Trial Title:
A Study of Sigvotatug Vedotin Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer (Be6A Lung-01).
NCT ID:
NCT06012435
Condition:
Carcinoma, Non-Small-Cell Lung
Conditions: Official terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Docetaxel
Conditions: Keywords:
NSCLC
Non-Small Lung Cancer
Seattle Genetics
Study type:
Interventional
Study phase:
Phase 3
Overall status:
Recruiting
Study design:
Allocation:
Randomized
Intervention model:
Parallel Assignment
Primary purpose:
Treatment
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
sigvotatug vedotin
Description:
Given into the vein (IV; intravenously) on Day 1 and 15 of a 28-day cycle
Arm group label:
Experimental Arm
Other name:
SGN-B6A; PF-08046047
Intervention type:
Drug
Intervention name:
docetaxel
Description:
75 mg/m^2 given into the vein (IV; intravenously) on Day 1 of a 21-day cycle
Arm group label:
Control Arm
Summary:
This clinical trial is studying nonsquamous non-small cell lung cancer (NSCLC).
Participants in this study must have cancer that has spread through their body or can't
be removed with surgery. Participants in this study must have been treated with no more
than a platinum-based chemotherapy and an anti-PD-(L)1 drug. Participants with tumors
that have certain treatable genomic alterations must have had at least 1 drug for that
genomic alteration, in addition to platinum-based chemotherapy.
This clinical trial uses an experimental drug called sigvotatug vedotin, which is a type
of antibody drug conjugate or ADC. ADCs are designed to stick to cancer cells and kill
them. This clinical trial also uses a drug called docetaxel. Docetaxel is an anticancer
drug that has been approved to treat non-small cell lung cancer. It is usually given to
patients who previously received another anticancer treatment. In this study, one group
of participants will get sigvotatug vedotin on Days 1 and 15 during each 28-day-cycle. A
second group of participants will get docetaxel on Day 1 during each 21-day cycle.
This study is being done to see if sigvotatug vedotin works better than docetaxel to
treat participants with NSCLC. This study will also test what side effects happen when
participants take these drugs. A side effect is anything a drug does to the body besides
treating the disease.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Histologically or cytologically confirmed diagnosis of locally advanced,
unresectable (Stage IIIB, IIIC), or metastatic Stage IV (M1a, M1b, or M1c) NSCLC
American Joint Committee on Cancer (AJCC) Staging Manual, Version 8.0, and the Union
for International Cancer Control (UICC) Staging System (Eighth edition).
- Participants must have NSCLC with nonsquamous histology
- Tumors with squamous, or predominantly squamous histology are excluded.
- Tumors with small cell elements are excluded.
- Participants who have NSCLC with known actionable genomic alteration (AGAs) are
permitted
- Participants must have received the following prior therapies and progressed during
or relapsed after receiving their most recent prior therapy:
- Participants with no known AGAs must fulfill 1 of the following conditions:
- Received a platinum-based combination therapy for the treatment of
metastatic or recurrent disease and a PD-(L)1 monoclonal antibody
(concurrently or sequentially with platinum-based chemotherapy), unless
contraindicated.
- Experienced disease progression within 6 months of the last dose of
platinum-based chemotherapy in the adjuvant or neoadjuvant setting and
received a PD-(L)1 monoclonal antibody at any time during the course of
treatment.
- Participants with known AGAs must fulfill the following conditions:
- Must have received at least 1 relevant AGA targeted therapy and in the
opinion of the investigator, additional AGA targeted therapy is not in the
best interest of the participant.
- Received a platinum-based combination therapy for the treatment of
metastatic or recurrent disease, or experienced disease progression within
6 months of the last dose of platinum-based chemotherapy in the adjuvant
or neoadjuvant setting
- May have received up to 1 PD-(L)1 monoclonal antibody (concurrently or
sequentially with platinum-based chemotherapy).
- Measurable disease based on RECIST v1.1
- Participants must have an Eastern Cooperative Oncology Group (ECOG) performance
status of 0 or 1, with adequate baseline hematologic, hepatic, and renal function
and measurable disease according to RECIST v1.1
Exclusion Criteria:
- Life expectancy of less than (<) 3 months
- Known allergies/hypersensitivity/intolerance to or contraindication of taxanes,
docetaxel, or any excipient contained in the drug formulation of sigvotatug vedotin
- History of another malignancy within 3 years before Cycle 1 Day 1, or any evidence
of residual disease from a previously diagnosed malignancy. Exceptions are
malignancies with a negligible risk of metastasis or death
- Participants with any of the following respiratory conditions:
- Evidence of noninfectious interstitial lung disease (ILD) or pneumonitis that:
- Was previous diagnosed and required systemic steroids, or
- Is currently diagnosed and managed, or
- Is suspected on radiologic imaging at screening
- Known diffusing capacity of the lung for carbon monoxide (DLCO) < 50%
- Any Grade greater than or equal to (≥) 3 pulmonary disease unrelated to
underlying malignancy
- Pre-existing peripheral neuropathy Grade greater than or equal to (≥) 2
- Uncontrolled diabetes mellitus
- Prior therapy:
- Prior treatment with antimicrotubule agents (taxanes, vinca alkaloids, or
MMAEs) in the locally advanced, unresectable/refractory, or metastatic setting
- Prior antimicrotubule agent exposure in curative settings (including adjuvant,
neoadjuvant, or chemoradiotherapy) is permissible.
