A Clinical Study of V940 Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)

Trial Title: A Clinical Study of V940 Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)

NCT ID: NCT05933577

Condition: Melanoma

Conditions: Official terms:
Melanoma
Pembrolizumab

Study type: Interventional

Study phase: Phase 3

Overall status: Active, not recruiting

Study design:

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Treatment

Masking: Triple (Participant, Investigator, Outcomes Assessor)

Masking description: Double blind

Intervention:

Intervention type: Biological
Intervention name: V940
Description: IM injection
Arm group label: V940 + Pembrolizumab

Other name: mRNA-4157

Other name: Individualized neoantigen therapy

Intervention type: Biological
Intervention name: Pembrolizumab
Description: IV infusion
Arm group label: Placebo + Pembrolizumab
Arm group label: V940 + Pembrolizumab

Other name: MK-3475

Other name: Keytruda®

Intervention type: Other
Intervention name: Placebo
Description: IM injection
Arm group label: Placebo + Pembrolizumab

Other name: Normal saline

Other name: Dextrose

Summary: The purpose of this study is to learn if V940 which is an individualized neoantigen therapy (INT; formerly, called messenger ribonucleic acid [mRNA]-4157) with pembrolizumab (MK-3475) is safe and prevents cancer from returning in people with high-risk melanoma. Researchers want to know if V940 with pembrolizumab is better than receiving pembrolizumab alone at preventing the cancer from returning.

Criteria for eligibility:
Criteria:
Inclusion Criteria: The main inclusion criteria include but are not limited to the following: - Has surgically resected and histologically/pathologically confirmed diagnosis of Stage IIB or IIC, III, or IV cutaneous melanoma - Has not received any prior systemic therapy for their melanoma beyond surgical resection - No more than 13 weeks have passed between final surgical resection that rendered the participant disease-free and the first dose of pembrolizumab - Is disease free at the time of providing documented consent for the study - Human immunodeficiency virus (HIV)-infected participants must have well controlled HIV on anti-retroviral therapy (ART) Exclusion Criteria: The main exclusion criteria include but are not limited to the following: - Has ocular or mucosal melanoma - Has cancer that has spread to other parts of the body and cannot be removed with surgery - Has heart failure within the past 6 months - Has received prior cancer therapy or another cancer vaccine - Has another known cancer that that has spread to other parts of the body or has required treatment within the past 3 years - Has severe reaction to study medications or any of their substance used to prepare a drug - Have not recovered from major surgery or have ongoing surgical complications

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: Highlands Oncology Group ( Site 1943)

Address:
City: Springdale
Zip: 72762
Country: United States

Facility:
Name: UCLA Hematology/Oncology - Westwood (Building 100) ( Site 1918)

Address:
City: Los Angeles
Zip: 90095
Country: United States

Facility:
Name: UCSF Medical Center at Mission Bay ( Site 1929)

Address:
City: San Francisco
Zip: 94158
Country: United States

Facility:
Name: Yale-New Haven Hospital-Yale Cancer Center ( Site 1933)

Address:
City: New Haven
Zip: 06510
Country: United States

Facility:
Name: Orlando Health Cancer Institute ( Site 1937)

Address:
City: Orlando
Zip: 32806
Country: United States

Facility:
Name: Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center ( Site 1945)

Address:
City: Tampa
Zip: 33612
Country: United States

Facility:
Name: Winship Cancer Institute of Emory University ( Site 1940)

Address:
City: Atlanta
Zip: 30322
Country: United States

Facility:
Name: Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 1950)

Address:
City: Marietta
Zip: 30060
Country: United States

Facility:
Name: University of Iowa-Holden Comprehensive Cancer Center ( Site 1935)

Address:
City: Iowa City
Zip: 52242
Country: United States

Facility:
Name: Johns Hopkins Hospital-Sidney Kimmel Comprehensive Cancer Center - Melanoma ( Site 1912)

Address:
City: Baltimore
Zip: 21287
Country: United States

Facility:
Name: Massachusetts General Hospital ( Site 1927)

