Trial Title:
IMM2510, a PD-L1 and VEGF Bispecific Fusion Protein, in Patients With Advanced Solid Tumors
NCT ID:
NCT05972460
Condition:
Advanced Solid Tumors
Conditions: Official terms:
Neoplasms
Study type:
Interventional
Study phase:
Phase 1
Overall status:
Recruiting
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Primary purpose:
Treatment
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
IMM2510
Description:
IMM2510 is administered intravenously every 2 weeks, every 28 days for a treatment cycle.
Arm group label:
IMM2510 in Advanced Solid Tumors
Other name:
IMM2510 Injection
Summary:
This trial is a first-in-human, open-label, multi-center, dose escalation phase 1a study
followed by cohort expansion phase 1b study to evaluate the safety, efficacy,
pharmacokinetics (PK) and pharmacodynamics (PD) of IMM2510, a PD-L1 and VEGF bispecific
fusion protein, in patients with advanced solid tumors.
Detailed description:
IMM2510 is administered via intravenous infusion every 2 weeks up to 52 weeks. Phase 1a
Dose Escalation: using accelerated titration followed by 3+3 dose escalation design to
explore the maximum tolerated dose (MTD) and the recommended dose (RDE). Phase 1b Cohort
Expansion: planing to enroll at least 60 patients with different advanced solid tumors
(multiple cohorts) to further observe the safety and antitumor activity of IMM2510, and
to determine the recommended phase II dose (RP2D).
Criteria for eligibility:
Criteria:
Inclusion Criteria:
1. Subjects must voluntarily sign the informed consent form; they were able to
communicate well with the investigator and comply with the study requirements.
2. Age ≥ 18 years old.
3. Advanced solid tumors confirmed by histology or cytology, failed standard therapy,
no standard therapy, or unable to tolerate current standard therapy.
4. Presence of at least one measurable tumor lesion (according to RECIST 1.1 criteria),
defined as the maximum longest diameter of 10 mm for imaging (CT/MRI) or 15 mm for a
single pathological lymph node lesion; the presence of at least one evaluable tumor
lesion is allowed in the dose escalation phase.
5. Life expectancy of at least 3 months.
6. Eastern Cooperative Oncology Group (ECOG) score of 0 or 1.
7. Organ or bone marrow function must meet the following criteria:
1. Hematology (no blood component or cell growth factor was used to support
therapy within 7 days prior to study treatment): absolute neutrophil count ≥
1.5×109/L; Hemoglobin ≥ 90 g/L; Platelet count ≥ 100×109/L.
2. Serum total bilirubin ≤ 1.5× upper limit of normal (ULN) (unless Gilbert
syndrome is confirmed); Aspartate aminotransferase (AST) and alanine
aminotransferase (ALT) ≤ 2.5×ULN; ALT and AST were ≤ 5.0×ULN when the elevation
was judged to be due to liver metastasis.
3. Prothrombin time (PT) ≤ 1.2×ULN, partial prothrombin kinase time (APTT) ≤
1.2×ULN; International Standardized ratio (INR) ≤ 1.2 (unless receiving
warfarin treatment); After 2 weeks of oral anticoagulant therapy, the dose is
stable. If warfarin is taken orally, the patient must have an INR ≤ 2.5 and no
bleeding.
4. Endogenous creatinine clearance ≥ 50 mL/min (Cockcroft-Gault formula), urinary
protein < 2+ or protein quantity < 1.0 g.
5. Left ventricular ejection fraction (LVEF) ≥50%.
8. Toxicity of previous treatment has been restored to grade 1 [NCI CTCAE 5.0 grading
standard was adopted] (except for hair loss and chemotherapy-induced neurotoxicity ≤
grade 2 and other toxicity judged by researchers to be without safety risk).
9. Women and men of childbearing age must agree, after signing an informed consent
form, to use effective contraception during the study period and within three months
after the final dose, and women of childbearing age must have a negative pregnancy
test result 72 hours before the dose.
10. The patient is willing and able to comply with protocol visits, treatment protocols,
laboratory tests, and other requirements of the study.
Exclusion Criteria:
1. Enrol in another clinical study at the same time, unless it is an observational,
non-interventional clinical study or the follow-up period of an interventional
study.