- Received more than 1 prior line of cytotoxic chemotherapy in the locally
advanced, unresectable/refractory, or metastatic setting
- Prior cytotoxic chemotherapy in curative settings is permissible
- At least 14 days must have elapsed from the last dose of radiotherapy until
Cycle 1 Day 1.
- Prior radiation therapy to the lung parenchyma that is >30 Gray (Gy) within 6
months of Cycle 1 Day 1.
- Any systemic anticancer therapy (standard or experimental) within 21 days prior
to Cycle 1 Day 1.
- Active central nervous system (CNS) lesions, including leptomeningeal metastasis,
are excluded. Participants with definitively treated brain metastases are eligible
in they meet the following criteria:
- Have been clinically stable for at least 4 weeks prior to treatment initiation
and baseline scans show no evidence of new or enlarged metastasis
- On a stable dose of less than or equal to (≤) 10mg/day of prednisone or
equivalent for a least 2 weeks (if requiring steroid treatment)
- Treatment with corticosteroids greater than (>) 1 month prior to Screening
visit
- No evidence of clinical and radiographic disease progression in the CNS for ≥
21 days after definitive radiotherapy and/or surgery
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Alaska Oncology and Hematology
Address:
City:
Anchorage
Zip:
99508
Country:
United States
Status:
Recruiting
Contact:
Last name:
Talia Wyckoff
Phone:
907-257-9851
Email:
talia@alaskaoncology.com
Investigator:
Last name:
Steven Liu, MD
Email:
Principal Investigator
Facility:
Name:
Arizona Oncology Associates
Address:
City:
Prescott
Zip:
86301
Country:
United States
Status:
Recruiting
Contact:
Last name:
Iyad Hamarneh
Email:
Iyad.hamarneh@usoncology.com
Investigator:
Last name:
Iyad Hamarneh
Email:
Principal Investigator
Facility:
Name:
Comprehensive Blood and Cancer Center TRIO
Address:
City:
Bakersfield
Zip:
93309
Country:
United States
Status:
Recruiting
Contact:
Last name:
Maria Carrillo
Phone:
661-322-2206 (X2123)
Email:
mcarrillo@cbccusa.com
Investigator:
Last name:
Ravi Patel
Email:
Principal Investigator
Facility:
Name:
Providence Medical Foundation
Address:
City:
Fullerton
Zip:
92835
Country:
United States
Status:
Recruiting
Contact:
Last name:
Rebeca Sanchez
Phone:
714-446-7819
Email:
Rebeca.sanchez@providence.org
Investigator:
Last name:
David J Park
Email:
Principal Investigator
Facility:
Name:
Cancer and Blood Specialty Clinic
Address:
City:
Los Alamitos
Zip:
92720
Country:
United States
Status:
Recruiting
Investigator:
Last name:
Vu Phan
Email:
Principal Investigator
Facility:
Name:
St. Joseph Hospital Orange
Address:
City:
Orange
Zip:
92868
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ronald Bati
Email:
Ron.Bati@stjoe.org
Investigator:
Last name:
Timothy Byun
Email:
Principal Investigator
Facility:
Name:
University of California, San Francisco | HDFCCC - Hematopoietic Malignancies
Address:
City:
San Francisco
Zip:
94158
Country:
United States
Status:
Recruiting
Contact:
Last name:
Lisa Tan
Phone:
415-866-7866
Email:
lisa.tan@ucsf.edu
Investigator:
Last name:
Michael Cheng
Email:
Principal Investigator
Facility:
Name:
Sansum Clinic
Address:
City:
Santa Barbara
Zip:
93105
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ben Singh
Email:
Ben.singh@scri.com
Investigator:
Last name:
Eric Bank
Email:
Principal Investigator
Facility:
Name:
Rocky Mountain Cancer Centers - Aurora
Address:
City:
Lone Tree
Zip:
80124
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ben Singh
Email:
Ben.singh@scri.com
Investigator:
Last name:
Robert Jotte
Email:
Principal Investigator
Facility:
Name:
Miami Cancer Institute at Baptist Health, Inc.
Address:
City:
Miami
Zip:
33176
Country:
United States
Status:
Recruiting
Contact:
Last name:
Xiaoou Pan
Email:
Xiaoou.Pan@baptisthealth.net
Investigator:
Last name:
Manmeet Ahluwalia
Email:
Principal Investigator
Facility:
Name:
Cancer Care Centers of Brevard, Inc.
Address:
City:
Palm Bay
Zip:
32901
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ben Singh
Email:
Ben.singh@scri.com
Investigator:
Last name:
Venkat Kancharla
Email:
Principal Investigator
Facility:
Name:
Illinois Cancer Care
Address:
City:
Niles
Zip:
60714
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ben Singh
Email:
Ben.singh@scri.com
Investigator:
Last name:
David Hakimian
Email:
Principal Investigator
Facility:
Name:
Cancer Center of Kansas
Address:
City:
Wichita
Zip:
67214
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ryan Ashkar
Email:
Ryan.ashkar@cancercenterofkansas.com
Investigator:
Last name:
Shaker R Dakhil
Email:
Principal Investigator
Facility:
Name:
Maryland Oncology Hematology, P.A.