Address:
City: Boston
Zip: 02114
Country: United States

Facility:
Name: Beth Israel Deaconess Medical Center ( Site 1957)

Address:
City: Boston
Zip: 02215
Country: United States

Facility:
Name: Dana-Farber Cancer Institute ( Site 1956)

Address:
City: Boston
Zip: 02215
Country: United States

Facility:
Name: University of Michigan ( Site 1915)

Address:
City: Ann Arbor
Zip: 48109
Country: United States

Facility:
Name: Cancer and Hematology Centers of Western Michigan ( Site 1932)

Address:
City: Grand Rapids
Zip: 49503
Country: United States

Facility:
Name: John Theurer Cancer Center at Hackensack University Medical Center ( Site 1944)

Address:
City: Hackensack
Zip: 07601
Country: United States

Facility:
Name: Atlantic Health System ( Site 1925)

Address:
City: Morristown
Zip: 07960
Country: United States

Facility:
Name: Valley Health Systems - Ridgewood Campus ( Site 1947)

Address:
City: Ridgewood
Zip: 07450
Country: United States

Facility:
Name: Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 1958)

Address:
City: Mineola
Zip: 11501
Country: United States

Facility:
Name: NYU Langone Health-Perlmutter Cancer Center ( Site 1917)

Address:
City: New York
Zip: 10016
Country: United States

Facility:
Name: Columbia University Irving Medical Center-CUIMC Herbert Irving Comprehensive Cancer Center Clinical

Address:
City: New York
Zip: 10032
Country: United States

Facility:
Name: Memorial Sloan Kettering Cancer Center ( Site 1914)

Address:
City: New York
Zip: 10065
Country: United States

Facility:
Name: University of North Carolina Medical Center-Lineberger Comprehensive Cancer Center ( Site 1949)

Address:
City: Chapel Hill
Zip: 27599
Country: United States

Facility:
Name: Duke Cancer Institute ( Site 1911)

Address:
City: Durham
Zip: 27710
Country: United States

Facility:
Name: Hospital of the University of Pennsylvania Perelman Center for Advanced Medicine ( Site 1905)

Address:
City: Philadelphia
Zip: 19104
Country: United States

Facility:
Name: UPMC Hillman Cancer Center ( Site 1909)

Address:
City: Pittsburgh
Zip: 15232
Country: United States

Facility:
Name: Medical University of South Carolina-Hollings Cancer Center ( Site 1934)

Address:
City: Charleston
Zip: 29425
Country: United States

Facility:
Name: Sanford Cancer Center ( Site 1951)

Address:
City: Sioux Falls
Zip: 57104
Country: United States

Facility:
Name: SCRI Oncology Partners ( Site 1910)

Address:
City: Nashville
Zip: 37203
Country: United States

Facility:
Name: Texas Oncology - Austin ( Site 1903)

Address:
City: Austin
Zip: 78731
Country: United States

Facility:
Name: Texas Oncology - Dallas (Sammons) ( Site 1902)

Address:
City: Dallas
Zip: 75246
Country: United States

Facility:
Name: University of Texas MD Anderson Cancer Center ( Site 1920)

Address:
City: Houston
Zip: 77030
Country: United States

Facility:
Name: Inova Schar Cancer Institute ( Site 1900)

Address:
City: Fairfax
Zip: 22031
Country: United States

Facility:
Name: Fred Hutchinson Cancer Center ( Site 1901)

Address:
City: Seattle
Zip: 98109
Country: United States

Facility:
Name: Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 2202)

Address:
City: Caba
Zip: C1199ABB
Country: Argentina

Facility:
Name: Instituto Alexander Fleming-Alexander Fleming ( Site 2203)

Address:
City: Ciudad Autónoma de Buenos Aires
Zip: 1426
Country: Argentina

Facility:
Name: Centro Privado de RMI Río Cuarto S.A. II ( Site 2201)

Address:
City: Río Cuarto
Zip: X5800ALB
Country: Argentina

Facility:
Name: Hospital Aleman ( Site 2200)

Address:
City: Buenos Aires
Zip: C1118AAT
Country: Argentina

Facility:
Name: Sanatorio Finochietto ( Site 2205)

