Trial Title:
A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.
NCT ID:
NCT05984277
Condition:
Metastatic Non-small Cell Lung Cancer
Conditions: Official terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Paclitaxel
Carboplatin
Pembrolizumab
Pemetrexed
Conditions: Keywords:
metastatic non-small cell lung cancer
non-squamous tumors
squamous tumors
PD-L1
Study type:
Interventional
Study phase:
Phase 3
Overall status:
Recruiting
Study design:
Allocation:
Randomized
Intervention model:
Parallel Assignment
Primary purpose:
Treatment
Masking:
None (Open Label)
Masking description:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
Volrustomig
Description:
Volrustomig
Arm group label:
Arm 1
Intervention type:
Drug
Intervention name:
Pembrolizumab
Description:
Pembrolizumab
Arm group label:
Arm 2
Intervention type:
Drug
Intervention name:
Carboplatin
Description:
Carboplatin
Arm group label:
Arm 1
Arm group label:
Arm 2
Intervention type:
Drug
Intervention name:
Paclitaxel
Description:
Paclitaxel
Arm group label:
Arm 1
Arm group label:
Arm 2
Intervention type:
Drug
Intervention name:
Pemetrexed
Description:
Pemetrexed
Arm group label:
Arm 1
Arm group label:
Arm 2
Summary:
The purpose of eVOLVE-Lung02 is to test the effectiveness (efficacy) and measure the
safety of volrustomig in combination with chemotherapy compared with pembrolizumab in
combination with chemotherapy as 1L treatment in participants with mNSCLC in PD-L1 < 50%.
Detailed description:
Adult patients with a histologically or cytologically documented metastatic NSCLC, with
tumors that lack activating EGFR, ALK, and ROS1 alterations are eligible for enrollment.
Patients will be randomized in a 1:1 ratio to receive treatment with volrustomig +
chemotherapy or pembrolizumab + chemotherapy. Tumor evaluation scans will be performed
until disease progression as efficacy assessment. All patients will be followed for
survival until the end of the study. An data monitoring committee (DMC) composed of
independent experts will be convened to confirm the safety and tolerability of the
proposed dose and schedule.
Criteria for eligibility:
Criteria:
Key Inclusion Criteria:
- Histologically or cytologically documented squamous or non-squamous NSCLC.
- Stage IV NSCLC (according to Version 8 of the IASLC Staging Manual in Thoracic
Oncology 2016), not amenable to curative surgery or radiation.
- Absence of sensitizing EGFR mutations and ALK and ROS1 rearrangements.
- Absence of documented tumor genomic alteration results from tests conducted as part
of standard local practice in any other actionable driver oncogenes for which there
are locally approved targeted first-line therapies.
Key Exclusion Criteria:
- Mixed small-cell lung cancer and NSCLC histology or sarcomatoid variant. Rare
subtypes are excluded.
- Spinal cord compression.
- Symptomatic brain metastases. Brain metastases may be treated or untreated, but
participants must be asymptomatic and off steroids for at least 14 days prior to
start of study intervention. A minimum of 2 weeks must have elapsed between the end
of whole brain radiotherapy and study enrollment.
- History of another primary malignancy except for:
1. Malignancy treated with curative intent with no known active disease ≥ 2 years
before the first dose of study intervention and of low potential risk for
recurrence.
2. Adequately treated non-melanoma skin cancer or lentigo maligna without evidence
of disease.