Address:
City:
Annapolis
Zip:
21401
Country:
United States
Status:
Recruiting
Contact:
Last name:
Corilynn Hughes
Phone:
301-424-6231
Email:
Corilynn.hughes@usoncology.com
Investigator:
Last name:
Benjamin Bridges
Email:
Principal Investigator
Facility:
Name:
Southcoast Health
Address:
City:
Fall River
Zip:
02720
Country:
United States
Status:
Recruiting
Contact:
Last name:
Sonia Seng
Email:
sengs@southcoast.org
Investigator:
Last name:
Sonia Seng
Email:
Principal Investigator
Facility:
Name:
Beth Israel Deaconess Medical Center
Address:
City:
Milton
Zip:
02215
Country:
United States
Status:
Recruiting
Contact:
Last name:
Malina Nguyen
Phone:
617-667-2100
Investigator:
Last name:
Deepa Rangachari
Email:
Principal Investigator
Facility:
Name:
Minnesota Oncology Hematology P.A.
Address:
City:
Minneapolis
Zip:
55404
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ben Singh
Email:
Ben.singh@scri.com
Investigator:
Last name:
Eric M. Lander
Email:
Principal Investigator
Facility:
Name:
Allina Health Cancer Institute
Address:
City:
Minneapolis
Zip:
55407
Country:
United States
Status:
Recruiting
Contact:
Last name:
Holly J Desma
Phone:
612-863-8950
Email:
holly.desma@allina.com
Investigator:
Last name:
Charlene Fares
Email:
Principal Investigator
Facility:
Name:
Hattiesburg Clinic Hematology/Oncology
Address:
City:
Hattiesburg
Zip:
39401
Country:
United States
Status:
Recruiting
Investigator:
Last name:
John Hrom
Email:
Principal Investigator
Facility:
Name:
Saint Luke's Cancer Institute LLC
Address:
City:
Kansas City
Zip:
64111
Country:
United States
Status:
Completed
Facility:
Name:
University of Nebraska Medical Center
Address:
City:
Omaha
Zip:
68198
Country:
United States
Status:
Recruiting
Contact:
Last name:
Debbie Vidlak
Phone:
402-559-5166
Email:
dvidlak@unmc.edu
Investigator:
Last name:
Omar Abughanimeh
Email:
Principal Investigator
Facility:
Name:
Comprehensive Cancer Centers of Nevada
Address:
City:
Las Vegas
Zip:
89169
Country:
United States
Status:
Recruiting
Contact:
Last name:
Meng-Yun (Megan) Wu
Email:
megan.wu@usoncology.com
Investigator:
Last name:
Edwin C Kingsley
Email:
Principal Investigator
Facility:
Name:
Summit Medical Group
Address:
City:
Florham Park
Zip:
07932
Country:
United States
Status:
Recruiting
Contact:
Last name:
Michelle Mackenzie
Phone:
973-436-1755
Email:
mmackenzie@smgnj.com
Investigator:
Last name:
Sarada Gurubhagavatula
Email:
Principal Investigator
Facility:
Name:
New Mexico Cancer Center
Address:
City:
Albuquerque
Zip:
87131
Country:
United States
Status:
Recruiting
Contact:
Last name:
Jessica White
Phone:
505-272-7414
Email:
jesswhite@salud.unm.edu
Investigator:
Last name:
Martha Mapalo
Email:
Principal Investigator
Facility:
Name:
NYU Langone Hospital
Address:
City:
Mineola
Zip:
11501
Country:
United States
Status:
Recruiting
Investigator:
Last name:
Jeffrey Schneider
Email:
Principal Investigator
Facility:
Name:
NYU Langone Hospital
Address:
City:
New York
Zip:
10016
Country:
United States
Status:
Recruiting
Contact:
Last name:
Zoe Swainson
Phone:
332-259-7524
Email:
Zoe.Swainson@nyulangone.org
Investigator:
Last name:
Jeffrey Schneider
Email:
Principal Investigator
Facility:
Name:
Oncology Hematology Care
Address:
City:
Cincinnati
Zip:
45242
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ben Singh
Email:
Ben.singh@scri.com
Investigator:
Last name:
David Waterhouse
Email:
Principal Investigator
Facility:
Name:
University Hospitals Cleveland Medical Center
Address:
City:
Cleveland
Zip:
44106
Country:
United States
Status:
Recruiting
Contact:
Last name:
Katie Peterson
Email:
Catherine.Peterson@UHhospitals.org
Investigator:
Last name:
Giselle Dutcher
Email:
Principal Investigator
Facility:
Name:
Cleveland Clinic Fairview Hospital
Address:
City:
Cleveland
Zip:
44111
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ellen Loftus
Email:
loftuse@ccf.org
Investigator:
Last name:
Nathan Pennell
Email:
Principal Investigator
Facility:
Name:
Cleveland Clinic, The
Address:
City:
Cleveland
Zip:
44195
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ellen Loftus
Phone:
216-442-5347
Email:
loftuse@ccf.org
Investigator:
Last name:
Nathan Pennell
Email:
Principal Investigator
Facility:
Name:
Cleveland Clinic Hillcrest Hospital
Address:
City:
Mayfield Heights
Zip:
44124
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ellen Loftus
Phone:
216-442-5347
Email:
loftuse@ccf.org
Investigator:
Last name:
Nathan Pennell
Email:
Principal Investigator
Facility:
Name:
Willamette Valley Cancer Institute and Research Center
Address:
City:
Eugene
Zip:
97401
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ben Singh
Email:
Ben.singh@scri.com
Investigator:
Last name:
Bo Wang
Email:
Principal Investigator
Facility:
Name:
Oregon Health and Science University
Address:
City:
Portland
Zip:
97239
Country:
United States
Status:
Recruiting
Contact:
Last name:
Enrica DiMicco
Phone:
971-262-9817
Email:
dimicco@ohsu.edu
Investigator:
Last name:
Ted Huang
Email:
Principal Investigator
Facility:
Name:
Northwest Cancer Centers, P.C.