Address:
City: Buenos Aires
Zip: C1187AAN
Country: Argentina

Facility:
Name: Clinica Adventista Belgrano-Oncology ( Site 2204)

Address:
City: Caba
Zip: 1430
Country: Argentina

Facility:
Name: Westmead Hospital-Department of Medical Oncology ( Site 1001)

Address:
City: Westmead
Zip: 2145
Country: Australia

Facility:
Name: Melanoma Institute Australia-Clinical Trials Unit ( Site 1000)

Address:
City: Wollstonecraft
Zip: 2065
Country: Australia

Facility:
Name: Princess Alexandra Hospital ( Site 1003)

Address:
City: Brisbane
Zip: 4102
Country: Australia

Facility:
Name: Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 1005)

Address:
City: Melbourne
Zip: 3000
Country: Australia

Facility:
Name: Paula Fox Melanoma & Cancer Centre ( Site 1004)

Address:
City: Melbourne
Zip: 3004
Country: Australia

Facility:
Name: One Clinical Research ( Site 1002)

Address:
City: Nedlands
Zip: 6009
Country: Australia

Facility:
Name: UZ Brussel-Medische oncologie ( Site 3405)

Address:
City: Brussels
Zip: 1090
Country: Belgium

Facility:
Name: Ziekenhuis Oost-Limburg, Campus St.-Jan ( Site 3402)

Address:
City: Genk
Zip: 3600
Country: Belgium

Facility:
Name: UZ Gent ( Site 3403)

Address:
City: Gent
Zip: 9000
Country: Belgium

Facility:
Name: UZ Leuven ( Site 3400)

Address:
City: Leuven
Zip: 3000
Country: Belgium

Facility:
Name: AZ Groeninge Campus Kennedylaan-Oncology ( Site 3401)

Address:
City: Kortrijk
Zip: 8500
Country: Belgium

Facility:
Name: Centro Avançado de Tratamento Oncológico- CENANTRON ( Site 2303)

Address:
City: Belo Horizonte
Zip: 30130-090
Country: Brazil

Facility:
Name: ONCOSITE - Centro de Pesquisa Clinica em Oncologia ( Site 2302)

Address:
City: Ijui
Zip: 98700-000
Country: Brazil

Facility:
Name: Hospital Nossa Senhora da Conceição ( Site 2309)

Address:
City: Porto Alegre
Zip: 91350-200
Country: Brazil

Facility:
Name: Instituto Nacional de Câncer - INCA-Pesquisa Clinica HC II ( Site 2305)

Address:
City: Rio de Janeiro
Zip: 20220-410
Country: Brazil

Facility:
Name: ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 2300)

Address:
City: Sao Paulo
Zip: 01246-000
Country: Brazil

Facility:
Name: Cross Cancer Institute ( Site 1104)

Address:
City: Edmonton
Zip: T6G 1Z2
Country: Canada

Facility:
Name: BC Cancer Vancouver-Clinical Trials Unit ( Site 1106)

Address:
City: Vancouver
Zip: V5Z 4E6
Country: Canada

Facility:
Name: William Osler Health System ( Site 1105)

Address:
City: Brampton
Zip: L6R 3J7
Country: Canada

Facility:
Name: Sunnybrook Research Institute ( Site 1103)

Address:
City: Toronto
Zip: M4N 3M5
Country: Canada

Facility:
Name: Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 1102)

Address:
City: Toronto
Zip: M5G 2M9
Country: Canada

Facility:
Name: Centre Hospitalier de l'Université de Montréal-Unité de Recherche Clinique en Oncologie et Hématolo

Address:
City: Montréal
Zip: H2X 0X9
Country: Canada

Facility:
Name: Centre intégré de cancérologie du CHU de Québec Université L-Hemato-Oncology ( Site 1101)

Address:
City: Quebec City
Zip: G1J 1Z4
Country: Canada

Facility:
Name: FALP-UIDO ( Site 2400)