3. Adequately treated carcinoma in situ without evidence of disease.
- As judged by the investigator, any condition that would interfere with evaluation of
the study intervention or interpretation of participant safety or study results.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Research Site
Address:
City:
Prescott
Zip:
86301
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Hot Springs National Park
Zip:
71913
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Springdale
Zip:
72762
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Palo Alto
Zip:
94304
Country:
United States
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Lone Tree
Zip:
80124
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Newark
Zip:
19713
Country:
United States
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Fort Myers
Zip:
33901
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Orlando
Zip:
32827
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Saint Petersburg
Zip:
33705
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Tallahassee
Zip:
32308
Country:
United States
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
West Palm Beach
Zip:
33401
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Indianapolis
Zip:
46202
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Des Moines
Zip:
50309
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Louisville
Zip:
40206
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Baton Rouge
Zip:
70809
Country:
United States
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Marrero
Zip:
70072
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Annapolis
Zip:
21401
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Baltimore
Zip:
21201
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Baltimore
Zip:
21215
Country:
United States
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Silver Spring
Zip:
20904
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Towson
Zip:
21204
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Detroit
Zip:
48202
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Hattiesburg
Zip:
39401
Country:
United States
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Grand Island
Zip:
68803
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Lincoln
Zip:
68506
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Omaha
Zip:
68130
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Belleville
Zip:
07109
Country:
United States
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Albany
Zip:
12206
Country:
United States
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
East Syracuse
Zip:
13057
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Fresh Meadows
Zip:
11366
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Westbury
Zip:
11590
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Cleveland
Zip:
44195
Country:
United States
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Columbus
Zip:
43210
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Columbus
Zip:
43219
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Dayton
Zip:
45428
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Portland
Zip:
97239
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Horsham
Zip:
19044
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Pittsburgh
Zip:
15213
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Memphis
Zip:
38104
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Nashville
Zip:
37203
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Nashville
Zip:
37212
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Houston
Zip:
77090
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Lancaster
Zip:
75216
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Fairfax
Zip:
22031
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Henrico
Zip:
23229
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Tacoma
Zip:
98405
Country:
United States
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Buenos Aires
Zip:
1058
Country:
Argentina
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Caba
Zip:
1425
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Caba
Zip:
C1061
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Caba
Zip:
C1425
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Ciudad de Córdoba
Zip:
X5800HHW
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Córdoba
Zip:
5000
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
La Plata
Zip:
1900
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
La Plata
Zip:
B1900AVG
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Rosario
Zip:
2000
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Clayton
Zip:
3168
Country:
Australia
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Fitzroy
Zip:
3065
Country:
Australia
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Heidelberg
Zip:
3084
Country:
Australia
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
South Brisbane
Zip:
4101
Country:
Australia
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Sydney
Zip:
NSW 2145
Country:
Australia
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Linz
Zip:
4021
Country:
Austria
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Wels
Zip:
4600
Country:
Austria
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Aalst
Zip:
9300
Country:
Belgium
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Antwerpen
Zip:
2020
Country:
Belgium
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Gent
Zip:
9000
Country:
Belgium
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Barretos
Zip:
14784-400
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Curitiba
Zip:
80730-150
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Florianópolis
Zip:
88034-000
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Fortaleza
Zip:
60336-045
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Natal
Zip:
59075-740
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Porto Alegre
Zip:
90619-900
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Porto Alegre
Zip:
91350200
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Rio De Janeiro
Zip:
22281-100
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Santa Cruz do Sul
Zip:
96810-110
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Sao Paulo
Zip:
01221-020
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Calgary
Zip:
T2N 4N2
Country:
Canada
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Edmonton
Zip:
T6G 1Z2
Country:
Canada
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Winnipeg
Zip:
R3E 0V9
Country:
Canada
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Halifax
Zip:
B3H 1V7
Country:
Canada
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Barrie
Zip:
L4M 6M2
Country:
Canada
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Oshawa
Zip:
L1G 2B9
Country:
Canada
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Toronto
Zip:
M4N 3M5
Country:
Canada
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Levis
Zip:
G6V 3Z1
Country:
Canada
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Trois-Rivières
Zip:
G8Z 3R0
Country:
Canada
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Chicoutimi
Zip:
G7H 5H6
Country:
Canada
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Beijing
Zip:
100142
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Chengdu
Zip:
610000
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Chengdu
Zip:
611135
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Hangzhou
Zip:
310022
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Wuhan
Zip:
430022
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Wuhan