Address:
City:
Tigard
Zip:
97223
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ben Singh
Email:
Ben.singh@scri.com
Investigator:
Last name:
Anthony Van Ho
Email:
Principal Investigator
Facility:
Name:
Alliance Cancer Specialists, PC
Address:
City:
Horsham
Zip:
19044
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ben Singh
Email:
Ben.singh@scri.com
Investigator:
Last name:
Joseph Potz
Email:
Principal Investigator
Facility:
Name:
Texas Oncology
Address:
City:
Austin
Zip:
78745
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ben Singh
Email:
Ben.singh@scri.com
Investigator:
Last name:
James V Uyeki
Email:
Principal Investigator
Facility:
Name:
Texas Oncology
Address:
City:
Odessa
Zip:
79761
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ben Singh
Email:
Ben.singh@scri.com
Investigator:
Last name:
Pankaj Khandelwal
Email:
Principal Investigator
Facility:
Name:
UT Health East Texas Hope Cancer Center
Address:
City:
Tyler
Zip:
75701
Country:
United States
Status:
Recruiting
Contact:
Last name:
Chaney Story
Email:
Chaney.Story@uthct.edu
Investigator:
Last name:
Robert Droder
Email:
Principal Investigator
Facility:
Name:
Texas Oncology
Address:
City:
Webster
Zip:
77598
Country:
United States
Status:
Recruiting
Contact:
Last name:
Ben Singh
Email:
Ben.singh@scri.com
Investigator:
Last name:
Pavel Levin
Email:
Principal Investigator
Facility:
Name:
Oncology and Hematology Associates of Southwest Virginia
Address:
City:
Blacksburg
Zip:
24060
Country:
United States
Status:
Recruiting
Contact:
Last name:
Katelyn Doxsee
Phone:
540-381-5291
Email:
Katelyn.Doxsee@usoncology.com
Investigator:
Last name:
Jerome Goldschmidt
Email:
Principal Investigator
Facility:
Name:
Vista Oncology Inc PS
Address:
City:
Olympia
Zip:
98506
Country:
United States
Status:
Recruiting
Contact:
Last name:
Yiqun (Lydia) Xue
Phone:
360-413-8880
Email:
yiqun.xue@aoncology.com
Investigator:
Last name:
Joseph Z Ye
Email:
Principal Investigator
Facility:
Name:
Sanatorio Parque
Address:
City:
Rosario
Zip:
S2000DSV
Country:
Argentina
Status:
Recruiting
Investigator:
Last name:
Gaston Martinengo
Email:
Principal Investigator
Facility:
Name:
Instituto de Oncologia de Rosario
Address:
City:
Rosario
Zip:
S2000KZE
Country:
Argentina
Status:
Recruiting
Investigator:
Last name:
Luis Enrique Fein
Email:
Principal Investigator
Facility:
Name:
Calvary Mater Newcastle
Address:
City:
Waratah
Zip:
2298
Country:
Australia
Status:
Recruiting
Investigator:
Last name:
Girish Mallesara Hiriyanna Gowda
Email:
Principal Investigator
Facility:
Name:
AKH - Medizinische Universitat Wien
Address:
City:
Vienna
Zip:
1090
Country:
Austria
Status:
Recruiting
Investigator:
Last name:
Barbara Kiesewetter-Wiederkehr
Email:
Principal Investigator
Facility:
Name:
Algemeen Ziekenhuis Klina
Address:
City:
Brasschaat
Zip:
2930
Country:
Belgium
Status:
Recruiting
Investigator:
Last name:
Wim Demey
Email:
Principal Investigator
Facility:
Name:
Universitair Ziekenhuis Antwerpen
Address:
City:
Edegem
Zip:
2650
Country:
Belgium
Status:
Recruiting
Investigator:
Last name:
Reinier Wener
Email:
Principal Investigator
Facility:
Name:
University Hospital Ghent
Address:
City:
Ghent
Zip:
9000
Country:
Belgium
Status:
Recruiting
Investigator:
Last name:
Karim Vermaelen
Email:
Principal Investigator
Facility:
Name:
Jessa Ziekenhuis - Campus Virga Jesse
Address:
City:
Hasselt
Zip:
3500
Country:
Belgium
Status:
Recruiting
Investigator:
Last name:
Kristof Cuppens
Email:
Principal Investigator
Facility:
Name:
CHU de Liege
Address:
City:
Liege
Zip:
4000
Country:
Belgium
Status:
Recruiting
Investigator:
Last name:
Marie Lecocq
Email:
Principal Investigator
Facility:
Name:
Tom Baker Cancer Centre
Address:
City:
Calgary
Zip:
T2N4N2
Country:
Canada
Status:
Recruiting
Investigator:
Last name:
Vishal Navani
Email:
Principal Investigator
Facility:
Name:
University of Alberta / Cross Cancer Institute
Address:
City:
Edmonton
Zip:
T6G 1Z2
Country:
Canada
Status:
Recruiting
Investigator:
Last name:
David Fenton
Email:
Principal Investigator
Facility:
Name:
William Osler Health Sciences
Address:
City:
East Brampton
Zip:
L6R 3J7
Country:
Canada
Status:
Recruiting
Investigator:
Last name:
Parneet Cheema, MD
Email:
Principal Investigator
Facility:
Name:
Ottawa Hospital Cancer Centre
Address:
City:
Ottawa
Zip:
K1H 8L6
Country:
Canada
Status:
Recruiting
Investigator:
Last name:
Sara Moore
Email:
Principal Investigator
Facility:
Name:
Sunnybrook Health Sciences Centre
Address:
City:
Toronto
Zip:
M4N 3M5
Country:
Canada
Status:
Recruiting
Investigator:
Last name:
Ines Menjak
Email:
Principal Investigator
Facility:
Name:
Centre Hospitalier de l'Universite de Montreal