2. Received the last systemic antitumor therapy, including chemotherapy, immunotherapy,
and biological agents, within 3 weeks before the first administration; Received
hormone antitumor therapy and small-molecule targeted therapy within 2 weeks before
the first administration; Palliative local therapy was performed for non-target
lesions within 2 weeks before the first administration; Nonspecific immunomodulatory
therapy (e.g., interleukin, interferon, thymosin, tumor necrosis factor, not IL-11
for thrombocytopenia) was administered within 2 weeks prior to initial
administration; Received Chinese herbal medicine or Chinese patent medicine with
anti-tumor indications within 1 week prior to initial administration.
3. Patients with active central nervous system (CNS) metastasis, but the following
patients were admitted: a. Treated patients with brain metastases (such as surgery
and radiotherapy), stable for at least 2 weeks after treatment (before the first
administration of the study drug), no evidence of new metastatic lesions or
metastatic lesion enlargement, and corticosteroid withdrawal ≥3 days before the
study drug administration; b. Untreated, asymptomatic subjects with brain metastases
who do not require corticosteroids and whose brain metastases are no more than 1.5
cm in length.
4. Receiving >1 programmed cell death protein-1 (PD-1) and its ligand (PD-L1)
inhibitors, such as pembrolimab, opdivo, Atzumab, or Devarumab, or > 1
anti-angiogenesis inhibitor, such as bevacizumab, ramolumab, Apatinib, or Regofenib;
Or received PD-1/PD-L1 inhibitors and antiangiogenic inhibitors at the same time
(including different time sequences of therapy).
5. Developed other malignant tumors within 5 years prior to enrollment. Exceptions: 1)
cured cervical carcinoma in situ and non-melanoma skin cancer; 2) Patients with
radical treatment, unless they had a complete response for at least 2 years prior to
enrollment and did not require additional treatment or did not require additional
treatment during the study period.
6. Active, known secondary primary cancer that has not recurred within five years;
Exceptions: 1) Both primary and secondary cancers were considered to benefit from
this study; 2) The investigators have clearly ruled out which primary tumor source
the metastases belong to.
7. History of autoimmune diseases, including but not limited to systemic lupus
erythematosus, psoriasis, rheumatoid arthritis, inflammatory bowel disease,
Hashimoto's thyroiditis, autoimmune thyroid disease, multiple sclerosis, etc. Except
the following diseases, they are allowed to be included in the group:
- Hypothyroidism that can be controlled with hormone replacement therapy alone
- Skin diseases that do not require systemic treatment (e.g. Vitiligo, psoriasis)
- Celiac disease under control.
8. Patients who had received major surgery within 4 weeks before enrollment; Had
received minor surgical procedures (including catheterization, but not peripheral
venipuncture central venous catheterization) within 2 days before enrollment.
9. High blood pressure that medications fail to control (systolic blood pressure
140mmHg and/or diastolic blood pressure 90mmHg) or pulmonary hypertension or
unstable angina pectoris; Previous myocardial infarction or bypass grafting or stent
surgery within 6 months prior to drug administration; History of chronic heart
failure with the New York Heart Association (NYHA) criteria of Grade 3-4; Clinically
significant valvular disease; Severe arrhythmias requiring treatment (except atrial
fibrillation, paroxysmal supraventricular tachycardia), Including QTcF 450ms for men
and 470ms for women (calculated by Fridericia formula); Cerebrovascular accident
(CVA) or transient ischemic attack (TIA) within 12 months before enrollment.
10. History of arterial thrombosis, deep vein thrombosis and pulmonary embolism within 6
months prior to enrollment.
11. Patients with skin wounds, surgical sites, wound sites, mucous membrane ulcers or
fractures that are not fully healed were judged by the researchers to be at risk of
bleeding when participating in the study.
12. Conditions that may cause bleeding or perforation of the digestive tract (e.g.
duodenal ulcer, intestinal obstruction, acute Crohn's disease, ulcerative colitis,
extensive removal of the stomach and small intestine, etc.); Patients with chronic
Crohn's disease and ulcerative colitis (except for total colon and rectal excision)
should be excluded even during inactive periods; Hereditary nonpolyposis colorectal
cancer or familial adenomatous polyposis syndrome; Patients with past history of
intestinal perforation and intestinal fistula, but not cured after surgical
treatment; Esophageal and gastric varices.
