Neoadjuvant Toripalimab for Non-squamous NSCLC With EGFR Mutation

Trial Title: Neoadjuvant Toripalimab for Non-squamous NSCLC With EGFR Mutation

NCT ID: NCT05962021

Condition: Non Squamous Non Small Cell Lung Cancer
EGFR Positive Non-small Cell Lung Cancer

Conditions: Official terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung

Conditions: Keywords:
Non squamous non small cell lung cancer
EGFR Mutation
Neoadjuvant immuno-chemotherapy
Predictive and prognostic biomarker

Study type: Interventional

Study phase: Phase 2

Overall status: Not yet recruiting

Study design:

Allocation: Non-Randomized

Intervention model: Parallel Assignment

Intervention model description: Patients were divided into the 19del and L858R groups according to their EGFR mutation status.

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: Toripalimab plus Chemotherapy
Description: Therapy was administered on a 21-day regimen for 3 cycles, with Toripalimab (240mg, d1), carboplatin (AUC=5, d1) + pemetrexed (500 mg/m2, d1) for patients with lung adenocarcinoma and carboplatin (AUC=5, d1) + albumin-bound paclitaxel (260 mg/m2, d1) for patients with other subtypes.
Arm group label: 19DEL cohort
Arm group label: L858R cohort

Summary: This study was designed to investigate the efficacy and safety of neoadjuvant Toripalimab (anti-PD1) plus chemotherapy for patients with resectable II-IIIB non-squamous NSCLC harboring EGFR mutation, and to explore the potential predictive and prognostic biomarkers, aiming to provide more abundant evidences for the preoperative treatment decision of non-squamous NSCLC patients.

Detailed description: Previous studies have confirmed the efficacy of neoadjuvant immunotherapy in NSCLC patients without driver gene mutation, while its efficacy in driver gene mutated patients is still controversial. This study was designed to investigate the efficacy and safety of neoadjuvant Toripalimab (anti-PD1) plus chemotherapy for patients with resectable II-IIIB non-squamous NSCLC harboring EGFR mutation, and to explore the potential predictive and prognostic biomarkers, aiming to provide more abundant evidences for the preoperative treatment decision of non-squamous NSCLC patients.

Criteria for eligibility:
Criteria:
Inclusion Criteria: 1. Provision of signed informed consent by the patient or legally acceptable representative; 2. Previously untreated, histologically confirmed resectable stage II-IIIA, IIIB(N2) (AJCC staging 8th edition) non-squamous non-small cell lung cancer; 3. Adequate tissue samples for PD-L1 immunohistochemical testing and gene mutations test by RT-pCR or NGS, or consent for blood RT-PCR or NGS if tissue samples are insufficient; 4. Harboring EGFR mutation (19del or L858R); 5. Aged 18-70 years, regardless of gender; 6. Eastern Cooperative Group (ECOG) Performance Status 0-1; 7. Acceptable cardiac function with a left ventricular ejection fraction >50%; 8. Acceptable respiratory function (FEV1>1.5L, DLCO>50%) and ability to tolerate radical lung cancer surgery; 9. Acceptable bone marrow haematopoiesis with leucocytes ≥ 4 x 10^9/L, neutrophils ≥ 1.5 x 10^9/L, haemoglobin ≥ 10g/dL and platelets ≥ 100 x 10^9/L; 10. Acceptable renal function with a glomerular filtration rate ≥ 60 mL/min; 11. Acceptable liver function with total bilirubin ≤ 1.5 x ULN, AST ≤ 3 x ULN, and ALT ≤ 3 x ULN; 12. Presence of measurable lesions as defined by RECIST 1.1 criteria; 13. Women of childbearing potential must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 3 days prior to the start of study treatment, and agree to use effective contraception for the duration of study drug use and for 120 days after the last dose. Women of childbearing potential were defined as sexually mature females who 1) had not undergone hysterectomy or bilateral oophorectomy and 2) had not experienced spontaneous menopause for 12 consecutive months (amenorrhea after cancer treatment did not preclude fertility) (menstruation had occurred at any time during the previous 12 consecutive months). Exclusion Criteria: 1. Pathological histologically confirmed small cell lung cancer, squamous epithelial cell carcinoma and other pathological subtypes cannot be enrolled; 2. Patients with advanced or metastatic lung cancer, or unresectable lung cancer, or who have received previous systemic anti-tumour therapy such as immunotherapy, chemotherapy or targeted therapy cannot be enrolled; 3. Patients with a history of active autoimmune disease or autoimmune disease that is likely to recur cannot be enrolled; 4. Patients with active hepatitis B and C requiring relevant antiviral therapy need to have HBV-DNA <500 IU/ml and have been on anti-HBV treatment for at least 14 days prior to study entry and continue treatment during the treatment period; HCV RNA-positive patients should be excluded; 5. Patients who are allergic to chemotherapeutic agents such as carboplatin, paclitaxel, albumin paclitaxel, pemetrexed; 6. Patients with a history of allergy to monoclonal antibody drugs; 7. Patients who have previously received an allogeneic stem cell transplant or organ transplant； 8. Patients with mental illness or any other illness that makes it impossible to comply with treatment； 9. Patients who are unable or unwilling to sign the informed consent form； 10. Patients with comorbidities or other conditions that, in the opinion of the investigator, may affect compliance with the protocol or make them unsuitable for participation in this study.

Gender: All

Minimum age: 17 Years

Maximum age: 70 Years

Healthy volunteers: No

Start date: August 1, 2023

Completion date: June 30, 2026

Lead sponsor:
Agency: Peking University People's Hospital
Agency class: Other

Collaborator:
Agency: Shanghai Junshi Bioscience Co., Ltd.
Agency class: Other

Source: Peking University People's Hospital

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT05962021