Address:
City: Santiago
Zip: 7500921
Country: Chile

Facility:
Name: Clínica UC San Carlos de Apoquindo-Hemato-Oncology ( Site 2402)

Address:
City: Santiago
Zip: 7620002
Country: Chile

Facility:
Name: Bradfordhill ( Site 2401)

Address:
City: Santiago
Zip: 8420383
Country: Chile

Facility:
Name: Clinica Somer-Unidad de Investigacion y Docencia ( Site 2506)

Address:
City: Rionegro
Zip: 054040
Country: Colombia

Facility:
Name: Oncomedica S.A.S ( Site 2503)

Address:
City: Montería
Zip: 230002
Country: Colombia

Facility:
Name: Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 2500)

Address:
City: Bogota
Zip: 111321
Country: Colombia

Facility:
Name: Fundación Valle del Lili ( Site 2505)

Address:
City: Cali
Zip: 760032
Country: Colombia

Facility:
Name: Herlev and Gentofte Hospital ( Site 3301)

Address:
City: Copenhagen
Zip: 2730
Country: Denmark

Facility:
Name: Aalborg Universitetshospital, Syd ( Site 3302)

Address:
City: Aalborg
Zip: 9000
Country: Denmark

Facility:
Name: Odense Universitetshospital ( Site 3300)

Address:
City: Odense C
Zip: 5000
Country: Denmark

Facility:
Name: Centre Hospitalier Universitaire de Nice - Hôpital l'Archet-Dermatology Department ( Site 1211)

Address:
City: Nice cedex 3
Zip: 06200
Country: France

Facility:
Name: Assistance Publique Hôpitaux de Marseille - Hôpital de la Ti-Service de Dermatologie et Cancérologi

Address:
City: Marseille
Zip: 13385
Country: France

Facility:
Name: Centre Georges François Leclerc ( Site 1210)

Address:
City: Dijon
Zip: 21079
Country: France

Facility:
Name: CHU Besançon ( Site 1209)

Address:
City: Besançon
Zip: 25030
Country: France

Facility:
Name: CHU de Bordeaux Hop St ANDRE-Service de Dermatologie ( Site 1204)

Address:
City: Bordeaux
Zip: 33075
Country: France

Facility:
Name: Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 1206)

Address:
City: Rennes
Zip: 35042
Country: France

Facility:
Name: Hopital Claude Huriez - CHU de Lille ( Site 1207)

Address:
City: Lille
Zip: 59037
Country: France

Facility:
Name: centre hospitalier lyon sud-Service de dermatologie ( Site 1202)

Address:
City: Pierre-Bénite
Zip: 69310
Country: France

Facility:
Name: CHU d'Amiens-Picardie - Hôpital Sud-Dermatologie ( Site 1208)

Address:
City: Amiens
Zip: 80054
Country: France

Facility:
Name: Gustave Roussy-Dermatologie ( Site 1201)

Address:
City: Villejuif
Zip: 94800
Country: France

Facility:
Name: Hôpital Saint-Louis ( Site 1200)

Address:
City: Paris
Zip: 75010
Country: France

Facility:
Name: Universitätsmedizin Mannheim ( Site 1305)

Address:
City: Mannheim
Zip: 68167
Country: Germany

Facility:
Name: Universitaetsklinikum Augsburg ( Site 1312)

Address:
City: Augsburg
Zip: 86156
Country: Germany

Facility:
Name: Klinik und Poliklinik für Dermatologie und Allergologie-Dermato-oncology ( Site 1315)

Address:
City: München
Zip: 80337
Country: Germany

Facility:
Name: Universitätsmedizin Rostock-Klinik und Poliklinik für Dermatologie und Venerologie ( Site 1310)

Address:
City: Rostock
Zip: 18057
Country: Germany

Facility:
Name: Universitätsmedizin Göttingen - Georg-August-Universität-Dermatology ( Site 1308)

Address:
City: Göttingen
Zip: 37075
Country: Germany

Facility:
Name: Universitaetsklinikum Essen-Klinik für Dermatologie, Venerologie und Allergologie ( Site 1300)

