Magnetic Resonance Elastography in Glioma: Exploring Tumor Stiffness and Adhesion

Trial Title: Magnetic Resonance Elastography in Glioma: Exploring Tumor Stiffness and Adhesion

NCT ID: NCT05990244

Condition: Glioma

Conditions: Official terms:
Glioma

Conditions: Keywords:
Magnetic Resonance Elastography
Brain tumor
Glioblastoma
MR elastography
Tumor molecular pathology

Study type: Interventional

Study phase: N/A

Overall status: Recruiting

Study design:

Allocation: N/A

Intervention model: Single Group Assignment

Primary purpose: Diagnostic

Masking: None (Open Label)

Intervention:

Intervention type: Diagnostic Test
Intervention name: Magnetic Resonance Elastography
Description: Undergo MRE and routine MRI
Arm group label: Diagnostic (MRE, tumor grade, tumor stiffness and adhesion)

Other name: MRE

Intervention type: Procedure
Intervention name: Assessment and Recording
Description: Undergo recording of tumor stiffness during surgery and molecular pathological classification through genetic analysis
Arm group label: Diagnostic (MRE, tumor grade, tumor stiffness and adhesion)

Summary: this study will investigate the relationship between tumor stiffness and adhesion in gliomas using MRE. By utilizing preoperative MRE and Intraoperative neuronavigation, followed by comprehensive molecular pathology analysis, we aim to explore the correlation of tumor stiffness and adhesion with molecular and genetic characteristics of gliomas. Additionally, the predictive value of MRE in terms of pathological staging and prognosis will be determined. This research may pave the way for improved clinical decision-making, personalized treatment approaches, and more accurate clinical trials for glioma patients.

Detailed description: Magnetic Resonance Elastography (MRE) is an advanced imaging technique that measures the mechanical properties of tissues, providing valuable information about tissue stiffness, elasticity, and adhesion. In the case of gliomas, a type of brain tumor arising from glial cells, MRE has shown promising potential in the diagnosis, classification, and prediction of pathological and molecular features. This clinical trial aims to investigate the relationship between tumor stiffness, adhesion, glioma grading, and genetic alterations by combining magnetic resonance elastography (MRE) imaging findings with molecular pathological analysis. Moreover, the study aims to predict patient survival based on the physical properties of the tumor. Preoperatively, we will use MRE to enhance the accuracy of navigation and determine tumor stiffness and adhesion properties. Intraoperatively, under the guidance of neuronavigation, tissue samples will be obtained, and the operating surgeon will assess the tumor's stiffness, elasticity, and degree of adhesion. Postoperatively, all tissue specimens will undergo molecular pathological analysis. The integration of MRE findings with molecular pathology data will enable precise classification and subtyping of gliomas. Furthermore, all patients will receive systematic treatment after surgery, and long-term follow-ups will be conducted. This comprehensive approach combining MRE, molecular pathology analysis, and clinical follow-up aims to investigate the predictive value of MRE in terms of molecular pathological features and prognosis in gliomas.

Criteria for eligibility:
Criteria:
Inclusion Criteria: - All patients undergoing glioma resection surgery are eligible for inclusion in the study cohort. Exclusion Criteria: - Patients with metallic implants or foreign bodies in their bodies (pacemakers, artificial metallic heart valves, metal joints, metal implants, and those who cannot remove dentures, insulin pumps, or contraceptive rings) - Pregnant women in the first trimester (within three months) - Patients with severe claustrophobia or anxiety - Patients with severe fever - Patients who can not tolerate MRE - Patients with vascular malformations and aneurysms. - Patients who do not sign an informed consent

Gender: All

Minimum age: 18 Years

Maximum age: 80 Years

Healthy volunteers: Accepts Healthy Volunteers

Locations:

Facility:
Name: Shengjing Hospital

Address:
City: Shenyang
Zip: 110000
Country: China

Status: Recruiting

Contact:
Last name: Yu Shi, MD

Phone: +8618940259980
Email: 18940259980@163.com

Contact backup:
Last name: Anhua Wu, MD

Phone: +8618900925766
Email: wuanhua@yahoo.com

Investigator:
Last name: Yu Shi, MD
Email: Principal Investigator

Investigator:
Last name: Anhua Wu, MD
Email: Principal Investigator

Investigator:
Last name: Wen Cheng, MD
Email: Principal Investigator

Start date: July 1, 2023

Completion date: July 1, 2026

Lead sponsor:
Agency: Shengjing Hospital
Agency class: Other

Source: Shengjing Hospital

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT05990244