Address:
City:
Montreal
Zip:
H2X 0C2
Country:
Canada
Status:
Recruiting
Investigator:
Last name:
Normand Blais
Email:
Principal Investigator
Facility:
Name:
McGill University Department of Oncology / McGill University Health Centre
Address:
City:
Montreal
Zip:
H4A 3J1
Country:
Canada
Status:
Recruiting
Investigator:
Last name:
Ramy Saleh
Email:
Principal Investigator
Facility:
Name:
Fakultni Nemocnice Olomouc (Fnol) - Onkologicka Klinika
Address:
City:
Olomouc
Zip:
779 00
Country:
Czechia
Status:
Recruiting
Investigator:
Last name:
Bohuslav Melichar
Email:
Principal Investigator
Facility:
Name:
Vseobecna fakultni nemocnice v Praze
Address:
City:
Prague
Zip:
128 08
Country:
Czechia
Status:
Recruiting
Investigator:
Last name:
Milada Zemanova
Email:
Principal Investigator
Facility:
Name:
Centre Hospitalier de Cholet
Address:
City:
Cholet
Zip:
49300
Country:
France
Status:
Recruiting
Investigator:
Last name:
Sylvere Guillemois
Email:
Principal Investigator
Facility:
Name:
Centre Hospitalier Intercommunal Creteil - CHI Creteil
Address:
City:
Creteil
Zip:
94000
Country:
France
Status:
Recruiting
Investigator:
Last name:
Christos Chouaid
Email:
Principal Investigator
Facility:
Name:
CHRU de Lille
Address:
City:
Lille
Zip:
59037
Country:
France
Status:
Recruiting
Investigator:
Last name:
Alexis Cortot
Email:
Principal Investigator
Facility:
Name:
Hopital Nord Marseille
Address:
City:
Marseille
Zip:
13015
Country:
France
Status:
Recruiting
Investigator:
Last name:
Laurent Greillier, PHS
Email:
Principal Investigator
Facility:
Name:
Centre de Cancerologie du Grand Montpellier
Address:
City:
Montpellier
Zip:
34070
Country:
France
Status:
Recruiting
Investigator:
Last name:
Catherine Becht
Email:
Principal Investigator
Facility:
Name:
Hopital Cochin
Address:
City:
Paris
Zip:
75014
Country:
France
Status:
Recruiting
Investigator:
Last name:
Marie Wislez
Email:
Principal Investigator
Facility:
Name:
Hopital Bichat-Claude Bernard - APHP
Address:
City:
Paris
Zip:
75018
Country:
France
Status:
Recruiting
Investigator:
Last name:
Gerard Zalcman
Email:
Principal Investigator
Facility:
Name:
CHU Bordeaux Hopital Haut-Leveque
Address:
City:
Pessac
Zip:
33604
Country:
France
Status:
Recruiting
Investigator:
Last name:
Remi Veillon
Email:
Principal Investigator
Facility:
Name:
Hospital Center De Cornouaille
Address:
City:
Quimper Cedex
Zip:
29 107
Country:
France
Status:
Recruiting
Investigator:
Last name:
Michel Andre
Email:
Principal Investigator
Facility:
Name:
Centre Hospitalier Universitaire de Rennes, Hopital Pontchaillou
Address:
City:
Rennes
Zip:
35000
Country:
France
Status:
Recruiting
Investigator:
Last name:
Yannick Le Guen
Email:
Principal Investigator
Facility:
Name:
Institut de cancerologie Strasbourg Europe
Address:
City:
Strasbourg
Zip:
67200
Country:
France
Status:
Recruiting
Investigator:
Last name:
Roland Schott
Email:
Principal Investigator
Facility:
Name:
Chits Sainte Musse
Address:
City:
Toulon
Zip:
83 000
Country:
France
Status:
Recruiting
Investigator:
Last name:
Clarisse Audigier-Valette
Email:
Principal Investigator
Facility:
Name:
CHU Toulouse - hopital Larrey
Address:
City:
Toulouse
Zip:
31059
Country:
France
Status:
Recruiting
Investigator:
Last name:
Julien Mazieres
Email:
Principal Investigator
Facility:
Name:
Institut Gustave Roussy
Address:
City:
Villejuif Cedex
Zip:
94805
Country:
France
Status:
Recruiting
Investigator:
Last name:
David Planchard
Email:
Principal Investigator
Facility:
Name:
University Hospital of Besancon
Address:
City:
Besancon Cedex
Zip:
25030
Country:
France
Status:
Recruiting
Investigator:
Last name:
Virginie Westeel
Email:
Principal Investigator
Facility:
Name:
Johanniter Krankenhaus Bonn
Address:
City:
Bonn
Zip:
53113
Country:
Germany
Status:
Recruiting
Investigator:
Last name:
Yon-Dschun Ko
Email:
Principal Investigator
Facility:
Name:
Klinikum Esslingen GmbH
Address:
City:
Esslingen
Zip:
73730
Country:
Germany
Status:
Recruiting
Investigator:
Last name:
Martin Faehling
Email:
Principal Investigator
Facility:
Name:
Asklepios Klinik Gauting GmbH
Address:
City:
Gauting
Zip:
82131
Country:
Germany
Status:
Recruiting
Investigator:
Last name:
Niels Reinmuth
Email:
Principal Investigator
Facility:
Name:
LungenClinic Grosshansdorf
Address:
City:
Grosshansdorf
Zip:
22927
Country:
Germany
Status:
Recruiting
Investigator:
Last name:
Martin Reck, MD
Email:
Principal Investigator
Facility:
Name:
Krankenhaus Martha-Maria Halle-Dölau GmbH
Address:
City:
Halle
Zip:
06120
Country:
Germany
Status:
Recruiting
Investigator:
Last name:
Wolfgang Schutte
Email:
Principal Investigator
Facility:
Name:
Universitatsklinikum Heidelberg
Address:
