kidney, bone marrow and immunodeficiency diseases, which
meet the requirements of the scheme: a) Routine blood examination: (Except
hemoglobin, no blood transfusion within 14 days before screening, no use of
granulocyte colony-stimulating factor [G-CSF] and no use of corrective treatment
within 7 days) i. Hemoglobin ≥ 90g/L. Ii. Neutrophil count ≥ 1.5× 109/L; Iii.
Platelet count ≥ 50× 109/L; B) Biochemical examination: (albumin was not transfused
within 14 days) i. Serum albumin ≥ 29g/L; Ii. Alanine aminotransferase (ALT) and
aspartate aminotransferase (AST)≤2.5 times the upper limit of normal value (ULN);
Iii. Total bilirubin (TBIL)≤1.5 times ULN；; Iv. Creatinine Cr≤1.5 times ULN or Cr
clearance rate > 50mL/min(Cockcroft-Gault formula is as follows) Male: Cr clearance
rate =((140- age) × body weight) /(72× blood Cr) Female: Cr clearance rate =((140-
age) × body weight)/(72 Blood Cr unit: mg/ml; V. Urine protein < 2+ (if urine
protein ≥2+, 24-hour (h) urine protein quantification can be performed, and 24-hour
urine protein quantification < 1.0g can be enrolled); C) Coagulation function: APTT
and INR)≤1.5×ULN (for anticoagulant therapy with stable dosage such as low molecular
weight heparin or warfarin and INR can be screened within the expected therapeutic
range of anticoagulant); D) thyroid stimulating hormone (TSH) ≤ ULN; If abnormal, T3
and T4 levels should be investigated, and normal T3 and T4 levels can be selected;
E) Color Doppler echocardiography: Left ventricular ejection fraction (LVEF) is
greater than or equal to 60%.
- If the patient suffers from active hepatitis B virus (HBV) infection: the HBV-
deoxyribonucleic acid (DNA) must be less than 2× 103 IU/ml and he is willing to
receive antiviral treatment (according to local standard treatment, such as
entecavir) during the study period, and the doctor will judge whether the patient is
eligible for enrollment according to the individual situation of the patient under
the condition of monitoring the virus copy number; Hepatitis C virus (HCV)
ribonucleic acid (RNA) positive patients must receive antiviral treatment according
to local standard treatment guidelines, and their liver function should be within
the level 1 increase of CTCAE1.
- Fertile women: they must agree to abstain from sex (avoid heterosexual intercourse)
or use reliable and effective methods of contraception for at least 120 days from
the signing of the informed consent form to the last administration of the study
drug. And the serum HCG test must be negative within 7 days before the start of the
study treatment; And must be non-lactating. If a female patient has menstruated, has
not yet reached the post-menopausal state (continuous non-menstrual period ≥12
months, and no other reasons have been found except menopause), and has not received
sterilization surgery (such as hysterectomy, bilateral tubal ligation or bilateral
oophorectomy), it is considered that the patient has fertility.
- For male patients whose partner is a woman of childbearing age, they must agree to
abstain from sex for at least 120 days from signing the informed consent form until
the last administration of the study drug, or to use reliable and effective methods
for contraception. Male subjects must also agree not to donate sperm during the same
period. Male subjects whose partners are pregnant must use condoms, and no other
contraceptive methods are needed.
Exclusion Criteria:
- Cholangiocarcinoma, sarcomatoid HCC, mixed cell carcinoma and fibreboard cell
carcinoma; Have other active malignant tumors except HCC within 5 years or at the
same time. Localized tumors that have been cured, such as basal cell carcinoma of
skin, squamous cell carcinoma of skin, superficial bladder cancer, prostate cancer
in situ, cervical cancer in situ, breast cancer in situ, etc., can be included in
the group;
- Patients who are ready to undergo or have previously received an organ or allogeneic
bone marrow transplantation;
- Received other experimental drugs within 28 days before starting the study
treatment;
- Moderate and severe ascites with clinical symptoms requires therapeutic puncture,
drainage or Child-Pugh score > 2 (except for those who only show a small amount of
ascites on imaging but are not accompanied by clinical symptoms); Uncontrolled or
moderate or above pleural effusion and pericardial effusion;
- Patients who have a history of gastrointestinal bleeding or have a clear tendency of
gastrointestinal bleeding within 6 months before the start of the study and
treatment, such as: bleeding-risk or severe esophageal and gastric varices, local
active gastrointestinal ulcer lesions, and persistent fecal occult blood positive,
can not be included in the group (if the fecal occult blood is positive in the
baseline period, it can be rechecked, if it is still positive after the recheck, it
needs to undergo gastroduodenoscopy (EGD), and if the EGD indicates bleeding-risk
esophageal and gastric varices, it can not be included).