Zip:
430079
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Olomouc
Zip:
77900
Country:
Czechia
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Ostrava - Vitkovice
Zip:
703 84
Country:
Czechia
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Praha 2
Zip:
128 08
Country:
Czechia
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Praha
Zip:
140 59
Country:
Czechia
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Angers
Zip:
49055
Country:
France
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Avignon
Zip:
84902
Country:
France
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Bayonne
Zip:
64100
Country:
France
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Bordeaux
Zip:
33076
Country:
France
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Caen
Zip:
14033
Country:
France
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Lille
Zip:
59037
Country:
France
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Limoges
Zip:
87042
Country:
France
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Marseille
Zip:
13273
Country:
France
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Montpellier
Zip:
34298
Country:
France
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Paris Cedex 5
Zip:
75248
Country:
France
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Quimper cedex
Zip:
29000
Country:
France
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Reims
Zip:
51092
Country:
France
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Saint-Malo
Zip:
35403
Country:
France
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Strasbourg Cedex
Zip:
67098
Country:
France
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Suresnes
Zip:
92150
Country:
France
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Berlin-Zehlendorf
Zip:
14165
Country:
Germany
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Bonn
Zip:
53127
Country:
Germany
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Dresden
Zip:
01307
Country:
Germany
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Essen
Zip:
45136
Country:
Germany
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Gauting
Zip:
82131
Country:
Germany
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Georgsmarienhuette
Zip:
49124
Country:
Germany
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Halle
Zip:
06120
Country:
Germany
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Hamburg
Zip:
22087
Country:
Germany
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Heidelberg
Zip:
69126
Country:
Germany
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Immenhausen
Zip:
34376
Country:
Germany
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Koblenz
Zip:
56068
Country:
Germany
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Nürnberg
Zip:
90419
Country:
Germany
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Tuebingen
Zip:
72076
Country:
Germany
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Budapest
Zip:
1083
Country:
Hungary
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Budapest
Zip:
1121
Country:
Hungary
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Budapest
Zip:
1122
Country:
Hungary
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Debrecen
Zip:
4032
Country:
Hungary
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Deszk
Zip:
6772
Country:
Hungary
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Gyöngyös - Mátraháza
Zip:
3200
Country:
Hungary
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Gyöngyös
Zip:
3200
Country:
Hungary
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Győr
Zip:
9024
Country:
Hungary
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Kecskemét
Zip:
6000
Country:
Hungary
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Pécs
Zip:
7624
Country:
Hungary
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Szekszárd
Zip:
7100
Country:
Hungary
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Székesfehérvár
Zip:
8000
Country:
Hungary
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Törökbálint
Zip:
2045
Country:
Hungary
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Bengaluru
Zip:
560085
Country:
India
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Delhi
Zip:
110029
Country:
India
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Hyderabad
Zip:
500032
Country:
India
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Kolkata
Zip:
700016
Country:
India
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Kolkata
Zip:
700099
Country:
India
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Mysuru
Zip:
570017
Country:
India
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Nagpur
Zip:
440001
Country:
India
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Nashik
Zip:
422011
Country:
India
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
New Delhi
Zip:
110085
Country:
India
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Varanasi
Zip:
221005
Country:
India
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Bari
Zip:
70124
Country:
Italy
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Bergamo
Zip:
24125
Country:
Italy
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Catanzaro
Zip:
88100
Country:
Italy
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Milano
Zip:
20162
Country:
Italy
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Padova
Zip:
35128
Country:
Italy
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Parma
Zip:
43126
Country:
Italy
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Pavia
Zip:
27100
Country:
Italy
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Ravenna
Zip:
48100
Country:
Italy
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Roma
Zip:
00128
Country:
Italy
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Roma
Zip:
00144
Country:
Italy
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Bunkyo-ku
Zip:
113-8677
Country:
Japan
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Fukuoka-shi
Zip:
812-8582
Country:
Japan
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Kashiwa
Zip:
277-8577
Country:
Japan
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Kawasaki-shi
Zip:
216-8511
Country:
Japan
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Koto-ku
Zip:
135-8550
Country:
Japan
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Matsuyama-shi
Zip:
791-0280
Country:
Japan
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Nagoya-shi
Zip:
464-8681
Country:
Japan
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Okayama-shi
Zip:
700-8558
Country:
Japan
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Osaka-shi
Zip:
541-8567
Country:
Japan
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Osakasayama-shi
Zip:
589-8511
Country:
Japan
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Sagamihara-shi
Zip:
252-0375
Country:
Japan
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Sapporo-Shi
Zip:
001-0013
Country:
Japan
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Sendai-shi
Zip:
980-0873
Country:
Japan
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Ube-shi
Zip:
755-0241
Country:
Japan
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Yokohama-shi
Zip:
241-8515
Country:
Japan
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Cheongju-si
Zip:
28644
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Incheon
Zip:
21565
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Jinju-si
Zip:
52727
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Seoul
Zip:
03080
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Seoul
Zip:
06351