City:
Heidelberg
Zip:
69126
Country:
Germany
Status:
Recruiting
Investigator:
Last name:
Farastuk Bozorgmehr
Email:
Principal Investigator
Facility:
Name:
Klinikum Kassel GmbH
Address:
City:
Kassel
Zip:
34125
Country:
Germany
Status:
Recruiting
Investigator:
Last name:
Martin Wolf
Email:
Principal Investigator
Facility:
Name:
Alexandra General Hospital of Athens
Address:
City:
Athens
Zip:
11528
Country:
Greece
Status:
Recruiting
Investigator:
Last name:
Flora Zagouri
Email:
Principal Investigator
Facility:
Name:
Metropolitan General Hospital
Address:
City:
Athens
Zip:
18547
Country:
Greece
Status:
Recruiting
Investigator:
Last name:
Helena Linardou
Email:
Principal Investigator
Facility:
Name:
University Hospital of Patras
Address:
City:
Patras
Zip:
26504
Country:
Greece
Status:
Recruiting
Investigator:
Last name:
Angelos Koutras
Email:
Principal Investigator
Facility:
Name:
National Koranyi Institute of Pulmonology
Address:
City:
Budapest
Zip:
1121
Country:
Hungary
Status:
Recruiting
Investigator:
Last name:
Andrea Fulop, MD
Email:
Principal Investigator
Facility:
Name:
Farkasgyepui Tudogyogyintezet
Address:
City:
Farkasgyepu
Zip:
8582
Country:
Hungary
Status:
Recruiting
Investigator:
Last name:
Zsolt Kiraly, MD
Email:
Principal Investigator
Facility:
Name:
Shaare Zedek Medical Center
Address:
City:
Jerusalem
Zip:
9103102
Country:
Israel
Status:
Recruiting
Investigator:
Last name:
Nir Peled
Email:
Principal Investigator
Facility:
Name:
Kaplan Medical Center
Address:
City:
Rehovot
Zip:
7661041
Country:
Israel
Status:
Recruiting
Investigator:
Last name:
Ella Evron
Email:
Principal Investigator
Facility:
Name:
Centro di Riferimento Oncologico di Aviano
Address:
City:
Aviano (Pordenone)
Zip:
33081
Country:
Italy
Status:
Recruiting
Investigator:
Last name:
Alessandra Bearz
Email:
Principal Investigator
Facility:
Name:
Azienda Ospedaliera Spedali Civili di Brescia
Address:
City:
Brescia
Zip:
25123
Country:
Italy
Status:
Recruiting
Investigator:
Last name:
Salvatore Grisanti
Email:
Principal Investigator
Facility:
Name:
Azienda Ospedaliera di Rilievo Nazionale Sant'Anna e San Sebastiano
Address:
City:
Caserta
Zip:
81100
Country:
Italy
Status:
Recruiting
Investigator:
Last name:
Michele Orditura
Email:
Principal Investigator
Facility:
Name:
A.O.U Policlinico G. Rodolico S. Marco
Address:
City:
Catania
Zip:
95123
Country:
Italy
Status:
Recruiting
Investigator:
Last name:
Hector Soto Parra
Email:
Principal Investigator
Facility:
Name:
Azienda Ospedaliera Universitaria San Martino
Address:
City:
Genova
Zip:
16132
Country:
Italy
Status:
Recruiting
Investigator:
Last name:
Carlo Genova
Email:
Principal Investigator
Facility:
Name:
IRCCS Istituto Romagnolo per lo Studio dei Tumori Dino Amadori- IRST S.r.l
Address:
City:
Meldola
Zip:
47014
Country:
Italy
Status:
Recruiting
Investigator:
Last name:
Angelo Del Monte
Email:
Principal Investigator
Facility:
Name:
Ospedale San Raffaele
Address:
City:
Milano
Zip:
20132
Country:
Italy
Status:
Recruiting
Investigator:
Last name:
Alessandra Bulotta
Email:
Principal Investigator
Facility:
Name:
Fondazione IRCCS San Gerardo dei Tintori
Address:
City:
Monza
Zip:
20900
Country:
Italy
Status:
Recruiting
Investigator:
Last name:
Diego Cortinovis
Email:
Principal Investigator
Facility:
Name:
Azienda Ospedaliero Universitaria di Parma
Address:
City:
Parma
Zip:
43126
Country:
Italy
Status:
Recruiting
Investigator:
Last name:
Marcello Tiseo
Email:
Principal Investigator
Facility:
Name:
Istituto Nazionale Tumori 'Regina Elena'
Address:
City:
Roma
Zip:
00144
Country:
Italy
Status:
Recruiting
Investigator:
Last name:
Federico Cappuzzo
Email:
Principal Investigator
Facility:
Name:
Policlinico Universitario Agostino Gemelli
Address:
City:
Roma
Zip:
00168
Country:
Italy
Status:
Recruiting
Investigator:
Last name:
Emilio Bria
Email:
Principal Investigator
Facility:
Name:
A.O.U. - Ospedali Riuniti di Ancona
Address:
City:
Torrette
Zip:
60126
Country:
Italy
Status:
Recruiting
Investigator:
Last name:
Rossana Berardi
Email:
Principal Investigator
Facility:
Name:
National Cancer Center Hospital
Address:
City:
Chuo-ku
Zip:
104-0045
Country:
Japan
Status:
Recruiting
Investigator:
Last name:
Hidehito Horinouchi
Email:
Principal Investigator
Facility:
Name:
The Cancer Institute Hospital of JFCR
Address:
City:
Koto-ku
Zip:
135-8550
Country:
Japan
Status:
Recruiting
Investigator:
Last name:
Ryo Ariyasu
Email:
Principal Investigator
Facility:
Name:
Aichi Cancer Center
Address:
City:
Nagoya-shi
Zip:
464-8681
Country:
Japan
Status:
Recruiting
Investigator:
Last name:
Junichi Shimizu
Email:
Principal Investigator
Facility:
Name:
Cryptex Investigacion Clinica S.C.