- Abdominal fistula, gastrointestinal perforation or abdominal abscess occurred within
6 months before the start of the study treatment;
- Known hereditary or acquired bleeding (such as coagulation dysfunction) or
thrombotic tendency, such as hemophilia patients; At present, or in the near future
(within 10 days before the start of the study treatment), full-dose oral or
injection anticoagulants or thrombolytic drugs have been used for therapeutic
purposes (low-dose aspirin and low-molecular-weight heparin are allowed for
preventive use);
- Aspirin (> 325mg/ day (maximum antiplatelet dose) or dipyridamole, ticlopidine,
clopidogrel and cilostazol are currently being used or recently used (within 10 days
before the start of the study treatment);
- Thrombosis or embolism occurred within 6 months before the start of the study, such
as cerebrovascular accident (including transient ischemic attack, cerebral
hemorrhage, cerebral infarction) and pulmonary embolism;
- There are clinical symptoms or diseases of the heart that are not well controlled,
such as: (1) Cardiac insufficiency above Grade II according to the standards of new
york Heart Association (NYHA) or cardiac color Doppler examination: LVEF (Left
Ventricular Ejection Fraction) < 50%; (2) Unstable angina pectoris; (3) myocardial
infarction occurred within one year before the start of study and treatment; (4)
Clinically significant supraventricular or ventricular arrhythmia needs treatment or
intervention; (5) QTc > 450 ms (male); QTc>470ms (female) (QTc interval is
calculated by Fridericia formula; If the QTc is abnormal, it can be continuously
detected for three times every 2 minutes, and the average value can be taken);
- Suffering from hypertension, which cannot be well controlled by antihypertensive
drugs (systolic blood pressure ≥140mmHg or diastolic blood pressure ≥90mmHg) (based
on the average of BP readings obtained by ≥2 measurements), it is allowed to realize
the above parameters by using antihypertensive therapy; Hypertensive crisis or
hypertensive encephalopathy has occurred in the past;
- Major vascular diseases (for example, aortic aneurysm requiring surgical repair or
recent peripheral artery thrombosis) occurred within 6 months before the start of
study treatment; Severe, unhealed or split wounds and active ulcers or untreated
fractures; Received major surgical treatment (except diagnosis) within 4 weeks
before the start of the study treatment or expected major surgical treatment during
the study period;
- Can't swallow pills, malabsorption syndrome or any condition that affects
gastrointestinal absorption; Have suffered from intestinal obstruction and/or had
clinical signs or symptoms of gastrointestinal obstruction within 6 months before
the start of the study, including incomplete obstruction related to the original
disease or requiring routine parenteral hydration, parenteral nutrition or tube
feeding: At the initial diagnosis, patients with signs/symptoms of incomplete
obstruction/obstruction syndrome/intestinal obstruction may be admitted to the study
if they receive definite (surgical) treatment to relieve symptoms;
- There is evidence that there is pneumoperitoneum that cannot be explained by
puncture or recent surgical operation;
- Past or present central nervous system metastasis; Metastatic diseases involving
major airways or blood vessels (for example, portal vein trunk or vena cava that is
completely occluded due to tumor invasion needs to be excluded from the group,
portal vein trunk refers to the confluence of the splenic vein and superior
mesenteric vein and the branch where hepatic portal vein divides into left and right
branches) or large mediastinal tumor mass in the center (less than 30 mm from
carina);
- Those with a history of hepatic encephalopathy; At present, patients with
interstitial pneumonia or interstitial lung disease, or patients with a previous
history of interstitial pneumonia or interstitial lung disease requiring hormone
therapy, or other subjects with pulmonary fibrosis, organized pneumonia (for
example, bronchiolitis obliterans), pneumoconiosis, drug-related pneumonia,
idiopathic pneumonia, or subjects with evidence of active pneumonia or severe
impairment of lung function on chest computed tomography (CT) during the screening
period are allowed to have radiation pneumonia in the radiation field. Active
tuberculosis;
- Active autoimmune disease or history of autoimmune disease and possible recurrence
(including but not limited to autoimmune hepatitis, interstitial pneumonia, uveitis,
enteritis, hypophysitis, vasculitis, nephritis, hyperthyroidism, hypothyroidism
[subjects who can only be controlled by hormone replacement therapy can be
included]); Subjects suffering from skin diseases without systematic treatment, such
as vitiligo, psoriasis, alopecia, controlled type I diabetes treated with insulin or
asthma in childhood have been completely relieved, and adults can be included
without any intervention; Asthmatic patients who need bronchodilators for medical
intervention cannot be included;
- Use immunosuppressant or systemic hormone therapy within 14 days before starting the
study treatment to achieve the purpose of immunosuppression (the dose is > 10mg/ day
of prednisone or other therapeutic hormones);
- Strong CYP3A4/CYP2C19 inducers used within 14 days before the start of study
treatment include rifampicin (and its analogues) and Hypericum perforatum or strong
CYP3A4/CYP2C19 inhibitors;
- It is known that there is a history of a severe allergy to any monoclonal antibody
and anti-angiogenesis targeted drugs;
- Severe infection within 4 weeks before the start of study and treatment, including
but not limited to hospitalization due to infection, bacteremia, or complications of
severe pneumonia; Therapeutic antibiotics were given orally or intravenously within
2 weeks before the start of the study treatment (patients receiving preventive
antibiotics (for example, patients who prevent urinary tract infection or
exacerbation of chronic obstructive pulmonary disease are eligible to participate in
the study);
- patients with congenital or acquired immunodeficiency (such as HIV-infected people);
- Co-infection with hepatitis B and hepatitis C;
- Previously received other anti-PD-1 antibody therapy or other immunotherapy against
PD-1/PD-L1, or previously received apatinib therapy;
- Patients have received live attenuated vaccine treatment within 28 days before the
start of the study treatment, or expected to need such vaccine within 60 days after
the last administration of adebelizumab.
- According to the researcher's judgment, the patient has other factors that may
affect the study results or cause the study to be forced to terminate halfway, such
as alcoholism, drug abuse, other serious diseases (including mental illness)
requiring combined treatment, serious laboratory examination abnormalities, and
family or society.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Sun Yat-sen Memorial Hospital
Address:
City:
Guangzhou
Zip:
510220
Country:
China
Status:
Recruiting
Contact:
Last name:
Lei Zhang, PhD
Phone:
+8613602730646
Email:
zhangl9@mail.sysu.edu.cn
Start date:
July 1, 2023
Completion date:
June 1, 2026
Lead sponsor:
Agency:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Agency class:
Other
Source:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05924997