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Seoul
Zip:
06591
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Suwon-si
Zip:
16499
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Suwon
Zip:
16247
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Ciudad de México
Zip:
03840
Country:
Mexico
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Ciudad de México
Zip:
06700
Country:
Mexico
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Culiacan
Zip:
80040
Country:
Mexico
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Guadalajara
Zip:
44638
Country:
Mexico
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Guadalajara
Zip:
44680
Country:
Mexico
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Mexico City
Zip:
'14080
Country:
Mexico
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Monterrey
Zip:
64060
Country:
Mexico
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Naucalpan
Zip:
53100
Country:
Mexico
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Amsterdam
Zip:
1081 HV
Country:
Netherlands
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Groningen
Zip:
9728 NT
Country:
Netherlands
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Nieuwegein
Zip:
3435 CM
Country:
Netherlands
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Tilburg
Zip:
5042AD
Country:
Netherlands
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Lublin
Zip:
20-090
Country:
Poland
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Olsztyn
Zip:
10-357
Country:
Poland
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Poznań
Zip:
60-569
Country:
Poland
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Przemysl
Zip:
37-700
Country:
Poland
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Radom
Zip:
26-600
Country:
Poland
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Rzeszów
Zip:
35-241
Country:
Poland
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Szklarska Poręba
Zip:
58-580
Country:
Poland
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Tomaszów Mazowiecki
Zip:
97-200
Country:
Poland
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Toruń
Zip:
87-100
Country:
Poland
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Warszawa
Zip:
01-138
Country:
Poland
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Warszawa
Zip:
02-781
Country:
Poland
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Łódź
Zip:
90-549
Country:
Poland
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
Banska Bystrica
Zip:
97517
Country:
Slovakia
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Bratislava
Zip:
82606
Country:
Slovakia
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Bratislava
Zip:
833 01
Country:
Slovakia
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Kosice
Zip:
041 91
Country:
Slovakia
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Trnava
Zip:
917 75
Country:
Slovakia
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Amanzimtoti
Zip:
4126
Country:
South Africa
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Bloemfontein
Zip:
9301
Country:
South Africa
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
George
Zip:
6529
Country:
South Africa
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
George
Zip:
6529
Country:
South Africa
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Johannesburg
Zip:
2196
Country:
South Africa
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Parktown
Zip:
2193
Country:
South Africa
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Pietermaritzburg
Zip:
3245
Country:
South Africa
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Pretoria
Zip:
0002
Country:
South Africa
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Rondebosch
Zip:
7700
Country:
South Africa
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Soweto
Zip:
2013
Country:
South Africa
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Alicante
Zip:
03010
Country:
Spain
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Barcelona
Zip:
08003
Country:
Spain
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Barcelona
Zip:
08025
Country:
Spain
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Bilbao (Vizcaya)
Zip:
48013
Country:
Spain
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Madrid
Zip:
28040
Country:
Spain
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Málaga
Zip:
29011
Country:
Spain
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Palma
Zip:
07198
Country:
Spain
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Hsinchu
Zip:
300
Country:
Taiwan
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Kaohsiung
Zip:
80756
Country:
Taiwan
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
New Taipei
Zip:
220
Country:
Taiwan
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Tainan
Zip:
70403
Country:
Taiwan
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Taipei City
Zip:
110
Country:
Taiwan
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Taipei
Zip:
100
Country:
Taiwan
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Taipei
Zip:
112
Country:
Taiwan
Status:
Active, not recruiting
Facility:
Name:
Research Site
Address:
City:
Taipei
Zip:
11490
Country:
Taiwan
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Taoyuan
Zip:
33305
Country:
Taiwan
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Yunlin
Zip:
640
Country:
Taiwan
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Lampang
Zip:
52000
Country:
Thailand
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Muang
Zip:
50200
Country:
Thailand
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Songkhla
Zip:
90110
Country:
Thailand
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Ankara
Zip:
6500
Country:
Turkey
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Antalya
Zip:
07059
Country:
Turkey
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Diyarbakir
Zip:
21280
Country:
Turkey
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Istanbul
Zip:
34722
Country:
Turkey
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
İzmir
Zip:
35100
Country:
Turkey
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Pamukkale
Zip:
20070
Country:
Turkey
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Çankaya
Zip:
06680
Country:
Turkey
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Birmingham
Zip:
B9 5SS
Country:
United Kingdom
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Blackpool
Zip:
FY3 8NR
Country:
United Kingdom
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Bury St Edmunds
Zip:
IP332QZ
Country:
United Kingdom
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
Colchester
Zip:
CO4 5JL
Country:
United Kingdom
Status:
Not yet recruiting
Facility:
Name:
Research Site
Address:
City:
London
Zip:
EC1A 7BE
Country:
United Kingdom
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
London
Zip:
NW3 2QG
Country:
United Kingdom
Status:
Withdrawn
Facility:
Name:
Research Site
Address:
City:
London
Zip:
SW10 9NH
Country:
United Kingdom
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
London
Zip:
SW170QT
Country:
United Kingdom
Status:
Recruiting
Facility:
Name:
Research Site
Address:
City:
Truro
Zip:
TR1 3LJ
Country:
United Kingdom
Status:
Recruiting
Start date:
October 24, 2023
Completion date:
May 16, 2029
Lead sponsor:
Agency:
AstraZeneca
Agency class:
Industry
Source:
AstraZeneca
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05984277
https://filehosting-v2.pharmacm.com/api/Attachment/Download?tenantId=80217111&parentIdentifier=D798AC00001&attachmentIdentifier=2b0100f7-99dd-4c7e-97dd-c32af12549d1&fileName=D798AC00001_CTIS_structured_data_update.pdf&versionIdentifier=