Address:
City:
Distrito Federal
Zip:
6100
Country:
Mexico
Status:
Recruiting
Investigator:
Last name:
Daniel Motola Kuba
Email:
Principal Investigator
Facility:
Name:
Maastricht UMC
Address:
City:
Maastricht
Zip:
6229 HX
Country:
Netherlands
Status:
Recruiting
Investigator:
Last name:
Lizza Hendriks
Email:
Principal Investigator
Facility:
Name:
Erasmus Medisch Centrum Daniel Den Hoed
Address:
City:
Rotterdam
Zip:
3015GD
Country:
Netherlands
Status:
Recruiting
Investigator:
Last name:
Joachim G. J. Aerts
Email:
Principal Investigator
Facility:
Name:
Vestre Viken Health Trust
Address:
City:
Drammen
Zip:
3004
Country:
Norway
Status:
Recruiting
Investigator:
Last name:
Odd Terje Brustugun
Email:
Principal Investigator
Facility:
Name:
Oslo University Hospital
Address:
City:
Oslo
Zip:
0450
Country:
Norway
Status:
Recruiting
Investigator:
Last name:
Maria Moksnes Bjaanaes
Email:
Principal Investigator
Facility:
Name:
St. Olavs Hospital
Address:
City:
Trondheim
Zip:
7030
Country:
Norway
Status:
Recruiting
Investigator:
Last name:
Bjorn Henning Gronberg
Email:
Principal Investigator
Facility:
Name:
Medical University of Gdansk
Address:
City:
Gdansk
Zip:
80-214
Country:
Poland
Status:
Recruiting
Investigator:
Last name:
Marcin Skrzypski
Email:
Principal Investigator
Facility:
Name:
Instytut MSF Sp zoo
Address:
City:
Lodz
Zip:
90-302
Country:
Poland
Status:
Recruiting
Investigator:
Last name:
Ewa Kalinka
Email:
Principal Investigator
Facility:
Name:
Institute of Genetics and Immunology GENIM LCC
Address:
City:
Lublin
Zip:
20-609
Country:
Poland
Status:
Recruiting
Investigator:
Last name:
Izabela Chmielewska
Email:
Principal Investigator
Facility:
Name:
Med Polonia Sp. z o. o.
