Predicting Radiotherapy Response and Toxicities in Soft Tissue Sarcoma of the Extremities - Cohort B

Trial Title: Predicting Radiotherapy Response and Toxicities in Soft Tissue Sarcoma of the Extremities - Cohort B

NCT ID: NCT05978024

Condition: Soft Tissue Sarcoma of the Extremities

Conditions: Official terms:
Sarcoma

Study type: Observational

Overall status: Recruiting

Study design:

Time perspective: Prospective

Summary: This is a multicentre prospective cohort study, primarily aimed at reporting the frequency and intensity of radiotherapy side-effects of patients with soft tissues sarcoma of the extremities (STSE). Two sub-studies are proposed within this study: - MRI radiation response assessment Aimed at establishing whether changes in median apparent diffusion coefficients (ADC) are predictive of pre-operative STSE response measured using histopathology. - Biomarker development and Immune mediators associated with radiotherapy Aimed at establishing prognostic markers which may refine selection of cases for pre-operative, palliative or no radiotherapy. Also, aimed at determining if radiotherapy stimulates the tumour microenvironment, resulting in measurable change in anti-tumour immunity and if certain subtypes could potentially benefit from the addition of immunotherapy with radiation. Patients participation in the sub-studies is optional.

Detailed description: This is a multicentre prospective cohort study, primarily aimed at validating the dose-volume parameters identified in the analyses of the VorteX and IMRiS trials datasets. • Delineation of healthy tissues Pre-defined outlining guidelines of normal tissues as bones, muscle compartments, joints, lymph drainage basins and subcutaneous tissue from Predict A will be delineated in radiotherapy planning computed tomography (CT) images. All cases will be delineated by a single observer (Rita Simoes). Verification of all outlines will be carried out by Dr Aisha Miah (clinical supervisor). • Dose-volume constraints validity testing Patients will be treated as per local protocol treatment technique. Radiotherapy, clinical and toxicities data will be collected, with no new intervention on the treatment. Patients enrolled will receive standard radiation prescription doses as described below: - Pre-operative radiotherapy- 50 Gy in 25 fractions equivalent (pre-operative radiotherapy). Where appropriate hypo-fractionated schedules as per institutional guidelines can considered: eg. 25 Gy/ 5 daily fractions. In myxoid liposarcomas, 36 Gy in 18 fractions can be considered where suitable; - Post-operative radiotherapy- 60 Gy in 30 fractions or 66 Gy in 33 fractions (positive resection margins); alternative hypo-fractionated schedules as per institutional guidelines can be considered; - Palliative radiotherapy- 30-36 Gy in 10-12 daily fractions, 40-45 Gy in 15 fractions, 30-36 Gy in 5-6 once weekly fractions or 25 Gy in 5 daily fractions. Toxicity will be assessed with the TESS and RTOG scoring instruments and Stern score for lymphoedema. Patients enrolled in the study will fill in a specific quality-of-life questionnaire to assess quality of life related functional outcomes following treatment for STSE. This questionnaire is based on validated questions for assessing quality-of-life. Patients will be followed up at 3, 6, 12, 18, and 24 months post-radiotherapy.

Criteria for eligibility:

Study pop:
The study population to be enrolled in this observational study will have had been diagnosed with STSE and referred to receive a course of radiotherapy either in the primary, palliative, pre-operative or post-operative settings.

Sampling method: Probability Sample
Criteria:
Inclusion Criteria: - Histopathological diagnosis of soft tissue sarcoma of the upper or lower limb or limb girdle; - Patients receiving pre-operative (neo-adjuvant), post-operative (adjuvant) or palliative radiotherapy; - Patients receiving radiotherapy planned as per local protocols (neoadjuvant chemotherapy will be allowed). Neoadjuvant chemotherapy patients may be approached as they commence chemotherapy; - WHO performance status 0-2; - Aged ≥16 years; - Patients fit enough to undergo radiotherapy treatment and willing to attend follow up visits, during two years; - Female patients of child-bearing potential and male patients with partners of child-bearing potential must agree to use adequate contraception methods, which must be continued for 3 months after completion of treatment; - Capable of giving written informed consent. Exclusion Criteria: - Previous radiotherapy to the same site; - Pregnancy; - Patients with concurrent or previous malignancy that could compromise assessment of primary and secondary endpoints of the trial.

Gender: All

Minimum age: 16 Years

Maximum age: N/A

Healthy volunteers: Accepts Healthy Volunteers

Locations:

Facility:
Name: Addenbrooke's Hospital

Address:
City: Cambridge
Zip: CB2 0QQ
Country: United Kingdom

Status: Recruiting

Contact:
Last name: Katy Cooper

Investigator:
Last name: Sarah Prewett
Email: Principal Investigator

Facility:
Name: The Royal Marsden NHS Foundation Trust

Address:
City: London
Zip: SW3 6JJ
Country: United Kingdom

Status: Recruiting

Contact:
Last name: Thuy-Giang Nguyen

Phone: +442078118090
Email: Thuy-Giang.Nguyen@rmh.nhs.uk

Investigator:
Last name: Aisha Miah
Email: Principal Investigator

Facility:
Name: University College London

Address:
City: London
Zip: WC1E 6BT
Country: United Kingdom

Status: Recruiting

Contact:
Last name: Carla Dalton

Investigator:
Last name: Mahbubl Ahmed
Email: Principal Investigator

Start date: April 16, 2021

Completion date: July 30, 2026

Lead sponsor:
Agency: Royal Marsden NHS Foundation Trust
Agency class: Other

Source: Royal Marsden NHS Foundation Trust

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT05978024