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Trial Title:
Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity
NCT ID:
NCT05998486
Condition:
Parkinson
Cerebellar Tumor
Rest Tremor
Diagnoses Disease
Movement; Abnormal, Involuntary
Conditions: Official terms:
Cerebellar Neoplasms
Parkinson Disease
Tremor
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Retrospective
Intervention:
Intervention type:
Diagnostic Test
Intervention name:
EMG in wrist flexor-pronators and extensor-supinators
Description:
The subject is asked to perform a series of tasks: resting posture, symmetrical posture
arms forward, unilateral distal movement. Each task lasts 10 seconds.
Arm group label:
Cerebellar tremor
Arm group label:
Tremor of rest
Summary:
Resting tremors associated with Parkinson's disease (PD) remains difficult to quantify
and track during disease progression. This study propose to explore the rhythmicity of
distal muscle contractions in the upper limb to characterize resting tremor and
discriminate it from cerebellar tremor (CT) based on the frequency spectrum of the EMG
signal.
Detailed description:
This retrospective study analyzed surface EMG recordings of wrist flexor-pronators and
extensor-supinators from patients with PD or CT bilaterally in five 10-second conditions:
rest with contralateral motor distraction, symmetrical arms extended forward posture with
hands pronated, semi-pronation, supination, and elbows flexed with hands pronated. The
rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak
to the total area of the spectrum between 1.5-12Hz.
Criteria for eligibility:
Study pop:
Patients with Parkinson's disease or cerebellar tremor diagnosis.
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- patient who performed surface EMG recordings of wrist flexor-pronators and
extensor-supinators in Laboratories;
- diagnosis of Parkinson's disease or cerebellar tremor.
Exclusion Criteria:
- Botulinium toxin injection in upper limb during a delay of 3 months before surface
EMG recordings;
- Levodopa drugs administrated during a delay of 12 hours before surface EMG
recordings;
- Tremor-favour drugs administrated during a delay of 30 days before surface EMG
recordings;
- Presence of an other neurologic disease or of any disease associated with motor
disorders in upper limb.
Gender:
All
Minimum age:
18 Years
Maximum age:
100 Years
Healthy volunteers:
No
Locations:
Facility:
Name:
Laboratoire Analyse et Restauration du Mouvement
Address:
City:
Créteil
Country:
France
Status:
Recruiting
Contact:
Last name:
Emilie Hutin, PhD
Phone:
+33149812549
Email:
emilie.hutin@aphp.fr
Start date:
April 3, 2023
Completion date:
December 31, 2023
Lead sponsor:
Agency:
Henri Mondor University Hospital
Agency class:
Other
Source:
Henri Mondor University Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT05998486