Address:
City:
Poznan
Zip:
60-693
Country:
Poland
Status:
Recruiting
Investigator:
Last name:
Rodryg Ramlau, MD
Email:
Principal Investigator
Facility:
Name:
Spitalul de Oncologie Monza SRL
Address:
City:
Bucuresti
Zip:
13823
Country:
Romania
Status:
Recruiting
Investigator:
Last name:
Ingrid Iordan
Email:
Principal Investigator
Facility:
Name:
Institutul Oncologic "Prof. Dr. I. Chiricuta" Cluj-Napoca
Address:
City:
Cluj-Napoca
Zip:
400015
Country:
Romania
Status:
Recruiting
Investigator:
Last name:
Alina-Simona Muntean
Email:
Principal Investigator
Facility:
Name:
Medisprof Cancer Center
Address:
City:
Cluj-Napoca
Zip:
400641
Country:
Romania
Status:
Recruiting
Investigator:
Last name:
Anghel Adrian Udrea
Email:
Principal Investigator
Facility:
Name:
Ovidius Clinical Hospital S.R.L
Address:
City:
Constanta
Zip:
905900
Country:
Romania
Status:
Recruiting
Investigator:
Last name:
Laura Mazilu
Email:
Principal Investigator
Facility:
Name:
Centrul de Oncologie Sf Nectarie
Address:
City:
Craiova
Zip:
200542
Country:
Romania
Status:
Recruiting
Investigator:
Last name:
Michael Schenker
Email:
Principal Investigator
Facility:
Name:
Oncocenter-Oncologie Clinica SRL
Address:
City:
Timisoara
Zip:
300166
Country:
Romania
Status:
Recruiting
Investigator:
Last name:
Roxana-Ioana Scheusan
Email:
Principal Investigator
Facility:
Name:
Complejo Hospitalario Universitario La Coruna
Address:
City:
A Coruna
Zip:
15009
Country:
Spain
Status:
Recruiting
Investigator:
Last name:
Maria Rosario Garcia Campelo
Email:
Principal Investigator
Facility:
Name:
Hospital Universitari Germans Trias i Pujol
Address:
City:
Badalona
Zip:
08916
Country:
Spain
Status:
Recruiting
Investigator:
Last name:
Enric Carcereny
Email:
Principal Investigator
Facility:
Name:
Hospital Universitari Vall d'Hebron
Address:
City:
Barcelona
Zip:
08035
Country:
Spain
Status:
Recruiting
Investigator:
Last name:
Enriqueta Felip Font
Email:
Principal Investigator
Facility:
Name:
Hospital General Universitario Gregorio Maranon
Address:
City:
Madrid
Zip:
28007
Country:
Spain
Status:
Recruiting
Investigator:
Last name:
Rosa Alvarez
Email:
Principal Investigator
Facility:
Name:
Hospital Universitario 12 de Octubre
Address:
City:
Madrid
Zip:
28041
Country:
Spain
Status:
Recruiting
Investigator:
Last name:
Luis Paz-Ares Rodriguez
Email:
Principal Investigator
Facility:
Name:
Hospital Quiron Salud Malaga
Address:
City:
Malaga
Zip:
29004
Country:
Spain
Status:
Recruiting
Investigator:
Last name:
Manuel Cobo Dols
Email:
Principal Investigator
Facility:
Name:
Hospital Universitario Son Espases
Address:
City:
Palma de Mallorca
Zip:
07120
Country:
Spain
Status:
Recruiting
Investigator:
Last name:
Raquel Marse Fabregat
Email:
Principal Investigator
Facility:
Name:
Fundación Instituto Valenciano de Oncología (FIVO)
Address:
City:
Valencia
Zip:
46009
Country:
Spain
Status:
Recruiting
Investigator:
Last name:
Sergio Sandiego Contreras
Email:
Principal Investigator
Facility:
Name:
Hospital Universitari i Politecnic La Fe de Valencia
Address:
City:
Valencia
Zip:
46026
Country:
Spain
Status:
Recruiting
Investigator:
Last name:
Oscar Jose Juan Vidal
Email:
Principal Investigator
Facility:
Name:
Hospital Clinico Universitario Lozano Blesa de Zaragoza
Address:
City:
Zaragoza
Zip:
50009
Country:
Spain
Status:
Recruiting
Investigator:
Last name:
Dolores Isla Casado
Email:
Principal Investigator
Facility:
Name:
Universitatsspital Basel
Address:
City:
Basel
Zip:
4031
Country:
Switzerland
Status:
Recruiting
Investigator:
Last name:
Andreas Schmitt
Email:
Principal Investigator
Facility:
Name:
Stiftung Kantonsspital Graubunden
Address:
City:
Chur
Zip:
7000
Country:
Switzerland
Status:
Recruiting
Investigator:
Last name:
Michael Mark
Email:
Principal Investigator
Facility:
Name:
University Hospital Lausanne CHUV
Address:
City:
Lausanne
Zip:
1011
Country:
Switzerland
Status:
Recruiting
Investigator:
Last name:
Hasna Bouchaab
Email:
Principal Investigator
Facility:
Name:
Universitatsspital Zurich
Address:
City:
Zurich
Zip:
CH-8091
Country:
Switzerland
Status:
Recruiting
Investigator:
Last name:
Lorenz Bankel
Email:
Principal Investigator
Facility:
Name:
Changhua Christian Hospital
Address:
City:
Changhua
Zip:
50006
Country:
Taiwan
Status:
Recruiting
Investigator:
Last name:
Sheng-Hao Lin
Email:
Principal Investigator
Facility:
Name:
National Taiwan University Hospital Yunlin Branch
Address:
City:
Douliou City
Zip:
640
Country:
Taiwan
Status:
Recruiting
Investigator:
Last name:
Chung-Yu Chen
Email:
Principal Investigator
Facility:
Name:
Kaohsiung Medical University Hospital
Address:
City:
Kaohsiung
Zip:
807
Country:
Taiwan
Status:
Recruiting
Investigator:
Last name:
Jen-Yu Hung
Email:
Principal Investigator
Facility:
Name:
Taipei Veterans General Hospital
Address:
City:
Taipei City
Zip:
11217
Country:
Taiwan
Status:
Recruiting
Investigator:
Last name:
Yung-Hung Luo
Email:
Principal Investigator
Facility:
Name:
Barts Health NHS Trust Saint Bartholomews Hospital
Address:
City:
London
Zip:
EC1A 7BE
Country:
United Kingdom
Status:
Recruiting
Investigator:
Last name:
Adam Januszewski
Email:
Principal Investigator
Facility:
Name:
Sarah Cannon Research Institute UK
Address:
City:
London
Zip:
W1G 6AD
Country:
United Kingdom
Status:
Recruiting
Investigator:
Last name:
Kroopa Joshi
Email:
Principal Investigator
Start date:
February 21, 2024
Completion date:
July 31, 2028
Lead sponsor:
Agency:
Seagen Inc.
Agency class:
Industry
Source:
Seagen Inc.
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06012435