Address:
City: Essen
Zip: 45147
Country: Germany

Facility:
Name: Universitaetsklinikum Koeln ( Site 1307)

Address:
City: Köln
Zip: 50937
Country: Germany

Facility:
Name: Johannes Wesling Klinikum Minden-Skin Cancer Center Minden ( Site 1301)

Address:
City: Minden
Zip: 32429
Country: Germany

Facility:
Name: Universitaetsklinikum des Saarlandes ( Site 1313)

Address:
City: Homburg
Zip: 66424
Country: Germany

Facility:
Name: SRH Wald-Klinikum Gera-Zentrum für klinische Studien ( Site 1306)

Address:
City: Gera
Zip: 07548
Country: Germany

Facility:
Name: Charité Universitaetsmedizin Berlin - Campus Mitte-Hauttumorcentrum Charité (HTCC) ( Site 1302)

Address:
City: Berlin
Zip: 10115
Country: Germany

Facility:
Name: Universitaetsklinikum Hamburg-Eppendorf ( Site 1309)

Address:
City: Hamburg
Zip: 20246
Country: Germany

Facility:
Name: General Hospital of Athens "Laiko"-First Department of Internal Medicine ( Site 3700)

Address:
City: Athens
Zip: 115 26
Country: Greece

Facility:
Name: Metropolitan Hospital-A' Oncology Dpt ( Site 3701)

Address:
City: Neo Faliro
Zip: 185 47
Country: Greece

Facility:
Name: Bioclinic Thessalonikis Private Clinic Single Member S.A.-Oncology ( Site 3703)

Address:
City: Thessaloniki
Zip: 546 22
Country: Greece

Facility:
Name: European Interbalkan Medical Center-Oncology Department ( Site 3702)

Address:
City: Thessaloniki
Zip: 57001
Country: Greece

Facility:
Name: Emek Medical Center ( Site 2003)

Address:
City: Afula
Zip: 1834111
Country: Israel

Facility:
Name: Hadassah Medical Center ( Site 2004)

Address:
City: Jerusalem
Zip: 9112001
Country: Israel

Facility:
Name: Rabin Medical Center ( Site 2000)

Address:
City: Petah Tikva
Zip: 4941492
Country: Israel

Facility:
Name: Sheba Medical Center ( Site 2001)

Address:
City: Ramat Gan
Zip: 5265601
Country: Israel

Facility:
Name: Istituto Europeo di Oncologia IRCCS ( Site 1404)

Address:
City: Milano
Zip: 20141
Country: Italy

Facility:
Name: Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1401)

Address:
City: Milan
Zip: 20133
Country: Italy

Facility:
Name: Azienda Ospedaliero Universitaria Senese-U.O.C. Immunoterapia Oncologica ( Site 1402)

Address:
City: Siena
Zip: 53100
Country: Italy

Facility:
Name: AO Santa Maria della Misericordia ( Site 1403)

Address:
City: Perugia
Zip: 06129
Country: Italy

Facility:
Name: Istituto Nazionale Tumori IRCCS Fondazione Pascale-s.c. melanoma, immunoterapia oncologica e terapi

Address:
City: Napoli
Zip: 80131
Country: Italy

Facility:
Name: Nagoya University Hospital ( Site 4201)

Address:
City: Nagoya
Zip: 466-8560
Country: Japan

Facility:
Name: Shizuoka Cancer Center ( Site 4202)

Address:
City: Nagaizumi-cho,Sunto-gun
Zip: 411-8777
Country: Japan

Facility:
Name: National Cancer Center Hospital ( Site 4200)

Address:
City: Chuo
Zip: 104-0045
Country: Japan

Facility:
Name: Kyungpook National University Chilgok Hospital-Hematology/oncology ( Site 3904)

Address:
City: Daegu
Zip: 41404
Country: Korea, Republic of

Facility:
Name: Chungnam national university hospital-Department of Internal Medicine ( Site 3903)

Address:
City: Daejeon
Zip: 35015
Country: Korea, Republic of

Facility:
Name: Seoul National University Hospital-Oncology ( Site 3902)