13. Present or past symptoms of idiopathic pulmonary fibrosis or idiopathic pneumonia;
Acute lung disease, interstitial lung disease or pneumonia (except local
interstitial pneumonia induced by radiotherapy), pulmonary fibrosis, etc.; Patients
with severe dyspnea, pulmonary insufficiency or continuous oxygen inhalation.
14. Uncontrolled fluid with repeated drainage or obvious symptoms in the chest, abdomen
and pericardium.
15. Subjects who required systemic corticosteroid (dose equivalent to > 10 mg/day of
prednisone) or other immunosuppressive drug treatment within 14 days prior to
enrollment or during the study period; The following conditions allow inclusion:
- Subjects are permitted to use topical or inhaled corticosteroids
- Short-term (≤ 7 days) use of glucocorticoids is permitted for the prevention or
treatment of non-autoimmune allergic diseases
16. Patients who were severely infected within the first 4 weeks of enrollment, or who
had any signs or symptoms of active infection within the first 2 weeks, or who
required antibiotic therapy within the first 2 weeks (except for prophylactic
antibiotics); Unexplained fever > 38.5℃ before the first administration (the
subjects could be enrolled if their fever was due to tumor, according to the
investigators).
17. People infected with active tuberculosis.
18. History of organ transplantation or hematopoietic stem cell transplantation.
19. History of human immunodeficiency virus (HIV) infection or other acquired or
congenital immunodeficiency diseases.
20. Hepatitis B surface antigen (HBs-Ag) positive, and HBV-DNA ≥ 2000 IU/mL or beyond
the normal line; Hepatitis C (HCV) ribonucleic acid (RNA) positive.
21. Attenuated vaccine is expected to be given 4 weeks before administration, during
treatment or within 30 days of the last administration.
22. Patients with previous severe allergic reactions to macromolecular protein
preparations/monoclonal antibodies.
23. Permanent discontinuation of the drug due to immune-related toxicity during previous
antitumor immunotherapy.
24. Poor compliance with a clear past history of neurological or psychiatric disorders,
such as epilepsy, dementia, or alcohol, drug or substance abuse.
25. Other conditions deemed unsuitable for participation in this clinical trial by the
investigator.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
The First Affiliated Hospital of Henan University of Science and Technology
Address:
City:
Luoyang
Country:
China
Status:
Recruiting
Contact:
Last name:
Ruinuo Jia, MD
Email:
jiaruinuo@163.com
Contact backup:
Last name:
Shegan Gao, Ph.D
Email:
gsg112258@163.com
Facility:
Name:
Shandong Provincial Institute of Cancer Prevention and Treatment
Address:
City:
Jinan
Country:
China
Status:
Recruiting
Contact:
Last name:
Yuping Sun, MD
Email:
13370582181@163.com
Facility:
Name:
Fudan University Shanghai Cancer Center
Address:
City:
Shanghai
Country:
China
Status:
Recruiting
Contact:
Last name:
Jian Zhang, MD
Email:
syner2000@163.com
Contact backup:
Last name:
Xichun Hu, MD
Email:
xchu2009@hotmail.com
Investigator:
Last name:
Xichun Hu, MD
Email:
Principal Investigator
Investigator:
Last name:
Jian Zhang, MD
Email:
Principal Investigator
Facility:
Name:
Zhejiang Cancer Hospital
Address:
City:
Hangzhou
Country:
China
Status:
Recruiting
Contact:
Last name:
Zhengbo Song, MD
Email:
songzb@zjcc.org.cn
Contact backup:
Last name:
Xiangdong Cheng, MD
Email:
chengxd516@126.com
Investigator:
Last name:
Xiangdong Cheng, MD
Email:
Principal Investigator
Start date:
August 18, 2021
Completion date:
October 2024
Lead sponsor:
Agency:
ImmuneOnco Biopharmaceuticals (Shanghai) Inc.
Agency class:
Other
Collaborator:
Agency:
Zhejiang Cancer Hospital
Agency class:
Other
Collaborator:
Agency:
Fudan University
Agency class:
Other
Source:
ImmuneOnco Biopharmaceuticals (Shanghai) Inc.
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05972460
