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Trial Title:
Fusobacterium Nucleatum at Colorectal Cancer Sites
NCT ID:
NCT05945082
Condition:
Colorectal Cancer
Periodontitis
Conditions: Official terms:
Colorectal Neoplasms
Periodontitis
Study type:
Interventional
Study phase:
N/A
Overall status:
Recruiting
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Primary purpose:
Screening
Masking:
None (Open Label)
Intervention:
Intervention type:
Other
Intervention name:
biopsy
Description:
biopsy of a colorectal cancer site
Summary:
Recent studies suggest an association of periodontitis with an overall increased cancer
risk but also with cancer development in specific anatomic regions, such as in the colon.
The gut microbiome in general and specifically Fusobacterium nucleatum have been
described to likely affect colorectal cancer (CRC) development. The present project
intends to evaluate the possible contribution of the oral cavity as a reservoir for
dissemination of F.nucleatum to the colon. Additionally, the gut microbiome and dietary
intake will be assessed as possible factors influencing colonization of CRC sites with F.
nucleatum and an association of F.nucleatum colonization in the colon with parameters in
the saliva and serum will be tested. One-hundred-fifty patients diagnosed with CRC will
be included; after cancer diagnosis and before starting cancer treatment a periodontal
examination will be done and saliva and serum samples and at the time-point of tumor
resection a biopsy of the CRC sites will be collected.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- diagnosis of colorectal cancer
Gender:
All
Minimum age:
18 Years
Maximum age:
120 Years
Healthy volunteers:
No
Locations:
Facility:
Name:
Skane University Hospital
Address:
City:
Malmö
Country:
Sweden
Status:
Recruiting
Contact:
Last name:
Klas Sjöberg
Start date:
November 29, 2017
Completion date:
December 31, 2025
Lead sponsor:
Agency:
Malmö University
Agency class:
Other
Collaborator:
Agency:
Skane University Hospital
Agency class:
Other
Source:
Malmö University
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05945082