Address:
City: Seoul
Zip: 03080
Country: Korea, Republic of

Facility:
Name: Severance Hospital, Yonsei University Health System-Medical oncology ( Site 3901)

Address:
City: Seoul
Zip: 03722
Country: Korea, Republic of

Facility:
Name: Samsung Medical Center-Division of Hematology/Oncology ( Site 3900)

Address:
City: Seoul
Zip: 06351
Country: Korea, Republic of

Facility:
Name: Capital, Coast and Hutt Valley District - Wellington Regional Hospital ( Site 1502)

Address:
City: Newtown
Zip: 6021
Country: New Zealand

Facility:
Name: Harbour Cancer & Wellness ( Site 1500)

Address:
City: Auckland
Zip: 1023
Country: New Zealand

Facility:
Name: Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2908)

Address:
City: Bydgoszcz
Zip: 85-796
Country: Poland

Facility:
Name: Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2903)

Address:
City: Siedlce
Zip: 08-110
Country: Poland

Facility:
Name: Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (

Address:
City: Warszawa
Zip: 02-781
Country: Poland

Facility:
Name: Bialostockie Centrum Onkologii ( Site 2905)

Address:
City: Bialystok
Zip: 15-027
Country: Poland

Facility:
Name: Uniwersyteckie Centrum Kliniczne-Klinika Chirurgii Onkologicznej, Transplantacyjnej i Ogólnej ( Site

Address:
City: Gdańsk
Zip: 80-214
Country: Poland

Facility:
Name: Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2907)

Address:
City: Gliwice
Zip: 44-101
Country: Poland

Facility:
Name: Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Onkologii Klinicznej, Dzial Ch

Address:
City: Kielce
Zip: 25-734
Country: Poland

Facility:
Name: Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 2909)

Address:
City: Poznan
Zip: 60-569
Country: Poland

Facility:
Name: Zachodniopomorskie Centrum Onkologii ( Site 2904)

Address:
City: Szczecin
Zip: 71-730
Country: Poland

Facility:
Name: Instituto Português de Oncologia de Lisboa Francisco Gentil ( Site 3601)

Address:
City: Lisbon
Zip: 1099-023
Country: Portugal

Facility:
Name: Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 3603)

Address:
City: Lisbon
Zip: 1649-035
Country: Portugal

Facility:
Name: Unidade Local de Saude Lisboa Ocidental - Hospital de São Francisco Xavier ( Site 3602)

Address:
City: Lisboa
Zip: 1449-005
Country: Portugal

Facility:
Name: Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 3604)

Address:
City: Porto
Zip: 4200-072
Country: Portugal

Facility:
Name: Medical Oncology Centre of Rosebank ( Site 4106)

Address:
City: Johannesburg
Zip: 2196
Country: South Africa

Facility:
Name: Wilgers Oncology Centre ( Site 4103)

Address:
City: Pretoria
Zip: 0040
Country: South Africa

Facility:
Name: Cape Town Oncology Trials ( Site 4100)

Address:
City: Cape Town
Zip: 7570
Country: South Africa

Facility:
Name: HOSPITAL CLÍNIC DE BARCELONA-ICHMO- Clinic Institut of Haematological and Oncological diseases ( Sit

Address:
City: Barcelona
Zip: 08036
Country: Spain

Facility:
Name: Hospital Universitario Ramón y Cajal ( Site 1602)

Address:
City: Madrid
Zip: 28034
Country: Spain

Facility:
Name: HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 1603)

Address:
City: Pozuelo de Alarcon
Zip: 28223
Country: Spain

Facility:
Name: H.R.U Málaga - Hospital General-Oncology ( Site 1605)

Address:
City: Málaga
Zip: 29011
Country: Spain

Facility:
Name: HOSPITAL CLINICO DE VALENCIA ( Site 1604)

Address:
City: Valencia
Zip: 46010
Country: Spain

Facility:
Name: Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1601)

Address:
City: Barcelona
Zip: 08035
Country: Spain

Facility:
Name: Skånes Universitetssjukhus Lund ( Site 3201)

Address:
City: Lund
Zip: 22185
Country: Sweden

Facility:
Name: Sahlgrenska Universitetssjukhuset ( Site 3200)

Address:
City: Gothenburg
Zip: 413 45
Country: Sweden

Facility:
Name: Kantonsspital Graubünden-Medizin ( Site 1703)

Address:
City: Chur
Zip: 7000
Country: Switzerland

Facility:
Name: UniversitätsSpital Zürich-Dermatology ( Site 1700)

Address:
City: Zürich Flughafen
Zip: 8058
Country: Switzerland

Facility:
Name: Chang Gung Memorial Hospital at Kaohsiung (Site 4000)

Address:
City: Kaohsiung
Zip: 83301
Country: Taiwan

Facility:
Name: National Cheng Kung University Hospital-Clinical Trial Center ( Site 4004)

Address:
City: Tainan
Zip: 704
Country: Taiwan

Facility:
Name: National Taiwan University Hospital (Site 4001)

Address:
City: Taipei
Zip: 10002
Country: Taiwan

Facility:
Name: Chang Gung Medical Foundation-Linkou Branch ( Site 4003)

Address:
City: Taoyuan
Zip: 33305
Country: Taiwan

Facility:
Name: Hacettepe Universite Hastaneleri ( Site 3006)

Address:
City: Ankara
Zip: 06230
Country: Turkey

Facility:
Name: Memorial Ankara Hastanesi-Medical Oncology ( Site 3010)

Address:
City: Ankara
Zip: 06520
Country: Turkey

Facility:
Name: Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 3002)

Address:
City: Ankara
Zip: 06800
Country: Turkey

Facility:
Name: Acibadem Universitesi Atakent Hastanesi-Medical Oncology ( Site 3008)

Address:
City: Istanbul
Zip: 34303
Country: Turkey

Facility:
Name: TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 3003)

Address:
City: Istanbul
Zip: 34722
Country: Turkey

Facility:
Name: Ege University Medical Faculty Hospital ( Site 3011)

Address:
City: Izmir
Zip: 35100
Country: Turkey

Facility:
Name: I.E.U. Medical Point Hastanesi-Oncology ( Site 3005)

Address:
City: Izmir
Zip: 35575
Country: Turkey

Facility:
Name: Bristol Haematology and Oncology Centre ( Site 1811)

Address:
City: Bristol
Zip: BS2 8ED
Country: United Kingdom

Facility:
Name: Addenbrooke's Hospital ( Site 1800)

Address:
City: Cambridge
Zip: CB2 2QQ
Country: United Kingdom

Facility:
Name: Norfolk and Norwich University Hospitals NHS Foundation Trust ( Site 1813)

Address:
City: Cringleford
Zip: NR4 7UY
Country: United Kingdom

Facility:
Name: ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 1804)

Address:
City: London
Zip: SW3 6JJ
Country: United Kingdom

Facility:
Name: University College London Hospital ( Site 1807)

Address:
City: London
Zip: NW1 2PG
Country: United Kingdom

Facility:
Name: Western General Hospital ( Site 1806)

Address:
City: Edinburgh
Zip: EH4 2XU
Country: United Kingdom

Facility:
Name: The Churchill Hospital ( Site 1805)

Address:
City: Oxford
Zip: OX3 7LE
Country: United Kingdom

Facility:
Name: St James's University Hospital-Leeds Cancer Centre ( Site 1808)

Address:
City: Leeds
Zip: LS9 7TF
Country: United Kingdom

Facility:
Name: The Christie NHS Foundation Trust ( Site 1814)

Address:
City: Manchester
Zip: m20 4bx
Country: United Kingdom

Start date: July 19, 2023

Completion date: September 26, 2030

Lead sponsor:
Agency: Merck Sharp & Dohme LLC
Agency class: Industry

Collaborator:
Agency: ModernaTX, Inc.
Agency class: Industry

Source: Merck Sharp & Dohme LLC

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT05933577
http://www.merckclinicaltrials.com
https://trialstransparency.merckclinicaltrials.com/Study.aspx?id=V940-001&&kw=V940-001